LOCUS       NM_016609               2372 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens solute carrier family 22 member 17 (SLC22A17),
            transcript variant 2, mRNA.
ACCESSION   NM_016609
VERSION     NM_016609.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Li,W., Shi,J., Yu,Z., Garcia-Gabilondo,M., Held,A., Huang,L.,
            Deng,W., Ning,M., Ji,X., Rosell,A., Wainger,B.J. and Lo,E.H.
  TITLE     SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in
            Cerebral Ischemia
  JOURNAL   Stroke 55 (6), 1650-1659 (2024)
   PUBMED   38738428
  REMARK    GeneRIF: SLC22A17 as a Cell Death-Linked Regulator of Tight
            Junctions in Cerebral Ischemia.
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Qin,W., Ding,C., Peng,F. and Wang,P.
  TITLE     The mRNA of solute carrier family 22, member 17 (SLC22A17) plays
            the potential diagnostic and prognostic role in advantage non-small
            cell lung cancer patients
  JOURNAL   Ann Biol Clin (Paris) 81 (6), 602-609 (2024)
   PUBMED   38391165
  REMARK    GeneRIF: The mRNA of solute carrier family 22, member 17 (SLC22A17)
            plays the potential diagnostic and prognostic role in advantage
            non-small cell lung cancer patients.
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Wang,M., Li,Z., Peng,Y., Fang,J., Fang,T., Wu,J. and Zhou,J.
  TITLE     Identification of immune cells and mRNA associated with prognosis
            of gastric cancer
  JOURNAL   BMC Cancer 20 (1), 206 (2020)
   PUBMED   32164594
  REMARK    GeneRIF: Identification of immune cells and mRNA associated with
            prognosis of gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Liu,F., Li,N., Yang,W., Wang,R., Yu,J. and Wang,X.
  TITLE     The expression analysis of NGAL and NGALR in clear cell renal cell
            carcinoma
  JOURNAL   Gene 676, 269-278 (2018)
   PUBMED   30138675
  REMARK    GeneRIF: Results showed the expression levels of NGAL and NGALR
            significantly downregulated in clear cell renal cell carcinoma
            samples.
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Liu,M.F., Jin,T., Shen,J.H., Shen,Z.Y., Zheng,Z.C., Zhang,Z.L.,
            Xu,L.Y., Li,E.M. and Xu,H.X.
  TITLE     NGAL and NGALR are frequently overexpressed in human gliomas and
            are associated with clinical prognosis
  JOURNAL   J Neurooncol 104 (1), 119-127 (2011)
   PUBMED   21184133
  REMARK    GeneRIF: This study suggested that NGAL and NGALR expression are
            frequently up-regulated in gliomas, and are closely associated with
            poor clinical outcome.
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Mao,S., Jiang,T., Shang,G., Wu,Z. and Zhang,N.
  TITLE     Increased expression of neutrophil gelatinase-associated lipocalin
            receptor by interleukin-1beta in human mesangial cells via MAPK/ERK
            activation
  JOURNAL   Int J Mol Med 27 (4), 555-560 (2011)
   PUBMED   21305251
  REMARK    GeneRIF: Neutrophil gelatinase-associated lipocalin receptor
            (NGALR) is differentially expressed in human glomerular disease and
            is significantly up-regulated by Il-1beta in HMC via MAPK/ERK
            activation.
REFERENCE   8  (bases 1 to 2372)
  AUTHORS   Cui,L., Xu,L.Y., Shen,Z.Y., Tao,Q., Gao,S.Y., Lv,Z., Du,Z.P.,
            Fang,W.K. and Li,E.M.
  TITLE     NGALR is overexpressed and regulated by hypomethylation in
            esophageal squamous cell carcinoma
  JOURNAL   Clin Cancer Res 14 (23), 7674-7681 (2008)
   PUBMED   19047093
  REMARK    GeneRIF: NGALR hypomethylation contributes to its expression in
            esophageal carcinomas and that this overexpression may play a role
            in the pathogenesis of esophageal carcinomas.
REFERENCE   9  (bases 1 to 2372)
  AUTHORS   Fang,W.K., Xu,L.Y., Lu,X.F., Liao,L.D., Cai,W.J., Shen,Z.Y. and
            Li,E.M.
  TITLE     A novel alternative spliced variant of neutrophil
            gelatinase-associated lipocalin receptor in oesophageal carcinoma
            cells
  JOURNAL   Biochem J 403 (2), 297-303 (2007)
   PUBMED   17253959
REFERENCE   10 (bases 1 to 2372)
  AUTHORS   Devireddy,L.R., Gazin,C., Zhu,X. and Green,M.R.
  TITLE     A cell-surface receptor for lipocalin 24p3 selectively mediates
            apoptosis and iron uptake
  JOURNAL   Cell 123 (7), 1293-1305 (2005)
   PUBMED   16377569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049829.4.
            
            On Jul 9, 2021 this sequence version replaced NM_016609.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX161416.1, SRR14038197.645179.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000354772.10/ ENSP00000346824.5
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on manual assertion,
                                        conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL049829.4         134704-134945       c
            243-746             AL049829.4         134006-134509       c
            747-850             AL049829.4         133810-133913       c
            851-1005            AL049829.4         131330-131484       c
            1006-1171           AL049829.4         130564-130729       c
            1172-1317           AL049829.4         130219-130364       c
            1318-1423           AL049829.4         129949-130054       c
            1424-1641           AL049829.4         129572-129789       c
            1642-1753           AL049829.4         129159-129270       c
            1754-2372           AL049829.4         128376-128994       c
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..2372
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /note="solute carrier family 22 member 17"
                     /db_xref="GeneID:51310"
                     /db_xref="HGNC:HGNC:23095"
                     /db_xref="MIM:611461"
     exon            1..242
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2042
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /note="isoform b is encoded by transcript variant 2;
                     non-AUG (CUG) translation initiation codon; solute carrier
                     family 22 (organic cation transporter), member 17; potent
                     brain type organic ion transporter; NGAL receptor;
                     neutrophil gelatinase-associated lipocalin receptor;
                     brain-type organic cation transporter; 24p3 receptor;
                     lipocalin-2 receptor"
                     /codon_start=1
                     /product="solute carrier family 22 member 17 isoform b"
                     /protein_id="NP_057693.4"
                     /db_xref="CCDS:CCDS9594.3"
                     /db_xref="GeneID:51310"
                     /db_xref="HGNC:HGNC:23095"
                     /db_xref="MIM:611461"
                     /translation="MAPRVATGTPEPNGGGGGKIDNTVEITPTSNGQVGTLGDAVPTE
                     QLQGEREREREGEGDAGGDGLGSSLSLAVPPGPLSFEALLAQVGALGGGQQLQLGLCC
                     LPVLFVALGMASDPIFTLAPPLHCHYGAFPPNASGWEQPPNASGVSVASAALAASAAS
                     RVATSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILF
                     ILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLL
                     AGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAP
                     CILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQDL
                     ENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYL
                     CSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNEAAITTF
                     SVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAF
                     LQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTRCDHVPLL
                     ATPNPAL"
     exon            243..746
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..850
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            851..1005
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1171
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1317
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1423
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1641
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1753
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..2372
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /note="hexamer: AATAAA"
     polyA_site      2372
                     /gene="SLC22A17"
                     /gene_synonym="24p3R; BOCT; BOIT; hBOIT; NGALR; NGALR2;
                     NGALR3"
                     /note="major polyA site"
ORIGIN      
        1 gcagagacca aggaggcgcc cgcggctgca gagctgcaga gcgggatctc ttcgagctgt
       61 ctgtgtccgg gcagccggcg cgcaactgag ccagaggaca gcgcatcctt tcggcgcggg
      121 ccggcagggc ccctgcggtc ggcaagctgg ctccccgggt ggccaccggg acccccgagc
      181 ccaatggcgg gggcggcggc aaaatcgaca acactgtaga gatcaccccc acctccaacg
      241 gacaggtcgg gaccctcgga gatgcggtgc ccacggagca gctgcagggt gagcgggagc
      301 gcgagcggga gggggaggga gacgcgggcg gcgacggact gggcagcagc ctgtcgctgg
      361 ccgtgccccc aggccccctc agctttgagg cgctgctcgc ccaggtgggg gcgctgggcg
      421 gcggccagca gctgcagctc ggcctctgct gcctgccggt gctcttcgtg gctctgggca
      481 tggcctcgga ccccatcttc acgctggcgc ccccgctgca ttgccactac ggggccttcc
      541 cccctaatgc ctctggctgg gagcagcctc ccaatgccag cggcgtcagc gtcgccagcg
      601 ctgccctagc agccagcgcc gccagccgtg tcgccaccag taccgacccc tcgtgcagcg
      661 gcttcgcccc gccggacttc aaccattgcc tcaaggattg ggactataat ggccttcctg
      721 tgctcaccac caacgccatc ggccagtggg atctggtgtg tgacctgggc tggcaggtga
      781 tcctggagca gatcctcttc atcttgggct ttgcctccgg ctacctgttc ctgggttacc
      841 ccgcagacag atttggccgt cgcgggattg tgctgctgac cttggggctg gtgggcccct
      901 gtggagtagg aggggctgct gcaggctcct ccacaggcgt catggccctc cgattcctct
      961 tgggctttct gcttgccggt gttgacctgg gtgtctacct gatgcgcctg gagctgtgcg
     1021 acccaaccca gaggcttcgg gtggccctgg caggggagtt ggtgggggtg ggagggcact
     1081 tcctgttcct gggcctggcc cttgtctcta aggattggcg attcctacag cgaatgatca
     1141 ccgctccctg catcctcttc ctgttttatg gctggcctgg tttgttcctg gagtccgcac
     1201 ggtggctgat agtgaagcgg cagattgagg aggctcagtc tgtgctgagg atcctggctg
     1261 agcgaaaccg gccccatggg cagatgctgg gggaggaggc ccaggaggcc ctgcaggacc
     1321 tggagaatac ctgccctctc cctgcaacat cctccttttc ctttgcttcc ctcctcaact
     1381 accgcaacat ctggaaaaat ctgcttatcc tgggcttcac caacttcatt gcccatgcca
     1441 ttcgccactg ctaccagcct gtgggaggag gagggagccc atcggacttc tacctgtgct
     1501 ctctgctggc cagcggcacc gcagccctgg cctgtgtctt cctgggggtc accgtggacc
     1561 gatttggccg ccggggcatc cttcttctct ccatgaccct taccggcatt gcttccctgg
     1621 tcctgctggg cctgtgggat tatctgaacg aggctgccat caccactttc tctgtccttg
     1681 ggctcttctc ctcccaagct gccgccatcc tcagcaccct ccttgctgct gaggtcatcc
     1741 ccaccactgt ccggggccgt ggcctgggcc tgatcatggc tctaggggcg cttggaggac
     1801 tgagcggccc ggcccagcgc ctccacatgg gccatggagc cttcctgcag cacgtggtgc
     1861 tggcggcctg cgccctcctc tgcattctca gcattatgct gctgccggag accaagcgca
     1921 agctcctgcc cgaggtgctc cgggacgggg agctgtgtcg ccggccttcc ctgctgcggc
     1981 agccaccccc tacccgctgt gaccacgtcc cgctgcttgc cacccccaac cctgccctct
     2041 gagcggcctc tgagtaccct ggcgggaggc tggcccacac agaaaggtgg caagaagatc
     2101 gggaagactg agtagggaag gcagggctgc ccagaagtct cagaggcacc tcacgccagc
     2161 catcgcggag agctcagagg gccgtcccca ccctgcctcc tccctgctgc tttgcattca
     2221 cttccttggc cagagtcagg ggacagggag agagctccac actgtaacca ctgggtctgg
     2281 gctccatcct gcgcccaaag acatccaccc agacctcatt atttcttgct ctatcattct
     2341 gtttcaataa agacatttgg aataaacgag ca
//
