LOCUS       NM_024103               3482 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 23 (SLC25A23), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_024103
VERSION     NM_024103.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3482)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3482)
  AUTHORS   Monne,M., Daddabbo,L., Giannossa,L.C., Nicolardi,M.C., Palmieri,L.,
            Miniero,D.V., Mangone,A. and Palmieri,F.
  TITLE     Mitochondrial ATP-Mg/phosphate carriers transport divalent
            inorganic cations in complex with ATP
  JOURNAL   J Bioenerg Biomembr 49 (5), 369-380 (2017)
   PUBMED   28695448
  REMARK    GeneRIF: direct measurements of Mg(2+), Mn(2+), Fe(2+), Zn(2+) and
            Cu(2+) showed that they are cotransported with ATP by both hAPCs
            and AtAPCs. It is likely that in vivo APCs transport free ATP and
            ATP-Mg complex to different degrees, and probably trace amounts of
            other Metals(2+) in complex with ATP.
REFERENCE   3  (bases 1 to 3482)
  AUTHORS   Sharma,V., Malgulwar,P.B., Purkait,S., Patil,V., Pathak,P.,
            Agrawal,R., Kulshreshtha,R., Mallick,S., Julka,P.K., Suri,A.,
            Sharma,B.S., Suri,V., Sharma,M.C. and Sarkar,C.
  TITLE     Genome-wide ChIP-seq analysis of EZH2-mediated H3K27me3 target gene
            profile highlights differences between low- and high-grade
            astrocytic tumors
  JOURNAL   Carcinogenesis 38 (2), 152-161 (2017)
   PUBMED   27993893
  REMARK    GeneRIF: Our results showed EZH2 to be highly overexpressed in
            astrocytic tumors with a significant positive correlation with
            grade.we identified SLC25A23 as important target of H3K27me3
            modification, which was downregulated in GBM and its low expression
            was associated with poor prognosis in glioblastomas (GBMs).
REFERENCE   4  (bases 1 to 3482)
  AUTHORS   Hou,T., Jian,C., Xu,J., Huang,A.Y., Xi,J., Hu,K., Wei,L., Cheng,H.
            and Wang,X.
  TITLE     Identification of EFHD1 as a novel Ca(2+) sensor for mitoflash
            activation
  JOURNAL   Cell Calcium 59 (5), 262-270 (2016)
   PUBMED   26975899
REFERENCE   5  (bases 1 to 3482)
  AUTHORS   Hoffman,N.E., Chandramoorthy,H.C., Shanmughapriya,S., Zhang,X.Q.,
            Vallem,S., Doonan,P.J., Malliankaraman,K., Guo,S., Rajan,S.,
            Elrod,J.W., Koch,W.J., Cheung,J.Y. and Madesh,M.
  TITLE     SLC25A23 augments mitochondrial Ca(2) uptake, interacts with MCU,
            and induces oxidative stress-mediated cell death
  JOURNAL   Mol Biol Cell 25 (6), 936-947 (2014)
   PUBMED   24430870
  REMARK    GeneRIF: SLC25A23 augments mitochondrial Ca(2) uptake, interacts
            with MCU, and induces oxidative stress-mediated cell death.
REFERENCE   6  (bases 1 to 3482)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3482)
  AUTHORS   Del Arco,A.
  TITLE     Novel variants of human SCaMC-3, an isoform of the ATP-Mg/P(i)
            mitochondrial carrier, generated by alternative splicing from
            3'-flanking transposable elements
  JOURNAL   Biochem J 389 (Pt 3), 647-655 (2005)
   PUBMED   15801905
REFERENCE   8  (bases 1 to 3482)
  AUTHORS   Bassi,M.T., Manzoni,M., Bresciani,R., Pizzo,M.T., Della Monica,A.,
            Barlati,S., Monti,E. and Borsani,G.
  TITLE     Cellular expression and alternative splicing of SLC25A23, a member
            of the mitochondrial Ca2+-dependent solute carrier gene family
  JOURNAL   Gene 345 (2), 173-182 (2005)
   PUBMED   15716113
  REMARK    GeneRIF: Northern blot analysis reveals the presence of the
            transcript in brain, heart, skeletal muscle, liver and small
            intestine. The SLC25A23 gene undergoes alternative splicing
            suggesting a modular nature of the encoded product.
REFERENCE   9  (bases 1 to 3482)
  AUTHORS   Fiermonte,G., De Leonardis,F., Todisco,S., Palmieri,L.,
            Lasorsa,F.M. and Palmieri,F.
  TITLE     Identification of the mitochondrial ATP-Mg/Pi transporter.
            Bacterial expression, reconstitution, functional characterization,
            and tissue distribution
  JOURNAL   J Biol Chem 279 (29), 30722-30730 (2004)
   PUBMED   15123600
  REMARK    GeneRIF: identification of three isoforms of the mitochondrial
            ATP-Mg/Pi carrier APC1, APC2 and APC3; they are most likely
            responsible for the net uptake or efflux of adenine nucleotides
            into or from the mitochondria
REFERENCE   10 (bases 1 to 3482)
  AUTHORS   del Arco,A. and Satrustegui,J.
  TITLE     Identification of a novel human subfamily of mitochondrial carriers
            with calcium-binding domains
  JOURNAL   J Biol Chem 279 (23), 24701-24713 (2004)
   PUBMED   15054102
  REMARK    GeneRIF: SCaMC-3 is a member of a novel human subfamily of
            mitochondrial carriers with calcium-binding domains
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010503.8, BG706035.1, BC001656.1, AJ619962.1 and AW379976.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024103.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY750170.1, SRR1803616.11162.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000301454.9/
                                                  ENSP00000301454.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC010503.8         23461-23482         c
            23-56               BG706035.1         28-61
            57-647              BC001656.1         16-606
            648-1735            AJ619962.1         581-1668
            1736-1852           AW379976.1         43-159              c
            1853-3482           AJ619962.1         1786-3415
FEATURES             Location/Qualifiers
     source          1..3482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3482
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /note="solute carrier family 25 member 23"
                     /db_xref="GeneID:79085"
                     /db_xref="HGNC:HGNC:19375"
                     /db_xref="MIM:608746"
     exon            1..320
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1571
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /note="short calcium-binding mitochondrial carrier 3;
                     calcium-binding mitochondrial carrier protein SCaMC-3;
                     mitochondrial Ca2+-dependent solute carrier protein 2;
                     short calcium-binding mitochondrial carrier protein 3;
                     mitochondrial ATP-Mg/Pi carrier protein 2; small
                     calcium-binding mitochondrial carrier protein 3;
                     mitochondrial Ca(2+)-dependent solute carrier protein 2;
                     solute carrier family 25 (mitochondrial carrier; phosphate
                     carrier), member 23"
                     /codon_start=1
                     /product="mitochondrial adenyl nucleotide antiporter
                     SLC25A23"
                     /protein_id="NP_077008.2"
                     /db_xref="CCDS:CCDS32882.1"
                     /db_xref="GeneID:79085"
                     /db_xref="HGNC:HGNC:19375"
                     /db_xref="MIM:608746"
                     /translation="MRGSPGDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGGG
                     NPDPGAQQGISSEGDADPDGGLDLEEFSRYLQEREQRLLLMFHSLDRNQDGHIDVSEI
                     QQSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHS
                     TVLDIGECLTVPDEFSKQEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHAS
                     KTNRLNILGGLRSMVLEGGIRSLWRGNGINVLKIAPESAIKFMAYEQIKRAILGQQET
                     LHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAF
                     YRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQI
                     ASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVS
                     ISYVVYENMKQALGVTSR"
     exon            321..447
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            448..535
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            536..647
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            648..806
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..959
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1067
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1235
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1386
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..3482
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3462..3467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /note="hexamer: AATAAA"
     polyA_site      3482
                     /gene="SLC25A23"
                     /gene_synonym="APC2; MCSC2; SCaMC-3; SCAMC3"
                     /note="major polyA site"
ORIGIN      
        1 gtcaccacct cccgcaagtg ccagagccga gcggactgcg cggaggctgc ggagccggcg
       61 gccgcgggag ctgaccctgc ggggtcccgg ggggggaggg ggagccgcga agcccccact
      121 gaggccgccg ctgccgggcc tcccctcccc cccgggcggg cgccatgcgg gggagcccgg
      181 gcgacgcgga gcggcggcag cgctggggtc gcctgttcga ggagctggac agtaacaagg
      241 atggccgcgt ggacgtgcac gagttgcgcc aggggctggc caggctgggc gggggcaacc
      301 cagaccccgg cgcccaacag ggtatctcct ctgagggtga tgctgaccca gatggcgggc
      361 tcgacctgga ggaattttcc cgctatctgc aggagcggga acagcgtctg ctgctcatgt
      421 ttcacagtct tgaccggaac caggatggtc acattgatgt ctctgagatc caacagagtt
      481 tccgagctct gggcatttcc atctcgctgg agcaggctga gaaaattttg cacagcatgg
      541 accgagacgg cacaatgacc attgactggc aagaatggcg cgaccacttc ctgttgcatt
      601 cgctggaaaa tgtggaggac gtgctgtatt tctggaagca ttccacggtc ctggacattg
      661 gcgagtgcct gacagtgccg gacgagttct caaagcaaga gaagctgacg ggcatgtggt
      721 ggaaacagct ggtggccggc gcagtggcag gtgccgtgtc acggacaggc acggcccctc
      781 tggaccgcct caaggtcttc atgcaggtcc atgcctcaaa gaccaaccgg ctgaacatcc
      841 ttggggggct tcgaagcatg gtccttgagg gaggcatccg ctccctgtgg cgcggcaatg
      901 gtattaatgt actcaagatt gcccccgagt cagctatcaa gttcatggcc tatgaacaga
      961 tcaagagggc catcctgggg cagcaggaga cactgcatgt gcaggagcgc ttcgtggctg
     1021 gctccctggc tggtgccaca gcccaaacca tcatttaccc tatggaggtg ctgaagacgc
     1081 ggctgacctt gcgccggacg ggccagtata aggggctgct ggactgcgcc aggcgtatcc
     1141 tggagaggga ggggccccgt gccttctacc gcggctacct ccccaacgtg ctgggcatca
     1201 tcccctatgc gggcatcgac ctggccgtct acgagactct gaagaactgg tggcttcagc
     1261 agtacagcca cgactcggca gacccaggca tcctcgtgct cctggcctgc ggtaccatat
     1321 ccagcacctg cggccagata gccagttacc cgctggccct ggtccggacc cgcatgcagg
     1381 cacaagcctc catcgagggt ggcccccagc tgtccatgct gggtctgcta cgtcacatcc
     1441 tgtcccagga gggcatgcgg ggcctctacc gggggatcgc ccccaacttc atgaaggtta
     1501 ttccagctgt gagcatctcc tatgtggtct acgagaacat gaagcaggcc ttgggggtca
     1561 cgtccaggtg agggacccgg agcccgtccc cccaatccct caccccccac acctcagcca
     1621 ctggagactg atgatccaac cacaggatcc ctactctttg gccacgagat cccagtaccc
     1681 agatcctgga tcctagactc ctatgcccca accattgggt catgggatcc cagcatccag
     1741 atcctggatc ctagactcct atgccccaac cactgggtca tgcgatcccc acccttcagc
     1801 cactagatcc cagatccccc tgtaaccata actgtggatc ccttacttca gcaactcaag
     1861 tctgctaccc taaccacaag attcaagatt atccacaccc cagcccttaa tccccatccc
     1921 ccaaatcact ggatcctgca gccccacatc ctaaggtgga tcccacgctt ccctgtgccc
     1981 cctactggat cctggacctc tacgtcttaa ccactggatc ccacacaaat cagtgaatgg
     2041 atcccaacac cccaaccaca ggagcacgga ttccctgtac ctcaacaccc agaccctgcc
     2101 tccctcaggc accagatcca gtgtcctagt gaaacgctgg atcctagatc cccaacccca
     2161 gatccccatg cctcgagccc tggatctcca agctcagctg ctggattctg gatgtcaaca
     2221 aacctcacca ctggatcctg acaaccacaa tgcctggatc ctggggcccc catcactgga
     2281 tcccagatcc cctcactcca cccactggat tcctgcattg gtttttggtt ttttgttttt
     2341 ttttaacctc gacactgggt ctcagatcct tctgctgact gccagatccc tgcatttcaa
     2401 gcactacgcc ttccaccccc aggcactgga tcccagattc ccaagccttc acccaccaga
     2461 ttctggctcc taaaacaagt gcgggggccc cagtggcaca gcaagtggat cctggcaact
     2521 gcagctgctg gattccagat tctgggtccc caatccctct gcccagtccc tcaatgttga
     2581 aacctcatct cttgaaggca gatcctgata ttccaaggca ctgaatccca agccctgaat
     2641 ccccggtttc tgatctgaat cttccaggcg ccgggtccca aatgttcagg ccccaagtct
     2701 agatcctggc agcccagtca cagagtatcc cacacacact ggtgcccaga gccggcttct
     2761 catgacatga aattgcatgg tcgagggagt ctgtggggaa ggaagcccag gtcctggctg
     2821 caacctgcac ggatgctgga ttccccctca ccccacctct gcatggccac cccctcccag
     2881 ccctgtgggg aaactgttcc ctggaaccac tccactccct gcatccccac acttcacagc
     2941 atcttccatc cccctcccac cttctaggcg aatagtcccc agagctgtgt tcctccaagg
     3001 ggtccgagga atcactcact cctggaggct ggcaaggaga cagtctgagg ccagggacac
     3061 atgaagggat gtccccaccc cagcactatc agggcctccc caggcttcca gagttgaaag
     3121 ccaggagaaa atcggcaaag accacccttc cctaaaccca agcacccaat gatgcaaaaa
     3181 acaaaaacaa aaaaaaacca ccaaatcccc aaattcattc cagatctatt tttctaccag
     3241 agagaggagc aaagtcctcc tcccctgcgc ccttacattc tgcacttcat agttggattc
     3301 tgagcttagg atcatctgga gaccccatgg agggacttgg aaaggggaac tgggatttgg
     3361 ggaggggctg gaggacttcc gcacgcttcc acctccttcg acctccactg cgccccacct
     3421 ccctgcctgt gtgtgttatt tcaaaggaaa agaacaaaag gaataaattt tctaagctct
     3481 tt
//
