LOCUS       NM_013386               4249 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 25 member 24 (SLC25A24),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_013386
VERSION     NM_013386.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4249)
  AUTHORS   Pannier,E., Sekri,A., Roux,N., Vasiljevic,A., El Khattabi,L.,
            Chatron,N., Grotto,S., Menzella,D., Grange,G., Thebault,F.,
            Massardier,J., Fourrage,C., Lohmann,L., Tsatsaris,V., Putoux,A.,
            Boutaud,L. and Attie-Bitach,T.
  TITLE     Prenatal diagnosis of SLC25A24 Fontaine progeroid syndrome:
            description of the fetal phenotype, genotype and detection of
            parental mosaicism
  JOURNAL   Birth Defects Res 116 (7), e2380 (2024)
   PUBMED   38980211
  REMARK    GeneRIF: Prenatal diagnosis of SLC25A24 Fontaine progeroid
            syndrome: description of the fetal phenotype, genotype and
            detection of parental mosaicism.
REFERENCE   2  (bases 1 to 4249)
  AUTHORS   Gao,L.F., Zhong,Y., Long,T., Wang,X., Zhu,J.X., Wang,X.Y., Hu,Z.Y.
            and Li,Z.G.
  TITLE     Tumor bud-derived CCL5 recruits fibroblasts and promotes colorectal
            cancer progression via CCR5-SLC25A24 signaling
  JOURNAL   J Exp Clin Cancer Res 41 (1), 81 (2022)
   PUBMED   35241150
  REMARK    GeneRIF: Tumor bud-derived CCL5 recruits fibroblasts and promotes
            colorectal cancer progression via CCR5-SLC25A24 signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4249)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 4249)
  AUTHORS   Farrow,E., Chiocchetti,A.G., Rogers,J.C., Pauli,R., Raschle,N.M.,
            Gonzalez-Madruga,K., Smaragdi,A., Martinelli,A., Kohls,G.,
            Stadler,C., Konrad,K., Fairchild,G., Freitag,C.M., Chechlacz,M. and
            De Brito,S.A.
  TITLE     SLC25A24 gene methylation and gray matter volume in females with
            and without conduct disorder: an exploratory epigenetic
            neuroimaging study
  JOURNAL   Transl Psychiatry 11 (1), 492 (2021)
   PUBMED   34561420
  REMARK    GeneRIF: SLC25A24 gene methylation and gray matter volume in
            females with and without conduct disorder: an exploratory
            epigenetic neuroimaging study.
            Erratum:[Transl Psychiatry. 2021 Oct 29;11(1):553. doi:
            10.1038/s41398-021-01643-w.. PMID: 34716293]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4249)
  AUTHORS   Gagne,V., Aubry-Morin,A., Plesa,M., Abaji,R., Petrykey,K.,
            St-Onge,P., Beaulieu,P., Laverdiere,C., Alos,N., Leclerc,J.M.,
            Sallan,S.E., Neuberg,D., Kutok,J.L., Silverman,L.B., Sinnett,D. and
            Krajinovic,M.
  TITLE     Genes identified through genome-wide association studies of
            osteonecrosis in childhood acute lymphoblastic leukemia patients
  JOURNAL   Pharmacogenomics 20 (17), 1189-1197 (2019)
   PUBMED   31686588
  REMARK    GeneRIF: This study confirms implication of the ACP1 gene in the
            treatment-related osteonecrosis in childhood acute lymphoblastic
            leukemia (ALL) and identifies novel, potentially causal variant of
            this complication.
REFERENCE   6  (bases 1 to 4249)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4249)
  AUTHORS   Fiermonte,G., De Leonardis,F., Todisco,S., Palmieri,L.,
            Lasorsa,F.M. and Palmieri,F.
  TITLE     Identification of the mitochondrial ATP-Mg/Pi transporter.
            Bacterial expression, reconstitution, functional characterization,
            and tissue distribution
  JOURNAL   J Biol Chem 279 (29), 30722-30730 (2004)
   PUBMED   15123600
  REMARK    GeneRIF: identification of three isoforms of the mitochondrial
            ATP-Mg/Pi carrier APC1, APC2 and APC3; they are most likely
            responsible for the net uptake or efflux of adenine nucleotides
            into or from the mitochondria
REFERENCE   8  (bases 1 to 4249)
  AUTHORS   del Arco,A. and Satrustegui,J.
  TITLE     Identification of a novel human subfamily of mitochondrial carriers
            with calcium-binding domains
  JOURNAL   J Biol Chem 279 (23), 24701-24713 (2004)
   PUBMED   15054102
  REMARK    GeneRIF: SCaMC-1 is the human orthologue of the rabbit Efinal
            protein, which was reported to be located in peroxisomes
REFERENCE   9  (bases 1 to 4249)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
REFERENCE   10 (bases 1 to 4249)
  AUTHORS   Velasco,D., Olney,A.H. and Starr,L.
  TITLE     SLC25A24 Fontaine Progeroid Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35679445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC309482.1, DC416591.1,
            DC340944.1, BC014519.1, BE243559.1, AW069035.1 and AL390036.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_013386.4.
            
            Summary: This gene encodes a carrier protein that transports ATP-Mg
            exchanging it for phosphate. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068561.1, SRR1660807.2328.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000565488.6/
                                                  ENSP00000457733.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC309482.1         16-28
            14-106              DC416591.1         23-115
            107-468             DC340944.1         107-468
            469-3469            BC014519.1         340-3340
            3470-3500           BE243559.1         32-62               c
            3501-3570           AW069035.1         26-95               c
            3571-4249           AL390036.17        148219-148897       c
FEATURES             Location/Qualifiers
     source          1..4249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..4249
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /note="solute carrier family 25 member 24"
                     /db_xref="GeneID:29957"
                     /db_xref="HGNC:HGNC:20662"
                     /db_xref="MIM:608744"
     exon            1..388
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1639
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     calcium-binding mitochondrial carrier 1; calcium-binding
                     transporter; calcium-binding mitochondrial carrier protein
                     SCaMC-1; mitochondrial ATP-Mg/Pi carrier protein 1; small
                     calcium-binding mitochondrial carrier protein 1;
                     mitochondrial Ca(2+)-dependent solute carrier protein 1;
                     solute carrier family 25 (mitochondrial carrier; phosphate
                     carrier), member 24; ATP-Mg/P(i) co-transporter 1; short
                     calcium-binding mitochondrial carrier protein 1;
                     mitochondrial adenyl nucleotide antiporter SLC25A24"
                     /codon_start=1
                     /product="mitochondrial adenyl nucleotide antiporter
                     SLC25A24 isoform 1"
                     /protein_id="NP_037518.3"
                     /db_xref="CCDS:CCDS41361.1"
                     /db_xref="GeneID:29957"
                     /db_xref="HGNC:HGNC:20662"
                     /db_xref="MIM:608744"
                     /translation="MLRWLRDFVLPTAACQDAEQPTRYETLFQALDRNGDGVVDIGEL
                     QEGLRNLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNN
                     DGKIEASEIVQSLQTLGLTISEQQAELILQSIDVDGTMTVDWNEWRDYFLFNPVTDIE
                     EIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRL
                     KIMMQVHGSKSDKMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYK
                     KLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTGQYSGIYDCAKKI
                     LKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCG
                     ALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPN
                     FMKVLPAVGISYVVYENMKQTLGVTQK"
     exon            389..515
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..603
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            604..715
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..874
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1027
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1135
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1303
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1454
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..4249
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /note="hexamer: AATATA"
     polyA_site      3472
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /note="major polyA site"
     regulatory      3548..3553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /note="hexamer: AATAAA"
     polyA_site      3570
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
     regulatory      4230..4235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
                     /note="hexamer: AATAAA"
     polyA_site      4249
                     /gene="SLC25A24"
                     /gene_synonym="APC1; SCAMC-1; SCAMC1"
ORIGIN      
        1 acaccctgcg ctccgcgcgg gctcgggtgg ggtctccgct cctgcgccct gcgccctgcg
       61 cgccgcagcc gcaaccccga cggcgcccca aacgctgttg cgccgcgcgc cccgcccagc
      121 ccggcctcgc gctggtcccg gtctcgcccc gcagccctcg atctcccgtg acttcctcgg
      181 ccaggccgcc tgcgcctctg ggaccatgtt gcgctggctg cgggacttcg tgctgcccac
      241 cgcggcctgc caggacgcgg agcagccgac gcgctacgag accctcttcc aggcactgga
      301 ccgcaatggg gacggagtgg tggacatcgg cgagctgcag gaggggctca ggaacctggg
      361 catccctctg ggccaggacg ccgaggagaa aatttttact actggagatg tcaacaaaga
      421 tgggaagctg gattttgaag aatttatgaa gtaccttaaa gaccatgaga agaaaatgaa
      481 attggcattt aagagtttag acaaaaataa tgatggaaaa attgaggctt cagaaattgt
      541 ccagtctctc cagacactgg gtctgactat ttctgaacaa caagcagagt tgattcttca
      601 aagcattgat gttgatggga caatgacagt ggactggaat gaatggagag actacttctt
      661 atttaatcct gttacagaca ttgaggaaat tatccgtttc tggaaacatt ctacaggaat
      721 tgacataggg gatagcttaa ctattccaga tgaattcacg gaagacgaaa aaaaatccgg
      781 acaatggtgg aggcagcttt tggcaggagg cattgctggt gctgtctctc gaacaagcac
      841 tgcccctttg gaccgtctga aaatcatgat gcaggttcac ggttcaaaat cagacaaaat
      901 gaacatattt ggtggctttc gacagatggt aaaagaagga ggtatccgct cgctttggag
      961 gggaaatggt acaaacgtca tcaaaattgc tcctgagaca gctgttaaat tctgggcata
     1021 tgaacagtac aagaagttac ttactgaaga aggacaaaaa ataggaacat ttgagagatt
     1081 tatttctggt tccatggctg gagcaactgc acagactttt atatatccaa tggaggttat
     1141 gaaaaccagg ctggctgtag gcaaaactgg gcagtactct ggaatatatg attgtgccaa
     1201 gaagattttg aaacatgaag gcttgggagc tttttacaaa ggctatgttc ccaatttatt
     1261 aggtatcata ccttatgcag gcatagatct tgctgtgtat gagctcttga agtcctattg
     1321 gctggataat tttgcaaaag attctgtaaa ccctggagtc atggtgttgc tgggatgcgg
     1381 tgccttatcc agcacctgtg gtcagctggc cagctaccca ttggctttgg tgagaactcg
     1441 catgcaggct caagccatgt tagaaggttc cccacagctg aatatggttg gcctctttcg
     1501 acgaattatt tccaaagaag gaataccagg actttacaga ggcatcaccc caaacttcat
     1561 gaaggtgctc cctgctgtag gcatcagtta tgtggtttat gaaaatatga agcaaacttt
     1621 aggagtaacc cagaaatgat gttgcatttt ttgctttagc ctgataattg aaactttcaa
     1681 caatctctgg agtgactttt tctcctcgaa ttgaaacaag tctatggcaa aagaagctgc
     1741 atttttttca caaaagggaa gatggtaaca atggtcactt caaacttttg ggctaaatta
     1801 tatgtacaca gaaatgttca aaatcatagt tttaatgtgt tttgaaaagg ccacacaatt
     1861 atactttatc ttttcttaat aatcctgcaa atctctgccc tgaatccgaa atctgaaaat
     1921 gtactggctt gaacaaaatt tgttttgtgt gttagagtta taaatcatta atctttattt
     1981 cgggtggttt acgtttatgc cagttccttt atatttaaat ttcttgtttt atatattttg
     2041 aatgtcttta tagatttctt taaatttcct tatagaacca ttaatagaaa atcattacat
     2101 ttaaaatata ccttacagca aaagcatcca aataagtata gggtttatgt ccttattttt
     2161 ctttcagctg aatacgaatg aacacagtgg tggaatttct gaagggaagt gatgaaatta
     2221 tatttatttc agtgggcact tttccatttt accactgtac cattatttgg ttcctggagt
     2281 tatacactaa ttttcagtat attactgtta aattaccaac acaaggcaat ttatttgaaa
     2341 gattccgttt atcctgccat tgctttgaaa agcagcagga aacgaaatcc tttgacttgt
     2401 atcagcttct gcagagcatc tttgttttcc tttgtccttt gtttcctacc ttttgaatca
     2461 gattccgttt tagtcaggaa gacttcttgg gaccattctt agtaacctga aatttctttt
     2521 ttaattgcat gaagtggatt gatcatgagc aaatgatgtg cttatttctc cctcactgtt
     2581 gaatatcttt gaacttgctg ttttcaatat gggcagcaca aaggtgagag atacatatta
     2641 atagtagtat gtattactct tatacattag atacctatat ttaaatgaaa ggcccaattt
     2701 gtaaacatat acattcatat tctctcttgc cccaagtttt aggaacatgt taggatatag
     2761 gagacttaat ttataataat gagagcattt ttttatttta ctaaagccat ttttatagtc
     2821 aactatcttt tcttatttgt gtgattagaa cttagaaaaa tatttactag ttgaagttat
     2881 tatcagtttt taatttagtt cttaaactca tttcacttct aataatttct gttataaatt
     2941 tccagcattt taatgaaaat ctaatgatgt aataggcatt ttctttattt gaacctacct
     3001 cttttatttt ctgaaccaaa gagaaagatg gactggtgtt tgtgaaacat ttttaaaaat
     3061 gtagtttcat ttatattagt tatgtttgat aaatgtctca gtatttttat aatatgataa
     3121 gcctgggatt ctacttttag ggttatttgt acttttgagt aatatataaa gtgacaatat
     3181 taaggtacat gatcagctct ttctattttt actcgtaaaa attatggaaa tgaataattt
     3241 tgctaacaac tttgaaattt caaacttctg gaaaatatga aaatattcat tgttcattat
     3301 gaatttaaat tgtaaggtat gaatgtgatt tgtctgtaca tcttgtatct tttccaaaaa
     3361 atgattctgt atcttttgga aaaaagccga gagttgaaga tagtatattt ctggtagtac
     3421 tgaatattta cttacagttt ctatcaaaaa tatatatttg tttctaaaat tacttgtttt
     3481 ccagttttta ttttttttag agaaaattct taagtctcag tttcctaatt gaaaaaaaaa
     3541 aattataaat aaagcaaaaa ttgtatccta cagcttagct agcttagatg tttggcacca
     3601 gtttgaatca tgctttttac agctggctcc atgtagtctt tccaaacatt ttggcctttc
     3661 ctgagcagcc cttgtagata ttgtctgtat gatgcatttt gacacaaggt gatatttttt
     3721 gtgatatcaa aattccacat ttacccatta gagttacagc cctggggttc acagtaccaa
     3781 gggggaccca gagcctcagg attggccagg ctcattttgc cgtggagtat cagtttgtct
     3841 tgaaattgtg ggaaaaaatt ctaagttgaa ttcactggta agtaattttt taaaatttca
     3901 taatgcagat tacatccaaa atttgattta aaaattaaaa cataagactg cagagaaatt
     3961 ctgcatttca actccaatac tatccagact tcagaaataa cttatcagtt atttctgtaa
     4021 gcttcttgct tacctggata cctgacaggt gagatggctg tagcagacac tggcagttcc
     4081 ctgcccacac acctgtccct gtccacagct gcacaaggca gctctgtgtg caattgccag
     4141 catctgctcc tctgttctca gggaatcttt gttagaaaaa tgctgccata tttgtttctc
     4201 acctattagt cttgtctccc agtcaagaga ataaatttat gcaagcaga
//
