LOCUS       NM_004256               2997 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 22 member 13 (SLC22A13), mRNA.
ACCESSION   NM_004256
VERSION     NM_004256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2997)
  AUTHORS   Vavra,J., Pavelcova,K., Masinova,J., Hasikova,L., Bubenikova,E.,
            Urbanova,A., Mancikova,A. and Stiburkova,B.
  TITLE     Examining the Association of Rare Allelic Variants in Urate
            Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and
            Gout
  JOURNAL   Dis Markers 2024, 5930566 (2024)
   PUBMED   38222853
  REMARK    GeneRIF: Examining the Association of Rare Allelic Variants in
            Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with
            Hyperuricemia and Gout.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2997)
  AUTHORS   Ohtsu,N., Ohgaki,R., Jin,C., Xu,M., Okanishi,H., Takahashi,R.,
            Matsui,A., Kishimoto,W., Ishiguro,N. and Kanai,Y.
  TITLE     Functional coupling of organic anion transporter OAT10 (SLC22A13)
            and monocarboxylate transporter MCT1 (SLC16A1) influencing the
            transport function of OAT10
  JOURNAL   J Pharmacol Sci 150 (1), 41-48 (2022)
   PUBMED   35926947
  REMARK    GeneRIF: Functional coupling of organic anion transporter OAT10
            (SLC22A13) and monocarboxylate transporter MCT1 (SLC16A1)
            influencing the transport function of OAT10.
REFERENCE   3  (bases 1 to 2997)
  AUTHORS   Shinoda,Y., Yamashiro,T., Hosooka,A., Yasujima,T. and Yuasa,H.
  TITLE     Functional characterization of human organic anion transporter 10
            (OAT10/SLC22A13) as an orotate transporter
  JOURNAL   Drug Metab Pharmacokinet 43, 100443 (2022)
   PUBMED   35144162
  REMARK    GeneRIF: Functional characterization of human organic anion
            transporter 10 (OAT10/SLC22A13) as an orotate transporter.
REFERENCE   4  (bases 1 to 2997)
  AUTHORS   Higashino,T., Morimoto,K., Nakaoka,H., Toyoda,Y., Kawamura,Y.,
            Shimizu,S., Nakamura,T., Hosomichi,K., Nakayama,A., Ooyama,K.,
            Ooyama,H., Shimizu,T., Ueno,M., Ito,T., Tamura,T., Naito,M.,
            Nakashima,H., Kawaguchi,M., Takao,M., Kawai,Y., Osada,N.,
            Ichida,K., Yamamoto,K., Suzuki,H., Shinomiya,N., Inoue,I.,
            Takada,T. and Matsuo,H.
  TITLE     Dysfunctional missense variant of OAT10/SLC22A13 decreases gout
            risk and serum uric acid levels
  JOURNAL   Ann Rheum Dis 79 (1), 164-166 (2020)
   PUBMED   31780526
  REMARK    GeneRIF: A dysfunctional missense variant of OAT10 decreases both
            gout risk and serum uric acid levels, suggesting OAT10 to be
            physiologically involved in urate reabsorption in the human kidney.
REFERENCE   5  (bases 1 to 2997)
  AUTHORS   AbuAli,G. and Grimm,S.
  TITLE     Isolation and characterization of the anticancer gene organic
            cation transporter like-3 (ORCTL3)
  JOURNAL   Adv Exp Med Biol 818, 213-227 (2014)
   PUBMED   25001539
  REMARK    GeneRIF: Since ORCTL3 targets fatty acid metabolism in transformed
            cells and induces an ER stress specifically in these cells, it
            reveals a novel therapeutic interference option for tumor cells.
            Review article
REFERENCE   6  (bases 1 to 2997)
  AUTHORS   Irshad,S., Mahul-Mellier,A.L., Kassouf,N., Lemarie,A. and Grimm,S.
  TITLE     Isolation of ORCTL3 in a novel genetic screen for tumor-specific
            apoptosis inducers
  JOURNAL   Cell Death Differ 16 (6), 890-898 (2009)
   PUBMED   19282870
  REMARK    GeneRIF: ORCTL3 protein causes cell death in v-src-transformed
            cells and in various human tumor cell lines but not in normal cells
            or untransformed cell lines.
REFERENCE   7  (bases 1 to 2997)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 2997)
  AUTHORS   Bahn,A., Hagos,Y., Reuter,S., Balen,D., Brzica,H., Krick,W.,
            Burckhardt,B.C., Sabolic,I. and Burckhardt,G.
  TITLE     Identification of a new urate and high affinity nicotinate
            transporter, hOAT10 (SLC22A13)
  JOURNAL   J Biol Chem 283 (24), 16332-16341 (2008)
   PUBMED   18411268
  REMARK    GeneRIF: SLC22A13 is a new urate and high affinity nicotinate
            transporter
REFERENCE   9  (bases 1 to 2997)
  AUTHORS   Daigo,Y., Isomura,M., Nishiwaki,T., Tamari,M., Ishikawa,S., Kai,M.,
            Murata,Y., Takeuchi,K., Yamane,Y., Hayashi,R., Minami,M.,
            Fujino,M.A., Hojo,Y., Uchiyama,I., Takagi,T. and Nakamura,Y.
  TITLE     Characterization of a 1200-kb genomic segment of chromosome
            3p22-p21.3
  JOURNAL   DNA Res 6 (1), 37-44 (1999)
   PUBMED   10231028
REFERENCE   10 (bases 1 to 2997)
  AUTHORS   Nishiwaki,T., Daigo,Y., Tamari,M., Fujii,Y. and Nakamura,Y.
  TITLE     Molecular cloning, mapping, and characterization of two novel human
            genes, ORCTL3 and ORCTL4, bearing homology to organic-cation
            transporters
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 251-255 (1998)
   PUBMED   10072596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA629311.1, AK315301.1,
            AB010438.1 and AP006193.1.
            
            On May 17, 2019 this sequence version replaced NM_004256.3.
            
            Summary: This gene encodes a member of the organic-cation
            transporter family. It is located in a gene cluster with another
            member of the family, organic cation transporter like 4. The
            encoded protein is a transmembrane protein involved in the
            transport of small molecules. This protein can function to mediate
            urate uptake and is a high affinity nicotinate exchanger in the
            kidneys and the intestine. [provided by RefSeq, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315301.1, AB010438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311856.9/ ENSP00000310241.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               DA629311.1         6-246
            242-1377            AK315301.1         242-1377
            1378-1554           AB010438.1         1350-1526
            1555-1705           AK315301.1         1555-1705
            1706-2555           AB010438.1         1678-2527
            2556-2997           AP006193.1         120711-121152       c
FEATURES             Location/Qualifiers
     source          1..2997
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..2997
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /note="solute carrier family 22 member 13"
                     /db_xref="GeneID:9390"
                     /db_xref="HGNC:HGNC:8494"
                     /db_xref="MIM:604047"
     exon            1..427
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1705
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /note="organic cationic transporter-like 3; organic-cation
                     transporter like 3; solute carrier family 22 (organic
                     anion transporter), member 13; solute carrier family 22
                     (organic anion/urate transporter), member 13; organic
                     anion transporter 10"
                     /codon_start=1
                     /product="solute carrier family 22 member 13"
                     /protein_id="NP_004247.2"
                     /db_xref="CCDS:CCDS2676.1"
                     /db_xref="GeneID:9390"
                     /db_xref="HGNC:HGNC:8494"
                     /db_xref="MIM:604047"
                     /translation="MAQFVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVL
                     DEPHHCAVAWVKNHTFNLSAAEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHR
                     FNETQPCDMGWEYPENRLPSLKNEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCD
                     RIGRKATILAQLLLFTLIGLATAFVPSFELYMALRFAVATAVAGLSFSNVTLLTEWVG
                     PSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGTAPGLLLFFYFWALPESAR
                     WLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPEKTGPSGNALDLFRHPQLRKVT
                     LIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPARCSSIFMMQRFGRKWS
                     QLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAELFPTILRQ
                     TGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGLK
                     DTLQDLELGPHPRSPKSVPSEKETEAKGRTSSPGVAFVSSTYF"
     exon            428..531
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..686
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..855
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            856..976
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1071
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1286
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1395
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1611
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..2997
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2002
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /note="major polyA site"
     polyA_site      2079
                     /gene="SLC22A13"
                     /gene_synonym="OAT10; OCTL1; OCTL3; ORCTL-3; ORCTL3"
                     /note="major polyA site"
ORIGIN      
        1 acagagctac cctagtgtcc ccaggctgag gaggtagtga ctggcataca tggctcagtt
       61 tgtccaggtc ctggctgaaa taggtgactt tggtcgcttc cagatacagc tattgatcct
      121 gctgtgtgtt ctcaacttcc tgtctccctt ctactttttt gcccatgtct tcatggtcct
      181 agatgagccc caccactgtg cagtggcttg ggtgaagaac cacactttca acctgagtgc
      241 tgctgaacag ctggtactga gcgtgcccct ggacactgca ggtcacccag agccctgcct
      301 catgttccgg ccaccccccg ccaatgccag cctgcaggac atcctcagcc accgcttcaa
      361 tgagacgcag ccttgtgata tgggctggga atatcctgag aacaggctcc catccctgaa
      421 gaatgagttc aacctggttt gtgatcggaa gcacctgaag gacaccacac agtcagtgtt
      481 catggctggg ctccttgttg gcaccctcat gtttgggccc ctctgcgacc ggattggccg
      541 caaggccaca atcctggcgc agctgctcct cttcaccctc atcggcctgg ccacagcttt
      601 tgtgcccagc tttgagctct acatggccct gcgctttgct gtggctactg ccgtcgctgg
      661 acttagcttc agcaatgtca ccctactgac agaatgggtg gggccctcat ggaggacgca
      721 ggccgtggtc ctggcccagt gcaacttctc cctcgggcag atggtgcttg cgggactcgc
      781 ctacggtttc cgcaactgga ggctccttca gatcaccggc actgcgcctg gcttactgct
      841 cttcttctac ttctgggctc tgccagaatc tgcacgttgg ctcctgaccc gtgggaggat
      901 ggacgaggcg atacaactga tccagaaggc ggcctcggtc aataggcgga aactctcccc
      961 ggagctcatg aaccagctgg tcccagagaa gacaggcccc tcagggaatg ccctggatct
     1021 gttcagacac ccccagctcc ggaaggtgac cctgattatc ttctgtgtct ggtttgtgga
     1081 cagtctgggg tactacggcc tgagcctcca agtgggggac ttcggcctgg acgtctatct
     1141 gacgcagctc atctttggag ctgttgaggt gcctgcccgc tgttccagca tcttcatgat
     1201 gcagaggttt ggccgcaagt ggagccagtt ggggaccttg gtcttgggtg gcctgatgtg
     1261 tatcatcatc atcttcatcc cagcagatct gcccgtggtg gtcaccatgc tggctgtggt
     1321 ggggaagatg gccacagctg ctgcctttac catctcctat gtgtactctg ccgagctttt
     1381 ccccaccatc ctccggcaga caggcatggg gctggtgggc atcttctcac ggatcggggg
     1441 catcctcaca ccacttgtga tcctgctggg agagtaccac gctgccctcc ccatgctcat
     1501 ctacggcagc ctccccatcg tggccggcct gctgtgcacc ctgctgccag agacgcatgg
     1561 ccagggcctg aaagacaccc tccaggacct ggagctgggg cctcacccac ggtcccccaa
     1621 atcagtgccc tcagagaagg aaacagaggc caagggaaga acttccagcc cgggagtggc
     1681 ctttgtgagc agcacatact tctgattgag gtctctaaga gctggaccat cagcagcagg
     1741 gagctgccta aacacctcct tggatatggc caggacccac agggacacag ggcaagacca
     1801 gccttgctta tggaggcagg acaccacaat ctggcccatg gctgtcacct cctgccgagt
     1861 ccaatcccag actgggaacc accatctgag acaggacctc ccggcctcct tcacctttct
     1921 catctccaga gccctgcccc caatactctg tctgggttag gatcttgggt atgtcttgga
     1981 attaacttgt cctctaacaa tcttcatggg gtatggctct cttgatctcc tcaatctgga
     2041 gtcccctgcc ctcaaaacac agtgatgttc agaacagaac acaaggtaag ccctttccaa
     2101 tttgtgggaa caggagggga gaggaaacaa atgtgaagtt gtggactcta cccaggcagg
     2161 tggatgaaaa tgctgtggat aaaaggaagg ttatgattcc ttctagcgga tggaccagat
     2221 tcctctggct aacgtatggc cccataggtc actgggtcat acagagagaa gattcagttc
     2281 agcctaaatc aaaacttcca ccttgtgttc acttcaaaga tggcccaacc cccgccctac
     2341 actcagctca tgcctaacct atgtgtggct cagggaccag cttggggaag gaaaggaggt
     2401 ttgttctgct ccccgcctca ccccgcctcc tcctgctcat gctcagctgc ttctggacct
     2461 tccagggccc atgcagggtg agggaaaggg tagaggtctt ttcaccgagc tgctgctggt
     2521 tgcagttctt tctggtgcac attggctaat gccagttggt gtgttttgtc aggcttctga
     2581 aagctgcctt ttccacgggc catcttcttg ggcttctcag agatcttctc aggccttggt
     2641 attgttcctt agaatgagca atatgctccc aatgcactcc cagctcctct tgggaccctt
     2701 ctccagcccc acccagcatt gctcctacaa cctgtcctac agctggcagc ccctgaccca
     2761 accaagatgg ccttcttggc tgggcgtggt ggttcatgcc tgtaatccca gcactttggg
     2821 aggctgaggc gggcggatta cctgaggtca ggaatttgag accagcctgg ctggcatggc
     2881 aaaaccctgt ctctactaaa aatacaaaaa ttagccctat atggtggtgc atgcctgtaa
     2941 tcccagctac ttgggaggct gaggcaggag aatcgcttga acctgggagg cggagtt
//
