LOCUS       NM_001010875            3663 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 30 (SLC25A30),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001010875 XM_170736
VERSION     NM_001010875.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Gorgoglione,R., Porcelli,V., Santoro,A., Daddabbo,L., Vozza,A.,
            Monne,M., Di Noia,M.A., Palmieri,L., Fiermonte,G. and Palmieri,F.
  TITLE     The human uncoupling proteins 5 and 6 (UCP5/SLC25A14 and
            UCP6/SLC25A30) transport sulfur oxyanions, phosphate and
            dicarboxylates
  JOURNAL   Biochim Biophys Acta Bioenerg 1860 (9), 724-733 (2019)
   PUBMED   31356773
REFERENCE   3  (bases 1 to 3663)
  AUTHORS   Shanmughapriya,S., Rajan,S., Hoffman,N.E., Higgins,A.M., Tomar,D.,
            Nemani,N., Hines,K.J., Smith,D.J., Eguchi,A., Vallem,S., Shaikh,F.,
            Cheung,M., Leonard,N.J., Stolakis,R.S., Wolfers,M.P., Ibetti,J.,
            Chuprun,J.K., Jog,N.R., Houser,S.R., Koch,W.J., Elrod,J.W. and
            Madesh,M.
  TITLE     SPG7 Is an Essential and Conserved Component of the Mitochondrial
            Permeability Transition Pore
  JOURNAL   Mol Cell 60 (1), 47-62 (2015)
   PUBMED   26387735
REFERENCE   4  (bases 1 to 3663)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   5  (bases 1 to 3663)
  AUTHORS   Haguenauer,A., Raimbault,S., Masscheleyn,S., Gonzalez-Barroso
            Mdel,M., Criscuolo,F., Plamondon,J., Miroux,B., Ricquier,D.,
            Richard,D., Bouillaud,F. and Pecqueur,C.
  TITLE     A new renal mitochondrial carrier, KMCP1, is up-regulated during
            tubular cell regeneration and induction of antioxidant enzymes
  JOURNAL   J Biol Chem 280 (23), 22036-22043 (2005)
   PUBMED   15809292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC322809.1, AK094133.1, AK095465.1 and AL627107.33.
            
            On Nov 22, 2018 this sequence version replaced NM_001010875.3.
            
            Summary: Although the outer mitochondrial membrane is permeable to
            many small metabolites, transport of solutes across the inner
            mitochondrial membrane is achieved by members of the mitochondrial
            carrier protein family, such as SLC25A30 (Haguenauer et al., 2005
            [PubMed 15809292]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094133.1, SRR1803617.183841.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000519676.6/
                                                  ENSP00000429168.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               DC322809.1         40-146
            108-913             AK094133.1         117-922
            914-1261            AK095465.1         776-1123
            1262-3663           AL627107.33        39800-42201         c
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.13"
     gene            1..3663
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /note="solute carrier family 25 member 30"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
     exon            1..74
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            75..193
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1005
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     kidney mitochondrial carrier protein 1; uncoupling protein
                     6"
                     /codon_start=1
                     /product="kidney mitochondrial carrier protein 1 isoform
                     1"
                     /protein_id="NP_001010875.1"
                     /db_xref="CCDS:CCDS31967.1"
                     /db_xref="GeneID:253512"
                     /db_xref="HGNC:HGNC:27371"
                     /db_xref="MIM:610793"
                     /translation="MSALNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKF
                     KEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPE
                     DETLPINVICGILSGVISSTIANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRG
                     LWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALAS
                     NPVDVVRTRMMNQRVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWN
                     IIFFVTYEQLKKLDL"
     exon            194..341
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..436
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..522
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..618
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            619..743
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..882
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..963
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..3663
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3646..3651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /note="hexamer: AATATA"
     polyA_site      3663
                     /gene="SLC25A30"
                     /gene_synonym="KMCP1"
                     /note="major polyA site"
ORIGIN      
        1 cttttctcca gcggcctcag gttcttgtta caactgagtc cgggttggag gaggtgtggg
       61 gccgctgccg ccaggaaaaa cagcactgga ggcaatgttt ctataaatca aagaagagac
      121 agtgtgagaa tgtcagccct caactggaag ccgtttgtgt acggggggct ggcctccatc
      181 actgctgagt gcggtacatt tccaattgat ttaaccaaga cacggctcca gattcaaggc
      241 cagacgaatg atgcaaaatt taaggaaatt agataccgag gaatgttgca cgcattagtg
      301 aggataggca gagaagaagg gctgaaagca ctctactcgg ggattgcccc cgcgatgtta
      361 cgccaggcat cctatggcac catcaagata ggcacttacc agagcttgaa gcgactattc
      421 attgaacgcc cagaagatga aactctaccg ataaatgtga tatgtggaat tctgtctgga
      481 gtcatatctt caaccattgc taatccaact gatgttttga aaattcggat gcaagcgcaa
      541 agcaacacca ttcaaggagg aatgataggc aacttcatga acatttacca gcaagagggg
      601 acaagaggac tgtggaaggg tgtgtccctt actgcgcaga gggctgctat tgttgttggt
      661 gtggagctgc cggtctatga catcaccaag aagcatctta ttctctcagg cctgatggga
      721 gacactgtgt atacccactt cctctcaagc ttcacctgtg gtctggcagg ggccctggcc
      781 tcaaaccctg ttgatgttgt gaggacacgt atgatgaatc agagagtgct tcgagatggc
      841 agatgttctg gctacacagg aaccctggat tgcttgttac agacatggaa gaatgaaggg
      901 ttttttgctc tctataaagg cttttggcca aattggttga gacttggtcc ttggaatatc
      961 attttctttg tgacatacga gcagttgaag aaattggatt tgtgacaagc caaggctgca
     1021 tgagacatct ttctgaaaat ggtaacttct gaaacagcaa agcttcctgt gtttcactct
     1081 gcttctcact gcttggctca tcacagattc tgggatgtga gcaacagatg aagactgggt
     1141 tagttgagat tgctgtgtgt tggcattgga tgctcttcat caaacgttta atggcataaa
     1201 ctaacatcca aacactagtc tttaccactg aagtgccctt caacatcaaa gataatatgt
     1261 gaaatgcatg tttcttgcta aagaaaactt gcaagaaaat caggagcgat gtattgtttt
     1321 attcagggag agtagctcct gatgcatctc agctcatgac tgagaatcag actgctctag
     1381 aaaagctcac tggaaccatg gaatggagcc tccgagaagg tgttatggtt tctgaatttc
     1441 tgggagattt tgctccttgt caactgaaga aatttcatgt atggagacct ggactgttca
     1501 accccaggta taaacggtgc aggaaatgga tcctaggaat atcacactgc tttatcattt
     1561 cctattttgg caggatcttc cacttataat aagtgatttt aagctttgaa gacttgacat
     1621 ttgtgagaaa ttgttacaaa gtaataatct ctaaattcgt ggtggtgtta tgtgttggct
     1681 ttgaaggttg caaggtctgt attggtgggg ggtgttttca agcagcttag gttctgtctt
     1741 aggtcatgtt agtaattagc tttatgattt ttagcaaagc atatgtattt ctcaatgagt
     1801 aaaatgggga taataacgtc tattgatgta gagggtcaaa tgaagaacaa atagtagctg
     1861 ctgctacttg actggaaagg taaatgtgtt tacatcatgc tgtggaacag ctctaaacag
     1921 tctatgtaga agaggggcat gttctcatgg gcttctcatg gtaattgtga atgaagccct
     1981 ttgttaaggt cttgttgaag aaagaacact gtataagttc aggctttagt acattttcct
     2041 tagcaaaatg ttggtagtga atcaaagagt tgatttttcc aggtttccag tttttacttt
     2101 agtttatgtt gtgcctgtct tggactttct gtttagtttg gatggaaaat acctgcttga
     2161 aattttaaaa atgatttctt tagtgcatct atttagctag tttctgatag gtggtatgta
     2221 atattttccc tttttctttc cttctgtaga cacaataagt cattctccct cttctttttt
     2281 tctttttcta ttttcttatt ctttactcta acctgcttca gagaaagagc cctcttcctt
     2341 cttgtcttca tcttagtctt ttcaaaataa aagatgactg tgagaacccc aagaacttcc
     2401 acttctggga ggcagccaca ggacagggaa catatttatt tgggtctctt cagttccccc
     2461 tttgagaaca acattaaata catgttagct ggggctccag ggcattctcc ttccacagta
     2521 gtgcggccaa attcccagtc tggccagtct ctttgttgag actgaataga aggactgcag
     2581 gtttttttgg aggatgagat aatttttcct cgcaggcatt tttcccttgc cttccttatg
     2641 catgaatggt ccctttgaat attatttcca aaagtgagag ctaagacaaa gtcatcaaaa
     2701 agagaggata acagaaggtg ggggcggggg cggggtgcag tggggtaggg ttacctgtta
     2761 attgctgaga ctcagatgaa agtccagctc tccctgggca accctagagg gcagcagagg
     2821 accccagagc tcattcaggc cttgctgctt gttctaaact acaccttagg attttttctt
     2881 ctttccaaaa cattccattg attttataaa gactttctat agagaggctt tcacttttga
     2941 gttctttgag tttaaagatt gcttttcttg aaatgctctt tttttaatgt agaaaaattt
     3001 tactttttca aatatgcata caatttttaa aacagtagaa gcaaattcat tttaatgacc
     3061 atgtaaagag cgaatgtcag acagtattat taccagttta ttcaaattac atacatgttc
     3121 ctaccaaggt ggaaagaaat tcaaacctca tggtaaaact taagcacgat ttaagataaa
     3181 agcatagtat ttcttcagtg tagacttatt aagtgcctta ttgaacagga tcttaacctg
     3241 ctttttctgt ttttttgaaa gagttaatgc aattgttgaa gcttctaacc aagaaacaac
     3301 ttaaggaatt gggagacttg gtcccctcgt tgtcagggtt ctggctataa gtacctcccc
     3361 acctttgggt tttcttaaat atgccaaaag gaattctagt ttttataacc aatgggtttt
     3421 tttgtttgtg tgcttatgga tttgtgtaat cattgatgct taatgttgtg gattcataat
     3481 ataaaaagtg gctcctgtcc tttatattta ttcatgtgct agaaatagta tgcattatat
     3541 aaagagtatg aagttttcat aagcctttat atttcaagct ctttatttaa acattgttgg
     3601 aatatgtggc ataagccttg tttcatttat ttaataaact ggagtaatat ataataataa
     3661 aaa
//
