LOCUS       NM_018484               3545 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens solute carrier family 22 member 11 (SLC22A11),
            transcript variant 1, mRNA.
ACCESSION   NM_018484
VERSION     NM_018484.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3545)
  AUTHORS   Vavra,J., Pavelcova,K., Masinova,J., Hasikova,L., Bubenikova,E.,
            Urbanova,A., Mancikova,A. and Stiburkova,B.
  TITLE     Examining the Association of Rare Allelic Variants in Urate
            Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and
            Gout
  JOURNAL   Dis Markers 2024, 5930566 (2024)
   PUBMED   38222853
  REMARK    GeneRIF: Examining the Association of Rare Allelic Variants in
            Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with
            Hyperuricemia and Gout.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3545)
  AUTHORS   Yu,Z., Wang,H. and You,G.
  TITLE     The regulation of human organic anion transporter 4 by insulin-like
            growth factor 1 and protein kinase B signaling
  JOURNAL   Biochem Pharmacol 215, 115702 (2023)
   PUBMED   37487877
  REMARK    GeneRIF: The regulation of human organic anion transporter 4 by
            insulin-like growth factor 1 and protein kinase B signaling.
REFERENCE   3  (bases 1 to 3545)
  AUTHORS   Louisse,J., Dellafiora,L., van den Heuvel,J.J.M.W., Rijkers,D.,
            Leenders,L., Dorne,J.C.M., Punt,A., Russel,F.G.M. and
            Koenderink,J.B.
  TITLE     Perfluoroalkyl substances (PFASs) are substrates of the renal human
            organic anion transporter 4 (OAT4)
  JOURNAL   Arch Toxicol 97 (3), 685-696 (2023)
   PUBMED   36436016
  REMARK    GeneRIF: Perfluoroalkyl substances (PFASs) are substrates of the
            renal human organic anion transporter 4 (OAT4).
REFERENCE   4  (bases 1 to 3545)
  AUTHORS   Giri,A.K., Prasad,G., Bandesh,K., Parekatt,V., Mahajan,A.,
            Banerjee,P., Kauser,Y., Chakraborty,S., Rajashekar,D., Sharma,A.,
            Mathur,S.K., Basu,A., McCarthy,M.I., Tandon,N. and Bharadwaj,D.
  CONSRTM   INDICO
  TITLE     Multifaceted genome-wide study identifies novel regulatory loci in
            SLC22A11 and ZNF45 for body mass index in Indians
  JOURNAL   Mol Genet Genomics 295 (4), 1013-1026 (2020)
   PUBMED   32363570
  REMARK    GeneRIF: our study discovered 3 novel population-specific
            functional genetic variants (rs6913677, rs2078267, rs8100011) in 2
            novel (SLC22A11 and ZNF45) and 1 earlier reported gene (BAI3) for
            BMI in Indians. Our study decodes key genomic loci underlying
            obesity phenotype in Indians that may serve as prospective drug
            targets in future
REFERENCE   5  (bases 1 to 3545)
  AUTHORS   Giri,A.K., Banerjee,P., Chakraborty,S., Kauser,Y., Undru,A.,
            Roy,S., Parekatt,V., Ghosh,S., Tandon,N. and Bharadwaj,D.
  TITLE     Genome wide association study of uric acid in Indian population and
            interaction of identified variants with Type 2 diabetes
  JOURNAL   Sci Rep 6, 21440 (2016)
   PUBMED   26902266
  REMARK    GeneRIF: The first genome-wide association study for serum uric
            acid level in Indians revealed association of SLC2A9, SLC22A11 and
            ABCG2 gene variants at genome wide significance level in Type 2
            diabetes patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3545)
  AUTHORS   Kimura,H., Takeda,M., Narikawa,S., Enomoto,A., Ichida,K. and
            Endou,H.
  TITLE     Human organic anion transporters and human organic cation
            transporters mediate renal transport of prostaglandins
  JOURNAL   J Pharmacol Exp Ther 301 (1), 293-298 (2002)
   PUBMED   11907186
REFERENCE   7  (bases 1 to 3545)
  AUTHORS   Babu,E., Takeda,M., Narikawa,S., Kobayashi,Y., Yamamoto,T.,
            Cha,S.H., Sekine,T., Sakthisekaran,D. and Endou,H.
  TITLE     Human organic anion transporters mediate the transport of
            tetracycline
  JOURNAL   Jpn J Pharmacol 88 (1), 69-76 (2002)
   PUBMED   11855680
  REMARK    GeneRIF: elucidation of the molecular mechanism for renal
            tetracycline transport by human organic anion transporters (hOATs)
            using proximal tubular cells stably expressing hOATs
REFERENCE   8  (bases 1 to 3545)
  AUTHORS   Sun,W., Wu,R.R., van Poelje,P.D. and Erion,M.D.
  TITLE     Isolation of a family of organic anion transporters from human
            liver and kidney
  JOURNAL   Biochem Biophys Res Commun 283 (2), 417-422 (2001)
   PUBMED   11327718
REFERENCE   9  (bases 1 to 3545)
  AUTHORS   Cha,S.H., Sekine,T., Kusuhara,H., Yu,E., Kim,J.Y., Kim,D.K.,
            Sugiyama,Y., Kanai,Y. and Endou,H.
  TITLE     Molecular cloning and characterization of multispecific organic
            anion transporter 4 expressed in the placenta
  JOURNAL   J Biol Chem 275 (6), 4507-4512 (2000)
   PUBMED   10660625
REFERENCE   10 (bases 1 to 3545)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC034384.1, AP001092.5,
            BI051409.1, AA331094.1 and BX094958.1.
            
            On May 17, 2019 this sequence version replaced NM_018484.3.
            
            Summary: The protein encoded by this gene is involved in the
            sodium-independent transport and excretion of organic anions, some
            of which are potentially toxic. The encoded protein is an integral
            membrane protein and is found mainly in the kidney and in the
            placenta, where it may act to prevent potentially harmful organic
            anions from reaching the fetus. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034384.1, AK290791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301891.9/ ENSP00000301891.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2197              BC034384.1         316-2512
            2198-2477           AP001092.5         14458-14737
            2478-2842           BI051409.1         77-441              c
            2843-3007           AA331094.1         104-268
            3008-3045           AP001092.5         15268-15305
            3046-3545           BX094958.1         22-521
FEATURES             Location/Qualifiers
     source          1..3545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3545
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="solute carrier family 22 member 11"
                     /db_xref="GeneID:55867"
                     /db_xref="HGNC:HGNC:18120"
                     /db_xref="MIM:607097"
     exon            1..452
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1712
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 22 (organic anion/cation
                     transporter), member 11; organic anion transporter 4;
                     solute carrier family 22 (organic anion/urate
                     transporter), member 11; organic anion:dicarboxylate
                     exchanger OAT4"
                     /codon_start=1
                     /product="solute carrier family 22 member 11 isoform 1"
                     /protein_id="NP_060954.1"
                     /db_xref="CCDS:CCDS8074.1"
                     /db_xref="GeneID:55867"
                     /db_xref="HGNC:HGNC:18120"
                     /db_xref="MIM:607097"
                     /translation="MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAI
                     PGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATA
                     TSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIW
                     GLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLM
                     VEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWL
                     PESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVL
                     DLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATT
                     ALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTI
                     YKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVV
                     LFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL"
     exon            453..556
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..711
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            712..880
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1001
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1117
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1332
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1441
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1648
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..3545
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="hexamer: AATAAA"
     polyA_site      2197
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="major polyA site"
ORIGIN      
        1 gcaatcggtt ccaaacagca gttaggtcag cagtccgctc agccgaggca gctctgttca
       61 tggcgttctc gaagctcttg gagcaagccg gaggcgtggg cctcttccag accctgcagg
      121 tgctcacctt catcctcccc tgcctcatga taccttccca gatgctcctg gagaacttct
      181 cagccgccat cccaggccac cgatgctgga cacacatgct ggacaatggc tctgcggttt
      241 ccacaaacat gacccccaag gcccttctga ccatctccat cccgccaggc cccaaccagg
      301 ggccccacca gtgccgccgc ttccgccagc cacagtggca gctcttggac cccaatgcca
      361 cggccaccag ctggagcgaa gctgacacgg agccgtgtgt ggacggctgg gtctatgacc
      421 gcagcgtctt cacctccacc atcgtggcca agtgggacct ggtgtgcagc tcccagggct
      481 tgaagcccct aagccagtcc atcttcatgt ccgggatcct ggtgggctcc tttatctggg
      541 gcctcctctc ctaccggttt gggaggaagc cgatgctgag ctggtgctgc ctgcagttgg
      601 ccgtggcggg caccagcacc atcttcgccc caacattcgt catctactgc ggcctgcggt
      661 tcgtggccgc ttttgggatg gccggcatct ttctgagttc actgacactg atggtggagt
      721 ggaccacgac cagcaggagg gcggtcacca tgacggtggt gggatgtgcc ttcagcgcag
      781 gccaggcggc gctgggcggc ctggcctttg ccctgcggga ctggaggact ctccagctgg
      841 cagcatcagt gcccttcttt gccatctccc tgatatcctg gtggctgcca gaatccgccc
      901 ggtggctgat tattaagggc aaaccagacc aagcacttca ggagctcaga aaggtggcca
      961 ggataaatgg ccacaaggag gccaagaacc tgaccataga ggtgctgatg tccagcgtga
     1021 aggaggaggt ggcctctgca aaggagccgc ggtcggtgct ggacctgttc tgcgtgcccg
     1081 tgctccgctg gaggagctgc gccatgctgg tggtgaattt ctctctattg atctcctact
     1141 atgggctggt cttcgacctg cagagcctgg gccgtgacat cttcctcctc caggccctct
     1201 tcggggccgt ggacttcctg ggccgggcca ccactgccct cttgctcagt ttccttggcc
     1261 gccgcaccat ccaggcgggt tcccaggcca tggccggcct cgccattcta gccaacatgc
     1321 tggtgccgca agatttgcag accctgcgtg tggtctttgc tgtgctggga aagggatgtt
     1381 ttgggataag cctaacctgc ctcaccatct acaaggctga actctttcca acgccagtgc
     1441 ggatgacagc agatggcatt ctgcatacag tgggccggct gggggctatg atgggtcccc
     1501 tgatcctgat gagccgccaa gccctgcccc tgctgcctcc tctcctctat ggcgttatct
     1561 ccattgcttc cagcctggtt gtgctgttct tcctcccgga gacccaggga cttccgctcc
     1621 ctgacactat ccaggacctg gagagccaga aatcaacagc agcccagggc aaccggcaag
     1681 aggccgtcac tgtggaaagt acctcgctct agaaattgtg cctgcatgga gcccctttag
     1741 tcaaagactc ctggaaagga gttgcctctt ctccaatcag agcgtggagg cgagttgggc
     1801 gacttcaagg gcctggcatg gcagaggcca ggcagccgtg gccgagtgga cagcgtggcc
     1861 gtctgctgtg gctgaaggca gcttccacag ctcactcctc ttctccctgc cctgatcaga
     1921 ttccccacct tacccgggcc ctacaggagc ctgtgcagat ggccatgccc aaccaataac
     1981 gagacggttc ccctcccttt ccctgccagg ctcatgtctt tacaccttca ctcagccacg
     2041 ccaaccagag actgggttcc aatctcaccc caccacatac agagccctca tctgtgaaat
     2101 gagaatgatc acgtgaccca ccccccaggg caggtatcag ggtgaactga tcttagcacc
     2161 ggccaaataa atggaacctg ctgagagagc tgccagatac aggtgtccag gttgtgcact
     2221 ggcccgaggc acgcagccaa ggaggcgtgt ggggtctgaa actcagcccc ggctacactg
     2281 gccccaccac ccaccctagc aaaggctgtg tcctctccaa aaaaaggagc tgttttaatc
     2341 acttttcatt tactcatcag tgagggaggg cttccagccc tatggttacg aagacggcca
     2401 aacacaccac caaacaccag acagaggagg ctggcagcag gttaccacac acgtgcgcag
     2461 agcccacgaa gatgacgctg cactgaggca tggggcgggg tgcactgagg atccgagcga
     2521 gcagccaggg ctgcaggaag gcagctttgg agcacaaagg gggtggggca actcctggct
     2581 tctgcgggaa ggtgtaatca gcttgtttca tcatgctgca ggctggcgag aaacggagcc
     2641 ttacaagcgt agggataaga ggaacccctc ttggtcccct cgatgagggt tgttgggccg
     2701 gggagcctca tccacagggc ggagtgaaag gggagaaggg gagctcacag gcaggcctgc
     2761 caaggccttc tggctttgcc agatgtcaag ggcagcacct aatactgaac cttaactttc
     2821 ggctttcaac caaacggcac ccttttgctg tttgttttct ggaggggaca ccttttcttg
     2881 attcatgccc agacctccct tgtccaggcc atgaaaactc tgggatggtc gaggccggct
     2941 gcccatctca gatgggcaag gaagcaaaag tgcagagtgg tggaggggcc agcttgcaga
     3001 aacacggccg aacccggccc tgatcctagc ccagggctct ttccagcaca ggaggctcct
     3061 agccctcgtc tccaaccctc catgccactg atatctgtgg ccctgccaca aagttaccct
     3121 catgcccttc cctggagacc ccactctggg ccacctcaat ctcaggcccc tcaactcacc
     3181 tctttcaccc tgtgtacact gggtcaatca ctcctgcctc ctcacagctc ccaaatccac
     3241 ctacttccct tcactctggc tacaccctgg ttcacaccac ggttgtagct ccaaactggt
     3301 ccctgatgtc tacattgcac tctgcacaac agccaccatg cttattaaga aacgcaatcc
     3361 aaaccaaatc cctccctgct gaaagccctc cagtggctca caataaggat cacacttctc
     3421 cccctgcctg gtcaggcagc catgggaccc cagcctttcc tcccacttcg gtaaatttta
     3481 aaggattcgg atcatacaaa gaatgttctt gaaccagcat ggaattaaat tagaaatcaa
     3541 ttatg
//
