LOCUS       NM_005847               2296 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens solute carrier family 23 member 1 (SLC23A1),
            transcript variant 1, mRNA.
ACCESSION   NM_005847
VERSION     NM_005847.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2296)
  AUTHORS   Kobayashi,T.A., Shimada,H., Sano,F.K., Itoh,Y., Enoki,S., Okada,Y.,
            Kusakizako,T. and Nureki,O.
  TITLE     Dimeric transport mechanism of human vitamin C transporter SVCT1
  JOURNAL   Nat Commun 15 (1), 5569 (2024)
   PUBMED   38956111
  REMARK    GeneRIF: Dimeric transport mechanism of human vitamin C transporter
            SVCT1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2296)
  AUTHORS   Toyoda,Y., Miyata,H., Uchida,N., Morimoto,K., Shigesawa,R.,
            Kassai,H., Nakao,K., Tomioka,N.H., Matsuo,H., Ichida,K.,
            Hosoyamada,M., Aiba,A., Suzuki,H. and Takada,T.
  TITLE     Vitamin C transporter SVCT1 serves a physiological role as a urate
            importer: functional analyses and in vivo investigations
  JOURNAL   Pflugers Arch 475 (4), 489-504 (2023)
   PUBMED   36749388
  REMARK    GeneRIF: Vitamin C transporter SVCT1 serves a physiological role as
            a urate importer: functional analyses and in vivo investigations.
REFERENCE   3  (bases 1 to 2296)
  AUTHORS   Hou,H., Zhang,Y., Wu,H., Huang,Z., Liu,S., Liang,H. and Xu,Y.
  TITLE     Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk for
            Preeclampsia in a Chinese Han Population
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 68 (5), 368-374 (2022)
   PUBMED   36310070
  REMARK    GeneRIF: Impact of SLC23A1 and SLC23A2 Polymorphisms on the Risk
            for Preeclampsia in a Chinese Han Population.
REFERENCE   4  (bases 1 to 2296)
  AUTHORS   Hayashi,K., Noguchi-Shinohara,M., Sato,T., Hosomichi,K., Kannon,T.,
            Abe,C., Domoto,C., Yuki-Nozaki,S., Mori,A., Horimoto,M.,
            Yokogawa,M., Sakai,K., Iwasa,K., Komai,K., Ishimiya,M.,
            Nakamura,H., Ishida,N., Suga,Y., Ishizaki,J., Ishigami,A.,
            Tajima,A. and Yamada,M.
  TITLE     Effects of functional variants of vitamin C transporter genes on
            apolipoprotein E E4-associated risk of cognitive decline: The
            Nakajima study
  JOURNAL   PLoS One 16 (11), e0259663 (2021)
   PUBMED   34780525
  REMARK    GeneRIF: Effects of functional variants of vitamin C transporter
            genes on apolipoprotein E E4-associated risk of cognitive decline:
            The Nakajima study.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2296)
  AUTHORS   Wohlrab,C., Vissers,M.C.M., Burgess,E.R., Nonis,M., Phillips,E.,
            Robinson,B.A. and Dachs,G.U.
  TITLE     Limited Association Between Ascorbate Concentrations and Vitamin C
            Transporters in Renal Cell Carcinoma Cells and Clinical Samples
  JOURNAL   Cell Physiol Biochem 55 (5), 553-568 (2021)
   PUBMED   34599650
  REMARK    GeneRIF: Limited Association Between Ascorbate Concentrations and
            Vitamin C Transporters in Renal Cell Carcinoma Cells and Clinical
            Samples.
REFERENCE   6  (bases 1 to 2296)
  AUTHORS   Wang,H., Dutta,B., Huang,W., Devoe,L.D., Leibach,F.H., Ganapathy,V.
            and Prasad,P.D.
  TITLE     Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary
            structure, functional characteristics and evidence for a
            non-functional splice variant
  JOURNAL   Biochim Biophys Acta 1461 (1), 1-9 (1999)
   PUBMED   10556483
REFERENCE   7  (bases 1 to 2296)
  AUTHORS   Rajan,D.P., Huang,W., Dutta,B., Devoe,L.D., Leibach,F.H.,
            Ganapathy,V. and Prasad,P.D.
  TITLE     Human placental sodium-dependent vitamin C transporter (SVCT2):
            molecular cloning and transport function
  JOURNAL   Biochem Biophys Res Commun 262 (3), 762-768 (1999)
   PUBMED   10471399
REFERENCE   8  (bases 1 to 2296)
  AUTHORS   Hogue,D.L. and Ling,V.
  TITLE     A human nucleobase transporter-like cDNA (SLC23A1): member of a
            transporter family conserved from bacteria to mammals
  JOURNAL   Genomics 59 (1), 18-23 (1999)
   PUBMED   10395795
REFERENCE   9  (bases 1 to 2296)
  AUTHORS   Tsukaguchi,H., Tokui,T., Mackenzie,B., Berger,U.V., Chen,X.Z.,
            Wang,Y., Brubaker,R.F. and Hediger,M.A.
  TITLE     A family of mammalian Na+-dependent L-ascorbic acid transporters
  JOURNAL   Nature 399 (6731), 70-75 (1999)
   PUBMED   10331392
REFERENCE   10 (bases 1 to 2296)
  AUTHORS   Faaland,C.A., Race,J.E., Ricken,G., Warner,F.J., Williams,W.J. and
            Holtzman,E.J.
  TITLE     Molecular characterization of two novel transporters from human and
            mouse kidney and from LLC-PK1 cells reveals a novel conserved
            family that is homologous to bacterial and Aspergillus nucleobase
            transporters
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 353-360 (1998)
   PUBMED   9804989
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA385445.1, AJ250807.1,
            BC050261.1 and AI478520.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005847.4.
            
            Summary: The absorption of vitamin C into the body and its
            distribution to organs requires two sodium-dependent vitamin C
            transporters. This gene encodes one of the two transporters. The
            encoded protein is active in bulk vitamin C transport involving
            epithelial surfaces. Previously, this gene had an official symbol
            of SLC23A2. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) represents the more
            predominant transcript and encodes the shorter isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF098277.1, AF170911.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348729.8/ ENSP00000302701.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               DA385445.1         55-563
            510-1839            AJ250807.1         536-1865
            1840-2292           BC050261.1         1847-2299
            2293-2296           AI478520.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..2296
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..2296
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /note="solute carrier family 23 member 1"
                     /db_xref="GeneID:9963"
                     /db_xref="HGNC:HGNC:10974"
                     /db_xref="MIM:603790"
     exon            1..80
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1841
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /note="isoform a is encoded by transcript variant 1;
                     sodium-dependent vitamin C transporter-1; yolk sac
                     permease-like molecule 3; solute carrier family 23
                     (nucleobase transporters), member 2; Na(+)/L-ascorbic acid
                     transporter 1; hSVCT1; solute carrier family 23
                     (nucleobase transporters), member 1; solute carrier family
                     23 (ascorbic acid transporter), member 1"
                     /codon_start=1
                     /product="solute carrier family 23 member 1 isoform a"
                     /protein_id="NP_005838.3"
                     /db_xref="CCDS:CCDS4212.1"
                     /db_xref="GeneID:9963"
                     /db_xref="HGNC:HGNC:10974"
                     /db_xref="MIM:603790"
                     /translation="MRAQEDLEGRTQHETTRDPSTPLPTEPKFDMLYKIEDVPPWYLC
                     ILLGFQHYLTCFSGTIAVPFLLAEALCVGHDQHMVSQLIGTIFTCVGITTLIQTTVGI
                     RLPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAI
                     MVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGDRAGSHWGISACSI
                     LLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDV
                     LPTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIE
                     SIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGIT
                     KVGSRRVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLFGMITAVGLSNLQFV
                     DMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLA
                     FILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIVKRITFLKYIPICP
                     VFKGFSSSSKDQIAIPEDTPENTETASVCTKV"
     exon            81..194
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            195..352
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..441
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            442..509
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            510..691
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..812
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..969
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1117
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1223
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1353
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1497
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1593
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1860
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2296
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2272..2277
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /note="hexamer: ATTAAA"
     polyA_site      2296
                     /gene="SLC23A1"
                     /gene_synonym="SLC23A2; SVCT1; YSPL3"
                     /note="major polyA site"
ORIGIN      
        1 atcccctctt ctcctcagga actgctcaaa cctgtgcccc aaagatgagg gcccaggagg
       61 acctcgaggg ccggacacag catgaaacca ccagggaccc ctcgaccccg ctacccacag
      121 agcctaagtt tgacatgttg tacaagatcg aggacgtgcc accttggtac ctgtgcatcc
      181 tgctgggctt ccagcactac ctgacatgct tcagtggtac catcgccgtg cccttcctgc
      241 tggctgaggc gctgtgtgtg ggccacgacc agcacatggt tagtcagctc atcggcacca
      301 tcttcacgtg cgtgggcatc accactctca tccagaccac cgtgggcatc cggctgccgc
      361 tgttccaggc cagtgccttt gcatttctgg ttccagccaa agccatactg gctctggaga
      421 gatggaaatg ccccccggaa gaggagatct acggtaactg gagtctgccc ctgaacacct
      481 ctcatatttg gcacccacgg atacgggagg tccagggtgc aatcatggtg tccagcgtgg
      541 tggaggtggt gattggcctg ctggggctgc ctggggccct gctcaactac attgggcctc
      601 tcacagtcac ccccactgtc tccctcattg gcctttctgt cttccaagct gctggcgacc
      661 gagctggctc ccactggggc atctcagctt gctccattct cctgatcatc ctcttctccc
      721 agtacctgcg caacctcacc ttcctgctgc ctgtctaccg ctggggcaag ggcctcactc
      781 tcctccgcat ccagatcttc aaaatgtttc ctatcatgct ggccatcatg accgtgtggc
      841 tgctctgcta tgtcctgacc ttgacagacg tgctgcccac agacccaaaa gcctatggct
      901 tccaggcacg aaccgatgcc cgtggtgaca tcatggctat tgcaccctgg atccgcatcc
      961 cctacccctg tcagtggggc ctgcccacgg tgactgcggc tgctgtcctg ggaatgttca
     1021 gcgccactct ggcaggcatc attgagtcca tcggagatta ctacgcctgt gcccgcctgg
     1081 ctggtgcacc accccctcca gtacatgcta tcaacagggg catcttcacc gaaggcattt
     1141 gctgcatcat cgcggggcta ttgggcacgg gcaacgggtc cacctcgtcc agtcccaaca
     1201 ttggcgtcct gggaattacc aaggtgggca gccggcgcgt ggtgcagtat ggtgcggcta
     1261 tcatgctggt cctgggcacc atcggcaagt tcacggccct cttcgcctcg ctccctgacc
     1321 ccatcctggg gggcatgttc tgcactctct ttggcatgat tacagctgtg gggctgtcca
     1381 acctgcaatt tgtggacatg aactcctctc gcaacctctt cgtgctggga ttttccatgt
     1441 tcttcgggct cacgctgccc aattacctgg agtccaaccc tggcgccatc aatacaggca
     1501 ttcttgaagt ggatcagatt ctgattgtgc tgctgaccac ggagatgttt gtgggcgggt
     1561 gccttgcttt catacttgac aacacagtgc cagggagccc agaggagcgt ggtctgatac
     1621 agtggaaagc tggggctcat gccaacagtg acatgtcttc cagcctcaag agctacgatt
     1681 tccccattgg gatgggcata gtaaaaagaa ttacctttct gaaatacatt cctatctgcc
     1741 cagtcttcaa aggattttct tcaagttcaa aagatcagat tgcaattcca gaagacactc
     1801 cagaaaatac agaaactgca tctgtgtgca ccaaggtctg aaaaatgact tccaggaaag
     1861 gaagcatggt atataacagg aaaagaaaac tacatgggga accagaagac ctaagcctga
     1921 aatcccagcc ctgcccctaa ctaacttctg tgtaaactca gataagtcac ctttctctgg
     1981 gattcaaatt tttgcatcag ttaaaaaaaa aggggtgggg gggaatgggc caaagtctga
     2041 gtcttagaga cttgtaccaa tgttatgcta tgtctctaaa tctttactct cctaagtaga
     2101 cttgtcagca tctaggaaga acagctagaa attttcctct gtgatatttt agactgcaag
     2161 ttgaaaaaaa taaaaagaaa tgagggcagg ttccagggcc tgaaatgtag gtatgctgca
     2221 aggcttttac attgaatttg accctacatc acttcaagac taatgcataa tattaaacat
     2281 catgttgaag aaataa
//
