LOCUS       NM_003057               1922 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens solute carrier family 22 member 1 (SLC22A1),
            transcript variant 1, mRNA.
ACCESSION   NM_003057
VERSION     NM_003057.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1922)
  AUTHORS   Mickols,E., Meyer,A., Handin,N., Stuwe,M., Eriksson,J.,
            Rudfeldt,J., Blom,K., Fryknas,M., Sellin,M.E., Lauschke,V.M.,
            Karlgren,M. and Artursson,P.
  TITLE     OCT1 (SLC22A1) transporter kinetics and regulation in primary human
            hepatocyte 3D spheroids
  JOURNAL   Sci Rep 14 (1), 17334 (2024)
   PUBMED   39068198
  REMARK    GeneRIF: OCT1 (SLC22A1) transporter kinetics and regulation in
            primary human hepatocyte 3D spheroids.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1922)
  AUTHORS   Yee,S.W., Macdonald,C.B., Mitrovic,D., Zhou,X., Koleske,M.L.,
            Yang,J., Buitrago Silva,D., Rockefeller Grimes,P., Trinidad,D.D.,
            More,S.S., Kachuri,L., Witte,J.S., Delemotte,L., Giacomini,K.M. and
            Coyote-Maestas,W.
  TITLE     The full spectrum of SLC22 OCT1 mutations illuminates the bridge
            between drug transporter biophysics and pharmacogenomics
  JOURNAL   Mol Cell 84 (10), 1932-1947 (2024)
   PUBMED   38703769
  REMARK    GeneRIF: The full spectrum of SLC22 OCT1 mutations illuminates the
            bridge between drug transporter biophysics and pharmacogenomics.
REFERENCE   3  (bases 1 to 1922)
  AUTHORS   Yu,S., Cui,X., Zhou,S., Li,Y., Feng,W., Zhang,X., Zhong,Y. and
            Zhang,P.
  TITLE     THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic
            target in cutaneous squamous cell carcinoma
  JOURNAL   J Transl Med 22 (1), 347 (2024)
   PUBMED   38605354
  REMARK    GeneRIF: THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a
            therapeutic target in cutaneous squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1922)
  AUTHORS   Zeng,Y.C., Sobti,M., Quinn,A., Smith,N.J., Brown,S.H.J.,
            Vandenberg,J.I., Ryan,R.M., O'Mara,M.L. and Stewart,A.G.
  TITLE     Structural basis of promiscuous substrate transport by Organic
            Cation Transporter 1
  JOURNAL   Nat Commun 14 (1), 6374 (2023)
   PUBMED   37821493
  REMARK    GeneRIF: Structural basis of promiscuous substrate transport by
            Organic Cation Transporter 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1922)
  AUTHORS   Singh,S., Shukla,A.K., Usman,K. and Banerjee,M.
  TITLE     Pharmacogenetic impact of SLC22A1 gene variant rs628031 (G/A) in
            newly diagnosed Indian type 2 diabetes patients undergoing
            metformin monotherapy
  JOURNAL   Pharmacogenet Genomics 33 (3), 51-58 (2023)
   PUBMED   36853844
  REMARK    GeneRIF: Pharmacogenetic impact of SLC22A1 gene variant rs628031
            (G/A) in newly diagnosed Indian type 2 diabetes patients undergoing
            metformin monotherapy.
REFERENCE   6  (bases 1 to 1922)
  AUTHORS   Zhang,L., Dresser,M.J., Gray,A.T., Yost,S.C., Terashita,S. and
            Giacomini,K.M.
  TITLE     Cloning and functional expression of a human liver organic cation
            transporter
  JOURNAL   Mol Pharmacol 51 (6), 913-921 (1997)
   PUBMED   9187257
REFERENCE   7  (bases 1 to 1922)
  AUTHORS   Liu,Y.Z. and Latchman,D.S.
  TITLE     The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long
            terminal repeat promoter and its transactivation by Tat
  JOURNAL   Biochem J 322 (Pt 1) (Pt 1), 155-158 (1997)
   PUBMED   9078256
REFERENCE   8  (bases 1 to 1922)
  AUTHORS   Liu,Y.Z., Lania,L. and Latchman,D.S.
  TITLE     Functional interaction between the HIV-1 Tat transactivator and the
            inhibitory domain of the Oct-2 cellular transcription factor
  JOURNAL   AIDS 10 (12), 1323-1329 (1996)
   PUBMED   8902060
REFERENCE   9  (bases 1 to 1922)
  AUTHORS   Jeang,K.T., Chun,R., Lin,N.H., Gatignol,A., Glabe,C.G. and Fan,H.
  TITLE     In vitro and in vivo binding of human immunodeficiency virus type 1
            Tat protein and Sp1 transcription factor
  JOURNAL   J Virol 67 (10), 6224-6233 (1993)
   PUBMED   7690421
REFERENCE   10 (bases 1 to 1922)
  AUTHORS   Berkhout,B. and Jeang,K.T.
  TITLE     Functional roles for the TATA promoter and enhancers in basal and
            Tat-induced expression of the human immunodeficiency virus type 1
            long terminal repeat
  JOURNAL   J Virol 66 (1), 139-149 (1992)
   PUBMED   1727476
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353625.5.
            
            On Nov 26, 2018 this sequence version replaced NM_003057.2.
            
            Summary: Polyspecific organic cation transporters in the liver,
            kidney, intestine, and other organs are critical for elimination of
            many endogenous small organic cations as well as a wide array of
            drugs and environmental toxins. This gene is one of three similar
            cation transporter genes located in a cluster on chromosome 6. The
            encoded protein contains twelve putative transmembrane domains and
            is a plasma integral membrane protein. Two transcript variants
            encoding two different isoforms have been found for this gene, but
            only the longer variant encodes a functional transporter. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer and
            predominant transcript, and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X98332.1, SRR5189655.81478.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2155590
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366963.9/ ENSP00000355930.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AL353625.5         108829-109360
            533-636             AL353625.5         117118-117221
            637-791             AL353625.5         119246-119400
            792-960             AL353625.5         120971-121139
            961-1075            AL353625.5         123234-123348
            1076-1182           AL353625.5         123558-123664
            1183-1397           AL353625.5         126667-126881
            1398-1506           AL353625.5         130555-130663
            1507-1619           AL353625.5         141812-141924
            1620-1719           AL353625.5         142989-143088
            1720-1922           AL353625.5         145530-145732
FEATURES             Location/Qualifiers
     source          1..1922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..1922
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /note="solute carrier family 22 member 1"
                     /db_xref="GeneID:6580"
                     /db_xref="HGNC:HGNC:10963"
                     /db_xref="MIM:602607"
     exon            1..532
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1786
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /note="isoform a is encoded by transcript variant 1;
                     organic cation transporter 1; solute carrier family 22
                     (organic cation transporter), member 1"
                     /codon_start=1
                     /product="solute carrier family 22 member 1 isoform a"
                     /protein_id="NP_003048.1"
                     /db_xref="CCDS:CCDS5274.1"
                     /db_xref="GeneID:6580"
                     /db_xref="HGNC:HGNC:10963"
                     /db_xref="MIM:602607"
                     /translation="MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGF
                     TPDHHCQSPGVAELSQRCGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSC
                     VDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFL
                     FGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLMAFSPNYMSMLLFRLLQGLVSKGNWM
                     AGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYALPHWRWLQLAVSLPTFLFL
                     LYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLEEDVTEKLSPSF
                     ADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDFLYSALVEIPGAFI
                     ALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITIAIQMIC
                     LVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLILFAVLGLLAAG
                     VTLLLPETKGVALPETMKDAENLGRKAKPKENTIYLKVQTSEPSGT"
     exon            533..636
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            637..791
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            792..960
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1075
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1182
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1397
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1506
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1619
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1719
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1922
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1922
                     /gene="SLC22A1"
                     /gene_synonym="HOCT1; OCT1; oct1_cds"
                     /note="major polyA site"
ORIGIN      
        1 acacttggac agcaaactga tttcaaacca ctccttttca aagatctctg agggagacat
       61 tgcacctggc cactgcagcc cagagcaggt ctggccacgg ccatgagcat gctgagccat
      121 catgcccacc gtggatgaca ttctggagca ggttggggag tctggctggt tccagaagca
      181 agccttcctc atcttatgcc tgctgtcggc tgcctttgcg cccatctgtg tgggcatcgt
      241 cttcctgggt ttcacacctg accaccactg ccagagtcct ggggtggctg agctgagcca
      301 gcgctgtggc tggagccctg cggaggagct gaactataca gtgccaggcc tggggcccgc
      361 gggcgaggcc ttccttggcc agtgcaggcg ctatgaagtg gactggaacc agagcgccct
      421 cagctgtgta gaccccctgg ctagcctggc caccaacagg agccacctgc cgctgggtcc
      481 ctgccaggat ggctgggtgt atgacacgcc cggctcttcc atcgtcactg agttcaacct
      541 ggtgtgtgct gactcctgga agctggacct ctttcagtcc tgtttgaatg cgggcttctt
      601 gtttggctct ctcggtgttg gctactttgc agacaggttt ggccgtaagc tgtgtctcct
      661 gggaactgtg ctggtcaacg cggtgtcggg cgtgctcatg gccttctcgc ccaactacat
      721 gtccatgctg ctcttccgcc tgctgcaggg cctggtcagc aagggcaact ggatggctgg
      781 ctacacccta atcacagaat ttgttggctc gggctccaga agaacggtgg cgatcatgta
      841 ccagatggcc ttcacggtgg ggctggtggc gcttaccggg ctggcctacg ccctgcctca
      901 ctggcgctgg ctgcagctgg cagtctccct gcccaccttc ctcttcctgc tctactactg
      961 gtgtgtgccg gagtcccctc ggtggctgtt atcacaaaaa agaaacactg aagcaataaa
     1021 gataatggac cacatcgctc aaaagaatgg gaagttgcct cctgctgatt taaagatgct
     1081 ttccctcgaa gaggatgtca ccgaaaagct gagcccttca tttgcagacc tgttccgcac
     1141 gccgcgcctg aggaagcgca ccttcatcct gatgtacctg tggttcacgg actctgtgct
     1201 ctatcagggg ctcatcctgc acatgggcgc caccagcggg aacctctacc tggatttcct
     1261 ttactccgct ctggtcgaaa tcccgggggc cttcatagcc ctcatcacca ttgaccgcgt
     1321 gggccgcatc taccccatgg ccatgtcaaa tttgttggcg ggggcagcct gcctcgtcat
     1381 gatttttatc tcacctgacc tgcactggtt aaacatcata atcatgtgtg ttggccgaat
     1441 gggaatcacc attgcaatac aaatgatctg cctggtgaat gctgagctgt accccacatt
     1501 cgtcaggaac ctcggagtga tggtgtgttc ctccctgtgt gacataggtg ggataatcac
     1561 ccccttcata gtcttcaggc tgagggaggt ctggcaagcc ttgcccctca ttttgtttgc
     1621 ggtgttgggc ctgcttgccg cgggagtgac gctacttctt ccagagacca agggggtcgc
     1681 tttgccagag accatgaagg acgccgagaa ccttgggaga aaagcaaagc ccaaagaaaa
     1741 cacgatttac cttaaggtcc aaacctcaga accctcgggc acctgagaga gatgttttgc
     1801 ggcgatgtcg tgttggaggg atgaagatgg agttatcctc tgcagaaatt cctagacgcc
     1861 ttcacttctc tgtattcttc ctcatacttg cctaccccca aattaatatc agtcctaaag
     1921 aa
//
