LOCUS       NM_031212               1526 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 28 (SLC25A28), mRNA.
ACCESSION   NM_031212
VERSION     NM_031212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1526)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1526)
  AUTHORS   Whiffin,N., Hosking,F.J., Farrington,S.M., Palles,C., Dobbins,S.E.,
            Zgaga,L., Lloyd,A., Kinnersley,B., Gorman,M., Tenesa,A.,
            Broderick,P., Wang,Y., Barclay,E., Hayward,C., Martin,L.,
            Buchanan,D.D., Win,A.K., Hopper,J., Jenkins,M., Lindor,N.M.,
            Newcomb,P.A., Gallinger,S., Conti,D., Schumacher,F., Casey,G.,
            Liu,T., Campbell,H., Lindblom,A., Houlston,R.S., Tomlinson,I.P. and
            Dunlop,M.G.
  CONSRTM   Swedish Low-Risk Colorectal Cancer Study Group
  TITLE     Identification of susceptibility loci for colorectal cancer in a
            genome-wide meta-analysis
  JOURNAL   Hum Mol Genet 23 (17), 4729-4737 (2014)
   PUBMED   24737748
REFERENCE   3  (bases 1 to 1526)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   4  (bases 1 to 1526)
  AUTHORS   Athanasiadis,G., Sabater-Lleal,M., Buil,A., Souto,J.C., Borrell,M.,
            Lathrop,M., Watkins,H., Almasy,L., Hamsten,A. and Soria,J.M.
  TITLE     Genetic determinants of plasma beta-glycoprotein I levels: a
            genome-wide association study in extended pedigrees from Spain
  JOURNAL   J Thromb Haemost 11 (3), 521-528 (2013)
   PUBMED   23279374
REFERENCE   5  (bases 1 to 1526)
  AUTHORS   Hung,H.I., Schwartz,J.M., Maldonado,E.N., Lemasters,J.J. and
            Nieminen,A.L.
  TITLE     Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human
            head and neck squamous carcinoma cells to photodynamic therapy
  JOURNAL   J Biol Chem 288 (1), 677-686 (2013)
   PUBMED   23135267
  REMARK    GeneRIF: Mitoferrin-2-dependent mitochondrial iron uptake
            sensitizes human head and neck squamous carcinoma cells to
            photodynamic therapy
REFERENCE   6  (bases 1 to 1526)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 1526)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1526)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 1526)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1526)
  AUTHORS   Li,F.Y., Nikali,K., Gregan,J., Leibiger,I., Leibiger,B.,
            Schweyen,R., Larsson,C. and Suomalainen,A.
  TITLE     Characterization of a novel human putative mitochondrial
            transporter homologous to the yeast mitochondrial RNA splicing
            proteins 3 and 4
  JOURNAL   FEBS Lett 494 (1-2), 79-84 (2001)
   PUBMED   11297739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD672723.1 and BC047312.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031212.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047312.1, AF327402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000370495.6/
                                                  ENSP00000359526.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CD672723.1         26-53
            29-1526             BC047312.1         1-1498
FEATURES             Location/Qualifiers
     source          1..1526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..1526
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /note="solute carrier family 25 member 28"
                     /db_xref="GeneID:81894"
                     /db_xref="HGNC:HGNC:23472"
                     /db_xref="MIM:609767"
     exon            1..395
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1199
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /note="putative mitochondrial solute carrier;
                     mitochondrial RNA splicing protein 3/4; mitochondrial iron
                     transporter 2; mitochondrial RNA-splicing protein 3/4
                     homolog; solute carrier family 25 (mitochondrial iron
                     transporter), member 28"
                     /codon_start=1
                     /product="mitoferrin-2"
                     /protein_id="NP_112489.3"
                     /db_xref="CCDS:CCDS41559.1"
                     /db_xref="GeneID:81894"
                     /db_xref="HGNC:HGNC:23472"
                     /db_xref="MIM:609767"
                     /translation="MELEGRGAGGVAGGPAAGPGRSPGESALLDGWLQRGVGRGAGGG
                     EAGACRPPVRQDPDSGPDYEALPAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQS
                     LQPDPAARYRNVLEALWRIIRTEGLWRPMRGLNVTATGAGPAHALYFACYEKLKKTLS
                     DVIHPGGNSHIANGAAGCVATLLHDAAMNPAEVVKQRMQMYNSPYHRVTDCVRAVWQN
                     EGAGAFYRSYTTQLTMNVPFQAIHFMTYEFLQEHFNPQRRYNPSSHVLSGACAGAVAA
                     AATTPLDVCKTLLNTQESLALNSHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIY
                     QIPSTAIAWSVYEFFKYLITKRQEEWRAGK"
     exon            396..624
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /inference="alignment:Splign:2.1.0"
     exon            625..681
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /inference="alignment:Splign:2.1.0"
     exon            682..1526
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /note="hexamer: AATAAA"
     polyA_site      1526
                     /gene="SLC25A28"
                     /gene_synonym="MFRN2; MRS3/4; MRS4L; NPD016"
                     /note="major polyA site"
ORIGIN      
        1 gggctctctg ggccgcgcct gaggcggaca ctacggggcc ggggggcggc ggcggcagtg
       61 gtggcagcgg cggcgggggt gggcgccgca gctggcccgg gtggatggag ttggaggggc
      121 ggggtgctgg cggtgtggcg ggggggccgg cggcagggcc cgggcggagc cccggggagt
      181 cggcgctgct ggacgggtgg ctgcagcggg gcgtgggccg gggggccggc ggcggggagg
      241 ccggggcctg caggcccccg gtacgacaag atccggactc cggcccggac tacgaggcgc
      301 tgccggctgg agccactgtc accacgcaca tggtggcagg cgccgtggca gggatcctgg
      361 agcactgcgt gatgtacccc atcgactgcg tcaagacccg gatgcagagt ctacagcctg
      421 acccagctgc ccgctatcgc aatgtgttgg aggccctctg gaggattata agaacggagg
      481 gcctatggag gcccatgagg gggctgaacg tcacagcaac aggcgcaggg cctgcccacg
      541 ccctttattt tgcctgctac gaaaagttaa aaaagacatt gagtgatgta atccaccctg
      601 ggggcaatag ccatattgcc aatggtgcgg ccgggtgtgt ggcaacatta cttcatgatg
      661 cagccatgaa ccctgcggaa gtggtcaagc agaggatgca gatgtacaac tcaccatacc
      721 accgggtgac agactgtgta cgggcagtgt ggcaaaatga aggggccggg gccttttacc
      781 gcagctacac cacccagctg accatgaacg ttcctttcca agccattcac ttcatgacct
      841 atgaattcct gcaggagcac tttaaccccc agagacggta caacccaagc tcccacgtcc
      901 tctctggagc ttgcgcagga gctgtagctg ccgcagccac aaccccactg gacgtttgca
      961 aaacactgct caacacccag gagtccttgg ctttgaactc acacattaca ggacatatca
     1021 caggcatggc tagtgccttc aggacggtat atcaagtagg tggggtgacc gcctatttcc
     1081 gaggggtgca ggccagagta atttaccaga tcccctccac agccatcgca tggtctgtgt
     1141 atgagttctt caaataccta atcactaaaa ggcaagaaga gtggagggct ggcaagtgaa
     1201 gtagcactga acgaagccag gggttcagat gacactgctg catcctggtc acattctctg
     1261 tctcctggaa tgctcccacc tcaagtggag ttagaaggaa ggtagagggg ctctccccca
     1321 ggattttggt gttttgacta acaccagttc ctgccaacct ctgttgccac cacctttcct
     1381 tccaggccct aagcacgtgc agcaaagcac accacagcac ctttgataac ctctctccat
     1441 cctgggcctg atgacctgct ctagactgtt atagagggat aagcagctca ttcccctggt
     1501 tcctaataaa aagcctttaa attaaa
//
