LOCUS       NM_001136506            2101 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 22 member 24 (SLC22A24),
            transcript variant 1, mRNA.
ACCESSION   NM_001136506 XM_001720420
VERSION     NM_001136506.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2101)
  AUTHORS   Yee,S.W., Stecula,A., Chien,H.C., Zou,L., Feofanova,E.V., van
            Borselen,M., Cheung,K.W.K., Yousri,N.A., Suhre,K., Kinchen,J.M.,
            Boerwinkle,E., Irannejad,R., Yu,B. and Giacomini,K.M.
  TITLE     Unraveling the functional role of the orphan solute carrier,
            SLC22A24 in the transport of steroid conjugates through metabolomic
            and genome-wide association studies
  JOURNAL   PLoS Genet 15 (9), e1008208 (2019)
   PUBMED   31553721
  REMARK    GeneRIF: Functional genomic studies reveal a previously
            uncharacterized protein involved in steroid homeostasis, opening up
            new possibilities for SLC22A24 as a pharmacological target for
            regulating steroid levels.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2101)
  AUTHORS   Agopian,A.J., Mitchell,L.E., Glessner,J., Bhalla,A.D., Sewda,A.,
            Hakonarson,H. and Goldmuntz,E.
  TITLE     Genome-wide association study of maternal and inherited loci for
            conotruncal heart defects
  JOURNAL   PLoS One 9 (5), e96057 (2014)
   PUBMED   24800985
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2101)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001858.4 and KF459672.1.
            
            On Jan 13, 2011 this sequence version replaced NM_001136506.1.
            
            Summary: SLC22A24 belongs to a large family of transmembrane
            proteins that function as uniporters, symporters, and antiporters
            to transport organic ions across cell membranes (Jacobsson et al.,
            2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments, including cow AAI12500.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2159080, SAMEA2162328
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000612278.4/ ENSP00000480336.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               AP001858.4         169337-169999       c
            664-844             KF459672.1         199-379             c
            845-948             AP001858.4         160443-160546       c
            949-1103            AP001858.4         144959-145113       c
            1104-1272           AP001858.4         144690-144858       c
            1273-1396           AP001858.4         129953-130076       c
            1397-1512           AP001858.4         121769-121884       c
            1513-1727           AP001858.4         109021-109235       c
            1728-1836           AP001858.4         107336-107444       c
            1837-2040           AP001858.4         106698-106901       c
            2041-2101           AP001858.4         105718-105778       c
FEATURES             Location/Qualifiers
     source          1..2101
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2101
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /note="solute carrier family 22 member 24"
                     /db_xref="GeneID:283238"
                     /db_xref="HGNC:HGNC:28542"
                     /db_xref="MIM:611698"
     exon            1..844
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..2101
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /note="isoform 1 is encoded by transcript variant 1;
                     steroid transmembrane transporter SLC22A24"
                     /codon_start=1
                     /product="steroid transmembrane transporter SLC22A24
                     isoform 1"
                     /protein_id="NP_001129978.2"
                     /db_xref="CCDS:CCDS73308.1"
                     /db_xref="GeneID:283238"
                     /db_xref="HGNC:HGNC:28542"
                     /db_xref="MIM:611698"
                     /translation="MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFT
                     PSHRCWVPLLDNDTVSDNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLN
                     GTFPNTNEPDTEPCVDGWVYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGG
                     LIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTF
                     ILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSS
                     WKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELVRSTMKKELDAVRIK
                     TSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGLILNLQHLGSNVSLFQILCGAVTFTA
                     RCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGSVSAASN
                     SASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILA
                     VPVILLLPETRDLPLPNTIQDVENDRKDSRNIKQEDTCMKVTQF"
     exon            845..948
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1103
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1272
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1396
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1512
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1727
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1836
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2040
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2101
                     /gene="SLC22A24"
                     /gene_synonym="NET46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaattcact ttggattttc taatatccca tttctaagaa gaatggcaga ctattgaaca
       61 ggtgtatttt aggtcacgtg gggactgcat ccacctgaaa atccaccgtt gacttatcag
      121 gaaactcaga gatcaggatc tttcacagag tagtctttta agaagattca gttgtcaaca
      181 gctagcagtc tctttgccaa ataattatat ctgtgacttc tgaaactatt tggctgccta
      241 aagttaaagg acttggggaa agtccttcca ctgctcttct gcagtagtgt cacaccactc
      301 agtgcagggc ccaccaagaa gaaagcagtg tcaggatcca catggcacta tggtaacttt
      361 gtgaaagggg acattttctc cctctgaact tctcttcata aagtcattgt gcttcctctt
      421 ggggatcacc tgttcagtct caatgggctt tgatgtgctc ctggatcaag tgggtggcat
      481 ggggagattc cagatttgtc tgatagcttt cttttgcatc accaacatcc tactgttccc
      541 taatattgtg ttggagaact tcactgcatt cacccctagt catcgctgct gggtccccct
      601 cctggacaat gacactgtgt ctgacaatga taccgggacc ctcagcaagg atgacctcct
      661 gagaatctcc atcccactgg actcaaacct gaggccacag aagtgtcagc gctttatcca
      721 tccccagtgg cagctccttc acctgaacgg gaccttcccc aacacaaatg agccagacac
      781 ggagccctgt gtggatggct gggtgtacga cagaagctct ttcctctcca ccatcgtgac
      841 tgagtgggac ctggtatgtg aatctcagtc actaaaatca atggttcaat ccctatttat
      901 ggctgggtca cttctgggag gtctaatata tggccatctt tcagacaggg ttggacggaa
      961 gatcatatgc aaattgtgtt tcctccagct ggccatctct aacacctgtg cggccttcgc
     1021 tcccaccttc cttgtttact gcatactgcg cttcttggca gggttctcca ccatgactat
     1081 tttgggaaac acttttattc tcagcttaga gtggacattg ccccggtcac gatctatgac
     1141 aataatggtg ctattatgtt cctacagtgt tgggcagatg ctcctaggag ggctggcttt
     1201 tgccattcag gactggcaca tattgcaact gactgtgtct acacccataa ttgtcctctt
     1261 cttgtcctct tggaagatgg tggagtctgc tcggtggctg attatcaaca atcagctaga
     1321 tgagggctta aaggagctta gaagagttgc acacataaat ggaaaaaaga atactgaaga
     1381 gacactgacc actgagcttg tgagatccac catgaagaag gagttggatg cagtccgaat
     1441 taaaacatcc attttttccc tgttccgtgc acccaaattg cgaatgagag tcttcggcct
     1501 gtgctttgtg agattcgcaa tcactgtacc cttttatggc ctgatactca acttgcagca
     1561 cttagggagc aatgtctccc tgttccagat tctctgtgga gctgtcacat tcacagccag
     1621 atgtgtttcc cttttgacac tgaatcatat gggtcgtcga ataagccaga tattgttcac
     1681 gttcccggtg ggacttttca ttctggtcaa cacctttttg ccccaagaaa tgcagatcct
     1741 gcgtgtggtt ttagcaactt tgggaattgg tagtgtttct gctgctagca acagtgcttc
     1801 tgtccaccac aacgagctcg tccccaccat attgaggtca acagttgcag gaatcaatgc
     1861 agtgtccggt aggactgggg cagcactggc tcctctgttg atgaccttaa tggcgtattc
     1921 tccccaccta ccctggattt cctatggagt cttccccatc cttgctgtcc ctgttatcct
     1981 cctccttcca gaaaccaggg atctacctct tcctaacacc atccaggatg tggaaaatga
     2041 cagaaaagat tcaagaaaca taaagcagga agatacttgc atgaaagtaa cacagtttta
     2101 a
//
