LOCUS       NM_080866               2366 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 22 member 9 (SLC22A9), mRNA.
ACCESSION   NM_080866
VERSION     NM_080866.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2366)
  AUTHORS   Nies,A.T., Weiss,S., Schaeffeler,E., Hannemann,A., Volker,U.,
            Wallaschofski,H. and Schwab,M.
  TITLE     The Membrane Transporter OAT7 (SLC22A9) Is Not a Susceptibility
            Factor for Osteoporosis in Europeans
  JOURNAL   Front Endocrinol (Lausanne) 11, 532 (2020)
   PUBMED   33013684
  REMARK    GeneRIF: The Membrane Transporter OAT7 (SLC22A9) Is Not a
            Susceptibility Factor for Osteoporosis in Europeans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2366)
  AUTHORS   Mathialagan,S., Costales,C., Tylaska,L., Kimoto,E., Vildhede,A.,
            Johnson,J., Johnson,N., Sarashina,T., Hashizume,K.,
            Isringhausen,C.D., Vermeer,L.M.M., Wolff,A.R. and Rodrigues,A.D.
  TITLE     In vitro studies with two human organic anion transporters: OAT2
            and OAT7
  JOURNAL   Xenobiotica 48 (10), 1037-1049 (2018)
   PUBMED   28945155
  REMARK    GeneRIF: two human organic anion transporters OAT2 and OAT7
            activities were assessed.
REFERENCE   3  (bases 1 to 2366)
  AUTHORS   Vildhede,A., Kimoto,E., Rodrigues,A.D. and Varma,M.V.S.
  TITLE     Quantification of Hepatic Organic Anion Transport Proteins OAT2 and
            OAT7 in Human Liver Tissue and Primary Hepatocytes
  JOURNAL   Mol Pharm 15 (8), 3227-3235 (2018)
   PUBMED   29906129
  REMARK    GeneRIF: Large interindividual variability was noted in the hepatic
            expression of OAT2 (16-fold in human liver tissue and 23-fold in
            hepatocytes). OAT7, on the other hand, showed less interindividual
            variability (4-fold) in the livers, but high variability for the
            hepatocyte lots (27-fold). A significant positive correlation in
            OAT2 and OAT7 expression was observed, but expression levels were
            neither associated with age nor sex.
REFERENCE   4  (bases 1 to 2366)
  AUTHORS   Emami Riedmaier,A., Burk,O., van Eijck,B.A., Schaeffeler,E.,
            Klein,K., Fehr,S., Biskup,S., Muller,S., Winter,S., Zanger,U.M.,
            Schwab,M. and Nies,A.T.
  TITLE     Variability in hepatic expression of organic anion transporter
            7/SLC22A9, a novel pravastatin uptake transporter: impact of
            genetic and regulatory factors
  JOURNAL   Pharmacogenomics J 16 (4), 341-351 (2016)
   PUBMED   26239079
  REMARK    GeneRIF: Pravastatin is the first identified OAT7 drug substrate.
            Substantial inter-individual variability in hepatic OAT7
            expression, majorly driven by HNF4alpha, may contribute to
            pravastatin drug disposition and might affect response.
REFERENCE   5  (bases 1 to 2366)
  AUTHORS   Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
            Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
            Laibson,D., Johannesson,M. and Visscher,P.M.
  TITLE     The genetic architecture of economic and political preferences
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8026-8031 (2012)
   PUBMED   22566634
REFERENCE   6  (bases 1 to 2366)
  AUTHORS   Zhou,F., Hong,M. and You,G.
  TITLE     Regulation of human organic anion transporter 4 by progesterone and
            protein kinase C in human placental BeWo cells
  JOURNAL   Am J Physiol Endocrinol Metab 293 (1), E57-E61 (2007)
   PUBMED   17341544
  REMARK    GeneRIF: Both progesterone and activation of PKC inhibited hOAT4
            activity through redistribution of the transporter from cell
            surface to the intracellular compartments.
REFERENCE   7  (bases 1 to 2366)
  AUTHORS   Ekaratanawong,S., Anzai,N., Jutabha,P., Miyazaki,H., Noshiro,R.,
            Takeda,M., Kanai,Y., Sophasan,S. and Endou,H.
  TITLE     Human organic anion transporter 4 is a renal apical organic
            anion/dicarboxylate exchanger in the proximal tubules
  JOURNAL   J Pharmacol Sci 94 (3), 297-304 (2004)
   PUBMED   15037815
REFERENCE   8  (bases 1 to 2366)
  AUTHORS   Ugele,B., St-Pierre,M.V., Pihusch,M., Bahn,A. and Hantschmann,P.
  TITLE     Characterization and identification of steroid sulfate transporters
            of human placenta
  JOURNAL   Am J Physiol Endocrinol Metab 284 (2), E390-E398 (2003)
   PUBMED   12409283
  REMARK    GeneRIF: uptake of steroid sulfates by isolated trophoblasts is
            mediated by OATP-B and OAT-4 suggesting a physiological role of
            both carrier proteins in placental uptake of fetal-derived steroid
            sulfates.
REFERENCE   9  (bases 1 to 2366)
  AUTHORS   Sun,W., Wu,R.R., van Poelje,P.D. and Erion,M.D.
  TITLE     Isolation of a family of organic anion transporters from human
            liver and kidney
  JOURNAL   Biochem Biophys Res Commun 283 (2), 417-422 (2001)
   PUBMED   11327718
REFERENCE   10 (bases 1 to 2366)
  AUTHORS   Cha,S.H., Sekine,T., Kusuhara,H., Yu,E., Kim,J.Y., Kim,D.K.,
            Sugiyama,Y., Kanai,Y. and Endou,H.
  TITLE     Molecular cloning and characterization of multispecific organic
            anion transporter 4 expressed in the placenta
  JOURNAL   J Biol Chem 275 (6), 4507-4512 (2000)
   PUBMED   10660625
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001880.4, AK074246.1, AF440402.1 and AP000484.5.
            
            On May 17, 2019 this sequence version replaced NM_080866.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF440402.1, AB074812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279178.4/ ENSP00000279178.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AP001880.4         141256-141259
            5-36                AK074246.1         1-32
            37-2331             AF440402.1         1-2295
            2332-2366           AP000484.5         24987-25021
FEATURES             Location/Qualifiers
     source          1..2366
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2366
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /note="solute carrier family 22 member 9"
                     /db_xref="GeneID:114571"
                     /db_xref="HGNC:HGNC:16261"
                     /db_xref="MIM:607579"
     exon            1..674
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1934
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /note="organic anion transporter 4; organic
                     anion/short-chain fatty acid exchanger; solute carrier
                     family 22 (organic anion/cation transporter), member 9;
                     solute carrier family 22 (organic anion transporter),
                     member 9"
                     /codon_start=1
                     /product="organic anion transporter 7"
                     /protein_id="NP_543142.2"
                     /db_xref="CCDS:CCDS8043.1"
                     /db_xref="GeneID:114571"
                     /db_xref="HGNC:HGNC:16261"
                     /db_xref="MIM:607579"
                     /translation="MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFI
                     PGHRCWVHILDNDTVSDNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLN
                     GTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGG
                     ILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTI
                     MLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTS
                     SWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKK
                     KPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILL
                     ANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALAN
                     TLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFI
                     SGFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF"
     exon            675..778
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            779..933
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1102
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1345
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1560
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1669
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1873
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2366
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2019..2024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /note="hexamer: AATAAA"
     polyA_site      2037
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /note="major polyA site"
     regulatory      2155..2160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /note="hexamer: AATACA"
     polyA_site      2173
                     /gene="SLC22A9"
                     /gene_synonym="HOAT4; OAT4; OAT7; ust3; UST3H"
                     /note="major polyA site"
ORIGIN      
        1 aaacacattt cattgtaaac gactgggagt atctgagcaa attatttctt acgtgacttt
       61 agagaaaacg gctacctatc tgaccccaaa acgacttgag gaaactgttt ccacggtcct
      121 gctgcagagg ggaagcacag tcgtcaagaa gagagtgggg tcaggatcaa aacacattta
      181 gtgtgactta gggaaagaaa acattttccc tctttgaacc tctctggata cagtcatttt
      241 gcctctactt gaggatcaac tgttcaacct caatggcctt tcaggacctc ctgggtcacg
      301 ctggtgacct gtggagattc cagatccttc agactgtttt tctctcaatc tttgctgttg
      361 ctacatacct tcattttatg ctggagaact tcactgcatt catacctggc catcgctgct
      421 gggtccacat cctggacaat gacactgtct ctgacaatga cactggggcc ctcagccaag
      481 atgcactctt gagaatctcc atcccactgg actcaaacat gaggccagag aagtgtcgtc
      541 gctttgttca tcctcagtgg cagctccttc acctgaatgg gaccttcccc aacacaagtg
      601 acgcagacat ggagccctgt gtggatggct gggtgtatga cagaatctcc ttctcatcca
      661 ccatcgtgac tgagtgggat ctggtatgtg actctcaatc actgacttca gtggctaaat
      721 ttgtattcat ggctggaatg atggtgggag gcatcctagg cggtcattta tcagacaggt
      781 ttgggagaag gttcgtgctc agatggtgtt acctccaggt tgccattgtt ggcacctgtg
      841 cagccttggc tcccaccttc ctcatttact gctcactacg cttcttgtct gggattgctg
      901 caatgagcct cataacaaat actattatgt taatagccga gtgggcaaca cacagattcc
      961 aggccatggg aattacattg ggaatgtgcc cttctggtat tgcatttatg accctggcag
     1021 gcctggcttt tgccattcga gactggcata tcctccagct ggtggtgtct gtaccatact
     1081 ttgtgatctt tctgacctca agttggctgc tagagtctgc tcggtggctc attatcaaca
     1141 ataaaccaga ggaaggctta aaggaactta gaaaagctgc acacaggagt ggaatgaaga
     1201 atgccagaga caccctaacc ctggagattt tgaaatccac catgaaaaaa gaactggagg
     1261 cagcacaaaa aaaaaaacct tctctgtgtg aaatgctcca catgcccaac atatgtaaaa
     1321 ggatctccct cctgtccttt acgagatttg caaactttat ggcctatttt ggccttaatc
     1381 tccatgtcca gcatctgggg aacaatgttt tcctgttgca gactctcttt ggtgcagtca
     1441 tcctcctggc caactgtgtt gcaccttggg cactgaaata catgaaccgt cgagcaagcc
     1501 agatgcttct catgttccta ctggcaatct gccttctggc catcatattt gtgccacaag
     1561 aaatgcagac gctgcgtgag gttttggcaa cactgggctt aggagcgtct gctcttgcca
     1621 atacccttgc ttttgcccat ggaaatgaag taattcccac cataatcagg gcaagagcta
     1681 tggggatcaa tgcaaccttt gctaatatag caggagccct ggctcccctc atgatgatcc
     1741 taagtgtgta ttctccaccc ctgccctgga tcatctatgg agtcttcccc ttcatctctg
     1801 gctttgcttt cctcctcctt cctgaaacca ggaacaagcc tctgtttgac accatccagg
     1861 atgagaaaaa tgagagaaaa gaccccagag aaccaaagca agaggatccg agagtggaag
     1921 tgacgcagtt ttaaggaatt ccaggagctg actgccgatc aatgagccag atgaagggaa
     1981 caatcaggac tattcctaga cactagcaaa atctagaaaa taaataacaa ggctgggtgc
     2041 ggtggctcac gcctgtaatc ccagcacctt gggaggctga ggcgggcaga tcatgaggtc
     2101 agaagataaa gaccaccctg gccaacatgg tgaaaccctg tctctactaa aacaaataca
     2161 aaacttcgct gggcacagtg gcacaggcct ttaattccag ctacttggga ggctgaggca
     2221 ggagaattac ttgaacccag gaggtggaaa ttgcaatgag ccaagattgg gccactgcat
     2281 tccagcctgg tgacagagcg agactgtctc aaaaaaaaaa aaaaaaaaaa aagaaagaag
     2341 gaaagaaaga aagaaaagaa aagaaa
//
