LOCUS       NM_015482               6634 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens solute carrier family 22 member 23 (SLC22A23),
            transcript variant 1, mRNA.
ACCESSION   NM_015482
VERSION     NM_015482.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6634)
  AUTHORS   Wu,X., Cao,C., Li,Z., Xie,Y., Zhang,S., Sun,W. and Guo,J.
  TITLE     Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by
            Activating HNRNPU Expression
  JOURNAL   Dig Dis Sci 69 (4), 1200-1213 (2024)
   PUBMED   38400886
  REMARK    GeneRIF: Circular RNA CircSLC22A23 Promotes Gastric Cancer
            Progression by Activating HNRNPU Expression.
REFERENCE   2  (bases 1 to 6634)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6634)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6634)
  AUTHORS   Serrano Leon,A., Amir Shaghaghi,M., Yurkova,N., Bernstein,C.N.,
            El-Gabalawy,H. and Eck,P.
  TITLE     Single-nucleotide polymorphisms in SLC22A23 are associated with
            ulcerative colitis in a Canadian white cohort
  JOURNAL   Am J Clin Nutr 100 (1), 289-294 (2014)
   PUBMED   24740203
  REMARK    GeneRIF: Genetic variations in the SLC22A23 locus contribute to the
            susceptibility to inflammatory bowel disease in a small fraction of
            white patients.
REFERENCE   5  (bases 1 to 6634)
  AUTHORS   Zheng,J.S., Arnett,D.K., Lee,Y.C., Shen,J., Parnell,L.D.,
            Smith,C.E., Richardson,K., Li,D., Borecki,I.B., Ordovas,J.M. and
            Lai,C.Q.
  TITLE     Genome-wide contribution of genotype by environment interaction to
            variation of diabetes-related traits
  JOURNAL   PLoS One 8 (10), e77442 (2013)
   PUBMED   24204828
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6634)
  AUTHORS   Torkvist,L., Halfvarson,J., Ong,R.T., Lordal,M., Sjoqvist,U.,
            Bresso,F., Bjork,J., Befrits,R., Lofberg,R., Blom,J., Carlson,M.,
            Padyukov,L., D'Amato,M., Seielstad,M. and Pettersson,S.
  TITLE     Analysis of 39 Crohn's disease risk loci in Swedish inflammatory
            bowel disease patients
  JOURNAL   Inflamm Bowel Dis 16 (6), 907-909 (2010)
   PUBMED   19760754
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 6634)
  AUTHORS   Henckaerts,L., Van Steen,K., Verstreken,I., Cleynen,I., Franke,A.,
            Schreiber,S., Rutgeerts,P. and Vermeire,S.
  TITLE     Genetic risk profiling and prediction of disease course in Crohn's
            disease patients
  JOURNAL   Clin Gastroenterol Hepatol 7 (9), 972-980 (2009)
   PUBMED   19422935
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6634)
  AUTHORS   Weersma,R.K., Stokkers,P.C., Cleynen,I., Wolfkamp,S.C.,
            Henckaerts,L., Schreiber,S., Dijkstra,G., Franke,A., Nolte,I.M.,
            Rutgeerts,P., Wijmenga,C. and Vermeire,S.
  TITLE     Confirmation of multiple Crohn's disease susceptibility loci in a
            large Dutch-Belgian cohort
  JOURNAL   Am J Gastroenterol 104 (3), 630-638 (2009)
   PUBMED   19174780
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 6634)
  AUTHORS   Anderson,C.A., Massey,D.C., Barrett,J.C., Prescott,N.J.,
            Tremelling,M., Fisher,S.A., Gwilliam,R., Jacob,J., Nimmo,E.R.,
            Drummond,H., Lees,C.W., Onnie,C.M., Hanson,C., Blaszczyk,K.,
            Ravindrarajah,R., Hunt,S., Varma,D., Hammond,N., Lewis,G.,
            Attlesey,H., Watkins,N., Ouwehand,W., Strachan,D., McArdle,W.,
            Lewis,C.M., Lobo,A., Sanderson,J., Jewell,D.P., Deloukas,P.,
            Mansfield,J.C., Mathew,C.G., Satsangi,J. and Parkes,M.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Investigation of Crohn's disease risk loci in ulcerative colitis
            further defines their molecular relationship
  JOURNAL   Gastroenterology 136 (2), 523-9 (2009)
   PUBMED   19068216
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6634)
  AUTHORS   Jacobsson,J.A., Haitina,T., Lindblom,J. and Fredriksson,R.
  TITLE     Identification of six putative human transporters with structural
            similarity to the drug transporter SLC22 family
  JOURNAL   Genomics 90 (5), 595-609 (2007)
   PUBMED   17714910
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160398.27 and AL445309.13.
            
            On Apr 30, 2020 this sequence version replaced NM_015482.1.
            
            Summary: SLC22A23 belongs to a large family of transmembrane
            proteins that function as uniporters, symporters, and antiporters
            to transport organic ions across cell membranes (Jacobsson et al.,
            2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2385290.1,
                                           SRR14038193.1561295.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406686.8/ ENSP00000385028.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1145              AL160398.27        109091-110235       c
            1146-1249           AL160398.27        68937-69040         c
            1250-1404           AL160398.27        63373-63527         c
            1405-1573           AL445309.13        111606-111774       c
            1574-1701           AL445309.13        85863-85990         c
            1702-1804           AL445309.13        77536-77638         c
            1805-2037           AL445309.13        74631-74863         c
            2038-2070           AL445309.13        72851-72883         c
            2071-2194           AL445309.13        71624-71747         c
            2195-6634           AL445309.13        56745-61184         c
FEATURES             Location/Qualifiers
     source          1..6634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..6634
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /note="solute carrier family 22 member 23"
                     /db_xref="GeneID:63027"
                     /db_xref="HGNC:HGNC:21106"
                     /db_xref="MIM:611697"
     exon            1..1145
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     CDS             492..2552
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /note="isoform a is encoded by transcript variant 1; ion
                     transporter protein"
                     /codon_start=1
                     /product="solute carrier family 22 member 23 isoform a"
                     /protein_id="NP_056297.1"
                     /db_xref="CCDS:CCDS47363.1"
                     /db_xref="GeneID:63027"
                     /db_xref="HGNC:HGNC:21106"
                     /db_xref="MIM:611697"
                     /translation="MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGP
                     GGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVLL
                     TWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPF
                     ATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSK
                     WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVAL
                     SVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFMITMVASFVAMAGQFLMPG
                     LAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRM
                     NPEGDIKGVIPELEKELSRRPKKVCIVKVVGTRNLWKNIVVLCVNSLTGYGIHHCFAR
                     SMMGHEVKVPLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASL
                     LQLGLLNLIGKYSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTV
                     IRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACCTLICIICILLLPESRDQ
                     NLPENISNGEHYTRQPLLPHKKGEQPLLLTNAELKDYSGLHDAAAAGDTLPEGATANG
                     MKAM"
     exon            1146..1249
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1404
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1573
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1701
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1804
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2037
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2070
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2194
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..6634
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6124..6129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /note="hexamer: AATAAA"
     polyA_site      6145
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
     regulatory      6615..6620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /note="hexamer: AATAAA"
     polyA_site      6634
                     /gene="SLC22A23"
                     /gene_synonym="C6orf85"
                     /note="major polyA site"
ORIGIN      
        1 aggctgggtc cagagctcgc ggcttccggg aggcgcccga agtcggagaa atacagcgcg
       61 gccaccccgg gagcagcagc ctttgcccgc accgccgccc gcagggccct gaaccgccgg
      121 caagggcgcg ggccgggcgc ggcgccggct cctcctcctg ccgcgtccgg cgcggagcag
      181 cggagagcgg cgggctcggc agccggcgcc cgggccgcgg aactgatgag ccgcggcggc
      241 tgagggcccg gccggcctct gcccgcctct gcccggcgcc cgagcggggc cgcagcgccc
      301 ggggcgcggg gtccggcggg tgacatgggg gcggcctgac gcacccggag ccgccgagcg
      361 ctctctctcg agccgcgggc cctcctcggc ggcagcggct gcaggcgcct ggcccggcgc
      421 gctgtgcccg gggcgcccgc ggagcctccg ccgcgctcta tgcgcctctg cgggagccgc
      481 gggcccgggc catggccata gaccggcggc gcgaggcggc gggcggcggg cctgggcggc
      541 agccggcccc ggccgaggag aacggctccc tgccgcccgg ggacgcggcg gcctcggcgc
      601 ccctcggggg acgcgcgggc cccggcggcg gcgcggagat ccagccgctg cccccactgc
      661 atcctggagg cggcccgcac ccgagctgct gctccgcggc tgcggccccg agcctcttgt
      721 tgctggacta tgacgggtcg gtgctgccct tcctcggggg cctgggcggg ggctatcaga
      781 agaccctcgt gctgctcacc tggatcccgg cgctgttcat cggcttcagc cagttctcgg
      841 actcgttcct cctggaccag cccaacttct ggtgccgcgg ggccggcaaa ggcaccgagc
      901 tggcaggggt caccaccaca ggccggggcg gggacatggg caactggacc agcctcccca
      961 ccaccccctt cgccactgcc ccctgggagg ctgcgggcaa ccggagcaac agcagcggcg
     1021 cggacggagg cgacacacca cccctgccat cccctccgga caagggggac aacgcctcca
     1081 actgtgactg ccgcgcatgg gactacggca tccgcgccgg cctcgtccag aacgtggtca
     1141 gcaagtggga tcttgtgtgt gataatgcct ggaaggtcca tatcgctaag ttctccttac
     1201 tggttggatt aatctttggc tacctaataa ctggatgcat tgctgactgg gtcggccggc
     1261 ggcctgtgct gctgttttcc atcatcttca ttctgatctt tggactgact gtggcactgt
     1321 cagtgaatgt gacaatgttc agcacactca ggttctttga aggattttgc ctggctggaa
     1381 tcattctcac cttgtatgct ttacgaatag agctgtgccc ccctggaaaa cggttcatga
     1441 ttacgatggt ggcgagcttc gtggccatgg cgggccagtt cctcatgcct gggctagccg
     1501 ccctgtgccg ggattggcag gtgctgcagg ccctcatcat ctgccccttc ctgctcatgc
     1561 tgctctactg gtcgatattc cccgagtccc tccggtggct aatggccacc cagcagtttg
     1621 agtctgcaaa gaggctgatc ctccacttca cacagaagaa tcgcatgaac cctgagggcg
     1681 acatcaaggg tgtgatacca gagctggaga aagagctttc ccggaggccc aagaaggtct
     1741 gcatcgtgaa ggtggtgggg acacggaacc tgtggaagaa cattgtggtc ctgtgtgtga
     1801 actcgctgac ggggtacggg atccaccact gctttgccag gagcatgatg ggccacgagg
     1861 tgaaggtgcc gctcctggag aacttctatg ctgactacta taccacggcc agcatcgcgc
     1921 tggtgtcctg cctggccatg tgcgtggtgg tccgattcct cgggcgcagg ggagggctgc
     1981 tgctcttcat gatcctcacc gccctggcct cactcctgca gctcggcctc ctcaacctga
     2041 ttggaaagta cagccagcac ccagactcag ggatgagtga cagcgtcaag gacaaatttt
     2101 ccatcgcgtt ttccatcgtg ggcatgtttg cctcccatgc ggtggggagc ctcagcgtgt
     2161 tcttctgtgc ggagatcacc ccgacggtga taaggtgtgg cgggctgggg ctggtgctgg
     2221 ccagcgcggg cttcggcatg ctgacggcac ccatcatcga gctgcacaac cagaaaggct
     2281 acttcctgca ccacatcatc tttgcctgct gcacgctcat ctgcatcatc tgcatcctcc
     2341 tgctgcccga gagcagggac cagaacctgc ctgagaacat ttctaacggg gagcactaca
     2401 cgcgccagcc gctgctgccg cacaagaagg gggagcagcc actgctgctc accaacgccg
     2461 agctcaagga ctactcgggc ctccacgatg ccgcagccgc gggtgacaca ctgcccgagg
     2521 gtgccacggc caacggcatg aaggccatgt agcccggcct gcggaacccg gggctccagg
     2581 gtctggggca gcttgggcac aggtttacag accagggacc gaacacgcag ccaggggtgg
     2641 gaaagctgcc tcagccaagc tgagcctctc aactggtgtg gggaaatcct gtctttccaa
     2701 aagtccaagg agcgcgggtc ggaggagaca aactctttgg aaataaccct ttcaagactt
     2761 tcttttctgc cgttaaatgt gtgtatttat tttggtcatt tttacgagaa gcactttatt
     2821 ccctctccct ctcactgatc acaaatggaa tcacctccct gggcagcgag acgcagttgc
     2881 tctgggaaga tgccacagtg accagggcca tggccggtcc ctctggggag atgggacacg
     2941 gctcctggca gcacccagga gccccccagg ctgcctgcct gcgtgcagag gcaggagagg
     3001 accgtggagc gtttccggga ctgcatttta gacggagtga aatgtacatg aatttggctt
     3061 ttgctagagt ctgtgtatgg ttttttaagg tcctttttcc ctttctgttt gtaaggtaag
     3121 agcttctgtt cgtgtgcagg gaaagcagct cacagacgcc gttaaaacca gcttcatctt
     3181 tccttcagga tcatcctttt gtacttgatg ctggaagctc ttggagaaaa agcttaaaca
     3241 tttcaccaga aatcttaatt gagcagcagt catatcgcca cagctttgtg agtacacagc
     3301 taacagatgc gtcgagacct gagatgtgct cgtttttatt cctcctctcc cagattggct
     3361 ccagcagaaa agtccctcgt gcacaggcag ctcttgtgcc ggcactactt gaaaacatgg
     3421 ctactttcta agctacaaac cattagaaaa taactcaaaa agatggcaga ggcaaatcca
     3481 cagaaggggg gctgccctcc acacacacac gcccgtcacc cacaccttga gcacacacca
     3541 tgaagatcac cagcttggat ggccgtcacc tcagacatca ctccagggag cacccgcagg
     3601 agctgggccc cctcacgcct gccttcctgg gccagcttcc tgcttgcagt cactcgcata
     3661 gcacagaggt ggggcttcgg gcagggagcg gagattcctc ataggtgagt ccaaatgacc
     3721 tccagcctct cgaaggcatc aagacaaatt gaaagaaagc aataactcac caaagctcaa
     3781 cgctgcccct gcctcgacct ccatgggtct cttcgtgttc ctcgtttcac cccagaaagt
     3841 ggaggtttcc tcttggcatt ttcggaggaa acttgtagga cacccaaggc gactaagaga
     3901 cagcctcctt ggcaagggca ggcaccactt tgtagcaact tgggcaccag cttttctgga
     3961 cagcctggct tcttactggc attgtccaac tcatcccttc tcgaagcatg tctttgccat
     4021 gggctgtgtc cttccaggga aattgtggtc tcgggcctgg gtgagacaat gaagtgactt
     4081 ccaaccgaca gttgctagaa ttcacagggc agaaaagggg ttgaccttct ccccttctgg
     4141 ctttccaccc ggcctgctgc ttgctgtcgc cactcatgtc tcctccacat gcggtccaca
     4201 catcagtaag ggcctggaga tgtgtaaaga cacagcaagg ggcaagcaga ctcttggcca
     4261 cgtgtttcca gtggctggac cacgccgaca cctgggatct tgagataccc aggaagggag
     4321 gctgtctggc cagcctctcc ctgcctccac ttgctccacg tccagctcct caccttccct
     4381 cttttttaaa gtcacatttc catgtttcaa cattagtttg cattcacctt tacaaaggcc
     4441 tttctttaga tctgtgcagc ctttgcgtgc caaacttgtg aaattccttt tacctttttt
     4501 ggagtacttg ctataaagcc acctgtcaac aaacccccat tatgtacaga ataggaccta
     4561 tccagtagcc aggccagtag gcagttgggg aaggtgggaa ggatccagcg aggcccctga
     4621 gcctgcacct ggacaggtgt acgtctgcac ccatcaccct cagcaccagg ccaccctgca
     4681 gtccacttac tgtactgtgt tgtggaagga tatgctaagt gatgaaagtt gcgagcagtc
     4741 tcactggtcg tgtaaacttt tttttttttt tggaaattga agctgtagag tgctgcccga
     4801 aatctctagg aagttggtgg caagggacag cactcacact cttctggtca tgatctctga
     4861 tctccacctc aaatgacaat aaaaaactgg tccaacgaag acactgctca gcacttcagc
     4921 catcaggact aatccatcga tgactggaaa agaggctagc tttgaggaaa acagcctggg
     4981 ctcttgggag cagagtccag tgggtgtgag gctgacttgc cgacggtcgg caggtaatgg
     5041 ctctcagccg gcgaggcggt cccacagctc tcctcccagg gcagcctgag gaggaggagg
     5101 ccgggtgcct gtttggtggc agcttcagcc tagggatacc tgaagctgtt gagcaacacc
     5161 tttatgaaat gttgccagag cagcaacact tccctgtggg cacagccccg ggaaatccgg
     5221 taccaagtga gcaaggtggc aggacccacc caagcctgat acgcatctgg gcccgccggg
     5281 ctcagcaggg gaggctgcta cggctgccca cttcccagca ccgtctgtca cgcttgaacc
     5341 cctctgtgct gttcccttcc tggctaatag ggagaccctt cgcaggcacc cactgtttca
     5401 acttgaccct cccaccccct gctactctcc tccacacacc cctccgttcc gctagcctac
     5461 cctgtcagcc tttcaataaa agttatgcac aaatgtgaac acctgagatg gagctgaaca
     5521 tttcttcact ttgttctttt tctgaagtca aactcttatc aaatgcccta aaattattac
     5581 cacccaagag aaacaggaaa aaggttacat gtttttgttt actgagagta agatcacctg
     5641 catctggaag acgggctggt aaattggttt ggctacagaa cagaaagaaa acaaaaacaa
     5701 acctcgtaag ggaagtatca cactcagaca ccaccgcttc ctagagccaa atgagcaatc
     5761 ccaaactgca agtgccataa gtgggcctgt gaggtcacac cgcccggccc gaggtatcgc
     5821 atgtgcgggg gaggtccaca ctacagctgt cctctcgtct agaaggcacc acctcgcttt
     5881 catgtcccgt gtgttttgga aaagcagtat ggtgtgtcat gtctagcggc gaacacttcc
     5941 ctccctgtcc ttgaggttgt aatataaaaa ctgtgtttct gtacgtgtgg gtgggaattc
     6001 tctgacggtg ctcgttcata gcacaagctt acgctgagtt ctgaactgtc gttcacagct
     6061 gcgtgtctgc atggtgtcgc atctgttgta cctttgggga aaatttgtat gtaaatgtac
     6121 agaaataaaa acgttgcccc attaacagat ttcctctgga atgtcttccc tacctcacct
     6181 gatggtatcc accgaagggc atttcactac cattaatggt gagtaataaa atcctccgtg
     6241 ttcattcaga cctcactgcg tcactacttt gaacgcctct gtaagctgtg tcttcactcg
     6301 ccccgaggtg ggtggaggga ggcctctcac tctgcttcga gtcctggtct taaaggtagt
     6361 cagaggcaga ggctggatta aacacacact gtttaccaag tgccactctc agaccacctg
     6421 agagacgggg gccatcagta aaattaagag gaattttttt cccttgttcg tgtatgttct
     6481 gctgatccgt ggcctgaagg ttcctagaga cgtcaagaaa tgaatatctt acactgtgat
     6541 tctgtgagga aagactggta acccaaaact ctcttctcta atgtattttt taacgaaaat
     6601 gacaatattt ctttaataaa gtatttatac caaa
//
