LOCUS       NM_003058               2409 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 22 member 2 (SLC22A2), mRNA.
ACCESSION   NM_003058
VERSION     NM_003058.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2409)
  AUTHORS   Chen,J., Wang,L., Tong,G., Ma,J., Liu,C. and Wang,L.
  TITLE     The SLC22A2 gene is a determinant of hematological toxicity of
            oxaliplatin in patients with colorectal cancer
  JOURNAL   Int J Clin Pharmacol Ther 61 (1), 1-7 (2023)
   PUBMED   36331012
  REMARK    GeneRIF: The SLC22A2 gene is a determinant of hematological
            toxicity of oxaliplatin in patients with colorectal cancer.
REFERENCE   2  (bases 1 to 2409)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   3  (bases 1 to 2409)
  AUTHORS   Abrahams-October,Z., Lloyd,S., Pearce,B., Johnson,R. and
            Benjeddou,M.
  TITLE     Promoter haplotype structure of solute carrier 22 member 2
            (SLC22A2) in the Xhosa population of South Africa and their
            differential effect on gene expression
  JOURNAL   Gene 820, 146292 (2022)
   PUBMED   35143948
  REMARK    GeneRIF: Promoter haplotype structure of solute carrier 22 member 2
            (SLC22A2) in the Xhosa population of South Africa and their
            differential effect on gene expression.
REFERENCE   4  (bases 1 to 2409)
  AUTHORS   Zhang,X. and Wright,S.H.
  TITLE     Transport Turnover Rates for Human OCT2 and MATE1 Expressed in
            Chinese Hamster Ovary Cells
  JOURNAL   Int J Mol Sci 23 (3), 1472 (2022)
   PUBMED   35163393
  REMARK    GeneRIF: Transport Turnover Rates for Human OCT2 and MATE1
            Expressed in Chinese Hamster Ovary Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2409)
  AUTHORS   Eltayeb,S.A., Ciarimboli,G., Beul,K., Seno Di Marco,G. and Barz,V.
  TITLE     Role of Organic Cation Transporter 2 in Autophagy Induced by
            Platinum Derivatives
  JOURNAL   Int J Mol Sci 23 (3), 1090 (2022)
   PUBMED   35163014
  REMARK    GeneRIF: Role of Organic Cation Transporter 2 in Autophagy Induced
            by Platinum Derivatives.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2409)
  AUTHORS   Grundemann,D. and Schomig,E.
  TITLE     Gene structures of the human non-neuronal monoamine transporters
            EMT and OCT2
  JOURNAL   Hum Genet 106 (6), 627-635 (2000)
   PUBMED   10942111
REFERENCE   7  (bases 1 to 2409)
  AUTHORS   Verhaagh,S., Schweifer,N., Barlow,D.P. and Zwart,R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
REFERENCE   8  (bases 1 to 2409)
  AUTHORS   Busch,A.E., Karbach,U., Miska,D., Gorboulev,V., Akhoundova,A.,
            Volk,C., Arndt,P., Ulzheimer,J.C., Sonders,M.S., Baumann,C.,
            Waldegger,S., Lang,F. and Koepsell,H.
  TITLE     Human neurons express the polyspecific cation transporter hOCT2,
            which translocates monoamine neurotransmitters, amantadine, and
            memantine
  JOURNAL   Mol Pharmacol 54 (2), 342-352 (1998)
   PUBMED   9687576
REFERENCE   9  (bases 1 to 2409)
  AUTHORS   Gorboulev,V., Ulzheimer,J.C., Akhoundova,A., Ulzheimer-Teuber,I.,
            Karbach,U., Quester,S., Baumann,C., Lang,F., Busch,A.E. and
            Koepsell,H.
  TITLE     Cloning and characterization of two human polyspecific organic
            cation transporters
  JOURNAL   DNA Cell Biol 16 (7), 871-881 (1997)
   PUBMED   9260930
REFERENCE   10 (bases 1 to 2409)
  AUTHORS   Koehler,M.R., Wissinger,B., Gorboulev,V., Koepsell,H. and Schmid,M.
  TITLE     The two human organic cation transporter genes SLC22A1 and SLC22A2
            are located on chromosome 6q26
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 198-200 (1997)
   PUBMED   9605850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162582.30.
            
            On Nov 22, 2018 this sequence version replaced NM_003058.3.
            
            Summary: Polyspecific organic cation transporters in the liver,
            kidney, intestine, and other organs are critical for elimination of
            many endogenous small organic cations as well as a wide array of
            drugs and environmental toxins. This gene is one of three similar
            cation transporter genes located in a cluster on chromosome 6. The
            encoded protein contains twelve putative transmembrane domains and
            is a plasma integral membrane protein. It is found primarily in the
            kidney, where it may mediate the first step in cation reabsorption.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039899.1, X98333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1970526,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366953.8/ ENSP00000355920.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-478               AL162582.30        63833-64310         c
            479-582             AL162582.30        62103-62206         c
            583-737             AL162582.30        56037-56191         c
            738-906             AL162582.30        54705-54873         c
            907-1021            AL162582.30        52673-52787         c
            1022-1128           AL162582.30        50928-51034         c
            1129-1343           AL162582.30        49061-49275         c
            1344-1452           AL162582.30        47783-47891         c
            1453-1565           AL162582.30        46963-47075         c
            1566-1665           AL162582.30        30194-30293         c
            1666-2409           AL162582.30        22244-22987         c
FEATURES             Location/Qualifiers
     source          1..2409
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..2409
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /note="solute carrier family 22 member 2"
                     /db_xref="GeneID:6582"
                     /db_xref="HGNC:HGNC:10966"
                     /db_xref="MIM:602608"
     exon            1..478
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1732
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /note="organic cation transporter 2; solute carrier family
                     22 (organic cation transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 22 member 2"
                     /protein_id="NP_003049.2"
                     /db_xref="CCDS:CCDS5276.1"
                     /db_xref="GeneID:6582"
                     /db_xref="HGNC:HGNC:10966"
                     /db_xref="MIM:602608"
                     /translation="MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLG
                     FTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFD
                     CVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGF
                     FIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGW
                     LIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFF
                     LLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPS
                     FLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAF
                     MIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIV
                     CLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAG
                     GLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN"
     exon            479..582
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..737
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..906
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1021
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1128
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1343
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1452
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1565
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1665
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..2409
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="SLC22A2"
                     /gene_synonym="OCT2"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgctc tcagcctcgc tccgggcacg tcgggcagcc tcgggccctc ctgcctgcag
       61 gatcatgccc accaccgtgg acgatgtcct ggagcatgga ggggagtttc actttttcca
      121 gaagcaaatg tttttcctct tggctctgct ctcggctacc ttcgcgccca tctacgtggg
      181 catcgtcttc ctgggcttca cccctgacca ccgctgccgg agccccggag tggccgagct
      241 gagtctgcgc tgcggctgga gtcctgcaga ggaactgaac tacacggtgc cgggcccagg
      301 acctgcgggc gaagcctccc caagacagtg taggcgctac gaggtggact ggaaccagag
      361 caccttcgac tgcgtggacc ccctggccag cctggacacc aacaggagcc gcctgccact
      421 gggcccctgc cgggacggct gggtgtacga gacgcctggc tcgtccatcg tcaccgagtt
      481 taacctggta tgtgccaact cctggatgtt ggacctattc cagtcatcag tgaatgtagg
      541 attctttatt ggctctatga gtatcggcta catagcagac aggtttggcc gtaagctctg
      601 cctcctaact acagtcctca taaatgctgc agctggagtt ctcatggcca tttccccaac
      661 ctatacgtgg atgttaattt ttcgcttaat ccaaggactg gtcagcaaag caggctggtt
      721 aataggctac atcctgatta cagaatttgt tgggcggaga tatcggagaa cagtggggat
      781 tttttaccaa gttgcctata cagttgggct cctggtgcta gctggggtgg cttacgcact
      841 tcctcactgg aggtggttgc agttcacagt ttctctgccc aacttcttct tcttgctcta
      901 ttactggtgc atacctgagt ctcccaggtg gctgatctcc cagaataaga atgctgaagc
      961 catgagaatc attaagcaca tcgcaaagaa aaatggaaaa tctctacccg cctcccttca
     1021 gcgcctgaga cttgaagagg aaactggcaa gaaattgaac ccttcatttc ttgacttggt
     1081 cagaactcct cagataagga aacatactat gatattgatg tacaactggt tcacgagctc
     1141 tgtgctctac cagggcctca tcatgcacat gggccttgca ggtgacaata tctacctgga
     1201 tttcttctac tctgccctgg ttgaattccc agctgccttc atgatcatcc tcaccatcga
     1261 ccgcatcgga cgccgttacc cttgggctgc atcaaatatg gttgcagggg cagcctgtct
     1321 ggcctcagtt tttatacctg gtgatctaca atggctaaaa attattatct catgcttggg
     1381 aagaatgggg atcacaatgg cctatgagat agtctgcctg gtcaatgctg agctgtaccc
     1441 cacattcatt aggaatcttg gcgtccacat ctgttcctca atgtgtgaca ttggtggcat
     1501 catcacgcca ttcctggtct accggctcac taacatctgg cttgagctcc cgctgatggt
     1561 tttcggcgtg cttggcttgg ttgctggagg tctggtgctg ttgcttccag aaactaaagg
     1621 gaaagctttg cctgagacca tcgaggaagc cgaaaatatg caaagaccaa gaaaaaataa
     1681 agaaaagatg atttacctcc aagttcagaa actagacatt ccattgaact aagaagagag
     1741 accgttgctg ctgtcatgac ctagctttga tggcagcaag accaaaagta gaaatccctg
     1801 cactcatcac aaagcccata caactcaacc aaacttaccc ctgagcccta tcaacctagg
     1861 tctacagcca gtggagtcta ttgtacactg tggaaaaata cccatgggac cagatcctgc
     1921 caaattcttc cagctcactt tattctcagc attcctagga cattggacat tggttttctg
     1981 gagggttttt tttccatctt tgtatttttt taaatttgat tcttttcttt gcaatgctat
     2041 ctaaccagaa tacatagggg aactgtgggc taggcaaaca aaatagaaaa aagtgtgaaa
     2101 aacagtaaag ttgggagagg agcatctatt ttcttaaaga aataaaacac ccaaaacaat
     2161 ataaagttgt ccagaatgta tgtcaagaat tttagatagg cctttcagta acacaggtga
     2221 agaaattttt aaaaatacat tgattattat ctaggttaga cttaaagtga atctcaaata
     2281 aaagaatcag gaatacaact taagtgatca tgaggtcctt ccatatttag attgggtaag
     2341 catgaatgtg tattttctac aaaagacctt gagaagagtt caataaaaaa tgttagcatt
     2401 ataaaacca
//
