LOCUS       NM_003059               2234 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 22 member 4 (SLC22A4), mRNA.
ACCESSION   NM_003059
VERSION     NM_003059.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Pochini,L., Barone,F., Console,L., Brunocilla,C., Galluccio,M.,
            Scalise,M. and Indiveri,C.
  TITLE     OCTN1 (SLC22A4) displays two different transport pathways for
            organic cations or zwitterions
  JOURNAL   Biochim Biophys Acta Biomembr 1866 (2), 184263 (2024)
   PUBMED   38092232
  REMARK    GeneRIF: OCTN1 (SLC22A4) displays two different transport pathways
            for organic cations or zwitterions.
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Lu,D., Cai,H., Li,Y., Chang,W., Liu,X., Dai,Q., Yu,W., Chen,W.,
            Qiao,G., Xie,H., Xiao,X. and Li,Z.
  TITLE     Investigating the ID3/SLC22A4 as immune-related signatures in
            ischemic stroke
  JOURNAL   Aging (Albany NY) 15 (24), 14803-14829 (2023)
   PUBMED   38112574
  REMARK    GeneRIF: Investigating the ID3/SLC22A4 as immune-related signatures
            in ischemic stroke.
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Grundemann,D., Hartmann,L. and Flogel,S.
  TITLE     The ergothioneine transporter (ETT): substrates and locations, an
            inventory
  JOURNAL   FEBS Lett 596 (10), 1252-1269 (2022)
   PUBMED   34958679
  REMARK    GeneRIF: The ergothioneine transporter (ETT): substrates and
            locations, an inventory.
            Review article
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Alcorn,J., Lu,X., Moscow,J.A. and McNamara,P.J.
  TITLE     Transporter gene expression in lactating and nonlactating human
            mammary epithelial cells using real-time reverse
            transcription-polymerase chain reaction
  JOURNAL   J Pharmacol Exp Ther 303 (2), 487-496 (2002)
   PUBMED   12388627
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Yabuuchi,H., Tamai,I., Nezu,J., Sakamoto,K., Oku,A., Shimane,M.,
            Sai,Y. and Tsuji,A.
  TITLE     Novel membrane transporter OCTN1 mediates multispecific,
            bidirectional, and pH-dependent transport of organic cations
  JOURNAL   J Pharmacol Exp Ther 289 (2), 768-773 (1999)
   PUBMED   10215651
REFERENCE   8  (bases 1 to 2234)
  AUTHORS   Urakami,Y., Okuda,M., Masuda,S., Saito,H. and Inui,K.I.
  TITLE     Functional characteristics and membrane localization of rat
            multispecific organic cation transporters, OCT1 and OCT2, mediating
            tubular secretion of cationic drugs
  JOURNAL   J Pharmacol Exp Ther 287 (2), 800-805 (1998)
   PUBMED   9808712
REFERENCE   9  (bases 1 to 2234)
  AUTHORS   Meyer-Wentrup,F., Karbach,U., Gorboulev,V., Arndt,P. and
            Koepsell,H.
  TITLE     Membrane localization of the electrogenic cation transporter rOCT1
            in rat liver
  JOURNAL   Biochem Biophys Res Commun 248 (3), 673-678 (1998)
   PUBMED   9703985
REFERENCE   10 (bases 1 to 2234)
  AUTHORS   Tamai,I., Yabuuchi,H., Nezu,J., Sai,Y., Oku,A., Shimane,M. and
            Tsuji,A.
  TITLE     Cloning and characterization of a novel human pH-dependent organic
            cation transporter, OCTN1
  JOURNAL   FEBS Lett 419 (1), 107-111 (1997)
   PUBMED   9426230
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA591407.1, BC028313.1 and
            AC008599.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 28, 2018 this sequence version replaced NM_003059.2.
            
            Summary: Polyspecific organic cation transporters in the liver,
            kidney, intestine, and other organs are critical for elimination of
            many endogenous small organic cations as well as a wide array of
            drugs and environmental toxins. The encoded protein is an organic
            cation transporter and plasma integral membrane protein containing
            eleven putative transmembrane domains as well as a
            nucleotide-binding site motif. Transport by this protein is at
            least partially ATP-dependent. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.246404.1,
                                           SRR3476690.258062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000200652.4/ ENSP00000200652.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DA591407.1         1-58
            59-1455             BC028313.1         1-1397
            1456-1456           AC008599.7         32815-32815         c
            1457-2234           BC028313.1         1399-2176
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..2234
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /note="solute carrier family 22 member 4"
                     /db_xref="GeneID:6583"
                     /db_xref="HGNC:HGNC:10968"
                     /db_xref="MIM:604190"
     exon            1..616
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1879
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /note="integral membrane transport protein; ET
                     transporter; ergothioneine transporter; organic
                     cation/carnitine transporter 1; solute carrier family 22
                     (organic cation/ergothioneine transporter), member 4;
                     solute carrier family 22 (organic cation/zwitterion
                     transporter), member 4; deafness, autosomal recessive 60"
                     /codon_start=1
                     /product="solute carrier family 22 member 4"
                     /protein_id="NP_003050.2"
                     /db_xref="CCDS:CCDS4153.1"
                     /db_xref="GeneID:6583"
                     /db_xref="HGNC:HGNC:10968"
                     /db_xref="MIM:604190"
                     /translation="MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAG
                     TPEHRCRVPDAANLSSAWRNNSVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRD
                     VDLGQLEQESCLDGWEFSQDVYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVS
                     GQLSDRFGRKNVLFATMAVQTGFSFLQIFSISWEMFTVLFVIVGMGQISNYVVAFILG
                     TEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRDWRMLLLALTVPGVLCVPLWWF
                     IPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSVEELNPLKQQKAFILDLFR
                     TRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSALIEIPAYITAWLLL
                     RTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSMLYVFTAE
                     LYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFP
                     ESLGMTLPETLEQMQKVKWFRSGKKTRDSMETEENPKVLITAF"
     exon            617..720
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..875
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1047
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1174
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1269
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1484
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1667
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1803
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2234
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /note="hexamer: AATAAA"
     polyA_site      2234
                     /gene="SLC22A4"
                     /gene_synonym="DFNB60; ETTh; OCTN1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgtacag tggcatcaag ctcagcgcga gctcccggga acgctccaac gccttcagcc
       61 tgtttcccag gaacggtccc cggcttcgcg ccccaatttc taacagcctg cctgtccccc
      121 gggaacgttc taacatcctt ggggagcgcc ccagctacaa gacactgtcc tgagaacgct
      181 gtcatcaccc gtagttgcaa gtttcggagc ggcagtggga agcatgcggg actacgacga
      241 ggtgatcgcc ttcctgggcg agtgggggcc cttccagcgc ctcatcttct tcctgctcag
      301 cgccagcatc atccccaatg gcttcaatgg tatgtcagtc gtgttcctgg cggggacccc
      361 ggagcaccgc tgtcgagtgc cggacgccgc gaacctgagc agcgcctggc gcaacaacag
      421 tgtcccgctg cggctgcggg acggccgcga ggtgccccac agctgcagcc gctaccggct
      481 cgccaccatc gccaacttct cggcgctcgg gctggagccg gggcgcgacg tggacctggg
      541 gcagctggag caggagagct gcctggatgg ctgggagttc agccaggacg tctacctgtc
      601 caccgtcgtg accgagtgga atctggtgtg tgaggacaac tggaaggtgc ccctcaccac
      661 ctccctgttc ttcgtaggcg tgctcctcgg ctccttcgtg tccgggcagc tgtcagacag
      721 gtttggcagg aagaacgttc tcttcgcaac catggctgta cagactggct tcagcttcct
      781 gcagattttc tccatcagct gggagatgtt cactgtgtta tttgtcatcg tgggcatggg
      841 ccagatctcc aactatgtgg tagccttcat actaggaaca gaaattcttg gcaagtcagt
      901 tcgtattata ttctctacat taggagtgtg cacatttttt gcagttggct atatgctgct
      961 gccactgttt gcttacttca tcagagactg gcggatgctg ctgctggcgc tgacggtgcc
     1021 gggagtgctg tgtgtcccgc tgtggtggtt cattcctgaa tctccccgat ggctgatatc
     1081 ccagagaaga tttagagagg ctgaagatat catccaaaaa gctgcaaaaa tgaacaacat
     1141 agctgtacca gcagtgatat ttgattctgt ggaggagcta aatcccctga agcagcagaa
     1201 agctttcatt ctggacctgt tcaggactcg gaatattgcc ataatgacca ttatgtcttt
     1261 gctgctatgg atgctgacct cagtgggtta ctttgctctg tctctggatg ctcctaattt
     1321 acatggagat gcctacctga actgtttcct ctctgccttg attgaaattc cagcttacat
     1381 tacagcctgg ctgctattgc gaaccctgcc caggcgttat atcatagctg cagtactgtt
     1441 ctggggagga ggtgtgcttc tcttcattca actggtacct gtggattatt acttcttatc
     1501 cattggtctg gtcatgctgg gaaaatttgg gatcacctct gctttctcca tgctgtatgt
     1561 cttcactgct gagctctacc caaccctggt caggaacatg gcggtggggg tcacatccac
     1621 ggcctccaga gtgggcagca tcattgcccc ctactttgtt tacctcggtg cttacaacag
     1681 aatgctgccc tacatcgtca tgggtagtct gactgtcctg attggaatcc tcaccctttt
     1741 tttccctgaa agtttgggaa tgactcttcc agaaacctta gagcagatgc agaaagtgaa
     1801 atggttcaga tctgggaaaa aaacaagaga ctcaatggag acagaagaaa atcccaaggt
     1861 tctaataact gcattctgaa aaaatatcta ccccatttgg tgaagtgaaa aacagaaaaa
     1921 taagaccctg tggagaaatt cgttgttccc actgaaatgg actgactgta acgattgaca
     1981 ccaaaatgaa ccttgctatc aagaaatgct cgtcatacag taaactctgg atgattcttc
     2041 cagataatgt ccttgcttta caaaccaacc atttctagag agtctcctta ctcattaatt
     2101 caatgaaatg gattggtaag atgtcttgaa aacatgttag tcaaggactg gtaaaataca
     2161 tataaagatt aacactcatt tccaatcata caaatactat ccaaataaaa ataacatcat
     2221 tgtattaacg caaa
//
