LOCUS       NM_001384763            1615 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens solute carrier family 22 member 31 (SLC22A31),
            transcript variant 1, mRNA.
ACCESSION   NM_001384763
VERSION     NM_001384763.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA,
            Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X,
            Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang
            B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P,
            Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe
            F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch
            C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras
            A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M,
            Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers
            C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM,
            Elliott P, Walsh T, Tenesa A, Fawkes A, Murphy L, Rowan K, Ponting
            CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry
            SC, Moutsianas L, Law A, Caulfield MJ and Baillie JK.
  CONSRTM   GenOMICC investigators; 23andMe investigators; COVID-19 Human
            Genetics Initiative
  TITLE     Whole-genome sequencing reveals host factors underlying critical
            COVID-19
  JOURNAL   Nature 607 (7917), 97-103 (2022)
   PUBMED   35255492
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G,
            Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E,
            Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM,
            Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C,
            Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M,
            Clark LM, Cohn JD, Denys M, Detter JC, Dickson M,
            Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos
            D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady
            DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand
            CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H,
            Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y,
            Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ,
            Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S,
            Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer
            J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH,
            Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R,
            Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M,
            Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL,
            Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA,
            Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler
            EE, Gilna P, Lucas SM, Myers RM, Rubin EM and Pennacchio LA.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009113.8.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9304717.743118.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148093,
                                           SAMEA2155770 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000682282.1/ ENSP00000508250.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC009113.8         65901-65960
            61-164              AC009113.8         66622-66725
            165-319             AC009113.8         66871-67025
            320-488             AC009113.8         67247-67415
            489-634             AC009113.8         67641-67786
            635-743             AC009113.8         67888-67996
            744-958             AC009113.8         68102-68316
            959-1070            AC009113.8         69029-69140
            1071-1615           AC009113.8         70133-70677
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..1615
                     /gene="SLC22A31"
                     /note="solute carrier family 22 member 31"
                     /db_xref="GeneID:146429"
                     /db_xref="HGNC:HGNC:27091"
     exon            1..60
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1377
                     /gene="SLC22A31"
                     /note="isoform a is encoded by transcript variant 1;
                     putative solute carrier family 22 member ENSG00000182157;
                     putative solute carrier family 22 member 31"
                     /codon_start=1
                     /product="putative solute carrier family 22 member 31
                     isoform a"
                     /protein_id="NP_001371692.1"
                     /db_xref="CCDS:CCDS92209.1"
                     /db_xref="GeneID:146429"
                     /db_xref="HGNC:HGNC:27091"
                     /translation="MPHQLSQNWNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRF
                     GRRAVFVASLVLTTGLGASEALAASFPTLLVLRLLHGGTLAGALLALYLARLELCDPP
                     HRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLLQGLGALMSGLLLLFWGFPALFPESP
                     CWLLATGQVARARKILWRFAEASGVGPGDSSLEENSLATELTMLSARSPQPRYHSPLG
                     LLRTRVTWRNGLILGFSSLVGGGIRASFRRSLAPQVPTFYLPYFLEAGLEAAALVFLL
                     LTADCCGRRPVLLLGTMVTGLASLLLLAGAQYLPGWTVLFLSVLGLLASRAVSALSSL
                     FAAEVFPTVIRGAGLGLVLGAGFLGQAAGPLDTLHGRQGFFLQQVVFASLAVLALLCV
                     LLLPESRSRGLPQSLQDADRLRRSPLLRGRPRQDHLPLLPPSNSYWAGHTPEQH"
     exon            61..164
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            165..319
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            320..488
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            489..634
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            635..743
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            744..958
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1070
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1615
                     /gene="SLC22A31"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1597..1602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A31"
                     /note="hexamer: GATAAA"
     polyA_site      1615
                     /gene="SLC22A31"
                     /note="major polyA site"
ORIGIN      
        1 acctgccctc ctcctgtttg gtgcctggat ccaggaatgc cccatcagct ttcccaaaac
       61 tggaaccttg tgtgtggaga cggctggaag gtcccgctgg agcaggtgag ccacctcctg
      121 ggctggctgc tgggctgtgt catcctggga gcaggctgtg accggtttgg acgccgggca
      181 gtttttgtgg cctccctggt gctgaccaca ggcctggggg ccagtgaggc cctggctgcc
      241 agcttcccta ccctgctggt cctgcgccta ctccacgggg gcacattggc aggggccctc
      301 ctcgccctgt atctggctcg cctggagttg tgtgaccctc cccaccgcct ggccttctcc
      361 atgggggctg gccttttctc ggtggtgggc accctgctgc tgcccggcct ggctgcgctt
      421 gtgcaggact ggcgtcttct gcaggggctg ggtgccctga tgagtggact cttgctgctc
      481 ttttgggggt tcccggccct gttccccgag tctccctgct ggctgctggc cacaggtcag
      541 gtagctcgag ccaggaagat cctgtggcgc tttgcagaag ccagtggcgt gggccccggg
      601 gacagttcct tggaggagaa ctccctggct acagagctga ccatgctgtc tgcacggagc
      661 ccccagcccc ggtaccactc cccactgggg cttctgcgta cccgagtcac ctggagaaac
      721 gggcttatct tgggcttcag ctcgctggtt ggtggaggca tcagagctag cttccgccgc
      781 agcctggcac ctcaggtgcc gaccttctac ctgccctact tcctggaggc cggcctggag
      841 gcggcagcct tggtcttcct gctcctgacg gcagattgct gtggacgccg ccccgtgctg
      901 ctgctgggca ccatggtcac aggcctggca tccctgctgc tcctcgctgg ggcccagtat
      961 ctgccaggct ggactgtgct gttcctctct gtcctggggc tcctggcctc ccgggctgtg
     1021 tccgcactca gcagcctctt cgcggccgag gtcttcccca cggtgatcag gggggccggg
     1081 ctgggcctgg tgctgggggc cgggttcctg ggccaggcag ccggccccct ggacaccctg
     1141 cacggccggc agggcttctt cctgcaacaa gtcgtcttcg cctcccttgc tgtccttgcc
     1201 ctgctgtgtg tcctgctgct gcctgagagc cgaagccggg ggctgcccca gtcactgcag
     1261 gacgccgacc gcctgcgccg ctccccactc ctgcggggcc gcccccgcca ggaccacctg
     1321 cctctgctgc cgccctccaa ctcctactgg gccggccaca cccccgagca gcactagtcc
     1381 tgcctggtgg ccctgggagc caggatggga ccaaagtcaa ggcctggggc atggctgagt
     1441 accccagacg tctggtccag ggcagacaca ttcctctcag aagcccgtgt ctcagtgcag
     1501 gtggagccgt ggggacagcg tgaaggtgtc tccagccagg ccccaggcac tgggaggccc
     1561 tgggtctccc cccagccaca cccagtaggt gtggaggata aaggcttctg tggaa
//
