LOCUS       NM_001320033            2157 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens solute carrier family 22 member 14 (SLC22A14),
            transcript variant 2, mRNA.
ACCESSION   NM_001320033 XM_005265584
VERSION     NM_001320033.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2157)
  AUTHORS   Kuang,W., Zhang,J., Lan,Z., Deepak,R.N.V.K., Liu,C., Ma,Z.,
            Cheng,L., Zhao,X., Meng,X., Wang,W., Wang,X., Xu,L., Jiao,Y.,
            Luo,Q., Meng,Z., Kee,K., Liu,X., Deng,H., Li,W., Fan,H. and Chen,L.
  TITLE     SLC22A14 is a mitochondrial riboflavin transporter required for
            sperm oxidative phosphorylation and male fertility
  JOURNAL   Cell Rep 35 (3), 109025 (2021)
   PUBMED   33882315
REFERENCE   2  (bases 1 to 2157)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2157)
  AUTHORS   Yokoyama,K., Urashima,M., Ohkido,I., Kono,T., Yoshida,T.,
            Muramatsu,M., Niu,T. and Hosoya,T.
  TITLE     L-type voltage-dependent calcium channel alpha subunit 1C is a
            novel candidate gene associated with secondary hyperparathyroidism:
            an application of haplotype-based analysis for multiple linked
            single nucleotide polymorphisms
  JOURNAL   Nephron Clin Pract 115 (4), c237-c243 (2010)
   PUBMED   20424473
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2157)
  AUTHORS   Daigo,Y., Nishiwaki,T., Kawasoe,T., Tamari,M., Tsuchiya,E. and
            Nakamura,Y.
  TITLE     Molecular cloning of a candidate tumor suppressor gene, DLC1, from
            chromosome 3p21.3
  JOURNAL   Cancer Res 59 (8), 1966-1972 (1999)
   PUBMED   10213508
REFERENCE   5  (bases 1 to 2157)
  AUTHORS   Daigo,Y., Isomura,M., Nishiwaki,T., Tamari,M., Ishikawa,S., Kai,M.,
            Murata,Y., Takeuchi,K., Yamane,Y., Hayashi,R., Minami,M.,
            Fujino,M.A., Hojo,Y., Uchiyama,I., Takagi,T. and Nakamura,Y.
  TITLE     Characterization of a 1200-kb genomic segment of chromosome
            3p22-p21.3
  JOURNAL   DNA Res 6 (1), 37-44 (1999)
   PUBMED   10231028
REFERENCE   6  (bases 1 to 2157)
  AUTHORS   Nishiwaki,T., Daigo,Y., Tamari,M., Fujii,Y. and Nakamura,Y.
  TITLE     Molecular cloning, mapping, and characterization of two novel human
            genes, ORCTL3 and ORCTL4, bearing homology to organic-cation
            transporters
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 251-255 (1998)
   PUBMED   10072596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB024161.1, AK315317.1, AP006193.1, HY221852.1 and AI446196.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001320033.1.
            
            Summary: This gene encodes a member of the organic-cation
            transporter family. It is located in a gene cluster with another
            member of the family, organic cation transporter like 3. The
            encoded protein is a transmembrane protein which is thought to
            transport small molecules and since this protein is conserved among
            several species, it is suggested to have a fundamental role in
            mammalian systems. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315317.1, SRR5189667.323595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448498.6/ ENSP00000396283.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DB024161.1         3-6
            5-855               AK315317.1         3-853
            856-920             AP006193.1         90416-90480         c
            921-1454            AK315317.1         919-1452
            1455-1455           AP006193.1         83880-83880         c
            1456-1724           AK315317.1         1454-1722
            1725-1725           AP006193.1         82998-82998         c
            1726-1831           AK315317.1         1724-1829
            1832-2060           HY221852.1         46-274              c
            2061-2116           AP006193.1         80934-80989         c
            2117-2157           AI446196.1         20-60               c
FEATURES             Location/Qualifiers
     source          1..2157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..2157
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /note="solute carrier family 22 member 14"
                     /db_xref="GeneID:9389"
                     /db_xref="HGNC:HGNC:8495"
                     /db_xref="MIM:604048"
     exon            1..46
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1831
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 14; organic cationic transporter-like
                     4; organic cation transporter-like 4"
                     /codon_start=1
                     /product="solute carrier family 22 member 14"
                     /protein_id="NP_001306962.1"
                     /db_xref="CCDS:CCDS2677.1"
                     /db_xref="GeneID:9389"
                     /db_xref="HGNC:HGNC:8495"
                     /db_xref="MIM:604048"
                     /translation="MAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAV
                     HTKQDDKFANLLDAVGEFGTFQQRLVALTFIPSIMSAFFMFADHFVFTAQKPYCNTSW
                     ILAVGPHLSKAEQLNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTDTCQDGWI
                     YPDAKKRSLINEFDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAILLSL
                     LGLIIFGFGTAFMNSFHLYLFFRFGISQSVVGYAISSISLATEWLVGEHRAHAIILGH
                     CFFAVGAVLLTGIAYSLPHWQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAK
                     QVLCYAASVNKKTIPSNLLDELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVS
                     YTYFTLSLRMRELGVSVHFRHVVPSIMEVPARLCCIFLLQQIGRKWSLAVTLLQAIIW
                     CLLLLFLPEGEDGLRLKWPRCPATELKSMTILVLMLREFSLAATVTVFFLYTAELLPT
                     VLRATGLGLVSLASVAGAILSLTIISQTPSLLPIFLCCVLAIVAFSLSSLLPETRDQP
                     LSESLNHSSQIRNKVKDMKTKETSSDDV"
     exon            47..562
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            563..666
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            667..821
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..990
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1111
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1209
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1424
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1578
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1779
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2157
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /note="hexamer: ATTAAA"
     polyA_site      2105
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /note="major polyA site"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /note="hexamer: AATAAA"
     polyA_site      2157
                     /gene="SLC22A14"
                     /gene_synonym="OCTL2; OCTL4; ORCTL4"
                     /note="major polyA site"
ORIGIN      
        1 aaaggttctg cttccaaggg tctggctggg cctggattgt ggtcagatgg caggagagga
       61 gaacttcaag gaagagctca gatcccagga tgcttccagg aacttgaacc agcatgaggt
      121 agcaggacat ccacattcct ggtctctgga gatgctgtta cgcagattga gggctgtcca
      181 caccaagcag gatgacaagt ttgccaacct cctggatgcg gtgggggagt ttggcacatt
      241 ccagcagagg ctagtagccc tcacctttat ccccagcatc atgtcggcct tcttcatgtt
      301 tgctgaccac ttcgtgttca cagcccagaa gccctattgc aataccagct ggatcctggc
      361 agtgggcccc cacctgtcca aagctgagca gctgaatctg accatacccc aagcacccaa
      421 tggcagtttc ctgacatgct tcatgtacct tcctgtgcct tggaatctgg attctatcat
      481 ccagtttggc ctcaatgaca cagacacatg ccaagatggg tggatctatc ctgacgctaa
      541 gaagcgatcg ctgatcaatg agtttgactt ggtatgtggc atggagacga agaaggacac
      601 tgcacagatc atgttcatgg cagggctccc gataggctct ctcatcttca ggctcataac
      661 tgacaagatg ggccgctacc ctgccatcct gctgtcactg ctggggctga tcatcttcgg
      721 ctttgggaca gccttcatga acagctttca cctgtatttg ttctttcgct ttggcatctc
      781 gcagtcagtg gtgggctacg ccatcagcag catttctttg gccactgagt ggttagtggg
      841 tgagcaccgg gcccatgcca ttatcctggg acactgcttt ttcgctgttg gggccgtgtt
      901 gctgacaggg atcgcctaca gtcttcccca ctggcagctg ctgtttctgg tgggtgggat
      961 acttgtgatc cccttcatct cctatatctg gattctcccg gagtccccgc ggtggctgat
     1021 gatgaaaggg aaggtgaagg aggccaagca ggtgctgtgc tacgccgcaa gtgtgaacaa
     1081 gaagaccatt ccttcaaatc tgctggacga gctgcagctg cccagaaaga aggtgactcg
     1141 ggcctctgtc ctggacttct gtaagaatag gcagctctgc aaggtgacct tggtgatgag
     1201 ctgtgtgtgg tttaccgtca gttacaccta ttttacgttg agcctgagaa tgagagagct
     1261 gggcgtgagc gtccacttca gacacgtggt ccccagcatc atggaggtgc ctgcccggct
     1321 gtgctgcatc tttctcctcc agcagattgg gaggaagtgg agcctggctg tgactctcct
     1381 ccaagccatc atctggtgct tgcttctcct tttcctccct gaaggggagg atggcctcag
     1441 actcaagtgg ccacgttgtc cggccacaga gctgaaatcc atgacgatct tggtgctcat
     1501 gctcagagag ttcagcctgg ccgccactgt cactgtgttc ttcctctaca ccgctgagct
     1561 cctccccact gtgctcaggg cgacaggtct ggggctggtg tctctggcct cggtggctgg
     1621 agccatcttg tccctgacaa tcatcagcca gaccccctcc ctcctgccca tctttctctg
     1681 ctgcgtctta gccatcgtgg ccttttccct ctcctccctg ctgccggaaa cgcgagatca
     1741 gcccctctcc gagagcctga accactcctc acagataagg aataaggtca aggacatgaa
     1801 gactaaggaa acatcatctg atgatgtctg aggaagcggc caagaatgtc attctcaatg
     1861 cccagatcct gagattggac ccataccctg tctccaaccc tgccttgaag caattcaata
     1921 aagaggaagc aaacagccag gctccctgag ggccaggccc ccagaccatc ttgggttgga
     1981 attgagtggc caagtatggg gtcatggatt ccaggccaca aattccaggc ctagttcagt
     2041 ctgggggcag ggtcagtcct tctcccaggc cagcccttga cattaaaaaa aatgccccct
     2101 ccttctgcag gagctctgct gtgattcatt ccaataaagg tacaatgttg gtcttga
//
