LOCUS       NM_031291               1812 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 31 (SLC25A31),
            transcript variant 1, mRNA.
ACCESSION   NM_031291
VERSION     NM_031291.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Trisolini,L., Laera,L., Favia,M., Muscella,A., Castegna,A.,
            Pesce,V., Guerra,L., De Grassi,A., Volpicella,M. and Pierri,C.L.
  TITLE     Differential Expression of ADP/ATP Carriers as a Biomarker of
            Metabolic Remodeling and Survival in Kidney Cancers
  JOURNAL   Biomolecules 11 (1), 38 (2020)
   PUBMED   33396658
  REMARK    GeneRIF: Differential Expression of ADP/ATP Carriers as a Biomarker
            of Metabolic Remodeling and Survival in Kidney Cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Marginedas-Freixa,I., Hattab,C., Bouyer,G., Halle,F., Chene,A.,
            Lefevre,S.D., Cambot,M., Cueff,A., Schmitt,M., Gamain,B.,
            Lacapere,J.J., Egee,S., Bihel,F., Le Van Kim,C. and Ostuni,M.A.
  TITLE     TSPO ligands stimulate ZnPPIX transport and ROS accumulation
            leading to the inhibition of P. falciparum growth in human blood
  JOURNAL   Sci Rep 6, 33516 (2016)
   PUBMED   27641616
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Gallerne,C., Touat,Z., Chen,Z.X., Martel,C., Mayola,E., Sharaf el
            dein,O., Buron,N., Le Bras,M., Jacotot,E., Borgne-Sanchez,A.,
            Lemoine,A., Lemaire,C., Pervaiz,S. and Brenner,C.
  TITLE     The fourth isoform of the adenine nucleotide translocator inhibits
            mitochondrial apoptosis in cancer cells
  JOURNAL   Int J Biochem Cell Biol 42 (5), 623-629 (2010)
   PUBMED   20060930
  REMARK    GeneRIF: data highlight a cytoprotective activity of ANT4, and
            provide a novel dichotomy in the ANT isoform sub-family with ANT1
            and 3 isoforms functioning as pro-apoptotic while ANT2 and 4
            isoforms render cells resistant to death inducing stimuli
REFERENCE   7  (bases 1 to 1812)
  AUTHORS   Brower,J.V., Lim,C.H., Jorgensen,M., Oh,S.P. and Terada,N.
  TITLE     Adenine nucleotide translocase 4 deficiency leads to early meiotic
            arrest of murine male germ cells
  JOURNAL   Reproduction 138 (3), 463-470 (2009)
   PUBMED   19556438
  REMARK    GeneRIF: Male mice with disruptions of Slc25a31 are sterile and
            display an early meiotic arrest phenotype.
REFERENCE   8  (bases 1 to 1812)
  AUTHORS   Kim,Y.H., Haidl,G., Schaefer,M., Egner,U., Mandal,A. and Herr,J.C.
  TITLE     Compartmentalization of a unique ADP/ATP carrier protein SFEC
            (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in
            the fibrous sheath of the human sperm flagellar principal piece
  JOURNAL   Dev Biol 302 (2), 463-476 (2007)
   PUBMED   17137571
  REMARK    GeneRIF: The co-localization of SFEC and glycolytic enzymes in the
            fibrous sheath supports a growing literature that the principal
            piece of the flagellum is capable of generating and regulating ATP
            independently from mitochondrial oxidation in the mid-piece.
REFERENCE   9  (bases 1 to 1812)
  AUTHORS   Dolce,V., Scarcia,P., Iacopetta,D. and Palmieri,F.
  TITLE     A fourth ADP/ATP carrier isoform in man: identification, bacterial
            expression, functional characterization and tissue distribution
  JOURNAL   FEBS Lett 579 (3), 633-637 (2005)
   PUBMED   15670820
REFERENCE   10 (bases 1 to 1812)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ438347.1, BC022032.2 and
            BG192958.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031291.3.
            
            Summary: The protein encoded by this gene is a member of the
            ADP/ATP carrier family of proteins that exchange cytosolic ADP for
            matrix ATP in the mitochondria. Cells over-expressing this gene
            have been shown to display an anti-apoptotic phenotype. This
            protein is also thought to play a role in spermatogenesis, where it
            is believed to associate with a part of the flagellar cytoskeleton
            and with glycolytic enzymes. Male mice with mutations in the mouse
            ortholog of this gene are sterile and spermatocytes display an
            early meiotic arrest phenotype. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.180379.1,
                                           SRR5189667.246184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000281154.6/
                                                  ENSP00000281154.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BQ438347.1         26-56
            32-1737             BC022032.2         5-1710
            1738-1812           BG192958.1         23-97               c
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.1"
     gene            1..1812
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /note="solute carrier family 25 member 31"
                     /db_xref="GeneID:83447"
                     /db_xref="HGNC:HGNC:25319"
                     /db_xref="MIM:610796"
     exon            1..378
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1094
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adenine nucleotide translocase 4; ADP/ATP translocase 4;
                     ADP,ATP carrier protein 4; adenine nucleotide translocator
                     4; sperm flagellar energy carrier protein; solute carrier
                     family 25 (mitochondrial carrier; adenine nucleotide
                     translocator), member 31"
                     /codon_start=1
                     /product="ADP/ATP translocase 4 isoform 1"
                     /protein_id="NP_112581.1"
                     /db_xref="CCDS:CCDS3733.1"
                     /db_xref="GeneID:83447"
                     /db_xref="HGNC:HGNC:25319"
                     /db_xref="MIM:610796"
                     /translation="MHREPAKKKAEKRLFDASSFGKDLLAGGVAAAVSKTAVAPIERV
                     KLLLQVQASSKQISPEARYKGMVDCLVRIPREQGFFSFWRGNLANVIRYFPTQALNFA
                     FKDKYKQLFMSGVNKEKQFWRWFLANLASGGAAGATSLCVVYPLDFARTRLGVDIGKG
                     PEERQFKGLGDCIMKIAKSDGIAGLYQGFGVSVQGIIVYRASYFGAYDTVKGLLPKPK
                     KTPFLVSFFIAQVVTTCSGILSYPFDTVRRRMMMQSGEAKRQYKGTLDCFVKIYQHEG
                     ISSFFRGAFSNVLRGTGGALVLVLYDKIKEFFHIDIGGR"
     exon            379..506
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            507..624
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            625..779
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            780..905
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1812
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1791..1796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /note="hexamer: AATAAA"
     polyA_site      1812
                     /gene="SLC25A31"
                     /gene_synonym="AAC4; ANT 4; ANT4; SFEC35kDa"
                     /note="major polyA site"
ORIGIN      
        1 gccggcgcgc ggctctctca gcgtcccaag agccactttc tcgccagtac gatgctgcag
       61 cggttttccg gttttccgct tcccttcatc gtagctcccg tactcatttt tagccactgc
      121 tgccggtttt tatatccttc tccatcatgc atcgtgagcc tgcgaaaaag aaggcagaaa
      181 agcggctgtt tgacgcctca tccttcggga aggaccttct ggccggcgga gtcgcggcag
      241 ctgtgtccaa gacagcggtg gcgcccatcg agcgggtgaa gctgctgctg caggtgcagg
      301 cgtcgtcgaa gcagatcagc cccgaggcgc ggtacaaagg catggtggac tgcctggtgc
      361 ggattcctcg cgagcagggt ttcttcagtt tttggcgtgg caatttggca aatgttattc
      421 ggtattttcc aacacaagct ctaaactttg cttttaagga caaatacaag cagctattca
      481 tgtctggagt taataaagaa aaacagttct ggaggtggtt tttggcaaac ctggcttctg
      541 gtggagctgc tggggcaaca tccttatgtg tagtatatcc tctagatttt gcccgaaccc
      601 gattaggtgt cgatattgga aaaggtcctg aggagcgaca attcaagggt ttaggtgact
      661 gtattatgaa aatagcaaaa tcagatggaa ttgctggttt ataccaaggg tttggtgttt
      721 cagtacaggg catcattgtg taccgagcct cttattttgg agcttatgac acagttaagg
      781 gtttattacc aaagccaaag aaaactccat ttcttgtctc ctttttcatt gctcaagttg
      841 tgactacatg ctctggaata ctttcttatc cctttgacac agttagaaga cgtatgatga
      901 tgcagagtgg tgaggctaaa cggcaatata aaggaacctt agactgcttt gtgaagatat
      961 accaacatga aggaatcagt tccttttttc gtggcgcctt ctccaatgtt cttcgcggta
     1021 cagggggtgc tttggtgttg gtattatatg ataaaattaa agaattcttt catattgata
     1081 ttggtggtag gtaatcggga gagtaaatta agaaatacat ggatttaact tgttaaacat
     1141 acaaattaca tagctgccat ttgcatacat tttgatagtg ttattgtctg tattttgtta
     1201 aagtgctagt tctgcaataa agcatacatt ttttcaagaa tttaaatact aaaaatcaga
     1261 taaatgtgga ttttcctccc acttagactc aaacacattt tagtgtgata tttcatttat
     1321 tataggtagt atattttaat ttgttagttt aaaattcttt ttatgattaa aaattaatca
     1381 tataatccta gattaatgct gaaatctagg aaatgaaagt agcgtctttt aaattgctat
     1441 tcatttaata tacctgtttt cccatctttt gaagtcatat ggtatgacat atttcttaaa
     1501 agcttatcaa tagatgtcat catatgtgta ggcagaaata agctttgttc tatatctctt
     1561 ctaagacagt tgttattact gtgtataata tttacagtat cagcctttga ttatagatgt
     1621 gatcatttaa aatttgataa tgactttagt gacattataa aactgaaact ggaaaataaa
     1681 atggcttatc tgctgatgtt tatctttaaa ataaataaaa tcttgctagt gtgaatatat
     1741 cttagaacaa aaggtatcct cttgaaaatt agtttgtata ttttgttgac aataaaggaa
     1801 gcttaactgt ta
//
