LOCUS       NM_153320               2559 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens solute carrier family 22 member 7 (SLC22A7),
            transcript variant 2, mRNA.
ACCESSION   NM_153320
VERSION     NM_153320.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2559)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   2  (bases 1 to 2559)
  AUTHORS   Mathialagan,S., Bi,Y.A., Costales,C., Kalgutkar,A.S.,
            Rodrigues,A.D. and Varma,M.V.S.
  TITLE     Nicotinic acid transport into human liver involves organic anion
            transporter 2 (SLC22A7)
  JOURNAL   Biochem Pharmacol 174, 113829 (2020)
   PUBMED   32001236
  REMARK    GeneRIF: Nicotinic acid transport into human liver involves organic
            anion transporter 2 (SLC22A7).
REFERENCE   3  (bases 1 to 2559)
  AUTHORS   Nishibeppu,K., Komatsu,S., Imamura,T., Kiuchi,J., Kishimoto,T.,
            Arita,T., Kosuga,T., Konishi,H., Kubota,T., Shiozaki,A.,
            Fujiwara,H., Okamoto,K. and Otsuji,E.
  TITLE     Plasma microRNA profiles: identification of miR-1229-3p as a novel
            chemoresistant and prognostic biomarker in gastric cancer
  JOURNAL   Sci Rep 10 (1), 3161 (2020)
   PUBMED   32081926
  REMARK    GeneRIF: Plasma microRNA profiles: identification of miR-1229-3p as
            a novel chemoresistant and prognostic biomarker in gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2559)
  AUTHORS   Kimoto,E., Mathialagan,S., Tylaska,L., Niosi,M., Lin,J.,
            Carlo,A.A., Tess,D.A. and Varma,M.V.S.
  TITLE     Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to
            the Clearance of High-Permeability-Low-Molecular-Weight Acid and
            Zwitterion Drugs: Evaluation Using 25 Drugs
  JOURNAL   J Pharmacol Exp Ther 367 (2), 322-334 (2018)
   PUBMED   30135178
  REMARK    GeneRIF: The role of OAT2-mediated hepatic uptake in determining
            the pharmacokinetics of several clinically important ECCS 1A drugs.
REFERENCE   5  (bases 1 to 2559)
  AUTHORS   Vildhede,A., Kimoto,E., Rodrigues,A.D. and Varma,M.V.S.
  TITLE     Quantification of Hepatic Organic Anion Transport Proteins OAT2 and
            OAT7 in Human Liver Tissue and Primary Hepatocytes
  JOURNAL   Mol Pharm 15 (8), 3227-3235 (2018)
   PUBMED   29906129
  REMARK    GeneRIF: Large interindividual variability was noted in the hepatic
            expression of OAT2 (16-fold in human liver tissue and 23-fold in
            hepatocytes). OAT7, on the other hand, showed less interindividual
            variability (4-fold) in the livers, but high variability for the
            hepatocyte lots (27-fold). A significant positive correlation in
            OAT2 and OAT7 expression was observed, but expression levels were
            neither associated with age nor sex.
REFERENCE   6  (bases 1 to 2559)
  AUTHORS   Kimura,H., Takeda,M., Narikawa,S., Enomoto,A., Ichida,K. and
            Endou,H.
  TITLE     Human organic anion transporters and human organic cation
            transporters mediate renal transport of prostaglandins
  JOURNAL   J Pharmacol Exp Ther 301 (1), 293-298 (2002)
   PUBMED   11907186
REFERENCE   7  (bases 1 to 2559)
  AUTHORS   Babu,E., Takeda,M., Narikawa,S., Kobayashi,Y., Yamamoto,T.,
            Cha,S.H., Sekine,T., Sakthisekaran,D. and Endou,H.
  TITLE     Human organic anion transporters mediate the transport of
            tetracycline
  JOURNAL   Jpn J Pharmacol 88 (1), 69-76 (2002)
   PUBMED   11855680
  REMARK    GeneRIF: elucidation of the molecular mechanism for renal
            tetracycline transport by human organic anion transporters (hOATs)
            using proximal tubular cells stably expressing hOATs
REFERENCE   8  (bases 1 to 2559)
  AUTHORS   Sun,W., Wu,R.R., van Poelje,P.D. and Erion,M.D.
  TITLE     Isolation of a family of organic anion transporters from human
            liver and kidney
  JOURNAL   Biochem Biophys Res Commun 283 (2), 417-422 (2001)
   PUBMED   11327718
REFERENCE   9  (bases 1 to 2559)
  AUTHORS   Kok,L.D., Siu,S.S., Fung,K.P., Tsui,S.K., Lee,C.Y. and Waye,M.M.
  TITLE     Assignment of liver-specific organic anion transporter (SLC22A7) to
            human chromosome 6 bands p21.2-->p21.1 using radiation hybrids
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 76-77 (2000)
   PUBMED   10773670
REFERENCE   10 (bases 1 to 2559)
  AUTHORS   Sekine,T., Cha,S.H., Tsuda,M., Apiwattanakul,N., Nakajima,N.,
            Kanai,Y. and Endou,H.
  TITLE     Identification of multispecific organic anion transporter 2
            expressed predominantly in the liver
  JOURNAL   FEBS Lett 429 (2), 179-182 (1998)
   PUBMED   9650585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA640137.1, BC033805.1 and
            AA705161.1.
            
            On Mar 28, 2006 this sequence version replaced NM_153320.1.
            
            Summary: The protein encoded by this gene is involved in the
            sodium-independent transport and excretion of organic anions, some
            of which are potentially toxic. The encoded protein is an integral
            membrane protein and appears to be localized to the basolateral
            membrane of the kidney. Alternatively spliced transcript variants
            encoding different isoforms have been described. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains an alternate segment
            in the 5' coding region compared to variant 1. The encoded isoform
            (b) is longer compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033805.1, AF097518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372585.10/ ENSP00000361666.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                DA640137.1         1-79
            80-2089             BC033805.1         1-2010
            2090-2559           AA705161.1         1-470               c
FEATURES             Location/Qualifiers
     source          1..2559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2559
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /note="solute carrier family 22 member 7"
                     /db_xref="GeneID:10864"
                     /db_xref="HGNC:HGNC:10971"
                     /db_xref="MIM:604995"
     exon            1..492
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1746
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /note="isoform b is encoded by transcript variant 2;
                     organic anion transporter 2; liver-specific transporter;
                     hOAT2; novel liver transporter; solute carrier family 22
                     (organic anion transporter), member 7; organic anion
                     transporter 11"
                     /codon_start=1
                     /product="solute carrier family 22 member 7 isoform b"
                     /protein_id="NP_696961.2"
                     /db_xref="CCDS:CCDS4893.2"
                     /db_xref="GeneID:10864"
                     /db_xref="HGNC:HGNC:10971"
                     /db_xref="MIM:604995"
                     /translation="MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAV
                     PAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRG
                     ELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAV
                     AFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMP
                     LELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLW
                     WVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSY
                     LDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLL
                     VYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAY
                     LFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGT
                     ALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN"
     exon            493..498
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..602
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..757
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..926
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1050
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1160
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1375
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1484
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1691
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2559
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2537..2542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /note="hexamer: AATAAA"
     polyA_site      2559
                     /gene="SLC22A7"
                     /gene_synonym="hOAT11; NLT; OAT2"
                     /note="major polyA site"
ORIGIN      
        1 actcccacct ccagagtcca agggtctatg tggtgggcag tttgagctgg ctggatacta
       61 gagggaggct gcacctgaag catttggtgg gtgagcagca tgggctttga ggagctgctg
      121 gagcaggtgg gcggctttgg gcccttccaa ctgcggaatg tggcactgct ggccctgccc
      181 cgagtgctgc taccactgca cttcctcctg cccatcttcc tggctgccgt gcctgcccac
      241 cgatgtgccc tgccgggtgc ccctgccaac ttcagccatc aggatgtgtg gctggaggcc
      301 catcttcccc gggagcctga tggcacgctc agctcctgcc tccgctttgc ctatccccag
      361 gctctcccca acaccacgtt gggggaagaa aggcagagcc gtggggagct ggaggatgaa
      421 cctgccacag tgccctgctc tcagggctgg gagtacgacc actcagaatt ctcctctacc
      481 attgcaactg agtcccagtg ggatctggtg tgtgagcaga aaggtctgaa cagagctgcg
      541 tccactttct tcttcgccgg tgtgctggtg ggggctgtgg cctttggata tctgtccgac
      601 aggtttgggc ggcggcgtct gctgctggta gcctacgtga gtaccctggt gctgggcctg
      661 gcatctgcag cctccgtcag ctatgtaatg tttgccatca cccgcaccct tactggctca
      721 gccctggctg gttttaccat catcgtgatg ccactggagc tggagtggct ggatgtggag
      781 caccgcaccg tggctggagt cctgagcagc accttctgga cagggggcgt gatgctgctg
      841 gcactggttg ggtacctgat acgggactgg cgatggcttc tgctagctgt caccctgcct
      901 tgtgccccag gcatcctcag cctctggtgg gtgcctgagt ctgcacgctg gcttctgacc
      961 caaggccatg tgaaagaggc ccacaggtac ttgctccact gtgccaggct caatgggcgg
     1021 ccagtgtgtg aggacagctt cagccaggag gctgtgagca aagtggccgc cggggaacgg
     1081 gtggtccgaa gaccttcata cctagacctg ttccgcacac cacggctccg acacatctca
     1141 ctgtgctgcg tggtggtgtg gttcggagtg aacttctcct attacggcct gagtctggat
     1201 gtgtcggggc tggggctgaa cgtgtaccag acacagctgt tgttcggggc tgtggaactg
     1261 ccctccaagc tgctggtcta cttgtcggtg cgctacgcag gacgccgcct cacgcaagcc
     1321 gggacactgc tgggcacggc cctggcgttc ggcactagac tgctagtgtc ctccgatatg
     1381 aagtcctgga gcactgtcct ggcagtgatg gggaaagctt tttctgaagc tgccttcacc
     1441 actgcctacc tgttcacttc agagttgtac cctacggtgc tcagacagac agggatgggg
     1501 ctgactgcac tggtgggccg gctggggggc tctttggccc cactggcggc cttgctggat
     1561 ggagtgtggc tgtcactgcc caagcttact tatgggggga tcgccctgct ggctgccggc
     1621 accgccctcc tgctgccaga gacgaggcag gcacagctgc cagagaccat ccaggacgtg
     1681 gagagaaaga gtgccccaac cagtcttcag gaggaagaga tgcccatgaa gcaggtccag
     1741 aactaagtgg gagtggaggc aggccctcca cagaagctct gcagcagggg ctgggagagc
     1801 agaagggcag gccctgcaac tcaggctggg agtatcgaac cctctgccta gggccggagt
     1861 tgctgccagt acccgctccc tctgctcatc catccttgat tatttggctt ctaggaacag
     1921 ttgacttccc agaatgcagt gggctgctgg gcacccctct cacggttggg gaggattctg
     1981 taaataaagg tgccccttgg gttggggcag tggtgacgag ctgtgggaag agccctggat
     2041 aggaagccac tgagtctgcc ctgggctctg ataaaacctt caccattaac ttgctgtgtg
     2101 accttgggca tgtggctttc cctctctggg cctcagtctg ttcatctccc aaatggataa
     2161 tgaagcctct tgggaggccc taccatagga tctgttgcca tgctcaaatg agttactgaa
     2221 taaggtgctt ctgcttcttc tagagatggt gctaaagaaa ggactagcat atgagacttc
     2281 tggtaccaat ggggctggtg ggcatgctgt ccactgtgtg gtgctaggac tgccaatgcc
     2341 aggcccaagg gacaaaaaga acagagcttt ttgttctcat ggctggccct gctacctccg
     2401 aggcaccctg cagggcaatg catgtcatcc caacccccac actccccatc ctccaaccca
     2461 ctggtctcat gcccaaagaa gagttgaagg catgggagcc aacattttat tgaagaagcc
     2521 acagaggctg aaattcaata aacacaagtt ttatgagta
//
