LOCUS       NM_152707               6581 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 16 (SLC25A16),
            transcript variant 1, mRNA.
ACCESSION   NM_152707 NM_005673
VERSION     NM_152707.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6581)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 6581)
  AUTHORS   Khan,S., Ansar,M., Khan,A.K., Shah,K., Muhammad,N., Shahzad,S.,
            Nickerson,D.A., Bamshad,M.J., Santos-Cortez,R.L.P., Leal,S.M. and
            Ahmad,W.
  TITLE     A homozygous missense mutation in SLC25A16 associated with
            autosomal recessive isolated fingernail dysplasia in a Pakistani
            family
  JOURNAL   Br J Dermatol 178 (2), 556-558 (2018)
   PUBMED   28504827
  REMARK    GeneRIF: The authors findings report an extreme rare missense
            mutation in SLC25A1 which supports the causality of this variant
            for autosomal recessive form of isolated fingernail dysplasia.
REFERENCE   3  (bases 1 to 6581)
  AUTHORS   Palmieri,F.
  TITLE     The mitochondrial transporter family SLC25: identification,
            properties and physiopathology
  JOURNAL   Mol Aspects Med 34 (2-3), 465-484 (2013)
   PUBMED   23266187
  REMARK    GeneRIF: Compares and contrasts all the known human SLC25A* genes
            and includes functional information.
            Review article
REFERENCE   4  (bases 1 to 6581)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6581)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 6581)
  AUTHORS   Prohl,C., Pelzer,W., Diekert,K., Kmita,H., Bedekovics,T., Kispal,G.
            and Lill,R.
  TITLE     The yeast mitochondrial carrier Leu5p and its human homologue
            Graves' disease protein are required for accumulation of coenzyme A
            in the matrix
  JOURNAL   Mol Cell Biol 21 (4), 1089-1097 (2001)
   PUBMED   11158296
REFERENCE   7  (bases 1 to 6581)
  AUTHORS   Rossi,E., Zarrilli,R. and Zuffardi,O.
  TITLE     Regional assignment of the gene coding for a human Graves' disease
            autoantigen to 10q21.3-q22.1
  JOURNAL   Hum Genet 90 (6), 653-654 (1993)
   PUBMED   8444471
REFERENCE   8  (bases 1 to 6581)
  AUTHORS   Fiermonte,G., Runswick,M.J., Walker,J.E. and Palmieri,F.
  TITLE     Sequence and pattern of expression of a bovine homologue of a human
            mitochondrial transport protein associated with Grave's disease
  JOURNAL   DNA Seq 3 (2), 71-78 (1992)
   PUBMED   1457817
REFERENCE   9  (bases 1 to 6581)
  AUTHORS   Zarrilli,R., Oates,E.L., McBride,O.W., Lerman,M.I., Chan,J.Y.,
            Santisteban,P., Ursini,M.V., Notkins,A.L. and Kohn,L.D.
  TITLE     Sequence and chromosomal assignment of a novel cDNA identified by
            immunoscreening of a thyroid expression library: similarity to a
            family of mitochondrial solute carrier proteins
  JOURNAL   Mol Endocrinol 3 (9), 1498-1505 (1989)
   PUBMED   2575220
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA023888.1, AK290255.1,
            AL713888.10, AL136233.14 and BU684567.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152707.3.
            
            Summary: This gene encodes a protein that contains three tandemly
            repeated mitochondrial carrier protein domains. The encoded protein
            is localized in the inner membrane and facilitates the rapid
            transport and exchange of molecules between the cytosol and the
            mitochondrial matrix space. This gene has a possible role in
            Graves' disease. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.192302.1,
                                           SRR1803615.159006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000609923.6/
                                                  ENSP00000476815.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                DA023888.1         1-71
            72-1300             AK290255.1         1-1229
            1301-1815           AL713888.10        2001-2515           c
            1816-2239           AL136233.14        138310-138733       c
            2240-2246           BU684567.1         19-25               c
            2247-6581           AL136233.14        133968-138302       c
FEATURES             Location/Qualifiers
     source          1..6581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..6581
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /note="solute carrier family 25 member 16"
                     /db_xref="GeneID:8034"
                     /db_xref="HGNC:HGNC:10986"
                     /db_xref="MIM:139080"
     exon            1..278
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1147
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /note="isoform a is encoded by transcript variant 1;
                     graves disease carrier protein; solute carrier family 25
                     (mitochondrial carrier; Graves disease autoantigen),
                     member 16; mitochondrial solute carrier protein homolog;
                     graves' didease protein"
                     /codon_start=1
                     /product="solute carrier family 25 member 16 isoform a"
                     /protein_id="NP_689920.1"
                     /db_xref="CCDS:CCDS7280.1"
                     /db_xref="GeneID:8034"
                     /db_xref="HGNC:HGNC:10986"
                     /db_xref="MIM:139080"
                     /translation="MAAATAAAALAAADPPPAMPQAAGAGGPTTRRDFYWLRSFLAGG
                     IAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIR
                     IFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLAF
                     QVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVGL
                     SHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPE
                     FEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFFHLN"
     exon            279..371
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            372..505
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            506..569
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            570..691
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            692..758
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            759..921
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            922..990
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     exon            991..6581
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /note="hexamer: AATGAA"
     polyA_site      1877
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /note="major polyA site"
     regulatory      6556..6561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /note="hexamer: AATAAA"
     polyA_site      6581
                     /gene="SLC25A16"
                     /gene_synonym="D10S105E; GDA; GDC; hGP; HGT.1; hML7; ML7"
                     /note="major polyA site"
ORIGIN      
        1 gtacgccatc agccggcgcc gcgccgccgg gtgttacttt gccccgccgg cggggcggtc
       61 agcctcctgt caccgcctgt tccggctatg gtcccgtccg gtgttctgta agttggcaac
      121 ctaggctcct gacgcgaccc tggtcctgat ggcggcggcg acggccgcgg cagccctggc
      181 ggcggccgat ccccctcccg caatgccgca ggcggcaggg gccggagggc ccacaacccg
      241 cagagacttc tactggctgc gctcctttct ggccggaggt attgctggat gctgtgccaa
      301 aacaacagtt gctccattgg atcgagtaaa ggttttatta caagctcaca atcaccatta
      361 caagcattta ggagtatttt ctgcattgcg tgctgttcct caaaaagaag gattccttgg
      421 attgtataaa ggaaatggtg caatgatgat tcgaatcttt ccctatggtg caatccagtt
      481 tatggcattt gagcattata aaacgttaat tactacgaag ctgggaattt caggtcatgt
      541 gcacagatta atggctggat ccatggcagg tatgacagca gttatctgta cttaccctct
      601 tgacatggtt agggtccgcc tagcattcca ggtgaaaggg gaacacagct atacaggaat
      661 tattcatgct ttcaaaacaa tttatgcaaa ggaaggtggt ttctttggat tttacagagg
      721 tctgatgcct actattttag gaatggctcc atatgcaggt gtttcatttt ttacttttgg
      781 taccttgaag agtgttgggc tttcccatgc tcctaccctt cttggcagac cttcatcaga
      841 caatcctaat gtcttagttt tgaaaactca tgtaaactta ctttgtggtg gtgttgctgg
      901 agcaatagcg cagacaatat cctacccatt tgatgtgact cgtcggcgaa tgcaattagg
      961 aactgttctg ccggaatttg aaaagtgcct taccatgcgg gatactatga agtatgtcta
     1021 tggacaccat ggaattcgaa aaggactcta tcgtggttta tctcttaatt acattcgctg
     1081 tattccctct caagcagtgg cttttacaac atacgaactt atgaagcagt tttttcacct
     1141 caactaaaaa aaaattatgg ttggtttttc ttaatacatt ctcagaggga gaaatgaaac
     1201 attactataa ttgtgggggg aacattactt gaatggggat atttaccctg tcacaagagc
     1261 cactggtatt ttagtacttg attatttttt ctttagtcac aaatcagaac tgcttaccat
     1321 actttttgat gccaaacatt ataccttaga acattgaaga aaatattcct aagctgatgc
     1381 tggctaaacc gctttaaagt tttatttgga agtagaacta gctttaaaac ggggttcaag
     1441 aggttgccat tagctttgtc atgctgttca aagtttttaa ttgttatcat ggtttttaaa
     1501 agactgacag tgtttattat tattaaaata aacagggttg gttatattgc aatagaataa
     1561 tgagaattga atttttaagt tctatgaaac agccagcatt gacattttat ttttgttatc
     1621 tctcttctca caattatgct ccactggata ataggaaaaa cacttctttc cttcattttt
     1681 taaataaaat taatgttgta tttaaaaggt agccatgtag agacacaaaa ataaatgaag
     1741 aagctggaca tggtgggatg ggcatgtggt cccagctact ctggaagctg aggtgagagg
     1801 atcacttgag ccctggaatt ccatgccagc ctatgcaaca tcatgaaacc ccacttaata
     1861 aatgaatgaa cgactaagtc ttgctcaaat gttattatga ggtactatga gtgacttaca
     1921 tgtgttttaa aatgtcagtg tgtttcccag aggcagaaat aaaaatactg aatatctttg
     1981 ctcttaaaaa aaaagtaaca ctatagattt gtttttgtta gatgatttgc tctatagtag
     2041 aatatttaag tagactgtga aatatttatt aatatagatg tgaatatcaa aaaatgtttc
     2101 taaggtatta tgatgcatca actagttctt ccatgtaaaa taattttagt gcaatatgaa
     2161 gacgtagaaa tgtaaaatat gatttgaatt gttatccttt atattaagaa aatgttttaa
     2221 aatgtaagaa ttccatttat tctgtttaga gtacttttta tgatttatta taagcgtgtc
     2281 ataaatggga agggaatatt taaagttctg tgttcagaaa gagtaatttg tagaactgat
     2341 gtgacttttt tttttttttt gagatggagt ctcgctctat cgcccaggct ggagtgcagt
     2401 ggcgcgatct cagctcactg caacctctgc ctcccgggtt caagtgattc tcctgcctca
     2461 gtctcccgag tagctgggac tacaggtgcc caccaccaaa aattcgcctg gctaattttt
     2521 gtatttttag tagagacggg atttcaccgt gttagccagg atggcctcga tctcctgaac
     2581 ctcatgatct gcccaccttg gtctcccaaa gtgctgagat tactggcgtg agccacggcg
     2641 cccggccctt tgatgtgact ttaaagacat tagaaggcca ggtgtggtgg ctcacgcctt
     2701 tattcccagc actttgggag gccgagttgg gtggatcacc tgaagtcagg agtttaagat
     2761 cagcatggtg aaaccccacc tctactaaaa atacaaaaag tagcaggtgt ggtggctcgt
     2821 gcctgtagtc ccagttactc gcgaggctga gacatgagaa ttgcttgagc tcgggaagcg
     2881 gaggttgcag tgagctgaga tcacaccact gcactccagc ctgggtgaca gaatgagcct
     2941 ccatctcaaa aaaaaggaga cattagaaaa ctaagttgag tccaggcgtg gtggctcttg
     3001 cctgtaaccc tagcactttg ggaggctgag gcgggaggat atcttgaccc caggagttcg
     3061 agaccagcct gggcaacata gtgagacccc gtttctttca aacaaaagaa ggaaaactaa
     3121 gttgaaagtg ttatttttgc ttcaattttt atttctttac ataaaaggtt tcttgtcata
     3181 ccttggtaaa aatttgatga gctggtttca ttttgaaagc ctttatttta aaaataagta
     3241 tgtatctttg tatgatttat aagtgtacca gtaggtagaa atacatgtgt tcttggccag
     3301 atgtggtggc tcacgcctgt aatcccagca ttttgggagg ctaaggcgag tggatcacct
     3361 gaggtcagga gttcaagacc agactggcca acgtggagaa accctgtctc tactaaaaat
     3421 acaaaaatca gccgggcatg gtggcgggcg cctgtaatcc cagctacttg ggaggctaag
     3481 gcagggagaa ttgcttgaac ccaggaggca caggttgcag tgagccaaga ttgcgccatt
     3541 gcactccagc ctgggtggct gtataaaagc ctgtataaaa atttctttta tacagagtga
     3601 gactgtataa aagaaaaaaa aaggctgtac aaaaatttct tttatacaga gactgtataa
     3661 aagaaaaaaa aaagaaatac atgtgttctt aaaaccattt gtatattttc atttctagac
     3721 cacactgtag ctaattattg ttattaaatg ttaagataat ttaagtatat aaaataagta
     3781 ttgagccggg catggtggct cacccctgta atctcagcac tttgggaggc tgaggcgggg
     3841 ggatcacgag gtcaggaaat cgagaccatt gtggctaaca cggtgaaaac ctatctctac
     3901 taaaaataca aaaaattagc tgggcgtggt ggcacgcacc tgtagtccca gttactcagg
     3961 aggctgagac aggagaatca cttgaacctg ggaggcggag cttgcagtga gccgagatcg
     4021 tgccactgca ttctaacctg ggcgacagag caagactcca tctcaaaaaa aaaaaaaaaa
     4081 aaaaaaaaga tacctcagtt aggttatcag taaaagggga ttgcaaatat cttttaaata
     4141 aaaatttgca ttctatatgt tatagaatac agaggatatt aaaaataaat tttatccatg
     4201 ttttgacaat ttctttcttt caactgttta catattgaag cacaaatgct aaacataagt
     4261 cagaatggaa gaatatttaa aataatgact gtgtttatat ctgatttatt tcagattgcc
     4321 caaagtgcat cttgccaggt tatcttccat ttgaagactg acattttatt tcttttttga
     4381 tctttattgt tcctctcttc cacctctcag tgggtatagc tctctggtct gtagaatggg
     4441 acagtggtct ggtttccaga ttgataagtg aggtatacct cctagttttc agtaattacc
     4501 tgtagaaggt ggagaagtta ctggatatgt ttaataatat ctcattacat tctttttttt
     4561 ttttttttaa cgagagtctt aactctgtca cccaagctgg agtgcagtgg tgcaatctcg
     4621 gctcactgca atctccacct ccgggttcaa gcgattttcc cgagtcatct ttccaagtaa
     4681 ctgggattac agctatgtgc taccatgccc agctgagttt tgtatttttc tttcttttct
     4741 ttcttttttt tttttttttt tgagacagag cctcactctg ttgcccaggc tggagtgccc
     4801 aggctggagt gcagtggtgt gatctcagct cactgcaacc tccacctcct gggttctagc
     4861 gattctcctg cttcagcctc ccgagtagct ggggttacaa gcacccgcca ccacgcccag
     4921 ctaatttttg tgtatttagt agagctgggt tttgccctgt tggccaggct ggtcttgaat
     4981 acctgacctc aagtgatctg cccccccgac ttcccaaaat gctgggacta ctggcatgag
     5041 ccagtgctcc tgtcctcatt ccattcttca ccgtggtact gaccatccat ttattcagca
     5101 ccaattgtgt gccagacctt gtgtcagcat tatggaggac ttcccttggg aggcttgtta
     5161 gctgtacttg caatctgatt tgggttccca aatcagcata taacaccagg tatttctcta
     5221 atagagtatg tgccacactt tctgctaact gcctgtttat cagtgtcccc acatcccaat
     5281 atctggttcc ttcaagggca gggagcacag ggtatggcgt cagagtggta ctcagtgatg
     5341 tttactggtg ggtagaagga agggttagtc cctgtttttg aagactttat gttctagcag
     5401 gcagaaatga agcacaaata gttcaagaaa taaacaattt aggaataaag tcatttggtt
     5461 tgcttcgcag aaatgtctta ttgctgattt gccagcatga gtggcaaata tataataaaa
     5521 cctggccggg catggtggct cacgcctgta atcccagcac tttgggaggc caaggtgggc
     5581 ggatcacgtg gtcaggagat caagaccatc ctggccaaca tggtgaaatc ccatctctac
     5641 taaaaatata aaaattagcc aggcatggtg gtgggcgcct gtagtcccag ctacttggga
     5701 ggctgaggta ggagaattgc ttgaacccag aaggcggagg ttgcagtgag ccaagattgc
     5761 cccactgcac tccagcctgg gtgacagagt gagactctgt cccaaaaaat aaaaataaaa
     5821 ataaatgaat atataaaata aaaaatatat gtatacatat catatatata tataaaataa
     5881 aacttataaa tagtttttat ggctgggtga agtgactcat gtctgtaatt ctagcccttt
     5941 gggaggctga gcgaggagga tcacttgagc ctaggcattc gagcccagcc tgggcaacat
     6001 tgcaagactc tgtctcattt ttttatataa aatgtttttt taaaaaaccc tatgtataat
     6061 tatttatttt ttttccccaa ggattattcc caaactatgt acaattaatg ggttgccttg
     6121 cagagttgga tcaataatac ctgacacact tgtatagcaa gcatacactt tacatagttc
     6181 ctcgcatcta ttctttgaaa cccagacaca ttctagtatt gggcactaga aactggtgat
     6241 aaataataac aattacatat atttcctgaa gaattatgtg gcattccttg ttttaagcac
     6301 ctttgatgcc ttagctcaat ctccattaca atactatgat ataagtacca tttaatattt
     6361 ctttttgaca gatgggaata atcgaggcct agggagatta aattacttgg ccaggttcat
     6421 gtaagtggca gatctaggat tcaaattcag ccggtctgaa tctagagcct attcttttag
     6481 ctatgatgct atactttaat acagtaatac actgttcaaa tgaaactgta acatgtcatt
     6541 aaatttgaac ttgtcaataa acataccaag caataaaata a
//
