LOCUS       NM_021977               3234 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens solute carrier family 22 member 3 (SLC22A3), mRNA.
ACCESSION   NM_021977
VERSION     NM_021977.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3234)
  AUTHORS   Wang,Q., McCormick,S., Leask,M.P., Watson,H., O'Sullivan,C.,
            Krebs,J.D., Hall,R., Whitfield,P., Merry,T.L., Murphy,R. and
            Shepherd,P.R.
  TITLE     A Polynesian-specific SLC22A3 variant associates with low plasma
            lipoprotein(a) concentrations independent of apo(a) isoform size in
            males
  JOURNAL   Biosci Rep 44 (7) (2024)
   PUBMED   38896441
  REMARK    GeneRIF: A Polynesian-specific SLC22A3 variant associates with low
            plasma lipoprotein(a) concentrations independent of apo(a) isoform
            size in males.
REFERENCE   2  (bases 1 to 3234)
  AUTHORS   Redeker,K.M., Schroder,S., Ducker,C., Brockmoller,J. and Gebauer,L.
  TITLE     Targeted mutagenesis of negatively charged amino acids outlining
            the substrate translocation path within the human organic cation
            transporter 3
  JOURNAL   Biochem Pharmacol 223, 116188 (2024)
   PUBMED   38580166
  REMARK    GeneRIF: Targeted mutagenesis of negatively charged amino acids
            outlining the substrate translocation path within the human organic
            cation transporter 3.
REFERENCE   3  (bases 1 to 3234)
  AUTHORS   Pearce,B., Jacobs,C. and Benjeddou,M.
  TITLE     Genetic preservation of SLC22A3 in the Admixed and Xhosa
            populations living in the Western Cape
  JOURNAL   Mol Biol Rep 50 (12), 10199-10206 (2023)
   PUBMED   37924453
  REMARK    GeneRIF: Genetic preservation of SLC22A3 in the Admixed and Xhosa
            populations living in the Western Cape.
REFERENCE   4  (bases 1 to 3234)
  AUTHORS   Chen,L., Zhao,M., Zhou,M., Luo,J., Li,S., Liu,X., Cheng,Z.,
            Zhuo,Y., Zeng,W., Zhang,Z. and Zhou,L.
  TITLE     LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene Polymorphisms
            Contribute to the Risk of Coronary Artery Disease in Chinese Han
            Population
  JOURNAL   DNA Cell Biol 42 (12), 746-752 (2023)
   PUBMED   37843894
  REMARK    GeneRIF: LncRNA RP1-276N6.2 Expression and RP1-276N6.2 Gene
            Polymorphisms Contribute to the Risk of Coronary Artery Disease in
            Chinese Han Population.
REFERENCE   5  (bases 1 to 3234)
  AUTHORS   Seo,E., Jee,B., Chung,J.H., Song,W., Sung,H.H., Jeon,H.G.,
            Jeong,B.C., Seo,S.I., Jeon,S.S., Lee,H.M. and Kang,M.
  TITLE     Repression of SLC22A3 by the AR-V7/YAP1/TAZ axis in
            enzalutamide-resistant castration-resistant prostate cancer
  JOURNAL   FEBS J 290 (6), 1645-1662 (2023)
   PUBMED   36254631
  REMARK    GeneRIF: Repression of SLC22A3 by the AR-V7/YAP1/TAZ axis in
            enzalutamide-resistant castration-resistant prostate cancer.
REFERENCE   6  (bases 1 to 3234)
  AUTHORS   Grundemann,D. and Schomig,E.
  TITLE     Gene structures of the human non-neuronal monoamine transporters
            EMT and OCT2
  JOURNAL   Hum Genet 106 (6), 627-635 (2000)
   PUBMED   10942111
REFERENCE   7  (bases 1 to 3234)
  AUTHORS   Verhaagh,S., Schweifer,N., Barlow,D.P. and Zwart,R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
REFERENCE   8  (bases 1 to 3234)
  AUTHORS   Wu,X., Kekuda,R., Huang,W., Fei,Y.J., Leibach,F.H., Chen,J.,
            Conway,S.J. and Ganapathy,V.
  TITLE     Identity of the organic cation transporter OCT3 as the
            extraneuronal monoamine transporter (uptake2) and evidence for the
            expression of the transporter in the brain
  JOURNAL   J Biol Chem 273 (49), 32776-32786 (1998)
   PUBMED   9830022
REFERENCE   9  (bases 1 to 3234)
  AUTHORS   Grundemann,D., Schechinger,B., Rappold,G.A. and Schomig,E.
  TITLE     Molecular identification of the corticosterone-sensitive
            extraneuronal catecholamine transporter
  JOURNAL   Nat Neurosci 1 (5), 349-351 (1998)
   PUBMED   10196521
REFERENCE   10 (bases 1 to 3234)
  AUTHORS   Kekuda,R., Prasad,P.D., Wu,X., Wang,H., Fei,Y.J., Leibach,F.H. and
            Ganapathy,V.
  TITLE     Cloning and functional characterization of a potential-sensitive,
            polyspecific organic cation transporter (OCT3) most abundantly
            expressed in placenta
  JOURNAL   J Biol Chem 273 (26), 15971-15979 (1998)
   PUBMED   9632645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314590.1 and AF078749.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021977.3.
            
            Summary: Polyspecific organic cation transporters in the liver,
            kidney, intestine, and other organs are critical for elimination of
            many endogenous small organic cations as well as a wide array of
            drugs and environmental toxins. This gene is one of three similar
            cation transporter genes located in a cluster on chromosome 6. The
            encoded protein contains twelve putative transmembrane domains and
            is a plasma integral membrane protein. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.175057.1,
                                           SRR1803617.175343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275300.3/ ENSP00000275300.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1713              AK314590.1         1-1713
            1714-3234           AF078749.1         137-1657
FEATURES             Location/Qualifiers
     source          1..3234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..3234
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /note="solute carrier family 22 member 3"
                     /db_xref="GeneID:6581"
                     /db_xref="HGNC:HGNC:10967"
                     /db_xref="MIM:604842"
     exon            1..471
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1713
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /note="organic cation transporter 3; EMT organic cation
                     transporter 3; extraneuronal monoamine transporter; solute
                     carrier family 22 (extraneuronal monoamine transporter),
                     member 3; solute carrier family 22 (organic cation
                     transporter), member 3"
                     /codon_start=1
                     /product="solute carrier family 22 member 3"
                     /protein_id="NP_068812.1"
                     /db_xref="CCDS:CCDS5277.1"
                     /db_xref="GeneID:6581"
                     /db_xref="HGNC:HGNC:10967"
                     /db_xref="MIM:604842"
                     /translation="MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGT
                     QPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSA
                     SATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAI
                     LNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVF
                     GKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITL
                     PSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLSSNYSEITVTDEEVS
                     NPSFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGIIGGNLYIDFFISGVVELP
                     GALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVATLGRLGITMAF
                     EIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPLIIFGILAS
                     ICGGLVMLLPETKGIALPETVDDVEKLGSPHSCKCGRNKKTPVSRSHL"
     exon            472..575
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            576..730
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            731..899
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1017
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1115
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1330
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1439
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1552
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1652
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..3234
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3211..3216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /note="hexamer: ATTAAA"
     polyA_site      3234
                     /gene="SLC22A3"
                     /gene_synonym="EMT; EMTH; OCT3"
                     /note="major polyA site"
ORIGIN      
        1 actccgaggc gcgggctgcg ggcggcgggc ggcgggcgca ccatgccctc cttcgacgag
       61 gcgctgcagc gggtgggcga gttcgggcgc ttccagaggc gcgtgttttt gctgctgtgc
      121 ctgacgggcg tcaccttcgc cttcctcttc gtcggcgtgg tcttcctggg cacgcagccc
      181 gaccactact ggtgccgcgg gccaagtgcc gcggcgctgg ccgagcgctg cggctggagc
      241 ccggaggagg agtggaaccg cacggcgccc gcctcccgcg gcccagagcc ccccgagcgc
      301 cgcggccgct gccagcgcta cctcctggag gcggccaacg acagcgcctc cgccactagc
      361 gctctcagct gcgcggaccc actcgccgcc ttccccaacc gctcggctcc ccttgtgccg
      421 tgccgcggcg gctggcgcta cgcccaggcc cactccacca tcgtcagcga gtttgacctt
      481 gtctgtgtca atgcgtggat gctggacctc acccaagcca tcctgaacct cggcttcctg
      541 actggagcat tcaccttagg ctatgcagca gacaggtatg gcaggatcgt catttacttg
      601 ctatcctgcc ttggtgttgg cgtcactggg gttgtggtgg cctttgcacc aaacttccct
      661 gtgtttgtga tcttccgctt cctgcaaggt gtatttggaa aggggacgtg gatgacttgc
      721 tacgtgattg tgacagaaat agtaggttcg aaacaaagga ggattgtggg aatcgtgatt
      781 caaatgttct ttacccttgg aatcataatt ctccctggaa ttgcctactt catccccaac
      841 tggcaaggaa tccagttagc catcacgctg cccagctttc tcttcctcct ttattactgg
      901 gtggtccctg agtctccccg ttggctgatt actcggaaga aaggagataa agcattacag
      961 atcctgagac gcattgctaa gtgcaatggg aaatacctct catcaaatta ctcagagatc
     1021 actgttacag atgaggaagt tagtaatcca tcctttttag atctggtgag aactccccaa
     1081 atgaggaaat gcacacttat tcttatgttt gcttggttca caagcgcagt ggtgtatcaa
     1141 ggacttgtca tgcgcctggg aattataggg ggcaacctct atatagactt tttcatctcg
     1201 ggcgtggtgg aactgccagg agctctcttg atcttactaa ccattgagcg ccttggacga
     1261 cgcctcccct ttgcggcaag caatatagtg gcaggggtgg catgccttgt cactgcgttc
     1321 ttaccagaag gaatagcatg gttgaggacc acagtggcta cattgggaag actagggata
     1381 accatggcct ttgaaattgt ttatttggta aattcagaat tgtacccaac aacattacga
     1441 aatttcggag tttcgctctg ttcaggtctg tgtgattttg ggggaatcat agccccattt
     1501 ctgctctttc ggctagcagc cgtgtggcta gaactacctc tgatcatctt tggtatcctg
     1561 gcatccatct gtggtggcct tgtgatgctt ttgcctgaaa ccaagggtat tgccttgcca
     1621 gagacagtgg atgatgtaga aaaacttggc agtccacatt cctgtaaatg tggcaggaat
     1681 aagaaaaccc cagtttcccg ctctcacctt tgaggccccc gacaaagaca gaaagaagga
     1741 gctatccagg agctgatcct ccttgcaaag ctgtgccttg cagagatgca cgtgtgcatt
     1801 tcagctacat catgccgcgc tgttgtaata ctgtataaag acctcaatct atccagagta
     1861 tttttatata atgttggatg agttaggatt tgtaatgctg ttgaagtttc tgggaacaca
     1921 taatatgtag ccagtttaac aaagaagctg tcaggtgcac agcccttcct gggttttttt
     1981 cttgtgttcc ctgtggtctc tgacccatta ggctaaagag agacaagaga agcccccaac
     2041 ctgattctca tgacagctcc atcaagaatg tgggatgtgc cgaccaagga tttgagaaag
     2101 ttgtacagaa atgtgttcat caaatctggt caagggacta agctcctagc tgaccattca
     2161 ttctgaagat tgcatggagg atgaacatct gggaatcctg ttaatgagaa ggctgaatca
     2221 caggcacctg ggccaaaggg tgtgagcatt catgttctct gctcaccttg gtttccgcac
     2281 accttcgcaa tgtgaacagg tcaggagtcc ctcccgtcca cctcctctgt aacagctggg
     2341 gttccaggca tggtttaggc cctgttccag caataagaac caatctgctg tacaatctga
     2401 ggacttggct ctgttattta caaaatgatg ctgtggttct gagattattt gggacatttt
     2461 tggctctcct ttagtggaca cctagagcca cagattccct tctttactaa acaaatccca
     2521 tggattctga tttctgggtc ttaggatttt aaaagtgaag ggatattttt cttatatttg
     2581 tgagttcagt tccgatggtg cccgtggtca aaagcgaaaa acatggacaa ttcctattca
     2641 ttcttagcac tttgacatgt cttggggaaa agcttacatt ttaatttaaa agaaagatca
     2701 attatatcca tgcttaacag gatcagcagg agctttataa atgactttac agagactaat
     2761 aagggatttg atctttcttt ttttgttatc gaggcttttg aaatgtggaa cttgtgtgtt
     2821 ctgctttata tgttatattc aatatctttt cagatgcagt ctatatttta tgctgagttt
     2881 taaaaatgaa atactttatg caaacaggca aaattggtac caaagggaaa cattaaccat
     2941 gaggaagagc atttttctaa ggagaacagg tgacaatata cacatgtgcg ctaatcgtaa
     3001 aatgagcatc ttagtcttta aaacacatca gaattgaata cgaataatct atttgtcgat
     3061 gaaataaaca caactctttg aggatttgag actacattca ccctttattc acagtcactt
     3121 gcagttttgc ttttctctgc atttctctgc tgtaagatga ctgttgcatt gttgaattgt
     3181 attttgagtg gatatttttg tttggtaaca attaaaattt taaatcgtaa aaaa
//
