LOCUS       NM_018420               4705 bp    mRNA    linear   PRI 15-JAN-2025
DEFINITION  Homo sapiens solute carrier family 22 member 15 (SLC22A15), mRNA.
ACCESSION   NM_018420
VERSION     NM_018420.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4705)
  AUTHORS   Flogel,S., Strater,M., Fischer,D. and Grundemann,D.
  TITLE     A creatine efflux transporter in oligodendrocytes
  JOURNAL   FEBS J (2025) In press
   PUBMED   39792585
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4705)
  AUTHORS   Yee,S.W., Buitrago,D., Stecula,A., Ngo,H.X., Chien,H.C., Zou,L.,
            Koleske,M.L. and Giacomini,K.M.
  TITLE     Deorphaning a solute carrier 22 family member, SLC22A15, through
            functional genomic studies
  JOURNAL   FASEB J 34 (12), 15734-15752 (2020)
   PUBMED   33124720
  REMARK    GeneRIF: Deorphaning a solute carrier 22 family member, SLC22A15,
            through functional genomic studies.
REFERENCE   3  (bases 1 to 4705)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   4  (bases 1 to 4705)
  AUTHORS   Eraly,S.A. and Nigam,S.K.
  TITLE     Novel human cDNAs homologous to Drosophila Orct and mammalian
            carnitine transporters
  JOURNAL   Biochem Biophys Res Commun 297 (5), 1159-1166 (2002)
   PUBMED   12372408
  REMARK    GeneRIF: Flipts might have a role in carnitine transport,
            particularly in brain
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL357137.7, BC026358.1, BC070033.1, AL365318.33 and AL353933.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018420.2.
            
            Summary: Organic ion transporters, such as SLC22A15, transport
            various medically and physiologically important compounds,
            including pharmaceuticals, toxins, hormones, neurotransmitters, and
            cellular metabolites. These transporters are also referred to as
            amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr
            2004].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.234612.1,
                                           SRR1660807.82985.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369503.9/ ENSP00000358515.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AL357137.7         78485-78686
            203-681             BC026358.1         217-695
            682-1326            BC070033.1         599-1243
            1327-2256           BC026358.1         1341-2270
            2257-3578           AL365318.33        71210-72531
            3579-4705           AL353933.1         2295-3421
FEATURES             Location/Qualifiers
     source          1..4705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.1"
     gene            1..4705
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /note="solute carrier family 22 member 15"
                     /db_xref="GeneID:55356"
                     /db_xref="HGNC:HGNC:20301"
                     /db_xref="MIM:608275"
     exon            1..202
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1759
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /note="fly-like putative organic ion transporter 1; solute
                     carrier family 22 (organic cation transporter), member 15;
                     trans-like protein; flipt 1; fly-like putative transporter
                     1"
                     /codon_start=1
                     /product="solute carrier family 22 member 15"
                     /protein_id="NP_060890.2"
                     /db_xref="CCDS:CCDS44198.1"
                     /db_xref="GeneID:55356"
                     /db_xref="HGNC:HGNC:20301"
                     /db_xref="MIM:608275"
                     /translation="MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGA
                     TPSYHWDLAELLPNQSHGNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWF
                     LIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSP
                     SYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLG
                     YFIRSWRTLAILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLK
                     CTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGG
                     SIYANLALSGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDT
                     GVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAP
                     FIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEA
                     LSLQALDPQQCVDKESSLGSESEEEEEFYDADEETQMIK"
     exon            203..415
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            416..548
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            549..713
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            714..843
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1059
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1200
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1286
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1407
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1480
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1669
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..4705
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4033..4038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /note="hexamer: ATTAAA"
     polyA_site      4056
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /note="major polyA site"
     regulatory      4685..4690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /note="hexamer: AATAAA"
     polyA_site      4705
                     /gene="SLC22A15"
                     /gene_synonym="FLIPT1; PRO34686"
                     /note="major polyA site"
ORIGIN      
        1 atccccgccc cggcgggtcc aagccggtgc cgggcgccca ggggttgccg cgctgggcgg
       61 gagggcagcg cctgagaggg cggtggggtg gcggggttcc tgcgcgcggc ccgccatgga
      121 ggtggaggag gcgttccagg cggtggggga gatgggcatc taccagatgt acttgtgctt
      181 cctgctggcc gtgctgctgc agctctacgt ggccacggag gccatcctca ttgcactggt
      241 tggggccacg ccatcctacc actgggacct ggcagagctc ctgccaaatc agagccacgg
      301 taaccagtca gctggtgaag accaggcctt tggggactgg ctcctgacag ccaacggcag
      361 tgagatccat aagcacgtgc atttcagcag cagcttcacc tccatcgcct cggagtggtt
      421 tttaattgcc aacagatcct acaaagtcag tgcagcaagc tcttttttct tcagtggtgt
      481 atttgttgga gttatctctt ttggtcagct ttcagatcgc ttcggaagga aaaaagtcta
      541 tctcacaggt tttgctcttg acatcttatt tgcaattgca aatggatttt ccccctcata
      601 tgagttcttt gcagtaactc gcttcctggt gggcatgatg aatggaggga tgtcgctggt
      661 ggcctttgtc ttgcttaatg aatgtgtggg caccgcctac tgggcacttg caggatcgat
      721 tggcggcctg ttctttgcag ttggcattgc ccaatatgcc ctgttaggat acttcatccg
      781 ctcctggagg accctagcca ttctggttaa cctgcaggga acggtggtct ttctcttatc
      841 tttattcatt cctgaatcac ctcgttggtt atactcccag ggtcgactga gtgaggctga
      901 agaggcgctg tacctcattg ccaagaggaa ccgcaaactc aagtgcacgt tctcactaac
      961 acacccagcc aacaggagct gcagggagac tggaagtttc ctggatctct ttcgttaccg
     1021 ggtcctgtta ggacacactt tgatcctgat gttcatctgg tttgtgtgca gcttggtgta
     1081 ttatggccta actctgagtg cgggtgatct aggtggaagt atttatgcca acctggccct
     1141 gtctggcctc atagagattc catcttaccc tctctgtatc tacttgatta accaaaaatg
     1201 gtttggtcgg aagcgaacat tatcagcatt tctgtgccta ggaggactgg cttgtcttat
     1261 tgtaatgttt cttccagaaa agaaagacac aggtgtgttt gcagtggtga acagccattc
     1321 cttgtccttg ctggggaagc tgaccatcag tgctgccttt aacattgttt atatctacac
     1381 ctctgagctt taccctacag tcatcaggaa tgttgggctt ggaacttgtt ccatgttctc
     1441 ccgagttggt gggattattg ctcccttcat cccctcactg aaatatgtgc aatggtcttt
     1501 accattcatt gtcttcggag ccacgggtct gacctccggc ctcctgagtt tgttattgcc
     1561 ggagaccctt aacagtccgc tgctagaaac attctccgac cttcaggtgt attcgtatcg
     1621 caggctggga gaagaagcat tatctttaca ggctttggac ccccaacagt gtgtggacaa
     1681 ggagagctct ttagggagtg agagtgagga agaggaagaa ttttatgatg cagatgaaga
     1741 gactcagatg atcaagtgaa gagccccaga ttccccctaa gaagcaaagg atcgtctttt
     1801 atgcctctgg ctaaggcagg ttcttccatg actcctaaga gagttgtaaa aatagaggct
     1861 tggcttgaat gtacatagat ggtacctggc atggactgat gtttttaggc acagaagttg
     1921 gagaagagat ttcatgaaag acaacatcac tgcattgaga gaatagttgt taatttgttt
     1981 agaatttaag ttctactcag aatcataaca tctggcagaa cagcccaaac ccacattcca
     2041 aagtggtagg ctcatttgtt tctagagatt tcatcatgtc gcttttcctt catcatgatc
     2101 taaataaagg cagatatgta aaatttctca ccattttggt ggggtaagat aagctattat
     2161 taagatttaa tccttatacc atgttggaca tttgccccta tcagttgctc ctcaggaatc
     2221 ttctggtaca ggttaacatc agcattttca ttttgtgtcc agggaaaagc acccagaggt
     2281 catctgtgtg tcccgagacc ctccagcttt ttcttagctg atgaaatatg agtcctcagc
     2341 ttggttccca gcctgctgat tgacttgggc tgctggtgcc ttgagtccca cagatgattc
     2401 attaggaaaa gccagatata ccaaagcggt ttactcagag tcaggggtgt agctctggct
     2461 gcctgtcagc tcccttggat actatattgt atgatttctt cctttcccac taatatgcac
     2521 atccagaaaa atttccatct gagattctag tacttcaaaa tcatgcatag taaatgagaa
     2581 agctttaagt agagggcagt taaacagtga catgttgagc acctggagga aaaaaaaggt
     2641 gcagttttta ataagagaga aaatgaaatt atctttgata aatttttgtt tgttttgctt
     2701 tcagcattgt gccatgaggg atttggacaa tatttaagaa cttcttgtcc tagatcagcc
     2761 ccaatctgtt taatcaaaat ggaaggttca gtaatttcat gggaaacctt ggtttttcat
     2821 taagtgctac caactttcaa gtgaatcttg tatttgattt cctaaaatca tgtcttgaaa
     2881 acatgttttc tcatgaaact tgaatactat ctcaaatagg aatataaacc tggagtcaac
     2941 aagcttaggc agcattgatt taggtcactt tcccagtgag gaaaatttct gtgttttcag
     3001 aatttccatt tctactaacc tcttggagaa aaagaaattg aattagaggt aaatagaaga
     3061 cgtcactgtg gctgcttctg gaagtgctgg aagcatcacc ccaattggct ccaaatactg
     3121 tcatgttttc ttgcacactg acttctggtt tccactgtat cagtatgtac ctttgtaatt
     3181 gttattttta tgtcttttat gcccttgatt attagttggg ctcttcataa acagaggcca
     3241 tctctactac tgtttatttt tccctgctgt gcccagaaca ttggcgtaga cacagtaaga
     3301 acctagtaaa tattactgtt tctagccatc agggagattg tggaactcct cccagtataa
     3361 tttttacaaa ctccaagcaa atctgaccca aactcccaaa ttgtcaagtc ctgcttaact
     3421 ttctctggaa aatagacccc ttctcaacat cagaatagga agagaggaag aacttacaaa
     3481 gacacttaaa agttattctt aaatggtggt tgggcattta aaacagtgaa ctaacatata
     3541 tataattttt gattagttgg agctttcttt gtattataag agtaatatat ctcattacag
     3601 aaaatttgga aactataaat ttagaaacgt atcacccata cgtccaacat cgaaagaaaa
     3661 ccagtgttat gactttgttc catttgaaga ctaattggga gtccatctct ctattggcac
     3721 tgggttcgat tgcctctggc taatagagtt caattagttc tatccctggg tttcctttct
     3781 tagctatggg gtggaagata ggagggggag atctacaatt tgaatatgtg ttacttaata
     3841 aggctaggct ggccatcagt tgcttatttc agatgtgtca ctaaattttc cttctagatg
     3901 gtccttgagc aaaacttaat aattactgtt ttttatttcc actgccttta taaaatcaaa
     3961 attttctcct tttgataaaa actgttgaat actattgatg tagagaatgt gtatatgtgt
     4021 atatttgcat tgattaaatt attggaaaac ttttcattga caggtaatgt attttggttg
     4081 tgcggatggt ttgtaaaaag tatcctgttt ttttaattct attcaaaatt aaaaattttt
     4141 tttcctaaaa taaagcaaga aaaataaatg taagatatat aagaaacccc agagtttcca
     4201 gggtgaaagt tcacattagc agcttgtcca aaatatttac acctcacaaa tattttgaaa
     4261 gaaaccatgt tgaaattttc tgattttgtg agttacaacc acagcccagt aaaaccaata
     4321 cttgttattt ggctactttc aagcaatgca gatattcttt agtatttaaa aatgagcaaa
     4381 taaacaaaat gaggcaaata aatgaagaaa atgagtttct gagacactgt ttaggtaacc
     4441 ataaatcaga cagatatttt tatggtgggc aaattgatga agatactttt agtaggtgat
     4501 ttatattcat aacaaataca tattgaaata attgtcacta ctgtatcaga attaaaaacc
     4561 agcttcacat taggacttct ccatacaaat gctttatcat tggttcttaa attggaaaaa
     4621 tatctataaa tgattacatt tttaagctaa ataaaatgca gatattttgg cttcttgtga
     4681 atgtaataaa gaatcataaa acata
//
