LOCUS       NM_001307985            3221 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens solute carrier family 22 member 11 (SLC22A11),
            transcript variant 2, mRNA.
ACCESSION   NM_001307985 XM_011545166
VERSION     NM_001307985.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3221)
  AUTHORS   Vavra,J., Pavelcova,K., Masinova,J., Hasikova,L., Bubenikova,E.,
            Urbanova,A., Mancikova,A. and Stiburkova,B.
  TITLE     Examining the Association of Rare Allelic Variants in Urate
            Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and
            Gout
  JOURNAL   Dis Markers 2024, 5930566 (2024)
   PUBMED   38222853
  REMARK    GeneRIF: Examining the Association of Rare Allelic Variants in
            Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with
            Hyperuricemia and Gout.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3221)
  AUTHORS   Yu,Z., Wang,H. and You,G.
  TITLE     The regulation of human organic anion transporter 4 by insulin-like
            growth factor 1 and protein kinase B signaling
  JOURNAL   Biochem Pharmacol 215, 115702 (2023)
   PUBMED   37487877
  REMARK    GeneRIF: The regulation of human organic anion transporter 4 by
            insulin-like growth factor 1 and protein kinase B signaling.
REFERENCE   3  (bases 1 to 3221)
  AUTHORS   Louisse,J., Dellafiora,L., van den Heuvel,J.J.M.W., Rijkers,D.,
            Leenders,L., Dorne,J.C.M., Punt,A., Russel,F.G.M. and
            Koenderink,J.B.
  TITLE     Perfluoroalkyl substances (PFASs) are substrates of the renal human
            organic anion transporter 4 (OAT4)
  JOURNAL   Arch Toxicol 97 (3), 685-696 (2023)
   PUBMED   36436016
  REMARK    GeneRIF: Perfluoroalkyl substances (PFASs) are substrates of the
            renal human organic anion transporter 4 (OAT4).
REFERENCE   4  (bases 1 to 3221)
  AUTHORS   Giri,A.K., Prasad,G., Bandesh,K., Parekatt,V., Mahajan,A.,
            Banerjee,P., Kauser,Y., Chakraborty,S., Rajashekar,D., Sharma,A.,
            Mathur,S.K., Basu,A., McCarthy,M.I., Tandon,N. and Bharadwaj,D.
  CONSRTM   INDICO
  TITLE     Multifaceted genome-wide study identifies novel regulatory loci in
            SLC22A11 and ZNF45 for body mass index in Indians
  JOURNAL   Mol Genet Genomics 295 (4), 1013-1026 (2020)
   PUBMED   32363570
  REMARK    GeneRIF: our study discovered 3 novel population-specific
            functional genetic variants (rs6913677, rs2078267, rs8100011) in 2
            novel (SLC22A11 and ZNF45) and 1 earlier reported gene (BAI3) for
            BMI in Indians. Our study decodes key genomic loci underlying
            obesity phenotype in Indians that may serve as prospective drug
            targets in future
REFERENCE   5  (bases 1 to 3221)
  AUTHORS   Giri,A.K., Banerjee,P., Chakraborty,S., Kauser,Y., Undru,A.,
            Roy,S., Parekatt,V., Ghosh,S., Tandon,N. and Bharadwaj,D.
  TITLE     Genome wide association study of uric acid in Indian population and
            interaction of identified variants with Type 2 diabetes
  JOURNAL   Sci Rep 6, 21440 (2016)
   PUBMED   26902266
  REMARK    GeneRIF: The first genome-wide association study for serum uric
            acid level in Indians revealed association of SLC2A9, SLC22A11 and
            ABCG2 gene variants at genome wide significance level in Type 2
            diabetes patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3221)
  AUTHORS   Kimura,H., Takeda,M., Narikawa,S., Enomoto,A., Ichida,K. and
            Endou,H.
  TITLE     Human organic anion transporters and human organic cation
            transporters mediate renal transport of prostaglandins
  JOURNAL   J Pharmacol Exp Ther 301 (1), 293-298 (2002)
   PUBMED   11907186
REFERENCE   7  (bases 1 to 3221)
  AUTHORS   Babu,E., Takeda,M., Narikawa,S., Kobayashi,Y., Yamamoto,T.,
            Cha,S.H., Sekine,T., Sakthisekaran,D. and Endou,H.
  TITLE     Human organic anion transporters mediate the transport of
            tetracycline
  JOURNAL   Jpn J Pharmacol 88 (1), 69-76 (2002)
   PUBMED   11855680
  REMARK    GeneRIF: elucidation of the molecular mechanism for renal
            tetracycline transport by human organic anion transporters (hOATs)
            using proximal tubular cells stably expressing hOATs
REFERENCE   8  (bases 1 to 3221)
  AUTHORS   Sun,W., Wu,R.R., van Poelje,P.D. and Erion,M.D.
  TITLE     Isolation of a family of organic anion transporters from human
            liver and kidney
  JOURNAL   Biochem Biophys Res Commun 283 (2), 417-422 (2001)
   PUBMED   11327718
REFERENCE   9  (bases 1 to 3221)
  AUTHORS   Cha,S.H., Sekine,T., Kusuhara,H., Yu,E., Kim,J.Y., Kim,D.K.,
            Sugiyama,Y., Kanai,Y. and Endou,H.
  TITLE     Molecular cloning and characterization of multispecific organic
            anion transporter 4 expressed in the placenta
  JOURNAL   J Biol Chem 275 (6), 4507-4512 (2000)
   PUBMED   10660625
REFERENCE   10 (bases 1 to 3221)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK129930.1, AP001092.5,
            BI051409.1, AA331094.1 and BX094958.1.
            
            On May 31, 2019 this sequence version replaced NM_001307985.1.
            
            Summary: The protein encoded by this gene is involved in the
            sodium-independent transport and excretion of organic anions, some
            of which are potentially toxic. The encoded protein is an integral
            membrane protein and is found mainly in the kidney and in the
            placenta, where it may act to prevent potentially harmful organic
            anions from reaching the fetus. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) lacks two in-frame exons in
            the 3' coding region compared to variant 1. It encodes isoform 2,
            which is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1870              AK129930.1         253-2122
            1871-2153           AP001092.5         14455-14737
            2154-2518           BI051409.1         77-441              c
            2519-2683           AA331094.1         104-268
            2684-2721           AP001092.5         15268-15305
            2722-3221           BX094958.1         22-521
FEATURES             Location/Qualifiers
     source          1..3221
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3221
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="solute carrier family 22 member 11"
                     /db_xref="GeneID:55867"
                     /db_xref="HGNC:HGNC:18120"
                     /db_xref="MIM:607097"
     exon            1..452
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1388
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     solute carrier family 22 (organic anion/cation
                     transporter), member 11; organic anion transporter 4;
                     solute carrier family 22 (organic anion/urate
                     transporter), member 11; organic anion:dicarboxylate
                     exchanger OAT4"
                     /codon_start=1
                     /product="solute carrier family 22 member 11 isoform 2"
                     /protein_id="NP_001294914.1"
                     /db_xref="CCDS:CCDS76425.1"
                     /db_xref="GeneID:55867"
                     /db_xref="HGNC:HGNC:18120"
                     /db_xref="MIM:607097"
                     /translation="MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAI
                     PGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATA
                     TSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIW
                     GLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLM
                     VEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWL
                     PESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVL
                     DLFCVPVLRWRSCAMLVVKMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVI
                     SIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL"
     exon            453..556
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..711
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            712..880
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1001
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1117
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1324
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..3221
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1842..1847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="hexamer: AATAAA"
     polyA_site      1873
                     /gene="SLC22A11"
                     /gene_synonym="hOAT4; OAT4"
                     /note="major polyA site"
ORIGIN      
        1 gcaatcggtt ccaaacagca gttaggtcag cagtccgctc agccgaggca gctctgttca
       61 tggcgttctc gaagctcttg gagcaagccg gaggcgtggg cctcttccag accctgcagg
      121 tgctcacctt catcctcccc tgcctcatga taccttccca gatgctcctg gagaacttct
      181 cagccgccat cccaggccac cgatgctgga cacacatgct ggacaatggc tctgcggttt
      241 ccacaaacat gacccccaag gcccttctga ccatctccat cccgccaggc cccaaccagg
      301 ggccccacca gtgccgccgc ttccgccagc cacagtggca gctcttggac cccaatgcca
      361 cggccaccag ctggagcgaa gctgacacgg agccgtgtgt ggacggctgg gtctatgacc
      421 gcagcgtctt cacctccacc atcgtggcca agtgggacct ggtgtgcagc tcccagggct
      481 tgaagcccct aagccagtcc atcttcatgt ccgggatcct ggtgggctcc tttatctggg
      541 gcctcctctc ctaccggttt gggaggaagc cgatgctgag ctggtgctgc ctgcagttgg
      601 ccgtggcggg caccagcacc atcttcgccc caacattcgt catctactgc ggcctgcggt
      661 tcgtggccgc ttttgggatg gccggcatct ttctgagttc actgacactg atggtggagt
      721 ggaccacgac cagcaggagg gcggtcacca tgacggtggt gggatgtgcc ttcagcgcag
      781 gccaggcggc gctgggcggc ctggcctttg ccctgcggga ctggaggact ctccagctgg
      841 cagcatcagt gcccttcttt gccatctccc tgatatcctg gtggctgcca gaatccgccc
      901 ggtggctgat tattaagggc aaaccagacc aagcacttca ggagctcaga aaggtggcca
      961 ggataaatgg ccacaaggag gccaagaacc tgaccataga ggtgctgatg tccagcgtga
     1021 aggaggaggt ggcctctgca aaggagccgc ggtcggtgct ggacctgttc tgcgtgcccg
     1081 tgctccgctg gaggagctgc gccatgctgg tggtgaagat gacagcagat ggcattctgc
     1141 atacagtggg ccggctgggg gctatgatgg gtcccctgat cctgatgagc cgccaagccc
     1201 tgcccctgct gcctcctctc ctctatggcg ttatctccat tgcttccagc ctggttgtgc
     1261 tgttcttcct cccggagacc cagggacttc cgctccctga cactatccag gacctggaga
     1321 gccagaaatc aacagcagcc cagggcaacc ggcaagaggc cgtcactgtg gaaagtacct
     1381 cgctctagaa attgtgcctg catggagccc ctttagtcaa agactcctgg aaaggagttg
     1441 cctcttctcc aatcagagcg tggaggcgag ttgggcgact tcaagggcct ggcatggcag
     1501 aggccaggca gccgtggccg agtggacagc gtggccgtct gctgtggctg aaggcagctt
     1561 ccacagctca ctcctcttct ccctgccctg atcagattcc ccaccttacc cgggccctac
     1621 aggagcctgt gcagatggcc atgcccaacc aataacgaga cggttcccct ccctttccct
     1681 gccaggctca tgtctttaca ccttcactca gccacgccaa ccagagactg ggttccaatc
     1741 tcaccccacc acatacagag ccctcatctg tgaaatgaga atgatcacgt gacccacccc
     1801 ccagggcagg tatcagggtg aactgatctt agcaccggcc aaataaatgg aacctgctga
     1861 gagagctgcc agatacaggt gtccaggttg tgcactggcc cgaggcacgc agccaaggag
     1921 gcgtgtgggg tctgaaactc agccccggct acactggccc caccacccac cctagcaaag
     1981 gctgtgtcct ctccaaaaaa aggagctgtt ttaatcactt ttcatttact catcagtgag
     2041 ggagggcttc cagccctatg gttacgaaga cggccaaaca caccaccaaa caccagacag
     2101 aggaggctgg cagcaggtta ccacacacgt gcgcagagcc cacgaagatg acgctgcact
     2161 gaggcatggg gcggggtgca ctgaggatcc gagcgagcag ccagggctgc aggaaggcag
     2221 ctttggagca caaagggggt ggggcaactc ctggcttctg cgggaaggtg taatcagctt
     2281 gtttcatcat gctgcaggct ggcgagaaac ggagccttac aagcgtaggg ataagaggaa
     2341 cccctcttgg tcccctcgat gagggttgtt gggccgggga gcctcatcca cagggcggag
     2401 tgaaagggga gaaggggagc tcacaggcag gcctgccaag gccttctggc tttgccagat
     2461 gtcaagggca gcacctaata ctgaacctta actttcggct ttcaaccaaa cggcaccctt
     2521 ttgctgtttg ttttctggag gggacacctt ttcttgattc atgcccagac ctcccttgtc
     2581 caggccatga aaactctggg atggtcgagg ccggctgccc atctcagatg ggcaaggaag
     2641 caaaagtgca gagtggtgga ggggccagct tgcagaaaca cggccgaacc cggccctgat
     2701 cctagcccag ggctctttcc agcacaggag gctcctagcc ctcgtctcca accctccatg
     2761 ccactgatat ctgtggccct gccacaaagt taccctcatg cccttccctg gagaccccac
     2821 tctgggccac ctcaatctca ggcccctcaa ctcacctctt tcaccctgtg tacactgggt
     2881 caatcactcc tgcctcctca cagctcccaa atccacctac ttcccttcac tctggctaca
     2941 ccctggttca caccacggtt gtagctccaa actggtccct gatgtctaca ttgcactctg
     3001 cacaacagcc accatgctta ttaagaaacg caatccaaac caaatccctc cctgctgaaa
     3061 gccctccagt ggctcacaat aaggatcaca cttctccccc tgcctggtca ggcagccatg
     3121 ggaccccagc ctttcctccc acttcggtaa attttaaagg attcggatca tacaaagaat
     3181 gttcttgaac cagcatggaa ttaaattaga aatcaattat g
//
