LOCUS       NM_153276               2127 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens solute carrier family 22 member 6 (SLC22A6),
            transcript variant 2, mRNA.
ACCESSION   NM_153276
VERSION     NM_153276.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2127)
  AUTHORS   Granados,J.C., Ermakov,V., Maity,K., Vera,D.R., Chang,G. and
            Nigam,S.K.
  TITLE     The kidney drug transporter OAT1 regulates gut microbiome-dependent
            host metabolism
  JOURNAL   JCI Insight 8 (2), e160437 (2023)
   PUBMED   36692015
  REMARK    GeneRIF: The kidney drug transporter OAT1 regulates gut
            microbiome-dependent host metabolism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2127)
  AUTHORS   Jamshidi,N. and Nigam,S.K.
  TITLE     Drug transporters OAT1 and OAT3 have specific effects on multiple
            organs and gut microbiome as revealed by contextualized metabolic
            network reconstructions
  JOURNAL   Sci Rep 12 (1), 18308 (2022)
   PUBMED   36316339
  REMARK    GeneRIF: Drug transporters OAT1 and OAT3 have specific effects on
            multiple organs and gut microbiome as revealed by contextualized
            metabolic network reconstructions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2127)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   4  (bases 1 to 2127)
  AUTHORS   Vavra,J., Mancikova,A., Pavelcova,K., Hasikova,L., Bohata,J. and
            Stiburkova,B.
  TITLE     Functional Characterization of Rare Variants in OAT1/SLC22A6 and
            OAT3/SLC22A8 Urate Transporters Identified in a Gout and
            Hyperuricemia Cohort
  JOURNAL   Cells 11 (7), 1063 (2022)
   PUBMED   35406626
  REMARK    GeneRIF: Functional Characterization of Rare Variants in
            OAT1/SLC22A6 and OAT3/SLC22A8 Urate Transporters Identified in a
            Gout and Hyperuricemia Cohort.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2127)
  AUTHORS   Zhang,J., Liu,C. and You,G.
  TITLE     Ubiquitin-specific peptidase 8 regulates the trafficking and
            stability of the human organic anion transporter 1
  JOURNAL   Biochim Biophys Acta Gen Subj 1864 (12), 129701 (2020)
   PUBMED   32818533
  REMARK    GeneRIF: Ubiquitin-specific peptidase 8 regulates the trafficking
            and stability of the human organic anion transporter 1.
REFERENCE   6  (bases 1 to 2127)
  AUTHORS   Cihlar,T., Lin,D.C., Pritchard,J.B., Fuller,M.D., Mendel,D.B. and
            Sweet,D.H.
  TITLE     The antiviral nucleotide analogs cidofovir and adefovir are novel
            substrates for human and rat renal organic anion transporter 1
  JOURNAL   Mol Pharmacol 56 (3), 570-580 (1999)
   PUBMED   10462545
REFERENCE   7  (bases 1 to 2127)
  AUTHORS   Race,J.E., Grassl,S.M., Williams,W.J. and Holtzman,E.J.
  TITLE     Molecular cloning and characterization of two novel human renal
            organic anion transporters (hOAT1 and hOAT3)
  JOURNAL   Biochem Biophys Res Commun 255 (2), 508-514 (1999)
   PUBMED   10049739
REFERENCE   8  (bases 1 to 2127)
  AUTHORS   Lu,R., Chan,B.S. and Schuster,V.L.
  TITLE     Cloning of the human kidney PAH transporter: narrow substrate
            specificity and regulation by protein kinase C
  JOURNAL   Am J Physiol 276 (2), F295-F303 (1999)
   PUBMED   9950961
REFERENCE   9  (bases 1 to 2127)
  AUTHORS   Hosoyamada,M., Sekine,T., Kanai,Y. and Endou,H.
  TITLE     Molecular cloning and functional expression of a multispecific
            organic anion transporter from human kidney
  JOURNAL   Am J Physiol 276 (1), F122-F128 (1999)
   PUBMED   9887087
REFERENCE   10 (bases 1 to 2127)
  AUTHORS   Reid,G., Wolff,N.A., Dautzenberg,F.M. and Burckhardt,G.
  TITLE     Cloning of a human renal p-aminohippurate transporter, hROAT1
  JOURNAL   Kidney Blood Press Res 21 (2-4), 233-237 (1998)
   PUBMED   9762842
  REMARK    Erratum:[Kidney Blood Press Res 1998;21(6):459]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033682.1.
            
            On Jun 2, 2019 this sequence version replaced NM_153276.2.
            
            Summary: The protein encoded by this gene is involved in the
            sodium-dependent transport and excretion of organic anions, some of
            which are potentially toxic. The encoded protein is an integral
            membrane protein and may be localized to the basolateral membrane.
            Four transcript variants encoding four different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2, also called OAT1-2) lacks an
            alternate in-frame segment compared to variant 1, resulting in a
            shorter isoform (b) compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033682.1, AK091879.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1970526,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360421.9/ ENSP00000353597.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2127              BC033682.1         17-2143
FEATURES             Location/Qualifiers
     source          1..2127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2127
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /note="solute carrier family 22 member 6"
                     /db_xref="GeneID:9356"
                     /db_xref="HGNC:HGNC:10970"
                     /db_xref="MIM:607582"
     exon            1..646
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1930
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /note="isoform b is encoded by transcript variant 2; renal
                     organic anion transporter 1; para-aminohippurate
                     transporter; hPAHT; hROAT1; PAH transporter; solute
                     carrier family 22 (organic anion transporter), member 6"
                     /codon_start=1
                     /product="solute carrier family 22 member 6 isoform b"
                     /protein_id="NP_695008.1"
                     /db_xref="CCDS:CCDS8041.1"
                     /db_xref="GeneID:9356"
                     /db_xref="HGNC:HGNC:10970"
                     /db_xref="MIM:607582"
                     /translation="MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAI
                     PTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGAT
                     EPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLG
                     RRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHT
                     RACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHS
                     SSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPT
                     LRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSL
                     GRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYP
                     TMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETL
                     GQPLPDTVQDLESRKGKQTRQQQEHQKYMVPLQASAQEKNGL"
     exon            647..750
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..905
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1074
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1198
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1314
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1529
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1638
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1842
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2127
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /note="hexamer: ATTAAA"
     polyA_site      2127
                     /gene="SLC22A6"
                     /gene_synonym="HOAT1; OAT1; PAHT; ROAT1"
                     /note="major polyA site"
ORIGIN      
        1 agcagaccct gaaagctgag ctgccctgac ccccaaagtg aggagaagct gcaagggaaa
       61 agggagggac agatcaggga gaccggggaa gaaggaggag cagccaagga ggctgctgtc
      121 cccccacaga gcagctcgga ctcagctccc ggagcaaccc agctgcggag gcaacggcag
      181 tgctgctcct ccagcgaagg acagcaggca ggcagacaga cagaggtcct gggactggaa
      241 ggcctcagcc cccagccact gggctgggcc tggcccaatg gcctttaatg acctcctgca
      301 gcaggtgggg ggtgtcggcc gcttccagca gatccaggtc accctggtgg tcctccccct
      361 gctcctgatg gcttctcaca acaccctgca gaacttcact gctgccatcc ctacccacca
      421 ctgccgcccg cctgccgatg ccaacctcag caagaacggg gggctggagg tctggctgcc
      481 ccgggacagg caggggcagc ctgagtcctg cctccgcttc acctccccgc agtggggact
      541 gccctttctc aatggcacag aagccaatgg cacaggggcc acagagccct gcaccgatgg
      601 ctggatctat gacaacagca ccttcccatc taccatcgtg actgagtggg accttgtgtg
      661 ctctcacagg gccctacgcc agctggccca gtccttgtac atggtggggg tgctgctcgg
      721 agccatggtg ttcggctacc ttgcagacag gctaggccgc cggaaggtac tcatcttgaa
      781 ctacctgcag acagctgtgt cagggacctg cgcagccttc gcacccaact tccccatcta
      841 ctgcgccttc cggctcctct cgggcatggc tctggctggc atctccctca actgcatgac
      901 actgaatgtg gagtggatgc ccattcacac acgggcctgc gtgggcacct tgattggcta
      961 tgtctacagc ctgggccagt tcctcctggc tggtgtggcc tacgctgtgc cccactggcg
     1021 ccacctgcag ctactggtct ctgcgccttt ttttgccttc ttcatctact cctggttctt
     1081 cattgagtcg gcccgctggc actcctcctc cgggaggctg gacctcaccc tgagggccct
     1141 gcagagagtc gcccggatca atgggaagcg ggaagaagga gccaaattga gtatggaggt
     1201 actccgggcc agtctgcaga aggagctgac catgggcaaa ggccaggcat cggccatgga
     1261 gctgctgcgc tgccccaccc tccgccacct cttcctctgc ctctccatgc tgtggtttgc
     1321 cactagcttt gcatactatg ggctggtcat ggacctgcag ggctttggag tcagcatcta
     1381 cctaatccag gtgatctttg gtgctgtgga cctgcctgcc aagcttgtgg gcttccttgt
     1441 catcaactcc ctgggtcgcc ggcctgccca gatggctgca ctgctgctgg caggcatctg
     1501 catcctgctc aatggggtga taccccagga ccagtccatt gtccgaacct ctcttgctgt
     1561 gctggggaag ggttgtctgg ctgcctcctt caactgcatc ttcctgtata ctggggaact
     1621 gtatcccaca atgatccggc agacaggcat gggaatgggc agcaccatgg cccgagtggg
     1681 cagcatcgtg agcccactgg tgagcatgac tgccgagctc tacccctcca tgcctctctt
     1741 catctacggt gctgttcctg tggccgccag cgctgtcact gtcctcctgc cagagaccct
     1801 gggccagcca ctgccagaca cggtgcagga cctggagagc aggaaaggga aacagacgcg
     1861 acagcaacaa gagcaccaga agtatatggt cccactgcag gcctcagcac aagagaagaa
     1921 tggactctga ggactgagaa ggggccttac agaaccctaa agggagggaa ggtcctacag
     1981 gtctccggcc acccacacaa ggaggaggaa gaggaaatgg tgacccaagt gtgggggttg
     2041 tggttcagga aagcatcttc ccaggggtcc acctcccttt ataaacccca ccagaaccac
     2101 atcattaaaa ggtttgactg cgcacca
//
