LOCUS       NM_003562               1692 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens solute carrier family 25 member 11 (SLC25A11),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_003562
VERSION     NM_003562.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Broeks,M.H., Meijer,N.W.F., Westland,D., Bosma,M., Gerrits,J.,
            German,H.M., Ciapaite,J., van Karnebeek,C.D.M., Wanders,R.J.A.,
            Zwartkruis,F.J.T., Verhoeven-Duif,N.M. and Jans,J.J.M.
  TITLE     The malate-aspartate shuttle is important for de novo serine
            biosynthesis
  JOURNAL   Cell Rep 42 (9), 113043 (2023)
   PUBMED   37647199
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Meng,K., Lu,S., Li,Y.Y., Hu,L.L., Zhang,J., Cao,Y., Wang,Y.,
            Zhang,C.Z. and He,Q.Y.
  TITLE     LINC00493-encoded microprotein SMIM26 exerts anti-metastatic
            activity in renal cell carcinoma
  JOURNAL   EMBO Rep 24 (6), e56282 (2023)
   PUBMED   37009826
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Lee,J.S., Lee,H., Lee,S., Kang,J.H., Lee,S.H., Kim,S.G., Cho,E.S.,
            Kim,N.H., Yook,J.I. and Kim,S.Y.
  TITLE     Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor
            formation
  JOURNAL   EBioMedicine 40, 184-197 (2019)
   PUBMED   30686754
  REMARK    GeneRIF: Cancer cells critically depended on the oxoglutarate
            carrier SLC25A11 for transporting NADH from cytosol to mitochondria
            as a malate form for the purpose of ATP production
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Palmisano,A., Zara,V., Honlinger,A., Vozza,A., Dekker,P.J.,
            Pfanner,N. and Palmieri,F.
  TITLE     Targeting and assembly of the oxoglutarate carrier: general
            principles for biogenesis of carrier proteins of the mitochondrial
            inner membrane
  JOURNAL   Biochem J 333 (Pt 1) (Pt 1), 151-158 (1998)
   PUBMED   9639574
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Piccininni,S., Iacobazzi,V., Lauria,G., Rocchi,M. and Palmieri,F.
  TITLE     Assignment of the oxoglutarate carrier gene (SLC20A4) to human
            chromosome 17p13.3
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 256-257 (1998)
   PUBMED   10072597
REFERENCE   8  (bases 1 to 1692)
  AUTHORS   Bisaccia,F., Capobianco,L., Mazzeo,M. and Palmieri,F.
  TITLE     The mitochondrial oxoglutarate carrier protein contains a disulfide
            bridge between intramembranous cysteines 221 and 224
  JOURNAL   FEBS Lett 392 (1), 54-58 (1996)
   PUBMED   8769314
REFERENCE   9  (bases 1 to 1692)
  AUTHORS   Bisaccia,F., Zara,V., Capobianco,L., Iacobazzi,V., Mazzeo,M. and
            Palmieri,F.
  TITLE     The formation of a disulfide cross-link between the two subunits
            demonstrates the dimeric structure of the mitochondrial
            oxoglutarate carrier
  JOURNAL   Biochim Biophys Acta 1292 (2), 281-288 (1996)
   PUBMED   8597574
REFERENCE   10 (bases 1 to 1692)
  AUTHORS   Iacobazzi,V., Palmieri,F., Runswick,M.J. and Walker,J.E.
  TITLE     Sequences of the human and bovine genes for the mitochondrial
            2-oxoglutarate carrier
  JOURNAL   DNA Seq 3 (2), 79-88 (1992)
   PUBMED   1457818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB155476.1, AK290376.1 and AA937945.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003562.4.
            
            Summary: The oxoglutarate/malate carrier transports 2-oxoglutarate
            across the inner membranes of mitochondria in an electroneutral
            exchange for malate or other dicarboxylic acids (summary by
            Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.254903.1,
                                           SRR1163657.466094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000225665.12/
                                                  ENSP00000225665.7
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               CB155476.1         122-249
            129-1495            AK290376.1         1-1367
            1496-1692           AA937945.1         10-206              c
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1692
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /note="solute carrier family 25 member 11"
                     /db_xref="GeneID:8402"
                     /db_xref="HGNC:HGNC:10981"
                     /db_xref="MIM:604165"
     exon            1..231
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1081
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 20 (oxoglutarate carrier), member 4;
                     mitochondrial 2-oxoglutarate/malate carrier protein; OGCP;
                     solute carrier family 25 (mitochondrial carrier;
                     oxoglutarate carrier), member 11; alpha-oxoglutarate
                     carrier"
                     /codon_start=1
                     /product="mitochondrial 2-oxoglutarate/malate carrier
                     protein isoform 1"
                     /protein_id="NP_003553.2"
                     /db_xref="CCDS:CCDS11059.1"
                     /db_xref="GeneID:8402"
                     /db_xref="HGNC:HGNC:10981"
                     /db_xref="MIM:604165"
                     /translation="MAATASAGAGGIDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDL
                     VKNRMQLSGEGAKTREYKTSFHALTSILKAEGLRGIYTGLSAGLLRQATYTTTRLGIY
                     TVLFERLTGADGTPPGFLLKAVIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRG
                     YKNVFNALIRITREEGVLTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDN
                     ILCHFCASMISGLVTTAASMPVDIAKTRIQNMRMIDGKPEYKNGLDVLFKVVRYEGFF
                     SLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG"
     exon            232..384
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     exon            385..591
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     exon            592..682
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     exon            683..773
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     exon            774..873
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     exon            874..925
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1692
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1488..1493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /note="hexamer: AATAAA"
     polyA_site      1510
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /note="major polyA site"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /note="hexamer: AAGAAA"
     polyA_site      1617
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
     regulatory      1645..1650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
                     /note="hexamer: TATAAA"
     polyA_site      1686
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
     polyA_site      1692
                     /gene="SLC25A11"
                     /gene_synonym="OGC; PGL6; PPGL6; SLC20A4"
ORIGIN      
        1 ggcttccagc gggtgtcgga cctgagagct ggaggggcgt gcgcgcgccc tcgctctgtt
       61 gcgcgcgcgg tgtcaccttg ggcgcgagcg gggccgcgcg cgcacgggac ccggagccga
      121 gggccattga gtggcgatgg cggcgacggc gagtgccggg gccggcggga tagacgggaa
      181 gccccgtacc tcccctaagt ccgtcaagtt cctgtttggg ggcctggccg ggatgggagc
      241 tacagttttt gtccagcccc tggacctggt gaagaaccgg atgcagttga gcggggaagg
      301 ggccaagact cgagagtaca aaaccagctt ccatgccctc accagtatcc tgaaggcaga
      361 aggcctgagg ggcatttaca ctgggctgtc ggctggcctg ctgcgtcagg ccacctacac
      421 cactacccgc cttggcatct ataccgtgct gtttgagcgc ctgactgggg ctgatggtac
      481 tccccctggc tttctgctga aggctgtgat tggcatgacc gcaggtgcca ctggtgcctt
      541 tgtgggaaca ccagccgaag tggctcttat ccgcatgact gccgatggcc ggcttccagc
      601 tgaccagcgc cgtggctaca aaaatgtgtt taacgccctg attcgaatca cccgggaaga
      661 gggtgtcctc acactgtggc ggggctgcat ccctaccatg gctcgggccg tcgtcgtcaa
      721 tgctgcccag ctcgcctcct actcccaatc caagcagttc ttactggact caggctactt
      781 ctctgacaac atcttgtgcc acttctgtgc cagcatgatc agcggtcttg tcaccactgc
      841 tgcctccatg cctgtggaca ttgccaagac ccgaatccag aacatgcgga tgattgatgg
      901 gaagccggaa tacaagaacg ggctggacgt gctgttcaaa gttgtccgct acgagggctt
      961 cttcagcctg tggaagggct tcacgccgta ctatgcccgc ctgggccccc acaccgtcct
     1021 caccttcatc ttcttggagc agatgaacaa ggcctacaag cgtctcttcc tcagtggctg
     1081 aagcggccgg gggctcccac tcgcctgctg cgcctatagc cactgcgccc tgggggcctg
     1141 ggctctgctg ccctggaccc ctctatttat ttcccttcca cagtgtggtt tcttcctctg
     1201 cggtaaagga cttggtctgt tctaccccct gctccagctt gccctgctcg tcctgatcct
     1261 gtgatttctc tgtccttggc tattcttgca gggagctgga aaacttctga ggatttctgg
     1321 cctccccctg ggttttagtt tcagggcaca caggacagca gaagatcccc tttgtcagtg
     1381 gggaaaccaa ggcagagctg aggggacagg gaggagcaga agccatcaag atggtcaaag
     1441 ggcctgcaga gggagatgtg gcccttcctc cccctcattg aggacttaat aaattggatt
     1501 gatgacacca gccccaaatc tggagagtct ggggggtggc taggagaggg gaggagactg
     1561 gacaaagaag ctggagaata ggaactggag tttttaagaa aaattgttaa agaaaaagca
     1621 gccgctggtt ttttgcaaat gctgtataaa tctgtcatgc cacagcagct gacagggcca
     1681 gaaaaactca aa
//
