LOCUS       NM_001144889            2322 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 23 member 3 (SLC23A3),
            transcript variant 2, mRNA.
ACCESSION   NM_001144889
VERSION     NM_001144889.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Hosoyamada,M., Tomioka,N.H., Watanabe,T., Yasuno,N., Uchida,S. and
            Shibata,S.
  TITLE     SLC23A3 is a renal hypoxanthine transporter
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 41 (12), 1279-1286 (2022)
   PUBMED   35094660
  REMARK    GeneRIF: SLC23A3 is a renal hypoxanthine transporter.
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Nikulin,S.V., Knyazev,E.N., Poloznikov,A.A., Shilin,S.A.,
            Gazizov,I.N., Zakharova,G.S. and Gerasimenko,T.N.
  TITLE     [Expression of SLC30A10 and SLC23A3 Transporter mRNAs in Caco-2
            Cells Correlates with an Increase in the Area of the Apical
            Membrane]
  JOURNAL   Mol Biol (Mosk) 52 (4), 667-674 (2018)
   PUBMED   30113032
  REMARK    GeneRIF: In the course of differentiation, the most pronounced
            changes in the expression levels were observed for the mRNAs that
            encode SLC30A10 and SLC23A3 transporters. Their increase correlated
            with an increase in the apical membrane area, indicating that
            SLC30A10 and SLC23A3 mRNA levels assessed by qRT-PCR may be
            employed as cell differentiation biomarkers in Caco-2 models.
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   4  (bases 1 to 2322)
  AUTHORS   Zhao,J., Li,M., Bradfield,J.P., Zhang,H., Mentch,F.D., Wang,K.,
            Sleiman,P.M., Kim,C.E., Glessner,J.T., Hou,C., Keating,B.J.,
            Thomas,K.A., Garris,M.L., Deliard,S., Frackelton,E.C., Otieno,F.G.,
            Chiavacci,R.M., Berkowitz,R.I., Hakonarson,H. and Grant,S.F.
  TITLE     The role of height-associated loci identified in genome wide
            association studies in the determination of pediatric stature
  JOURNAL   BMC Med Genet 11, 96 (2010)
   PUBMED   20546612
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2322)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   6  (bases 1 to 2322)
  AUTHORS   Guimaraes,M.J., Bazan,J.F., Zlotnik,A., Wiles,M.V., Grimaldi,J.C.,
            Lee,F. and McClanahan,T.
  TITLE     A new approach to the study of haematopoietic development in the
            yolk sac and embryoid bodies
  JOURNAL   Development 121 (10), 3335-3346 (1995)
   PUBMED   7588067
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC361649.1, AK298256.1 and AC068946.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001144889.1.
            
            Transcript Variant: This variant (2) uses alternate in-frame splice
            sites and contains an alternate in-frame exon, compared to variant
            1. The resulting protein (isoform 2) is longer than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298256.1, DRR138522.1675937.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153733 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409878.8/ ENSP00000386473.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DC361649.1         70-94
            26-1167             AK298256.1         2-1143
            1168-1168           AC068946.4         59571-59571         c
            1169-2181           AK298256.1         1145-2157
            2182-2322           AC068946.4         55823-55963         c
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2322
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /note="solute carrier family 23 member 3"
                     /db_xref="GeneID:151295"
                     /db_xref="HGNC:HGNC:20601"
                     /db_xref="MIM:620339"
     exon            1..207
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1878
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     E2-binding protein 3; HPC E2-binding protein 3; solute
                     carrier family 23 (nucleobase transporters), member 3;
                     sodium-dependent vitamin C transporter 3; Na(+)/L-ascorbic
                     acid transporter 3"
                     /codon_start=1
                     /product="solute carrier family 23 member 3 isoform 2"
                     /protein_id="NP_001138361.1"
                     /db_xref="CCDS:CCDS46518.1"
                     /db_xref="GeneID:151295"
                     /db_xref="HGNC:HGNC:20601"
                     /db_xref="MIM:620339"
                     /translation="MSRSPLNPSQLRSVGSQDALAPLPPPAPQNPSTHSWDPLCGSLP
                     WGLSCLLALQHVLVMASLLCVSHLLLLCSLSPGGLSYSPSQLLASSFFSCGMSTILQT
                     WMGSRLPLVQAPSLEFLIPALVLTSQKLPRAIQTPGNSSLMLHLCRGPSCHGLGHWNT
                     SLQEVSGAVVVSGLLQGMMGLLGSPGHVFPHCGPLVLAPSLVVAGLSAHREVAQFCFT
                     HWGLALLVILLMVVCSQHLGSCQFHVCPWRRASTSSTHTPLPVFRLLSVLIPVACVWI
                     VSAFVGFSVIPQELSAPTKAPWIWLPHPGEWNWPLLTPRALAAGISMALAASTSSLGC
                     YALCGRLLHLPPPPPHACSRGLSLEGLGSVLAGLLGSPMGTASSFPNVGKVGLIQAGS
                     QQVAHLVGLLCVGLGLSPRLAQLLTTIPLPVVGGVLGVTQAVVLSAGFSSFYLADIDS
                     GRNIFIVGFSIFMALLLPRWFREAPVLFSTGWSPLDVLLHSLLTQPIFLAGLSGFLLE
                     NTIPGTQLERGLGQGLPSPFTAQEARMPQKPREKAAQVYRLPFPIQNLCPCIPQPLHC
                     LCPLPEDPGDEEGGSSEPEEMADLLPGSGEPCPESSREGFRSQK"
     exon            208..365
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..463
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..537
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            538..719
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..843
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..958
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1212
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1318
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1486
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1582
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..2322
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /note="hexamer: AATAAA"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /note="hexamer: AATAAT"
     polyA_site      2317
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /note="major polyA site"
     polyA_site      2322
                     /gene="SLC23A3"
                     /gene_synonym="E2BP3; SVCT3; Yspl1"
                     /note="major polyA site"
ORIGIN      
        1 aactctggtc ccgggcagcc aagacaaagc gaaaggcaag gcagcatgag ccgatcaccc
       61 ctcaatccca gccaactccg atcagtgggc tcccaggatg ccctggcccc cttgcctcca
      121 cctgctcccc agaatccctc cacccactct tgggaccctt tgtgtggatc tctgccttgg
      181 ggcctcagct gtcttctggc tctgcagcat gtcttggtca tggcttctct gctctgtgtc
      241 tcccacctgc tcctgctttg cagtctctcc ccaggaggac tctcttactc cccttctcag
      301 ctcctggcct ccagcttctt ttcatgtggt atgtctacca tcctgcaaac ttggatgggc
      361 agcaggctgc ctcttgtcca ggctccatcc ttagagttcc ttatccctgc tctggtgctg
      421 accagccaga agctaccccg ggccatccag acacctggaa actcctccct catgctgcac
      481 ctttgtaggg gacctagctg ccatggcctg gggcactgga acacttctct ccaggaggtg
      541 tccggggcag tggtagtatc tgggctgctg cagggcatga tggggctgct ggggagtccc
      601 ggccacgtgt tcccccactg tgggcccctg gtgctggctc ccagcctggt tgtggcaggg
      661 ctctctgccc acagggaggt agcccagttc tgcttcacac actgggggtt ggccttgctg
      721 gttatcctgc tcatggtggt ctgttctcag cacctgggct cctgccagtt tcatgtgtgc
      781 ccctggaggc gagcttcaac gtcatcaact cacactcctc tccctgtctt ccggctcctt
      841 tcggtgctga tcccagtggc ctgtgtgtgg attgtttctg cctttgtggg attcagtgtt
      901 atcccccagg aactgtctgc ccccaccaag gcaccatgga tttggctgcc tcacccaggt
      961 gagtggaatt ggcctttgct gacgcccaga gctctggctg caggcatctc catggccttg
     1021 gcagcctcca ccagttccct gggctgctat gccctgtgtg gccggctgct gcatttgcct
     1081 cccccacctc cacatgcctg cagtcgaggg ctgagcctgg aggggctggg cagtgtgctg
     1141 gccgggctgc tgggaagccc catgggcact gcatccagct tccccaacgt gggcaaagtg
     1201 ggtcttatcc aggctggatc tcagcaagtg gctcacttag tggggctact ctgcgtgggg
     1261 cttggactct cccccaggtt ggctcagctc ctcaccacca tcccactgcc tgttgttggt
     1321 ggggtgctgg gggtgaccca ggctgtggtt ttgtctgctg gattctccag cttctacctg
     1381 gctgacatag actctgggcg aaatatcttc attgtgggct tctccatctt catggccttg
     1441 ctgctgccaa gatggtttcg ggaagcccca gtcctgttca gcacaggctg gagccccttg
     1501 gatgtattac tgcactcact gctgacacag cccatcttcc tggctggact ctcaggcttc
     1561 ctactagaga acacgattcc tggcacacag cttgagcgag gcctaggtca agggctacca
     1621 tctcctttca ctgcccaaga ggctcgaatg cctcagaagc ccagggagaa ggctgctcaa
     1681 gtgtacagac ttcctttccc catccaaaac ctctgtccct gcatccccca gcctctccac
     1741 tgcctctgcc cactgcctga agaccctggg gatgaggaag gaggctcctc tgagccagaa
     1801 gagatggcag acttgctgcc tggctcaggg gagccatgcc ctgaatctag cagagaaggg
     1861 tttaggtccc agaaatgacc agaacgccta cttctgccct ggttaattta gccctaactc
     1921 tcatctgctg gagagtcagc tcccaaactg ttctttcttg taggcagagg atatgtgtgt
     1981 gtgtattaca tgggactgtc tagaggttcc atttcccaat agggtgggtt gcctttcctt
     2041 gtcttaatta ggcctaactg ttccagagca gaggccatga tttagtggac catgaatgat
     2101 tgagattttg cctgtgtact atcaatgcca cttgaacccc agcattcact ttaatactta
     2161 ctgagcatct cccatgtgca aggtcctgga actacaggga taagacaggg tccatgccgt
     2221 ctcaaggcat ttacggttta aaaagacctt tgtaattact aacgaaaatg caaagcagaa
     2281 agcagtctgt aataaagatt aaaataatgc cgtgggagca aa
//
