LOCUS       NM_005116               6953 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 23 member 2 (SLC23A2),
            transcript variant 1, mRNA.
ACCESSION   NM_005116
VERSION     NM_005116.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6953)
  AUTHORS   Portugal,C.C.
  TITLE     Ascorbate and its transporter SVCT2: The dynamic duo's integrated
            roles in CNS neurobiology and pathophysiology
  JOURNAL   Free Radic Biol Med 212, 448-462 (2024)
   PUBMED   38182073
  REMARK    GeneRIF: Ascorbate and its transporter SVCT2: The dynamic duo's
            integrated roles in CNS neurobiology and pathophysiology.
            Review article
REFERENCE   2  (bases 1 to 6953)
  AUTHORS   Teafatiller,T., Perez,O., Kitazawa,M., Agrawal,A. and
            Subramanian,V.S.
  TITLE     Nedd4-1 regulates human sodium-dependent vitamin C transporter-2
            functional expression in neuronal and epithelial cells
  JOURNAL   J Nutr Biochem 120, 109413 (2023)
   PUBMED   37423323
  REMARK    GeneRIF: Nedd4-1 regulates human sodium-dependent vitamin C
            transporter-2 functional expression in neuronal and epithelial
            cells.
REFERENCE   3  (bases 1 to 6953)
  AUTHORS   Toyoda,Y., Miyata,H., Shigesawa,R., Matsuo,H., Suzuki,H. and
            Takada,T.
  TITLE     SVCT2/SLC23A2 is a sodium-dependent urate transporter: functional
            properties and practical application
  JOURNAL   J Biol Chem 299 (8), 104976 (2023)
   PUBMED   37390985
  REMARK    GeneRIF: SVCT2/SLC23A2 is a sodium-dependent urate transporter:
            functional properties and practical application.
REFERENCE   4  (bases 1 to 6953)
  AUTHORS   Han,Q.Q., Wu,P.F., Li,Y.H., Cao,Y., Chen,J.G. and Wang,F.
  TITLE     SVCT2-mediated ascorbic acid uptake buffers stress responses via
            DNA hydroxymethylation reprogramming of S100 calcium-binding
            protein A4 gene
  JOURNAL   Redox Biol 58, 102543 (2022)
   PUBMED   36436457
  REMARK    GeneRIF: SVCT2-mediated ascorbic acid uptake buffers stress
            responses via DNA hydroxymethylation reprogramming of S100
            calcium-binding protein A4 gene.
REFERENCE   5  (bases 1 to 6953)
  AUTHORS   Hou,H., Zhang,Y., Wu,H., Huang,Z., Liu,S., Liang,H. and Xu,Y.
  TITLE     Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for
            Preeclampsia in a Chinese Han Population
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 68 (5), 368-374 (2022)
   PUBMED   36310070
  REMARK    GeneRIF: Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk
            for Preeclampsia in a Chinese Han Population.
REFERENCE   6  (bases 1 to 6953)
  AUTHORS   Daruwala,R., Song,J., Koh,W.S., Rumsey,S.C. and Levine,M.
  TITLE     Cloning and functional characterization of the human
            sodium-dependent vitamin C transporters hSVCT1 and hSVCT2
  JOURNAL   FEBS Lett 460 (3), 480-484 (1999)
   PUBMED   10556521
REFERENCE   7  (bases 1 to 6953)
  AUTHORS   Rajan,D.P., Huang,W., Dutta,B., Devoe,L.D., Leibach,F.H.,
            Ganapathy,V. and Prasad,P.D.
  TITLE     Human placental sodium-dependent vitamin C transporter (SVCT2):
            molecular cloning and transport function
  JOURNAL   Biochem Biophys Res Commun 262 (3), 762-768 (1999)
   PUBMED   10471399
REFERENCE   8  (bases 1 to 6953)
  AUTHORS   Hogue,D.L. and Ling,V.
  TITLE     A human nucleobase transporter-like cDNA (SLC23A1): member of a
            transporter family conserved from bacteria to mammals
  JOURNAL   Genomics 59 (1), 18-23 (1999)
   PUBMED   10395795
REFERENCE   9  (bases 1 to 6953)
  AUTHORS   Tsukaguchi,H., Tokui,T., Mackenzie,B., Berger,U.V., Chen,X.Z.,
            Wang,Y., Brubaker,R.F. and Hediger,M.A.
  TITLE     A family of mammalian Na+-dependent L-ascorbic acid transporters
  JOURNAL   Nature 399 (6731), 70-75 (1999)
   PUBMED   10331392
REFERENCE   10 (bases 1 to 6953)
  AUTHORS   Faaland,C.A., Race,J.E., Ricken,G., Warner,F.J., Williams,W.J. and
            Holtzman,E.J.
  TITLE     Molecular characterization of two novel transporters from human and
            mouse kidney and from LLC-PK1 cells reveals a novel conserved
            family that is homologous to bacterial and Aspergillus nucleobase
            transporters
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 353-360 (1998)
   PUBMED   9804989
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121890.34, D87075.2,
            BC013112.2 and AI742576.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005116.5.
            
            Summary: The absorption of vitamin C into the body and its
            distribution to organs requires two sodium-dependent vitamin C
            transporters. This gene encodes one of the two required
            transporters and the encoded protein accounts for tissue-specific
            uptake of vitamin C. Previously, this gene had an official symbol
            of SLC23A1. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) occurs more frequently.
            Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87075.2, SRR14038194.4391752.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338244.6/ ENSP00000344322.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL121890.34        14190-14200         c
            12-760              D87075.2           1-749
            761-1387            BC013112.2         739-1365
            1388-6952           D87075.2           1377-6941
            6953-6953           AI742576.1         12-12               c
FEATURES             Location/Qualifiers
     source          1..6953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..6953
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /note="solute carrier family 23 member 2"
                     /db_xref="GeneID:9962"
                     /db_xref="HGNC:HGNC:10973"
                     /db_xref="MIM:603791"
     exon            1..105
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            106..232
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            233..494
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..2339
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /note="sodium-dependent vitamin C transporter-2; solute
                     carrier family 23 (nucleobase transporters), member 1;
                     Na(+)/L-ascorbic acid transporter 2; yolk sac
                     permease-like molecule 2; nucleobase transporter-like 1
                     protein; testicular secretory protein Li 48; solute
                     carrier family 23 (nucleobase transporters), member 2;
                     solute carrier family 23 (ascorbic acid transporter),
                     member 2"
                     /codon_start=1
                     /product="solute carrier family 23 member 2"
                     /protein_id="NP_005107.4"
                     /db_xref="CCDS:CCDS13085.1"
                     /db_xref="GeneID:9962"
                     /db_xref="HGNC:HGNC:10973"
                     /db_xref="MIM:603791"
                     /translation="MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGAT
                     SSGEQDNEDTELMAIYTTENGIAEKSSLAETLDSTGSLDPQRSDMIYTIEDVPPWYLC
                     IFLGLQHYLTCFSGTIAVPFLLADAMCVGYDQWATSQLIGTIFFCVGITTLLQTTFGC
                     RLPLFQASAFAFLAPARAILSLDKWKCNTTDVSVANGTAELLHTEHIWYPRIREIQGA
                     IIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGERAGKHWGIAMLT
                     IFLVLLFSQYARNVKFPLPIYKSKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTD
                     VFPPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASII
                     ESIGDYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGI
                     TKVGSRRVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLFGMITAVGLSNLQF
                     IDLNSSRNLFVLGFSIFFGLVLPSYLRQNPLVTGITGIDQVLNVLLTTAMFVGGCVAF
                     ILDNTIPGTPEERGIRKWKKGVGKGNKSLDGMESYNLPFGMNIIKKYRCFSYLPISPT
                     FVGYTWKGLRKSDNSRSSDEDSQATG"
     exon            495..593
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..710
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            711..868
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            869..957
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1028
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1210
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1331
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1488
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1636
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1742
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1872
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2010
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2106
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..6953
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6932..6937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /note="hexamer: AATAAA"
     polyA_site      6953
                     /gene="SLC23A2"
                     /gene_synonym="NBTL1; SLC23A1; SVCT2; YSPL2"
                     /note="major polyA site"
ORIGIN      
        1 gccattttgc aggcggctgt cgcggggacc ggaggcggag gctgcagcgg gcactgcggc
       61 gccgaggcgc ggcggcagga cgggaaccac gcgagctgca gccagctagg tcttgactcc
      121 actaacgggg acttctcata cggctttgaa cttggacctt ggtgcataag caaatgtaac
      181 tcagcgaatt gtaatggaaa gcatatggac aggtctacgc cacatcactt aggtgctaag
      241 agatgccgtt tgcaggcctc atctctgctt gagaatcggg ggctccaggc actagaagag
      301 ccggctgatc ctgggctcct agcttgaata agccttcact tccagctgct ctccccaacg
      361 gctgtgtaaa ctactcgttt ctcttaatga tgggtattgg taagaatacc acatccaaat
      421 caatggaggc tggaagttca acagaaggca aatacgaaga cgaggcaaag cacccagctt
      481 tcttcactct tccggtggtg ataaatggag gcgccacctc cagcggtgag caggacaatg
      541 aggacactga gctcatggcg atctacacta cggaaaacgg cattgcagaa aagagctctc
      601 tcgctgagac cctggatagc actggcagtc tggaccccca gcgatcagac atgatttata
      661 ccatagaaga tgttcctccc tggtacctgt gtatatttct ggggctacag cactacctga
      721 catgcttcag cggcacgatc gcagtgccct tcctgttggc cgatgccatg tgtgtggggt
      781 acgaccagtg ggccaccagc cagctcattg ggaccatttt cttctgtgtg ggaatcacta
      841 ctttgctaca gacaacgttt ggatgcaggt tacccctgtt tcaggccagt gcttttgcat
      901 ttttggcccc tgctcgagcc atcctgtctt tagataaatg gaaatgtaac accacagatg
      961 tttcagttgc caatggaaca gcagagctgt tgcacacaga acacatctgg tatccccgga
     1021 tccgagagat ccagggggcc atcatcatgt cctcactgat agaagtagtc atcggcctcc
     1081 tcggcctgcc tggggctcta ctgaagtaca tcggtccctt gaccattaca cccacggtgg
     1141 ccctaattgg cctctctggt ttccaggcag cgggggagag agccgggaag cactggggca
     1201 ttgccatgct gacaatattc ctagtattac tgttttctca atacgccaga aatgttaaat
     1261 ttcctctccc gatttataaa tccaagaaag gatggactgc gtacaagtta cagctgttca
     1321 aaatgttccc tatcatcctg gccatcctgg tatcctggct gctctgcttc atcttcacgg
     1381 tgacagatgt cttccctccc gacagcacaa agtatggctt ctatgctcgc acagatgcca
     1441 ggcaaggcgt gcttctggta gccccgtggt ttaaggttcc atacccattt cagtggggac
     1501 tgcccaccgt gtctgcggcc ggtgtcatcg gcatgctcag tgccgtggtc gccagcatca
     1561 tcgagtctat tggtgactac tacgcctgtg cacggctgtc ctgtgcccca ccccccccca
     1621 tccacgcaat aaacagggga attttcgtgg aaggcctctc ctgtgttctt gatggcatat
     1681 ttggtactgg gaatggctct acttcatcca gtcccaacat tggagttttg ggaattacaa
     1741 aggtcggcag ccgccgcgtg atacagtgcg gagcagccct catgctcgct ctgggcatga
     1801 tcgggaagtt cagcgccctc tttgcgtccc ttccggatcc tgtgctggga gccctgttct
     1861 gcacgctctt tggaatgatc acagctgttg gcctctctaa cctgcagttc attgatttaa
     1921 attcttcccg gaacctcttt gtgcttggat tttcgatctt ctttgggctc gtccttccaa
     1981 gttacctcag acagaaccct ctggtcacag ggataacagg aatcgatcaa gtgttgaacg
     2041 tccttctcac aactgctatg tttgtagggg gctgtgtggc ttttatcctg gataacacca
     2101 tcccaggcac tccagaggaa agaggaatcc ggaaatggaa gaagggtgtg ggcaaaggga
     2161 acaaatcact cgacggcatg gagtcgtaca atttgccatt tggcatgaac attataaaaa
     2221 aatacagatg cttcagctac ttacccatca gcccaacctt tgtgggctac acatggaaag
     2281 gcctcaggaa gagcgacaac agccggagtt cagatgaaga ctcccaggcc acgggatagc
     2341 ctttgctgtg ccctgtggcc tggccgcagt gaggcatgta tctgtagttc cttgctgagt
     2401 aacaagaagt aaaatacatg tttgtatatc tacatttaca ttctgcgccc cagagctaag
     2461 acagactgcg aatcactttt ctgctgtgag ggtgatggtg cctgatgcgg tgtctcgcct
     2521 atctccttat ttaagccctt aactccttgc cctttgagag tgtccattgc tggccatggt
     2581 cactaaattt gaagttccag tcctcccttt ggagtggaca tttaaaatct gcagccattc
     2641 cttgcttcag ttcccttcca ccacccaggg ctggctttcc tataagccac ctccagggtc
     2701 caggggcttt ctctctctct ccgaagcccc tggacctgtt tccttgtcat ttgaccctcg
     2761 tctgtgcccg cggagacctc ctctgaccaa ggggcactag tatgccttgc gctatcatga
     2821 ctgactggcc cagtatgatt ctgttgtcgc tgatctcccg gaggaggagg ctgttgacct
     2881 gaaaacagtg gcgtggctcc cctgtgccca gatctggcca tgggtgaggc ctgcacagat
     2941 gttgaatgaa catctgtttg gggcattgga gggaaaagga aaggaccctg aagccaatat
     3001 ctgattctcg gctgcacctt ctcttggcca ccctggccct gaccgggcca gcacgtgcac
     3061 actggcctct tttcatttca ctagtggccg agacaccctc tctggcattt atcactgttg
     3121 gccggtgtga tgagtataga gtgccaccca aggcaccagt cacacaagct gatgggcgtc
     3181 ttggctctgc cgtcatgtgg atgttattgt cgcgcgcgtc tataattaca aggttttatt
     3241 cctatttaat gttattgact atagcagatt ttggaaatca gtgttttcca tgtgaccctc
     3301 tttccttgca tccctattcc ttgtccccca cccactcttc cccccatcaa gaaaagaacc
     3361 agcatttgta aagctgtgga caccatcagg gaagcttgtt gtaacggctt ttgaaggcca
     3421 gtaaccattg ttgtggttgt gttttgtatt gcttgatacc atgaaagtgt aaatactgta
     3481 atgcctaatc tatttatcaa aactgactac tggaccggag cccagaaacc atgggtcaag
     3541 ttacacgtga atttgttttg tgaagaaggg aagctggggc aggtaacacg cagagccgcc
     3601 acgtggaacg gtctgtccgc cggtctgtcc cgcttgccgg gcttctgttg caagtcttgg
     3661 cttaaggaga cttcctgtgg gttgccatgt cgcacgtccg ttagatcttg attttacagg
     3721 tgagggtggt tgccaaaggt gataagaaaa gcagccaaca ggctccctct cacttaagag
     3781 agttctaatt aataacacta aattcttcct gagaaatgac tcctcttggt ttggtttgaa
     3841 gtttttcagt gaaggaaaag gcctgagata ggaagcagtg ccctcgcttc atgaggtggc
     3901 acatcttcgg tggccgttgg cctggtcgag ctttggtcag ctgcgtgggt gcctgtctcc
     3961 tgtctccagc ggcagggcat ggttcttggc agcctggtgt ccacacggtg cattcctgtc
     4021 cccctcggcc ccaggctggc tcagctctcc agtgctgcgg cgctgtcttt gcagcattgc
     4081 catgtcaccg tagccccctt cactcttgga agtttggggc ttcaaggttt attctggcaa
     4141 gaacacctcg gagccactgc attgttttgc caaaaactta ctgcagatta agtaaagaac
     4201 ttagatgcta aattacatct aattttgtat gtttttttaa atgtgtcttt gatgcatact
     4261 ttagaagcac actggctcgc ggtttccatc cctcttgcct tgggacactc ttgaggctgg
     4321 cagccctcct gcaatgagtt gctctcagtt ccttctgttt ggattttgct caacatctcc
     4381 agtttctctg ctctgaaaaa tggggaaaac tgctaaacat cccagagatt tgcaatcttc
     4441 tagctctcca ggtgagcaga aagaccaaat atccaaataa aagcctgaaa gccattggtg
     4501 atccaggggc accttctctt cagcttgact gggcgtcttc cgctgcataa cactcaaggt
     4561 gtctgctcta gtcatccaga aacccactcc cttctgaagc ccctccttgg gccgggttgt
     4621 atcaggagga ttcaaccccg ctaacatgtg gggtgccctc tgtaggcctt cacacaggga
     4681 aggaagccct accctttcaa ctcctgttgg agtgagagtt tcctgttctg attccactgt
     4741 ggccaaccca ataattctgt ccgaggaggg gtaagggaat aggaggtggg gagcaaagag
     4801 ggcagcctga ctagatgccc ctgctgaatc tggtactttc tgcacagcct tgagtgattg
     4861 gagtccccta atgactaata aacttgaaca tgtaacacac acacacacac acacacacac
     4921 cattttagga agtggttctc ctactggaaa atatgctaca gaatgaaagt ttgtaattga
     4981 aagaaaaaga atgtattcat ctgcttcttg ggtttaagca cacacctgaa ggggagatat
     5041 tgggggacac ggtggccact cgcggtctgt gtcatgacac ttcccattca catcattggc
     5101 ctgcgttgct ggggctttga accaccaccc cgtactttgt tttgcctgta gagtgttgta
     5161 aaatattttg gatgtgaatg tccttgcagg ccggttagtc tccagtttcc acagagacca
     5221 cctacccacc accttcccag gtcacctgcc tggtccctga aagaaagcat ttgtgtgggc
     5281 aatcccaaca tgaaatgtag acagcgtgaa tacggacagg aggtgatgcc atattcacag
     5341 tgggggatgg agggccccca cccctgcttc acagaataat gggaagtgac tctagtcttt
     5401 gtaagcaatt ttcattctca ttaggaagtt aaatgtagat tcacagatac atttactttc
     5461 agaatcctca agaggatttc aaatgctaac ttttagtttc ttgggattga tcaaggcaag
     5521 agaagtggct ttaaccatgc cagccagaat gaagcatcat gggtcctgat ggtttcccgt
     5581 tttcatggta acaaattcgc acagaggttt tgctttatgc tgtagaatac cgactttcat
     5641 gatgacaact tggtttatgc atgaatattg cagtatttcc atatagcaaa ataacatttc
     5701 tacccaggat aatagtcaca gttttccagg gagggaatga tataattttc atgacaatgt
     5761 catgtgatga tagaatttct ccattgatga atctctagta tgtgtgtata ctttatttac
     5821 ccatacgtat attttatgac catgagctaa gttgttattt ctttcattca tatccctgct
     5881 gaaatattgg tactagcaac ttaaagttgg caagtctcat cttcagtaat acggatgcca
     5941 tgggagtggc caggccagat tgaaggtgaa tatggagcag tagcagaagc ctcattccag
     6001 aacccatctg gccagagaag cagcagcatc ctgggggatg gccgtgcatg gggtgtacac
     6061 tcgctatagg cataggcccg gcatggctgt cgctggacgc cagctgtgca cacccagcca
     6121 cacctgctgc acgccgcgtt agtgtgcggc tccgggcctg agcattcgca aagctcgctt
     6181 ctccagggag cctcctcttg gctttggaaa agagcccagg gacttaacgt gctgcctgtt
     6241 gtactctgtc ccctcatgac tttttagaca cagggactag gacatcgacc accctctgcc
     6301 cctcctgcag tcagaacccg agtagtgcaa gaacggccac ccggttttgc cagcgttcag
     6361 cgtctgccca tggacccata aggcacatta gcgttggggg tctcttttca gcagcctcac
     6421 agacattccc gtcctttctg gttggtgttg actgtgtttc agcatcactc taccctccca
     6481 tgtccttagc attgctgtgc gtgtttccag gcacttagga cacccttccc cacgttgcca
     6541 tcttactgac agttcaaatg actctccttt tttgttcgtt agtaacaatc ttcatttgac
     6601 accttaatac atttctgact gttcttaaaa cagtggggat gcctatattt tccttgagtt
     6661 tttgtgactg actttggcta tatatacctt tctggggttt tgtttgtttt ttatttttat
     6721 tttgattacc gagggtattt ggggtggggt tgttttttga gatgtgtaat tcttttatgg
     6781 agtttttaaa aagaattttc atattgtttt tctaacatgg cttcattaaa cgtttaagta
     6841 ttttaaaaat atgtaatatt tggaccagat gttgtgaata atagtagaga taaagctatt
     6901 ttattctgta tttttaaaac tgttccgtac aaataaaagc tctcctggac aca
//
