LOCUS       NM_199352               8192 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens solute carrier family 22 member 25 (SLC22A25),
            transcript variant 1, mRNA.
ACCESSION   NM_199352 XM_370628
VERSION     NM_199352.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8192)
  AUTHORS   Yamada,Y., Sakuma,J., Takeuchi,I., Yasukochi,Y., Kato,K., Oguri,M.,
            Fujimaki,T., Horibe,H., Muramatsu,M., Sawabe,M., Fujiwara,Y.,
            Taniguchi,Y., Obuchi,S., Kawai,H., Shinkai,S., Mori,S., Arai,T. and
            Tanaka,M.
  TITLE     Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel
            susceptibility loci for atrial fibrillation by an exome-wide
            association study
  JOURNAL   Mol Med Rep 16 (5), 5823-5832 (2017)
   PUBMED   28849223
  REMARK    GeneRIF: TNFSF13, SPATC1L, SLC22A25 and SALL4 may thus be novel
            susceptibility loci for atrial fibrillation in the Japanese
            population
REFERENCE   2  (bases 1 to 8192)
  AUTHORS   Zair,Z.M., Eloranta,J.J., Stieger,B. and Kullak-Ublick,G.A.
  TITLE     Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT
            (SLC15) transporters in the intestine, liver and kidney
  JOURNAL   Pharmacogenomics 9 (5), 597-624 (2008)
   PUBMED   18466105
  REMARK    GeneRIF: Review summarizes current knowledge on the functional and
            phenotypic consequences of genetic variation in intestinally,
            hepatically and renally expressed members of solute carrier family
            (SLC) member 25.
            Review article
REFERENCE   3  (bases 1 to 8192)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
REFERENCE   4  (bases 1 to 8192)
  AUTHORS   Eraly,S.A., Monte,J.C. and Nigam,S.K.
  TITLE     Novel slc22 transporter homologs in fly, worm, and human clarify
            the phylogeny of organic anion and cation transporters
  JOURNAL   Physiol Genomics 18 (1), 12-24 (2004)
   PUBMED   15054140
  REMARK    GeneRIF: cloning of a novel human slc22 family member, UST6,
            expressed exclusively in liver in both embryo and adult, is
            reported [UST6]
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001880.4 and AP003420.2.
            
            On Apr 22, 2021 this sequence version replaced NM_199352.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            CDS exon combination :: AY437532.1, BC101316.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306494.11/ ENSP00000307443.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AP001880.4         14905-15070         c
            167-585             AP001880.4         10188-10606         c
            586-717             AP001880.4         9352-9483           c
            718-1563            AP001880.4         722-1567            c
            1564-1598           AP001880.4         1-35                c
            1599-1667           AP003420.2         82274-82342         c
            1668-1822           AP003420.2         71394-71548         c
            1823-1991           AP003420.2         71127-71295         c
            1992-2115           AP003420.2         37507-37630         c
            2116-2231           AP003420.2         34473-34588         c
            2232-2446           AP003420.2         19857-20071         c
            2447-2555           AP003420.2         18339-18447         c
            2556-8192           AP003420.2         12250-17886         c
FEATURES             Location/Qualifiers
     source          1..8192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..8192
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /note="solute carrier family 22 member 25"
                     /db_xref="GeneID:387601"
                     /db_xref="HGNC:HGNC:32935"
                     /db_xref="MIM:610792"
     exon            1..166
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            167..585
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            586..717
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            718..1563
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     CDS             1162..2805
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /note="isoform a is encoded by transcript variant 1;
                     putative UST1-like organic anion transporter; organic
                     anion transporter UST6; MGI:2442751, MGI:2385316,
                     MGI:3042283, MGI:3645714, MGI:3605624, MGI:2442750"
                     /codon_start=1
                     /product="solute carrier family 22 member 25 isoform a"
                     /protein_id="NP_955384.3"
                     /db_xref="CCDS:CCDS31592.1"
                     /db_xref="GeneID:387601"
                     /db_xref="HGNC:HGNC:32935"
                     /db_xref="MIM:610792"
                     /translation="MAFQDLLDQVGGLGRFQILQMVFLIMFNVIVYHQTQLENFAAFI
                     LDHRCWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLN
                     GTFPNTSEPDTEPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGG
                     NLYGHLSDRFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSIIVNTV
                     LLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFS
                     RWLAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKK
                     HSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLA
                     NCVAPWALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGIT
                     CSTAQENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILS
                     GLVVLLLPETRNQPLLDSIQDVENEGVNSLAAPQRSSVL"
     exon            1564..1667
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1822
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1991
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2115
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2231
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2446
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2555
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..8192
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /note="hexamer: AGTAAA"
     polyA_site      3357
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /note="major polyA site"
     regulatory      8172..8177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /note="hexamer: AATAAA"
     polyA_site      8192
                     /gene="SLC22A25"
                     /gene_synonym="HIMTP; UST6"
                     /note="major polyA site"
ORIGIN      
        1 actccagcag ctcctgaggc ttgatggagt tgtcggtata aatgcacagc tttttggcag
       61 tcagtgggct ggactctttg agcctggagg ccaggaacat gcagacagca cccaggagtt
      121 gcagatggga ctttgaagtt gggatcctgg cgaagaaaca gtccagggat aatctcttca
      181 gcctcaatgg tatttcagga cttcttggat caagttggtg gcttggggag atttcagatc
      241 cttcagatgg tttttcttat catctccacc tttatagttt gccctcgtgt tgtatggaga
      301 atttcactgc attcatcctg gtcaccactg ctaggtgcac atcatagaca atgtcatcgt
      361 cttggacgaa gaaactgtga tcctcagcca agatgccctc ctgagaatct ctatctcact
      421 ggactcaaac ctgaggccac agaaacgttg tcacttcatc catccccagt ggcagctcct
      481 tcacctgaat gggacattcc tcaatatgaa tgaaccagac atggaaccgt gtgtggacag
      541 cagggtgtac aacagaagct ccttcctctc caccatcgtg actggtggga cctggtatgt
      601 ggatctcagt cactgaattt agtggctaca ttcttattca tggagtggtg gtgaaaggca
      661 tccaatatgg ccatttatca gacagatgag catctctgtt caaagatcac tatactaaga
      721 aaagaaaaag cactttgcct ttgagtccca cagattacac gttctggaaa gactgcatac
      781 caagtagcag atttatttta gtttgtttac aaaaaaatgt gcagaccaaa gttcaatgct
      841 gctattgggg agctactaaa gacatcaata agtagatgtc taatgtttaa acacatttca
      901 ttgaaaatgg ttggaagtat ctgagccaat tatttcttat gtgaccctaa agaaaacaga
      961 tacctacctg accccaaaac tacttgagga aattgcttcc gtgaccctgc tgcagatggg
     1021 agagagggcc cattaagaag agagtggggt caggatcaac acacacactt agtgtgattt
     1081 aaggaaagga aatattttct ctttgaactt atctggatac agtcattttg tctcctcttg
     1141 gggatcactt gtccagcctc aatggccttt caggacctcc tagatcaagt tggaggcctg
     1201 gggagattcc agatccttca gatggttttc cttataatgt tcaacgtcat agtataccat
     1261 caaactcagc tggagaactt cgcagcattc atacttgatc atcgctgctg ggttcatata
     1321 ctggacaatg acactatccc tgacaatgac cctgggaccc tcagccagga tgccctcctg
     1381 agaatctcca tcccattcga ctcaaatctg aggccagaga agtgtcgtcg ctttgtccat
     1441 ccccagtgga agctcattca tctgaatggg accttcccca acacgagtga gccagataca
     1501 gagccctgtg tggatggctg ggtatatgac caaagctcct tcccttccac cattgtgact
     1561 aagtgggatc tggtatgcga atctcaacca ctgaattcag tagctaaatt tctattcatg
     1621 gctggaatga tggtgggagg caacctatat ggccatttgt cagacaggtt tgggagaaag
     1681 ttcgtgctca gatggtctta cctccagctc gccattgtag gcacctgtgc ggcctttgct
     1741 cccaccatcc tcgtatactg ctccctgcgc ttcttggctg gggctgctac atttagcatc
     1801 attgtaaata ctgttttgtt aattgtagag tggataactc accaattctg tgccatggca
     1861 ttgacattga cactttgtgc tgctagtatt ggacatataa ccctgggaag cctggctttt
     1921 gtcattcgag accagtgcat cctccagttg gtgatgtctg caccatgctt tgtcttcttt
     1981 ctgttctcaa ggtggctggc agagtctgct cggtggctca ttatcaacaa caaaccagaa
     2041 gagggcttaa aggaacttag aaaagctgca cacaggaatg gaatgaagaa tgctgaagac
     2101 atcctaacca tggaggtttt gaaatccacc atgaagcaag aactggaggc agcacagaaa
     2161 aagcattctc tttgtgaatt gctccgcata cccaacatat gtaaaagaat ctgtttcctg
     2221 tcctttgtga gatttgcaag taccatccct ttttggggcc ttactttgca cctccagcat
     2281 ctgggaaaca atgttttcct gttgcagact ctctttggtg cagtcaccct cctggccaat
     2341 tgtgttgcac cttgggcact gaatcacatg agccgtcgac taagccagat gcttctcatg
     2401 ttcctactgg caacctgcct tctggccatc atatttgtgc ctcaagaaat gcagaccctg
     2461 cgtgtggttt tggcaaccct gggtgtggga gctgcttctc ttggcattac ctgttctact
     2521 gcccaagaaa atgaactaat tccttccata atcaggggaa gagctactgg aatcactgga
     2581 aactttgcta atattggggg agccctggct tccctcatga tgatcctaag catatattct
     2641 cgacccctgc cctggatcat ctatggagtc tttgccatcc tctctggcct tgttgtcctc
     2701 ctccttcctg aaaccaggaa ccagcctctt cttgacagca tccaggatgt ggaaaatgag
     2761 ggagtaaata gcctagctgc ccctcagagg agctctgtgc tataggtctg tgctgaggaa
     2821 agcaaaacac catttagggc taccatcccc caaaaaggct tagatctggg ctattcccat
     2881 gtagtcagtg cctttgcctt tggtgtatcc tcatcccttc cacagtgacc tcatacatcc
     2941 cctgagcctc actagatcac acagaccatc tctgcccagc ctgtccagga ggttaatttg
     3001 tggtgaaaag accaaaatta ggtgacctct gcccttcctg ccctggtatg acatgcatac
     3061 tcttgaaggt attctacaaa catgcaggga tccaaacacc atcttctcat ccctggggag
     3121 ccctcagccc agtgagtgta cctgttagct gtctgggatt gccagtgctt acaggcctga
     3181 ctcccaggac actgaagaat ttgtgagaga ctgtatagaa aataagagcc cctcccacag
     3241 atgagaagtc cttttgtatc acatgtgaga ttcagtctat ctaattttca cgggggaaaa
     3301 aaagcgttgg aaaaggggaa aagaagtgat aagtaaagga attttttaag taatgaagaa
     3361 tgagaaaagg ttctaaaact tttctgtgct tctcttgcct tttccaaaat ccctttggtc
     3421 aatgccatgg tgtccaagtg tgagagttga agctattcaa gctgccttcc cagatcctag
     3481 gctgggagct tggtttttta cttcacaagg tttacacaaa cacttgcggg cagaggcatg
     3541 ttttttatta aagctagtgg gcaaagaatc agtatgtcct aaagaatgca ggacttatat
     3601 gtttagtcca tgtctttcat ttttgagctt ttttgtttgt tggtttcatt atatttgcac
     3661 caggagaaga tgctccagaa aagcagggca ggaagatacc tgcagcaaag tgacacaatt
     3721 ttaaggaatt ccaggtgctg attgctgatt aaacagcaag ataaaggaaa aatcgagacc
     3781 atttctagat actactaaaa tttagaaaat aaataaataa caagatataa tggataaata
     3841 cattccattt acaactgtga ttctaaatgg ttaaatataa aatatctaca aataatcata
     3901 agaagtttga agaaaatcat aacactttaa aaggaatcat aatagaacat ttgtataatt
     3961 atatacatct cacatgtttc tggatatgaa gatggaataa tatttaaaac aatgattctt
     4021 ccttaattat ttaatagagt aattgcttaa ataattacaa tgtaaaaaat gaaaaaagtg
     4081 gaaaaacctc attttcaagc tgcatacttt tataagaaca taaaaaatag ttccaaaact
     4141 ggatatccat atgcagaaga ataaaactag aactctctca ccatatacaa aaatcaaatc
     4201 aaaatgcatt aaaaacttga atctaagacc tcaaactatg aaactgctac aagaaaacat
     4261 tggagaaatt ttccagtaca ttagactggc caaagatttc ttgagtaata ccccacaagt
     4321 acaggaaaac aaagcaaatg tggacaaatg ggatcacagc aagttaaaaa acttctgcac
     4381 agcaaaggat acattcaaca aagtaaagag gcaacccaca gaatgggaga aaatacttgc
     4441 aaactacccc tctgacaaag gactaatcac cagaatatat aaggagctca aacaactcta
     4501 taggaaaaat caaataatct catcaaacaa tgggcaacgt gaataggtat ttctcaaaag
     4561 aagacataca gatgtcaaac agtcatagga aaaagtgctg aacatcattg atcctcagag
     4621 aaatgcaaat caaaactaca atgagatctc atcttacctc agttaaaatg gctgatatcc
     4681 aaaagacagg caagaacaaa tgctggtgag aatgtggaga aaagggaacc ctcatacact
     4741 gttggtggga atgtaaatta gtacaatcac tatggagaag agtttggaga ttcctcaaaa
     4801 aaattaaaaa tagagctaac atttgaccca gcaattccac tgcatcattg tattagtcca
     4861 ttttcaagct gctgttaaaa acatacctga gactggataa tttacaaagg aaagaggttt
     4921 aatggactca cagttccaca tagctggtga agcctcacaa tcctggtgga gggcgaaagg
     4981 cacgtcttac atggcagcag gcaaaaagat aatttttgca gggaaactcc cttttataaa
     5041 accatcagat catgtgagat ttattcacta tcataggaag agcatgggaa acactcaccc
     5101 ccatgattca gttacctccc actggatccc tcccatgatg tgtgggaatt gtgggagcta
     5161 caattcaaga tgagattggg taggcggaca cagtcaaacc atatcattct gcccctggcc
     5221 cctcccaaat ctcatgtcct cacatttcaa aactaatcat gccttcccaa cagtccccca
     5281 aagttttaac tcatttcagc attaactcaa aagtctacag tccaaagtct catctgagac
     5341 aaggcaagtc ctttccacct atgaccttgc aaaatcaaaa gaaattggtt acttcctaga
     5401 tacaatgggg gtacaggcat tggataaata catccattcc aaatgggaga aattgaccaa
     5461 aacaaaagga tgaggctgta cctagataaa aggcactgac tacatgggaa tcgtcttcca
     5521 ccatgattgt gaggcctcac cagccacatg gagctgtgag tccattaaac cttttttctt
     5581 tataaattat ccagtctcag gtatgtcttt atcagcagct tgaaaatgga ctaatacaat
     5641 ggtgcagtgg aactgttggg tcaaatgtta gctttacttt taattttttt gaggaacctc
     5701 caaactgttc tccatagcag ttttactaaa ggccccatac aattccaaaa tccagcaggg
     5761 aagtccaatc ttaaagctcc aaagttatct cctttgactg catgtctcac atttgggtca
     5821 caatgatgca aaaggtgggt ttccatgctc ttgggcagct ctgcttctgt ggctttgcag
     5881 ggtacagcct ccctcctggc tgcttttgtg acctggcatt gagtgtctgc agcttttcca
     5941 ggtgtgcagt gcaagctgtc aatgccttta caattctggg gtctggaggt cgaagaccct
     6001 cttctcacag ctccactaag cagtctccga tggagactct gtgtatggac ttcaacccca
     6061 catcttcctt tcacaccgcc caagcagagg ttctccatga ggaccccacc cctgcagcaa
     6121 acttctacct gggcatccag gcatttccat acatcctctg aaatctaggt ggaggttccc
     6181 aaacctcaat tcttgacttc tttgcacctg taggctcaac accacatgga agctgtcaag
     6241 gcttggggct tgcaccctct gaagccacag cctgatctgt accttggccc cttttagcca
     6301 tggctagagt ggctgagaca cagggcacca agtcactaag gctgcacaca gcaggggcac
     6361 ctggacctcc taggcctcca ggcctgtgat aggaagggct gtcacaaagg tctctgacat
     6421 gccctggaga cattttcccc attgtcttag ggattaacct ttggttcctc attacttatg
     6481 caaatttctg cagcaggctt gaatttctcc tcagaaaatg ggtttttatt ttctatcaca
     6541 tcaccaggct gcaaattttt caaacttttt tgctgagttt cccttttaaa actgactgct
     6601 tttaacagca cccgtcacat cttgaatgct ttgctgctta aaaatttctt ctgacagata
     6661 ccctaaatca tcttactcaa gttcaaagtt ccacaaatct ctaggacagg agtaaacgct
     6721 gccagtctct ttactaaaat atagcaagag tcacctttac tccagttacc aacaagttct
     6781 tcatcttcat ctgagaccac ctcagcctgg atttcatttt ccatatcatt atcagcattt
     6841 cagtcaaagc cattcaacaa gtctctagga agttccaaac tttccaacat tttcctgtct
     6901 tcttctgagc cctccaaata ttgccccagt tccaaagttg cttccacatt tgtgggtatc
     6961 tttacagaag cacttcactc tatcagtacc aatttactat attagtccat ttctcatgct
     7021 gctgataaag acatacctga gactgggtaa gttataaaga aaagaggttt aatgtactca
     7081 cagttccacc tggctgggga agcctcacaa tcacggcaga aggtgaaagg cacaacttac
     7141 atggcagcag ggaaaagaga atttctgcag ggaaactccc ccttataaaa ccctcagatc
     7201 tcatgaaact tattcagtat cacaagaata gcacgggaaa gacctggccc catgattcaa
     7261 ttacctccca caggctccct cccatgacag gtgggaacta tgggagctat aattcaagat
     7321 gagatttggg tgggggtgca gccaaatcat atcaaaggca tatacccaaa agaaaggaaa
     7381 taagtatatc aaagacgtat ctgcactccc acatttgttg cagaactgtt cacaatggcc
     7441 aaggtttgga agcaacctaa gtgtccatca gcagatgaat tgataaagaa aatgtggtac
     7501 atatacacaa tgaagtacta ttcagccata aaataaagaa tgagatcctg tcatttgcag
     7561 caacatggat ggaactggag atcattatgt taagtgaaat aagccaggca cagaaagaca
     7621 aacatcacat gttcttgctt atttgtgtga gataaaaata aaaacaattg aactcataga
     7681 catagagaga gaaggatgat taccagaggc tgagaagggt attgggtgct tcaggggaag
     7741 tgggaatagt taatgggggg aaaaaaggaa gttggaaaga atgaataaga tctactattt
     7801 gatagcacaa caggatgact atagtcaata ataacttaat tcatttttaa ataactaaaa
     7861 aagtataatt ggattgtttg taatcacaaa gaataaacgc ttgagggaca gataccccat
     7921 gctgcataat gtgattatta atatccagta tttgataaca caacagggtg ctgtagtcaa
     7981 aataatttaa ttgtacattt taaaataact aaaggagtat aactggattg tttgtaacac
     8041 aaaggataaa tgactgagaa gatggatacc ccattctcca tgacaagata attacacatt
     8101 gcatacctat atcagaacat ctcatacacc ccataaatat atccatctac tatgtagcca
     8161 caaaaattaa aaataaaaca ttttaaaata ta
//
