LOCUS       NM_002635               5984 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 3 (SLC25A3),
            transcript variant 2, mRNA.
ACCESSION   NM_002635
VERSION     NM_002635.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5984)
  AUTHORS   Wang,P., Zhou,W., Chen,F., Zhang,X., Zhang,Q., Chen,Y. and Zhang,N.
  TITLE     METTL14-mediated methylation of SLC25A3 mitigates mitochondrial
            damage in osteoblasts, leading to the improvement of osteoporosis
  JOURNAL   Exp Gerontol 194, 112496 (2024)
   PUBMED   38897394
  REMARK    GeneRIF: METTL14-mediated methylation of SLC25A3 mitigates
            mitochondrial damage in osteoblasts, leading to the improvement of
            osteoporosis.
REFERENCE   2  (bases 1 to 5984)
  AUTHORS   Xiao,F., Jia,Y., Zhang,S., Liu,N., Zhang,X., Wang,T., Qiao,J.,
            Yang,G., Che,X., Chen,K., Pan,P., Zhou,L., Sun,B., Chen,J. and
            Wan,P.
  TITLE     SLC25A3 negatively regulates NLRP3 inflammasome activation by
            restricting the function of NLRP3
  JOURNAL   J Biol Chem 300 (5), 107233 (2024)
   PUBMED   38552738
  REMARK    GeneRIF: SLC25A3 negatively regulates NLRP3 inflammasome activation
            by restricting the function of NLRP3.
REFERENCE   3  (bases 1 to 5984)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 5984)
  AUTHORS   Cobine,P.A., Moore,S.A. and Leary,S.C.
  TITLE     Getting out what you put in: Copper in mitochondria and its impacts
            on human disease
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118867 (2021)
   PUBMED   32979421
  REMARK    GeneRIF: Getting out what you put in: Copper in mitochondria and
            its impacts on human disease.
            Review article
REFERENCE   5  (bases 1 to 5984)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5984)
  AUTHORS   Marsh,S., Carter,N.P., Dolce,V., Iacobazzi,V. and Palmieri,F.
  TITLE     Chromosomal localization of the mitochondrial phosphate carrier
            gene PHC to 12q23
  JOURNAL   Genomics 29 (3), 814-815 (1995)
   PUBMED   8575787
REFERENCE   7  (bases 1 to 5984)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 5984)
  AUTHORS   Jabs,E.W., Thomas,P.J., Bernstein,M., Coss,C., Ferreira,G.C. and
            Pedersen,P.L.
  TITLE     Chromosomal localization of genes required for the terminal steps
            of oxidative metabolism: alpha and gamma subunits of ATP synthase
            and the phosphate carrier
  JOURNAL   Hum Genet 93 (5), 600-602 (1994)
   PUBMED   8168843
REFERENCE   9  (bases 1 to 5984)
  AUTHORS   Dolce,V., Iacobazzi,V., Palmieri,F. and Walker,J.E.
  TITLE     The sequences of human and bovine genes of the phosphate carrier
            from mitochondria contain evidence of alternatively spliced forms
  JOURNAL   J Biol Chem 269 (14), 10451-10460 (1994)
   PUBMED   8144629
REFERENCE   10 (bases 1 to 5984)
  AUTHORS   Dolce,V., Fiermonte,G., Messina,A. and Palmieri,F.
  TITLE     Nucleotide sequence of a human heart cDNA encoding the
            mitochondrial phosphate carrier
  JOURNAL   DNA Seq 2 (2), 133-135 (1991)
   PUBMED   1777677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI458030.1, X60036.1,
            BX647062.1 and AC013283.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002635.3.
            
            Summary: The protein encoded by this gene catalyzes the transport
            of phosphate into the mitochondrial matrix, either by proton
            cotransport or in exchange for hydroxyl ions. The protein contains
            three related segments arranged in tandem which are related to
            those found in other characterized members of the mitochondrial
            carrier family. Both the N-terminal and C-terminal regions of this
            protein protrude toward the cytosol. Multiple alternatively spliced
            transcript variants have been isolated. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (2) represents the predominant
            transcript. Variants 2 and 3 encode the same isoform (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.93257.1,
                                           SRR1803611.491331.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000552981.6/
                                                  ENSP00000448708.2
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BI458030.1         101-111
            12-1093             X60036.1           1-1082
            1094-1603           BX647062.1         2711-3220
            1604-1610           AC013283.23        48597-48603
            1611-1617           BX647062.1         3228-3234
            1618-5984           AC013283.23        48611-52977
FEATURES             Location/Qualifiers
     source          1..5984
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.1"
     gene            1..5984
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /note="solute carrier family 25 member 3"
                     /db_xref="GeneID:5250"
                     /db_xref="HGNC:HGNC:10989"
                     /db_xref="MIM:600370"
     exon            1..55
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            56..216
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1145
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; phosphate transport protein; solute carrier
                     family 25 (mitochondrial carrier; phosphate carrier),
                     member 3"
                     /codon_start=1
                     /product="solute carrier family 25 member 3 isoform b
                     precursor"
                     /protein_id="NP_002626.1"
                     /db_xref="CCDS:CCDS9065.1"
                     /db_xref="GeneID:5250"
                     /db_xref="HGNC:HGNC:10989"
                     /db_xref="MIM:600370"
                     /translation="MFSSVAHLARANPFNTPHLQLVHDGLGDLRSSSPGPTGQPRRPR
                     NLAAAAVEEYSCEFGSAKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGI
                     FNGFSVTLKEDGVRGLAKGWAPTFLGYSMQGLCKFGFYEVFKVLYSNMLGEENTYLWR
                     TSLYLAASASAEFFADIALAPMEAAKVRIQTQPGYANTLRDAAPKMYKEEGLKAFYKG
                     VAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECSKPEQLVVTFVAGYIAGVFC
                     AIVSHPADSVVSVLNKEKGSSASLVLKRLGFKGVWKGLFARIIMIGTLTALQWFIYDS
                     VKVYFRLPRPPPPEMPESLKKKLGLTQ"
     exon            217..338
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            339..518
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            519..700
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            701..873
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            874..984
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            985..5984
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /note="hexamer: AATAAA"
     polyA_site      1325
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /note="major polyA site"
     regulatory      1552..1557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /note="hexamer: ATTATA"
     polyA_site      1563
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
     regulatory      5971..5976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
                     /note="hexamer: AATAAA"
     polyA_site      5984
                     /gene="SLC25A3"
                     /gene_synonym="OK/SW-cl.48; PHC; PiC; PTP"
ORIGIN      
        1 ctctgtgagc cgcaaccttt ccaagggagt ggttgtgtga tcgccatctt agggaaaaga
       61 tgttctcgtc cgtggcgcac ctggcgcggg cgaacccctt caacacgcca catctgcagc
      121 tggtgcacga tggtctcggg gacctccgca gcagctcccc agggcccacg ggccagcccc
      181 gccgccctcg caacctggca gccgccgccg tggaagagta cagttgtgaa tttggctccg
      241 cgaagtatta tgcactgtgt ggctttggtg gggtcttaag ttgtggtctg acacacactg
      301 ctgtggttcc cctggattta gtgaaatgcc gtatgcaggt ggacccccaa aagtacaagg
      361 gcatatttaa cggattctca gttacactta aagaggatgg tgttcgtggt ttggctaaag
      421 gatgggctcc gactttcctt ggctactcca tgcagggact ctgcaagttt ggcttttatg
      481 aagtctttaa agtcttgtat agcaatatgc ttggagagga gaatacttat ctctggcgca
      541 catcactata tttggctgcc tctgccagtg ctgaattctt tgctgacatt gccctggctc
      601 ctatggaagc tgctaaggtt cgaattcaaa cccagccagg ttatgccaac actttgaggg
      661 atgcagctcc caaaatgtat aaggaagaag gcctaaaagc attctacaag ggggttgctc
      721 ctctctggat gagacagata ccatacacca tgatgaagtt cgcctgcttt gaacgtactg
      781 ttgaagcact gtacaagttt gtggttccta agccccgcag tgaatgttca aagccagagc
      841 agctggttgt aacatttgta gcaggttaca tagctggagt cttttgtgca attgtttctc
      901 accctgctga ttctgtggta tctgtgttga ataaagaaaa aggtagcagt gcttctctgg
      961 tcctcaagag acttggattt aaaggtgtat ggaagggact gtttgcccgt atcatcatga
     1021 ttggtaccct gactgcacta cagtggttta tctatgactc cgtgaaggtc tacttcagac
     1081 ttcctcgccc tcctccaccc gagatgccag agtctctgaa gaagaagctt gggttaactc
     1141 agtagttaga tcaaagcaaa tgtggactga atctgcttgt tgatcagtgt tgaagaaagt
     1201 gcaaaaggaa cttttatata tttgacagtg taggaaattg tctattcctg atataattac
     1261 tgtagtactc ttgcttaagg caagagtttc agatttactg ttgaaataaa cccaactctt
     1321 catgatttgc ctgtgactta tttttaaaac ttttttaaaa aagatttagc tttaaaatag
     1381 ttggaaagaa tgaagtatat aagttaagga aaaaatacaa aactgaccat gaccattgtt
     1441 ggttgaatat tccagttgct attcagaaat tgtcatatgt ctcaagtttt atcacacaaa
     1501 gttcctgtat ttctagggaa gcagacttta aatttctaaa aacttgattt aattatagtt
     1561 aaatatgtgt agtcatttgt ggttattttg gcaagtaaat gtcagtgtat acttacattt
     1621 ttgcagcatg tactacacct tttttatgtt ggtgagtttg ctaatcctta tttgtaagac
     1681 aaggtaaacc aaattaggct gattcttaga atgacagtaa aggaccaaag tgattgacag
     1741 ctgaaaacaa ttttcaggta cactaattct ctttacacag atctgacttt tttttttttt
     1801 gagacggagt ttcactcttg ttgcccagac gagtgtagtg tcgcgatctc gcctcacggc
     1861 aacctctgcc tcccaggttc aagcgattgt tctgcctcag cctcccaagt agctgggatt
     1921 tcaggcatgt gccaccacgc ccagctaatt ttgtattttt agtagagacg gggtttccct
     1981 gtgttggtca ggctggtctc gaacttccaa cctcaggtga tccgcccgcc tcagcctccc
     2041 aaactgctgg gattataggc atgagccacc gtgcccggct ctgacttttt acagaaaatt
     2101 gaactatttt cagtctggta ttttaagaaa ggtactgctt gacagctgaa ctatatgaat
     2161 gccactgggg aaaaagcatt ccatcatact tagatacgag attggattgt aggtttaagc
     2221 ccatttttaa agagctccta gaaagtgaat tagtttttgt gtttagattc cccttaagtt
     2281 tgattaggaa gtgtataaaa gttcaatctt ttgtaatgac agcccaccac tggaaaaaaa
     2341 acgaaaaacc tagtgtaata tataacatgc tgtttttcaa acactagatt ttacctagag
     2401 tccttatgtg taatacgtgg gttggttaac agtccctacg taaagcgtac agatggcctg
     2461 gagagaaaaa ctttttcaga gattggagag aaatgttact acaaactcat ggtaaggtca
     2521 gtgaactcaa tttagaagcc agtgcagcta gttgcatgtt aacttcttta tatcatcatt
     2581 gcctgaactt gttaaaggtt ccaacatttt acctgtgctg caggaaaaaa ggaaaagttg
     2641 taggtacaaa tttggaccaa actttaaaaa ggtaaagtag gatgtcttct gaacccaacc
     2701 aagtggtggc tgtggtgctt agcagtatca actgtatatt atttcttgct atgttagcaa
     2761 agcatccaaa gatcaatggt gtatgataag cttttctgtg ggtgaagaac tcgggagtat
     2821 cagactcttc tggttctgag tctcatgaag cttttcactt ctgagctgaa aggatgctct
     2881 ttgtgctttt cactattagt ggtatagtct ttcccgaaaa tctctagcat ggtggcttca
     2941 gggcagctgg acttaggtgg tattttgggg ctccaggaga gcttggcaga gttggctttt
     3001 taggacttat ccttcaatgt cacataacat cacttttacc atgctcttgg ttacaacagt
     3061 gatgtctcag aaaccaagtc ccagattgag gaaaaaagga acatagtctc tacctcttcc
     3121 tgagaggaaa gtcagtcaac gtgtaagagg agcagtagaa acgcattagt ccagccaacg
     3181 tgaaagtgga ccgtagatct aaaacatttt gggtatgcag ttcagccagc ccttactgag
     3241 gcagttctgc caatcaggat tcaagtttta tttcctaaga gttataatag gttttatttg
     3301 tgggcattga tacaaaatac gctgtgttca agctatggag cctgccactg tagttactag
     3361 agttacggtt caaagctatt tctgagagaa agccacttca tcctcaaaac ccaagaggcc
     3421 cacttaaagt gatgcgaatt ctcatttcag gtttttaaat tatactaaaa gattctagta
     3481 agaaaatttt aatatgtatg tattggtgtt ctttttacat ttcatttaat gaaatgtcta
     3541 ctgtcaatac gataaagcag aacccagtgg agtaagaata cacgaaactg ccaggcacag
     3601 tgggtcatgc ctgtaaaccc agcattctgg gaggccgagg cgggtggatc acctgaggtc
     3661 gggagttcaa gaccagcctg accaacatgg agaaaccctg tctctactaa aaatacaaaa
     3721 ttagctgcgg tggtggtgcg tgcctgtaat cccagctact caggaggctg aggcaggaga
     3781 atcgcttgaa cccgggaggc ggaggttgtg gtgagccaag attgcgccat tgcactccag
     3841 cctgggcaac aacagcgaaa ctctgtctca aaaaaaaaaa atatatatat atatatatat
     3901 atatgaagct gatagttgaa ttatgttgat tcagggacaa gatagcattg catagtaact
     3961 tccagtagga tcaaatattt tgagagtggt taaaacgcca aggaatcctg attttatgaa
     4021 attatgcctt ctgataggtg caacaaaatt gaacagaaga gtaacagctt aactaaacct
     4081 ccattgtgtg aaagttttat gaaatgtttt gacttttttt tttttttccc tagagaacag
     4141 ggttcttgct ttgtcgccca ggctggagta cagccttgaa ctcctgggct caagcgatcc
     4201 tcctgcctca gcctcccagt tagctgacac aattgggatg tgccactact tgctcctgtt
     4261 ttttcataga cgggtcctgc tgttgctcag gctggtctcg gattcctggc ctcaagcaac
     4321 tttcctgccc cagctcctaa agcggccagg gttacaggta gccgccttgt ctgtcccgtt
     4381 tcgaccatat tttatttttg agaaggtctt gctctgtcgc cagactggag tgcagtggca
     4441 cgatgatagc tcactgcagc ctcgatctcc caagctcaag tgatcctccc acctcagcct
     4501 cttgaataac tgggactgca agtgtggacc accatgtctg gctaatgttt tttattttta
     4561 gcagaaatga ggtcttgcta tgttgccaag gctagtcttg aactcctgag ctcaagcgag
     4621 ccttctgcct tggccttcca aagggctggg attagagggc tgagccacca cacttggcca
     4681 accatatttt attttttata tttttatttt atttgatcct tgttctgaaa ccataaagtg
     4741 agtttaacat ttctggctgg gcacagtggc tcatgcctgt aattctaaca ctttaggaga
     4801 ccaaggcagg aggatgcctt gagcccagga gtttgagacc atcctggaca acataatgag
     4861 aaaagaaaat acaaaaatta aggggtgtgg tgacacatgc ctgtagtctc aactatttgg
     4921 gaggctgagg caggaggatt gcttgagccc gagaggttga ggctacagtg agccatgttt
     4981 acgccattgc agtccagcct gggcgacaga gtgaaaccct gtctcaaaaa aaaagtaaca
     5041 tttctatatg atttttggga tcgacatgtc cataatgtta atgaagcgca tagcagtcac
     5101 tagtaaatta ggagttatac attgcttcta tagcatcaga aattgtatat caggccaggt
     5161 gcaaaagctc actcctgaaa tccaagcact ttgggaggct gaggtgggcg gattgcttga
     5221 ggtcaggagt tcaagaacag cctggccaac atgatgaaac cccaggtctc tactaaaaat
     5281 acaaaaattg gtcaggcatg gtggtgcatg cctgtaattc cagctactcg ggaggctgag
     5341 gcaggagaat tgcttgaacc cgggaggcag aggttgcagt gagccaagat tgtgccactg
     5401 cactccagcc tgggcgacag agccagactg tctgaggaag aaattgtata tcaggctggg
     5461 cacagtggct catacccgta atcccagcac tttgggaggc ccaggctggg tatcacttga
     5521 gcccaggagt tggagaccag cctgggcaac aaagtgagac ccctctctct acaaaaaata
     5581 aattagccag gcatggtggc acgtgcctgt aatctcagct acttaggaag ctgaaggagg
     5641 atcgtctgag cccaggagtt tgaggctgca atgagctaca atcacacccc tgcactccgg
     5701 cctgggcgac agagtgataa cctgtctaaa aaaataaaaa taaattgtat aatcatattg
     5761 caattttctt tgcattactg atgaggaaaa atctcaaagt aattgtaaaa aatcctggat
     5821 atcacatagt tgagaaacaa agttatttta aacttacagg actctgtagt tcacagttga
     5881 acactgtggc ttcctgaaat atcaaagaat aatgtacatt aataagccag ctactatcgg
     5941 catcttgtaa aaattaaaaa attaaacata aataaaagtt caaa
//
