LOCUS       NM_006358               2226 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens solute carrier family 25 member 17 (SLC25A17),
            transcript variant 1, mRNA.
ACCESSION   NM_006358
VERSION     NM_006358.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Costa,C.F., Lismont,C., Chornyi,S., Koster,J., Li,H.,
            Hussein,M.A.F., Van Veldhoven,P.P., Waterham,H.R. and Fransen,M.
  TITLE     The solute carrier SLC25A17 sustains peroxisomal redox homeostasis
            in diverse mammalian cell lines
  JOURNAL   Free Radic Biol Med 212, 241-254 (2024)
   PUBMED   38159891
  REMARK    GeneRIF: The solute carrier SLC25A17 sustains peroxisomal redox
            homeostasis in diverse mammalian cell lines.
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Shi,Y., Huang,J., Hu,Y. and Shen,Y.
  TITLE     Multiomics data analyses to identify SLC25A17 as a novel biomarker
            to predict the prognosis and immune microenvironment in head and
            neck squamous cell carcinoma
  JOURNAL   BMC Bioinformatics 24 (1), 269 (2023)
   PUBMED   37386359
  REMARK    GeneRIF: Multiomics data analyses to identify SLC25A17 as a novel
            biomarker to predict the prognosis and immune microenvironment in
            head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Aranovich,A., Hua,R., Rutenberg,A.D. and Kim,P.K.
  TITLE     PEX16 contributes to peroxisome maintenance by constantly
            trafficking PEX3 via the ER
  JOURNAL   J Cell Sci 127 (Pt 17), 3675-3686 (2014)
   PUBMED   25002403
  REMARK    GeneRIF: PEX16 mediates the peroxisomal trafficking of two distinct
            peroxisomal membrane proteins, PEX3 and PMP34, via the endoplasmic
            reticulum
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Jones,J.M., Morrell,J.C. and Gould,S.J.
  TITLE     Multiple distinct targeting signals in integral peroxisomal
            membrane proteins
  JOURNAL   J Cell Biol 153 (6), 1141-1150 (2001)
   PUBMED   11402059
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Honsho,M. and Fujiki,Y.
  TITLE     Topogenesis of peroxisomal membrane protein requires a short,
            positively charged intervening-loop sequence and flanking
            hydrophobic segments. study using human membrane protein PMP34
  JOURNAL   J Biol Chem 276 (12), 9375-9382 (2001)
   PUBMED   11121399
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   Sacksteder,K.A., Jones,J.M., South,S.T., Li,X., Liu,Y. and
            Gould,S.J.
  TITLE     PEX19 binds multiple peroxisomal membrane proteins, is
            predominantly cytoplasmic, and is required for peroxisome membrane
            synthesis
  JOURNAL   J Cell Biol 148 (5), 931-944 (2000)
   PUBMED   10704444
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Wylin,T., Baes,M., Brees,C., Mannaerts,G.P., Fransen,M. and Van
            Veldhoven,P.P.
  TITLE     Identification and characterization of human PMP34, a protein
            closely related to the peroxisomal integral membrane protein PMP47
            of Candida boidinii
  JOURNAL   Eur J Biochem 258 (2), 332-338 (1998)
   PUBMED   9874197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC397321.1, BC012998.2 and BX647991.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006358.3.
            
            Summary: This gene encodes a peroxisomal membrane protein that
            belongs to the family of mitochondrial solute carriers. It is
            expressed in the liver, and is likely involved in transport.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.261954.1,
                                           SRR1660805.115473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000435456.7/
                                                  ENSP00000390722.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DC397321.1         54-80
            28-1774             BC012998.2         1-1747
            1775-2226           BX647991.1         1608-2059
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2226
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="solute carrier family 25 member 17"
                     /db_xref="GeneID:10478"
                     /db_xref="HGNC:HGNC:10987"
                     /db_xref="MIM:606795"
     exon            1..152
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1022
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal membrane protein PMP34; solute carrier family
                     25 (mitochondrial carrier; peroxisomal membrane protein,
                     34kDa), member 17"
                     /codon_start=1
                     /product="peroxisomal membrane protein PMP34 isoform 1"
                     /protein_id="NP_006349.1"
                     /db_xref="CCDS:CCDS14005.1"
                     /db_xref="GeneID:10478"
                     /db_xref="HGNC:HGNC:10987"
                     /db_xref="MIM:606795"
                     /translation="MASVLSYESLVHAVAGAVGSVTAMTVFFPLDTARLRLQVDEKRK
                     SKTTHMVLLEIIKEEGLLAPYRGWFPVISSLCCSNFVYFYTFNSLKALWVKGQHSTTG
                     KDLVVGFVAGVVNVLLTTPLWVVNTRLKLQGAKFRNEDIVPTNYKGIIDAFHQIIRDE
                     GISALWNGTFPSLLLVFNPAIQFMFYEGLKRQLLKKRMKLSSLDVFIIGAVAKAIATT
                     VTYPLQTVQSILRFGRHRLNPENRTLGSLRNILYLLHQRVRRFGIMGLYKGLEAKLLQ
                     TVLTAALMFLVYEKLTAATFTVMGLKRAHQH"
     exon            153..213
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            214..280
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            281..432
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            433..549
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            550..695
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            696..791
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            792..874
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     exon            875..2226
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1273
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="major polyA site"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="hexamer: AATAAA"
     polyA_site      1776
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="major polyA site"
     regulatory      1926..1931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="hexamer: AATAAA"
     polyA_site      1947
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
                     /note="hexamer: ATTAAA"
     polyA_site      2226
                     /gene="SLC25A17"
                     /gene_synonym="PMP34"
ORIGIN      
        1 gcgactctca caccctgagc tccggtgctc ctttcctaac tccactggct gcggcatctg
       61 tgggaaaagt gtggctgggt cttcgaggag ccgcaccaat ggcttccgtg ctgtcctacg
      121 aaagcctggt ccacgccgtg gccggagccg tgggaagcgt gacagcaatg acagtgtttt
      181 ttcccctgga tacagctaga cttcgacttc aggttgatga gaaaagaaaa tccaaaacta
      241 cacacatggt gctcctggag atcattaaag aagaaggact cctggcacca tatcgagggt
      301 ggtttccagt gatttccagt ctctgctgct ccaattttgt ctatttctac acttttaata
      361 gcctcaaagc actctgggtc aaaggtcaac attctaccac tggaaaagat ctggtagttg
      421 ggtttgttgc aggagtggtt aatgtgttgc taacaactcc actctgggtg gtaaacacca
      481 gactgaagct tcaaggagca aaatttagga atgaagacat tgtaccaaca aactacaaag
      541 gtatcattga tgcttttcat cagatcattc gcgatgaagg aatctcggct ttatggaatg
      601 gcacatttcc ctcattgctg ttggtcttca atcctgccat ccagttcatg ttttatgaag
      661 gtttaaaacg gcagctttta aagaaacgga tgaagctttc ttccttggat gtgttcatca
      721 ttggtgcagt agccaaagcg attgccacca cggtgaccta tcccctgcag acggtacagt
      781 caattctgag gtttgggcgt catagactaa acccagaaaa cagaacattg ggaagtcttc
      841 ggaatattct ctatcttctt caccaacgag taagacgttt tggaataatg ggactctaca
      901 aaggccttga agccaaactg ctgcagacag tcctcactgc tgctctcatg ttccttgttt
      961 atgagaaact gacagctgcc accttcacag ttatggggct gaagcgtgca caccaacact
     1021 gagacgcctt cccatgaaaa attccgaaga tgctcaagag ggaggtttcc tcctgagtga
     1081 agagaagtga ttctcccttg actctggctc ctgccaccac aaatgttacc ctcattggct
     1141 tgaaaagcat ccaagggtgc acagggagta tggccaactg gacctgttgt caccttaatt
     1201 gtcatgctgg ctggttggat tttggggtgg cagttggact aatgtgaaaa aaacattgct
     1261 gaaaacctaa aaatgaaagt ttgtgagtgt ttattggttt tcttaagaga aatggactat
     1321 tttgctctca tgtgtaatgt tttctattta aatctttctt aaatatacca gctgttctct
     1381 ttccctgaac tctcccccag gttctaggac aaatttaata acatgtaatt ctcctcaaat
     1441 acttttgtat gtctcagtgt tggtgttttc ctccctaaaa ctaacattag ggctgtgcca
     1501 cgggcatgac tttatttttg ttgggctttt ttttccctgc ttaaggagag gtgtcttttt
     1561 tggatatgag ctatttattt tgtgaaatga aaattgttca cccaaatgat tctcttataa
     1621 actatttgta aatgtcactt attcattagt gtttgacata atttttagaa tatttatttt
     1681 gaatcaatcc tttcattacg aaagacttga agttttgtgt ccattcttac aagccctggt
     1741 cagtcaagtc ccaataaatg gtcagcacaa aaaagatatt cttgaaaatt gctctttatt
     1801 aaggtattac gttgagtttg caaccagatg ggaaaaatca caaaaatgag aaggggagca
     1861 gatatcttgt tgaggtctgg atattatctc cctttataaa cttggtgtag gccgtatatt
     1921 ttgaaaataa acatctggtt gaggttattt catttggaaa ccttccttag agtcctgttg
     1981 ctcagtgtgg tccatcagac ggtagtactg ccacaagctg agagcttgct gggcacgcaa
     2041 cccagagttt ctgaatcctg ttccgtattt taacattccc aggtgattca cagccacatt
     2101 aaagttcagg agaccatagg acccctgacc catgagaaga agtgattggt ttcgattata
     2161 gacatcaaga taaagatttt tctcaaagga aagagattaa tgtattaaaa caacctctga
     2221 aaaatc
//
