LOCUS       NM_020689               3922 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 24 member 3 (SLC24A3), mRNA.
ACCESSION   NM_020689
VERSION     NM_020689.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3922)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   2  (bases 1 to 3922)
  AUTHORS   Jalloul,A.H., Szerencsei,R.T. and Schnetkamp,P.P.
  TITLE     Cation dependencies and turnover rates of the human K-dependent
            Na-Ca(2) exchangers NCKX1, NCKX2, NCKX3 and NCKX4
  JOURNAL   Cell Calcium 59 (1), 1-11 (2016)
   PUBMED   26631410
REFERENCE   3  (bases 1 to 3922)
  AUTHORS   Kanazawa,T., Ikeda,M., Glatt,S.J., Tsutsumi,A., Kikuyama,H.,
            Kawamura,Y., Nishida,N., Miyagawa,T., Hashimoto,R., Takeda,M.,
            Sasaki,T., Tokunaga,K., Koh,J., Iwata,N. and Yoneda,H.
  TITLE     Genome-wide association study of atypical psychosis
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 162B (7), 679-686 (2013)
   PUBMED   24132900
REFERENCE   4  (bases 1 to 3922)
  AUTHORS   Imboden,M., Bouzigon,E., Curjuric,I., Ramasamy,A., Kumar,A.,
            Hancock,D.B., Wilk,J.B., Vonk,J.M., Thun,G.A., Siroux,V., Nadif,R.,
            Monier,F., Gonzalez,J.R., Wjst,M., Heinrich,J., Loehr,L.R.,
            Franceschini,N., North,K.E., Altmuller,J., Koppelman,G.H.,
            Guerra,S., Kronenberg,F., Lathrop,M., Moffatt,M.F., O'Connor,G.T.,
            Strachan,D.P., Postma,D.S., London,S.J., Schindler,C.,
            Kogevinas,M., Kauffmann,F., Jarvis,D.L., Demenais,F. and
            Probst-Hensch,N.M.
  TITLE     Genome-wide association study of lung function decline in adults
            with and without asthma
  JOURNAL   J Allergy Clin Immunol 129 (5), 1218-1228 (2012)
   PUBMED   22424883
REFERENCE   5  (bases 1 to 3922)
  AUTHORS   Siedlinski,M., Cho,M.H., Bakke,P., Gulsvik,A., Lomas,D.A.,
            Anderson,W., Kong,X., Rennard,S.I., Beaty,T.H., Hokanson,J.E.,
            Crapo,J.D. and Silverman,E.K.
  CONSRTM   COPDGene Investigators; ECLIPSE Investigators
  TITLE     Genome-wide association study of smoking behaviours in patients
            with COPD
  JOURNAL   Thorax 66 (10), 894-902 (2011)
   PUBMED   21685187
REFERENCE   6  (bases 1 to 3922)
  AUTHORS   Yang,H., Kim,T.H., Lee,H.H., Choi,K.C. and Jeung,E.B.
  TITLE     Distinct expression of the calcium exchangers, NCKX3 and NCX1, and
            their regulation by steroid in the human endometrium during the
            menstrual cycle
  JOURNAL   Reprod Sci 18 (6), 577-585 (2011)
   PUBMED   21321244
  REMARK    GeneRIF: NCKX3 is abundantly expressed within the human endometrium
            at the transcriptional and translational levels, and its level is
            regulated by steroid hormones (particularly estradiol) during the
            human menstrual cycle.
REFERENCE   7  (bases 1 to 3922)
  AUTHORS   Cheng,Y.C., Kao,W.H., Mitchell,B.D., O'Connell,J.R., Shen,H.,
            McArdle,P.F., Gibson,Q., Ryan,K.A., Shuldiner,A.R. and Pollin,T.I.
  TITLE     Genome-wide association scan identifies variants near Matrix
            Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly
            associated with serum MMP-1 levels
  JOURNAL   Circ Cardiovasc Genet 2 (4), 329-337 (2009)
   PUBMED   20031604
REFERENCE   8  (bases 1 to 3922)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 3922)
  AUTHORS   Kraev,A., Quednau,B.D., Leach,S., Li,X.F., Dong,H., Winkfein,R.,
            Perizzolo,M., Cai,X., Yang,R., Philipson,K.D. and Lytton,J.
  TITLE     Molecular cloning of a third member of the potassium-dependent
            sodium-calcium exchanger gene family, NCKX3
  JOURNAL   J Biol Chem 276 (25), 23161-23172 (2001)
   PUBMED   11294880
  REMARK    GeneRIF: Plasma membrane ion transporter.Displayed K(+)-dependent
            Na(+)/Ca(2+) exchanger activity when assayed in heterologous
            expression systems, using digital imaging of fura-2 fluorescence,
            electrophysiology, or radioactive (45)Ca(2+) uptake.
            Erratum:[J Biol Chem. 2006 Mar 31;281(13):8996]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136090.12, AL049647.7, AL034425.9, AL139429.8, AL121830.25 and
            AL121761.5.
            
            On May 17, 2019 this sequence version replaced NM_020689.3.
            
            Summary: Plasma membrane sodium/calcium exchangers are an important
            component of intracellular calcium homeostasis and electrical
            conduction. Potassium-dependent sodium/calcium exchangers such as
            SLC24A3 are believed to transport 1 intracellular calcium and 1
            potassium ion in exchange for 4 extracellular sodium ions (Kraev et
            al., 2001 [PubMed 11294880]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288087.1, AF169257.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328041.11/ ENSP00000333519.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AL136090.12        169337-169679
            344-472             AL049647.7         52281-52409
            473-549             AL034425.9         105731-105807
            550-624             AL139429.8         53611-53685
            625-709             AL139429.8         58582-58666
            710-813             AL139429.8         59052-59155
            814-888             AL121830.25        37721-37795
            889-914             AL121830.25        49523-49548
            915-968             AL121830.25        57260-57313
            969-1102            AL121830.25        65517-65650
            1103-1263           AL121830.25        67835-67995
            1264-1525           AL121830.25        68759-69020
            1526-1692           AL121830.25        76918-77084
            1693-1807           AL121830.25        80456-80570
            1808-1920           AL121830.25        82227-82339
            1921-1986           AL121761.5         13893-13958
            1987-3922           AL121761.5         17356-19291
FEATURES             Location/Qualifiers
     source          1..3922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..3922
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /note="solute carrier family 24 member 3"
                     /db_xref="GeneID:57419"
                     /db_xref="HGNC:HGNC:10977"
                     /db_xref="MIM:609839"
     exon            1..343
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2136
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /note="sodium/potassium/calcium exchanger 3; sodium
                     calcium exchanger; Na(+)/K(+)/Ca(2+)-exchange protein 3;
                     solute carrier family 24 (sodium/potassium/calcium
                     exchanger), member 3"
                     /codon_start=1
                     /product="sodium/potassium/calcium exchanger 3 precursor"
                     /protein_id="NP_065740.2"
                     /db_xref="CCDS:CCDS13140.1"
                     /db_xref="GeneID:57419"
                     /db_xref="HGNC:HGNC:10977"
                     /db_xref="MIM:609839"
                     /translation="MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLR
                     EQKELDLMDLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTN
                     EDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSS
                     APELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSI
                     YYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMV
                     NGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMI
                     TSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPD
                     RGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKW
                     AFTWPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIP
                     DVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTL
                     AVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCF
                     SIMTEFNVFTFVNLPMCGDH"
     exon            344..472
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..549
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            550..624
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..709
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..813
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..888
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..914
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..968
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1102
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1263
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1525
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1692
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1807
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1920
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..1986
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..3922
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3873..3878
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /note="hexamer: AATAAA"
     polyA_site      3893
                     /gene="SLC24A3"
                     /gene_synonym="NCKX3"
                     /note="major polyA site"
ORIGIN      
        1 gatagcgacg aggagggcga cgacgaggag acgggcagcg gcgaggagga ggaagaggag
       61 gcggaggcgg cggccgggtg ggagcgcagc gaggacgcgc ggctgctgcg cgcagggctg
      121 cctcctgccg ctgtccccgc cgcggccgcc cgcgacagga gcggccgccg cccgccgagg
      181 ccgccgcccg gccgcccgag gatgcggccg tccggcgacg aggaccgcgc gcgtcgccgc
      241 cgccgccgcc gccgccggag ggaccttctg ctgagccagc tctgcttcct ggcctcggtg
      301 gcgctgctgc tctggtcgct gtcgagcctg cgagagcaga aggagcttga cctcatggac
      361 ctcgtagggg aagacagaaa gtggatgatg gcgaggaagc tgatgcaggt gaacgacact
      421 ctgacttccg aagatgccgg actccggaac agcaagaact gcaccgaacc agccctgcat
      481 gaattcccca atgacatctt cacaaacgag gatagaagac aaggtgcggt ggtcctccat
      541 gtgctctgtg ccatatacat gttctatgcg ctggccattg tgtgtgatga cttcttcgtc
      601 ccttccttgg aaaagatctg tgagcgcctg cacctcagtg aagatgtggc tggggccaca
      661 ttcatggcag cgggaagttc ggccccagag ctgttcacat cggtcatagg ggtcttcatc
      721 accaaaggcg atgtgggagt tggcaccatc gtgggctcag cggtattcaa catcctgtgc
      781 atcattggtg tctgtgggct ctttgctggg caggttgtgg ctctttcctc ctggtgcctg
      841 ctgagggatt ctatttacta cacgctgtct gtgatcgcgc tcatcgtgtt tatttatgat
      901 gaaaaagttt cctggtggga gtctttagtc cttgtgctga tgtatcttat ctacattgtc
      961 atcatgaaat ataacgcttg catacatcag tgctttgaga ggaggacaaa aggtgccggg
     1021 aacatggtca acggattggc caacaatgct gaaattgatg acagcagcaa ctgcgacgca
     1081 actgtggtgc tacttaagaa agcaaatttc caccgcaaag catcagtgat catggtagac
     1141 gagctgctgt cagcctaccc acaccagctt tccttctctg aggctggcct tcgaatcatg
     1201 ataaccagcc actttccccc caagacccgg ctctccatgg ccagtcgcat gttgatcaat
     1261 gagagacaaa gattgataaa cagcagggct tataccaacg gggaatctga ggtggccatc
     1321 aaaatcccaa ttaagcacac cgtggagaat gggacagggc ccagcagtgc cccagacagg
     1381 ggcgtgaatg ggacacggag ggacgatgtt gtggctgagg ctggcaacga aacagagaat
     1441 gaaaatgagg acaatgagaa tgatgaggag gaagaggagg acgaggatga tgatgaagga
     1501 ccgtacacac cattcgacac cccctcgggt aaactggaaa cagtgaaatg ggcgttcacc
     1561 tggccgctga gtttcgtctt atacttcact gtacccaact gcaacaagcc gcgctgggag
     1621 aaatggttca tggtgacgtt tgcttcctcc acgctgtgga tcgcagcctt ctcctacatg
     1681 atggtgtgga tggtcacaat cattggttac accctgggga ttcctgacgt catcatgggg
     1741 atcaccttcc tggctgctgg gaccagcgtg cctgactgca tggccagcct cattgtggcc
     1801 agacaaggga tgggggacat ggctgtgtcc aactccattg ggagcaacgt gtttgacatc
     1861 ctgattggcc tcggtctccc ctgggctctg cagaccctgg ctgtggatta cggatcctac
     1921 atccggctga atagcagggg gctgatctac tccgtaggct tgctcctggc ctctgttttt
     1981 gtcacggtgt tcggcgtcca cctgaacaag tggcagctgg acaagaagct gggctgtggg
     2041 tgcctcctcc tgtatggtgt gttcctgtgc ttctccatca tgactgagtt caacgtgttc
     2101 acctttgtga acctgcccat gtgcggggac cactgagccg ccgggtgccc acagaggctc
     2161 agctccttct tttctgtgca atacgagacc cggccgcacc ccgagtcaca caggcccccg
     2221 gggccacggc gttcgtctct cctgtgctgt cctcaggcct ccgctcctgt tttggtggcc
     2281 caggctctcc cctgacccat cctcgctccc ccacctcctt gggtcatgcc cacccaccct
     2341 ttcctgcctc ctccgtgtga agacatccaa catccacgtg acttttccag ctccattttt
     2401 gaacagtgac tgagattcta gaaaaactgg ctgctaactg gcctgagcca ggcaacactg
     2461 attccaatcc ctcctccttt tttaagttat ttgatggaag actcacctaa tttgtgacct
     2521 gagactgttg aagaaataga gaggaggggg cccgttgatt acagagagca tttgggattt
     2581 tgtttggttt ggagatgatg cctaggttac tgggtttggg gggattgttt tcttttgggg
     2641 gccttcccct tttactcctt ttcttccaga gatcaagagc ttctcttgca tcttcttcca
     2701 ctgggctctg gattaatcaa ttacccaaag gctgcacctg ccgtgttgtc tgggcttgca
     2761 tcccagatgt gttggagtat gcatggatgt agtgcttttt agaggagcca ctgggcaagg
     2821 ccaccaagaa caaatgcatg acattttata gccaaggacg cctcgctaaa gtcttatggg
     2881 cgtcccctgg ggttgggggg gcacaaggtt ttggaggaag aagacaactt ccctcattcc
     2941 atcatcacca tctctttctc actaggttct ttctagtttt caagcaatag ttctagcctg
     3001 ccttggacaa gggggcccca gttaaacaaa ctacccatcc atgagctgcc aggcagtcaa
     3061 aaacagaagc ttccccgact tgtgagtccc tgagatgtgc tcttgttgtt tggcatttgg
     3121 ggtgacaggg agtgacccag aggccaccac tgcttttcat gcaggagtta cagacactgg
     3181 tttcttggaa aatggagaga agcgcacttt gcacagacgt cgtcaattaa gtcccaattt
     3241 gccacttggt attgagtaca ctggaccctg accactggct cttgggcaaa cgtccttcct
     3301 cacggggcgc ctccgccaag ccggcccagc tgcacccctc ccttcctgga gggatggcca
     3361 gggaaggaga aaacagagaa ctgacacctt tgaaaccaca gaatgtgtta catgcagact
     3421 cgctcaaggg cataagttat tgtgaacgtt tttgccaatc actgctcaac agccctgcta
     3481 gattttgtat gatgctgaat tattatgcag actaattcca cccagttgag acacaccatg
     3541 cttgttcact tgtatttatt gaaactgtgg attcttgccc gtgctgtccc ttgtatttac
     3601 tttaagcact gatcacttat cattcattcg gtatggtttt ccctgtccct tgtacacatt
     3661 ctggtatgaa tttgtaaaaa taacctgcta caaattggtt gaatgtttct gtctgtggtg
     3721 cgaaccagca ttaacggatg gggcacgtgc ccaactgagg aacaggagaa gaaatcacca
     3781 atttgggctc tcagagctaa gacacactta ttgattctgt tgcacatttt gcactggttt
     3841 atggcgattg ttttcttgga cggatagtgt aaaataaact tctctgttct ctatccttcc
     3901 cagagcagag tgcattactt tc
//
