LOCUS       NM_012140               1942 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 25 member 10 (SLC25A10),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012140
VERSION     NM_012140.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1942)
  AUTHORS   Zhou,B., Mai,Z., Ye,Y., Song,Y., Zhang,M., Yang,X., Xia,W. and
            Qiu,X.
  TITLE     The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis
            and apoptosis through SLC25A10 in colorectal cancer
  JOURNAL   Hum Cell 35 (6), 1900-1911 (2022)
   PUBMED   36104652
  REMARK    GeneRIF: The role of PYCR1 in inhibiting 5-fluorouracil-induced
            ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
REFERENCE   2  (bases 1 to 1942)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1942)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1942)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1942)
  AUTHORS   Cai,T., Hua,B., Luo,D., Xu,L., Cheng,Q., Yuan,G., Yan,Z., Sun,N.,
            Hua,L. and Lu,C.
  TITLE     The circadian protein CLOCK regulates cell metabolism via the
            mitochondrial carrier SLC25A10
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1866 (8), 1310-1321 (2019)
   PUBMED   30943427
  REMARK    GeneRIF: identified a new protein-protein interaction mechanism in
            which CLOCK can directly regulate cell metabolism via the
            mitochondrial membrane transporter SLC25A10.
REFERENCE   6  (bases 1 to 1942)
  AUTHORS   Damrauer,S.M., Studer,P., da Silva,C.G., Longo,C.R., Ramsey,H.E.,
            Csizmadia,E., Shrikhande,G.V., Scali,S.T., Libermann,T.A.,
            Bhasin,M.K. and Ferran,C.
  TITLE     A20 modulates lipid metabolism and energy production to promote
            liver regeneration
  JOURNAL   PLoS One 6 (3), e17715 (2011)
   PUBMED   21437236
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1942)
  AUTHORS   Huypens,P., Pillai,R., Sheinin,T., Schaefer,S., Huang,M.,
            Odegaard,M.L., Ronnebaum,S.M., Wettig,S.D. and Joseph,J.W.
  TITLE     The dicarboxylate carrier plays a role in mitochondrial malate
            transport and in the regulation of glucose-stimulated insulin
            secretion from rat pancreatic beta cells
  JOURNAL   Diabetologia 54 (1), 135-145 (2011)
   PUBMED   20949348
REFERENCE   8  (bases 1 to 1942)
  AUTHORS   Mizuarai,S., Miki,S., Araki,H., Takahashi,K. and Kotani,H.
  TITLE     Identification of dicarboxylate carrier Slc25a10 as malate
            transporter in de novo fatty acid synthesis
  JOURNAL   J Biol Chem 280 (37), 32434-32441 (2005)
   PUBMED   16027120
  REMARK    GeneRIF: Slc25a10 plays an important role in supplying malate for
            citrate transport required for fatty acid synthesis and its
            inhibition might effectively reduce lipid accumulation in adipose
            tissues
REFERENCE   9  (bases 1 to 1942)
  AUTHORS   Fiermonte,G., Dolce,V., Arrigoni,R., Runswick,M.J., Walker,J.E. and
            Palmieri,F.
  TITLE     Organization and sequence of the gene for the human mitochondrial
            dicarboxylate carrier: evolution of the carrier family
  JOURNAL   Biochem J 344 Pt 3 (Pt 3), 953-960 (1999)
   PUBMED   10585886
REFERENCE   10 (bases 1 to 1942)
  AUTHORS   Pannone,E., Fiermonte,G., Dolce,V., Rocchi,M. and Palmieri,F.
  TITLE     Assignment of the human dicarboxylate carrier gene (DIC) to
            chromosome 17 band 17q25.3
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 238-239 (1998)
   PUBMED   10072589
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI081980.1, BC007355.2,
            AC139530.3 and HY259124.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012140.4.
            
            Summary: This gene encodes a member of a family of proteins that
            translocate small metabolites across the mitochondrial membrane.
            The encoded protein exchanges dicarboxylates, such as malate and
            succinate, for phosphate, sulfate, and other small molecules,
            thereby providing substrates for metabolic processes including the
            Krebs cycle and fatty acid synthesis. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.163719.1,
                                           SRR1163657.327340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 10585886; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000350690.10/
                                                  ENSP00000345580.5
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AI081980.1         49-105
            58-1792             BC007355.2         1-1735
            1793-1793           AC139530.3         8825-8825           c
            1794-1942           HY259124.1         37-185              c
FEATURES             Location/Qualifiers
     source          1..1942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1942
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /note="solute carrier family 25 member 10"
                     /db_xref="GeneID:1468"
                     /db_xref="HGNC:HGNC:10980"
                     /db_xref="MIM:606794"
     exon            1..236
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1007
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /note="isoform 2 is encoded by transcript variant 2;
                     dicarboxylate ion carrier; mitochondrial dicarboxylate
                     carrier; solute carrier family 25 (mitochondrial carrier;
                     dicarboxylate transporter), member 10"
                     /codon_start=1
                     /product="mitochondrial dicarboxylate carrier isoform 2"
                     /protein_id="NP_036272.2"
                     /db_xref="CCDS:CCDS11786.1"
                     /db_xref="GeneID:1468"
                     /db_xref="HGNC:HGNC:10980"
                     /db_xref="MIM:606794"
                     /translation="MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRM
                     TGMALRVVRTDGILALYSGLSASLCRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEK
                     VLLGSVSGLAGGFVGTPADLVNVRMQNDVKLPQGQRRNYAHALDGLYRVAREEGLRRL
                     FSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVASFIAGGCATFLCQ
                     PLDVLKTRLMNSKGEYQGVFHCAVETAKLGPLAFYKGLVPAGIRLIPHTVLTFVFLEQ
                     LRKNFGIKVPS"
     exon            237..356
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            357..471
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            472..520
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            521..562
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            563..606
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            607..677
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            678..770
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            771..848
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            849..905
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1942
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1922..1927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /note="hexamer: AATAAA"
     polyA_site      1942
                     /gene="SLC25A10"
                     /gene_synonym="DIC; MTDPS19"
                     /note="major polyA site"
ORIGIN      
        1 gcattggctg tgcggggtgc gggcgcgcgg gcggcgcttt gaaccgggcg cggggcgcgg
       61 ggcgcggggc gctgcggccg gtacacgccg gggtagggcc ggggtcgggt tgtggtcggg
      121 ccgggattgg gctctcctgg gccatggcag ccgaggcgcg cgtgtcgcgc tggtacttcg
      181 gggggctggc ctcctgcggg gccgcctgct gcacgcaccc gctggacctg ctcaaggtgc
      241 atctgcagac gcagcaggag gtgaagctgc gcatgacggg catggcgctg cgggtggtgc
      301 gtaccgacgg catcctggca ctctacagcg gcctgagcgc ctcgctgtgc agacagatga
      361 cctactccct gactcggttc gccatctacg agactgtgcg ggaccgtgtg gccaagggca
      421 gccaggggcc tctccccttc cacgagaagg tgttgctggg ctccgtcagc ggtttagctg
      481 gaggcttcgt ggggacgccc gcagacttgg tcaacgtcag gatgcagaac gacgtgaagc
      541 tgccccaggg tcagcggcgc aactacgccc atgcgctgga tggcctgtac cgcgtagctc
      601 gtgaagaggg tctcaggaga ctgttctcgg gtgcaaccat ggcatccagc cgaggggcct
      661 tagtcactgt gggccagctg tcctgctacg accaggccaa gcagctggtc cttagcaccg
      721 ggtacctctc tgacaacatc ttcactcact ttgtcgccag ctttattgca ggtggatgtg
      781 ccacgttcct gtgccagccc ctggatgtgc tgaagactcg cctgatgaac tccaaggggg
      841 agtatcaggg cgttttccac tgcgccgtgg agacagcgaa gctcgggcct ctggcctttt
      901 acaagggcct cgtcccagct ggcatccgcc tcatccccca caccgtgctc acttttgtgt
      961 ttctggaaca gctacgcaaa aactttggca tcaaagtgcc atcctgacca gccgtgggaa
     1021 tggctgggct gccaggccag acacgctagg ttcttccaaa gagtcccaag cccagcacct
     1081 gctcctgggg ccacgacctc cctggccgtg gccacccgtc ctccgcagca ggcccctgct
     1141 gtccccccac ctgctggctg agctcctcct ggcctcgtcc cctctcagct gtagctgcac
     1201 cacccccgct ctggctacca ggctctcccg gctgggcact gcgtggcctt gcccctctcc
     1261 cgctggcagc tcctcagggg aacaggggct accagaggct gatttctccc ctctcctggg
     1321 ccaggggagg ggtattatcc ctgcctcctg cccccgatgc ccaaagcagc atcttccagc
     1381 actttccatc gaggacttgg gtggcagagt gtgggtgcag cctggctgtt gctcacccaa
     1441 gtgctagctc tgcacttcgt gtctgctgag agcaaccaga ccttccatgt cctcgggcag
     1501 ctgcaactcc ccgcgagacc ccgcagctgg gtgggatgaa caagcaacgc agaccacaag
     1561 cgagtgcctg ggagggagtg gcccagggtg gttctggagc cattgtgggt gagggtcgag
     1621 ggccaccgag gtcccgcgca ccgctgcctg ccctgcagtg gctttaacag ttagttttgc
     1681 caaagcctct ccactcacca gcaggcggtc tctgtcttca gggattgtgc ctgcgtccct
     1741 cgggcacctg ggcccccccg cttggctccc tgggggaatg gcccaggcgg gccgcggttc
     1801 ctccttaggg ccttctcccc gacaaggagt ccgacggggc ggatgctgca tcctctgcct
     1861 ccctggtcgc tgggcttcac cccacctggg aagggcagtg tgctctgtgg gggctgcaat
     1921 caataaatgc cgggagctgc ca
//
