LOCUS       NM_005415               3297 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens solute carrier family 20 member 1 (SLC20A1), mRNA.
ACCESSION   NM_005415
VERSION     NM_005415.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3297)
  AUTHORS   Cho,W.C., Prieto,V.G. and Yang,R.K.
  TITLE     Spitz Melanoma With SLC20A1::ALK Fusion: A Novel Fusion Previously
            Undescribed in Spitz Melanocytic Neoplasm
  JOURNAL   Am J Dermatopathol 46 (10), 700-703 (2024)
   PUBMED   38941542
  REMARK    GeneRIF: Spitz Melanoma With SLC20A1::ALK Fusion: A Novel Fusion
            Previously Undescribed in Spitz Melanocytic Neoplasm.
REFERENCE   2  (bases 1 to 3297)
  AUTHORS   Kulesza,T., Typiak,M., Rachubik,P., Rogacka,D., Audzeyenka,I.,
            Saleem,M.A. and Piwkowska,A.
  TITLE     Pit 1 transporter (SLC20A1) as a key factor in the NPP1-mediated
            inhibition of insulin signaling in human podocytes
  JOURNAL   J Cell Physiol 238 (8), 1921-1936 (2023)
   PUBMED   37269459
  REMARK    GeneRIF: Pit 1 transporter (SLC20A1) as a key factor in the
            NPP1-mediated inhibition of insulin signaling in human podocytes.
REFERENCE   3  (bases 1 to 3297)
  AUTHORS   Zechner,C., Henne,W.M., Sathe,A.A., Xing,C., Hernandez,G., Sun,S.
            and Cheong,M.C.
  TITLE     Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1
            and phosphate uptake are controlled post-transcriptionally by ESCRT
  JOURNAL   J Biol Chem 298 (6), 101945 (2022)
   PUBMED   35447110
  REMARK    GeneRIF: Cellular abundance of sodium phosphate cotransporter
            SLC20A1/PiT1 and phosphate uptake are controlled
            post-transcriptionally by ESCRT.
REFERENCE   4  (bases 1 to 3297)
  AUTHORS   Chen,Y., Hua,Q., Wan,H. and Xi,Y.
  TITLE     Long Noncoding RNA SLC20A1-1 Induces Nucleus Pulposus Apoptosis by
            Sponging miR-146a-5p
  JOURNAL   Genet Test Mol Biomarkers 26 (3), 127-132 (2022)
   PUBMED   35349375
  REMARK    GeneRIF: Long Noncoding RNA SLC20A1-1 Induces Nucleus Pulposus
            Apoptosis by Sponging miR-146a-5p.
REFERENCE   5  (bases 1 to 3297)
  AUTHORS   Olah,Z., Lehel,C., Anderson,W.B., Eiden,M.V. and Wilson,C.A.
  TITLE     The cellular receptor for gibbon ape leukemia virus is a novel high
            affinity sodium-dependent phosphate transporter
  JOURNAL   J Biol Chem 269 (41), 25426-25431 (1994)
   PUBMED   7929240
REFERENCE   6  (bases 1 to 3297)
  AUTHORS   Kavanaugh,M.P., Miller,D.G., Zhang,W., Law,W., Kozak,S.L., Kabat,D.
            and Miller,A.D.
  TITLE     Cell-surface receptors for gibbon ape leukemia virus and
            amphotropic murine retrovirus are inducible sodium-dependent
            phosphate symporters
  JOURNAL   Proc Natl Acad Sci U S A 91 (15), 7071-7075 (1994)
   PUBMED   8041748
REFERENCE   7  (bases 1 to 3297)
  AUTHORS   Johann,S.V., Gibbons,J.J. and O'Hara,B.
  TITLE     GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a
            phosphate permease of Neurospora crassa and is expressed at high
            levels in the brain and thymus
  JOURNAL   J Virol 66 (3), 1635-1640 (1992)
   PUBMED   1531369
REFERENCE   8  (bases 1 to 3297)
  AUTHORS   Takeuchi,Y., Vile,R.G., Simpson,G., O'Hara,B., Collins,M.K. and
            Weiss,R.A.
  TITLE     Feline leukemia virus subgroup B uses the same cell surface
            receptor as gibbon ape leukemia virus
  JOURNAL   J Virol 66 (2), 1219-1222 (1992)
   PUBMED   1309898
REFERENCE   9  (bases 1 to 3297)
  AUTHORS   Kaelbling,M., Eddy,R., Shows,T.B., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Klinger,H.P. and O'Hara,B.
  TITLE     Localization of the human gene allowing infection by gibbon ape
            leukemia virus to human chromosome region 2q11-q14 and to the
            homologous region on mouse chromosome 2
  JOURNAL   J Virol 65 (4), 1743-1747 (1991)
   PUBMED   1672162
REFERENCE   10 (bases 1 to 3297)
  AUTHORS   O'Hara,B., Johann,S.V., Klinger,H.P., Blair,D.G., Rubinson,H.,
            Dunn,K.J., Sass,P., Vitek,S.M. and Robins,T.
  TITLE     Characterization of a human gene conferring sensitivity to
            infection by gibbon ape leukemia virus
  JOURNAL   Cell Growth Differ 1 (3), 119-127 (1990)
   PUBMED   2078500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB086768.1, AC079922.5,
            AK312738.1 and BC075818.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005415.4.
            
            Summary: The protein encoded by this gene is a sodium-phosphate
            symporter that absorbs phosphate from interstitial fluid for use in
            cellular functions such as metabolism, signal transduction, and
            nucleic acid and lipid synthesis. The encoded protein is also a
            retroviral receptor, causing human cells to be susceptible to
            infection by gibbon ape leukemia virus, simian sarcoma-associated
            virus, feline leukemia virus subgroup B, and 10A1 murine leukemia
            virus.[provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019944.1, SRR1660803.248478.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272542.8/ ENSP00000272542.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               DB086768.1         83-228
            147-147             AC079922.5         28477-28477
            148-462             DB086768.1         230-544
            463-759             AK312738.1         464-760
            760-760             AC079922.5         29523-29523
            761-2497            AK312738.1         762-2498
            2498-3228           BC075818.1         1089-1819
            3229-3229           AC079922.5         46149-46149
            3230-3297           BC075818.1         1821-1888
FEATURES             Location/Qualifiers
     source          1..3297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..3297
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /note="solute carrier family 20 member 1"
                     /db_xref="GeneID:6574"
                     /db_xref="HGNC:HGNC:10946"
                     /db_xref="MIM:137570"
     exon            1..191
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            192..791
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..2497
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /note="gibbon ape leukemia virus receptor 1; leukemia
                     virus receptor 1 homolog; solute carrier family 20
                     (phosphate transporter), member 1"
                     /codon_start=1
                     /product="sodium-dependent phosphate transporter 1"
                     /protein_id="NP_005406.3"
                     /db_xref="CCDS:CCDS2099.1"
                     /db_xref="GeneID:6574"
                     /db_xref="HGNC:HGNC:10946"
                     /db_xref="MIM:137570"
                     /translation="MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDV
                     ANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLL
                     MAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVM
                     SWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGA
                     PLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKN
                     SLKEDHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLP
                     SVDLKEETSIDSTVNGAVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELL
                     HKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGEEMEKLTW
                     PNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDK
                     PEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLL
                     YGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTH
                     CKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM"
     exon            792..932
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1018
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1115
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1235
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1505
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..2064
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2250
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2335
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..3297
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3270..3275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /note="hexamer: AATAAA"
     polyA_site      3297
                     /gene="SLC20A1"
                     /gene_synonym="Glvr-1; GLVR1; PiT-1; PIT1"
                     /note="major polyA site"
ORIGIN      
        1 ggagtgatgg ctgccggcgc tctctgcgtg gttcttcttc tcggccgctg aaacccccgc
       61 ggctgcttcc tgggaaggtc gtgagtcccg ctgagctgtc cccggtgccg ccgacccggg
      121 ccgtgtgccc gtggctccag ccgctgtcgc ctcgatctcc tcgtctcccg ctccgccctc
      181 ccttttccct ggatgaactt gcgtcctttc tcttctccgc catggaattc tgctccgtgc
      241 ttttagccct cctgagccaa agaaacccca gacaacagat gcccatacgc agcgtatagc
      301 agtaactccc cagctcggtt tctgtgccgt agtttacagt atttaatttt atataatata
      361 tattatttat tatagcattt ttgatacctc atattctgtt tacacatctt gaaaggcgct
      421 cagtagttct cttactaaac aaccactact ccagagaatg gcaacgctga ttaccagtac
      481 tacagctgct accgccgctt ctggtccttt ggtggactac ctatggatgc tcatcctggg
      541 cttcattatt gcatttgtct tggcattctc cgtgggagcc aatgatgtag caaattcttt
      601 tggtacagct gtgggctcag gtgtagtgac cctgaagcaa gcctgcatcc tagctagcat
      661 ctttgaaaca gtgggctctg tcttactggg ggccaaagtg agcgaaacca tccggaaggg
      721 cttgattgac gtggagatgt acaactcgac tcaagggctg ctgatggccg gctcagtcag
      781 tgctatgttt ggttctgctg tgtggcaact cgtggcttcg tttttgaagc tccctatttc
      841 tggaacccat tgtattgttg gtgcaactat tggtttctcc ctcgtggcaa aggggcagga
      901 gggtgtcaag tggtctgaac tgataaaaat tgtgatgtct tggttcgtgt ccccactgct
      961 ttctggaatt atgtctggaa ttttattctt cctggttcgt gcattcatcc tccataaggc
     1021 agatccagtt cctaatggtt tgcgagcttt gccagttttc tatgcctgca cagttggaat
     1081 aaacctcttt tccatcatgt atactggagc accgttgctg ggctttgaca aacttcctct
     1141 gtggggtacc atcctcatct cggtgggatg tgcagttttc tgtgccctta tcgtctggtt
     1201 ctttgtatgt cccaggatga agagaaaaat tgaacgagaa ataaagtgta gtccttctga
     1261 aagcccctta atggaaaaaa agaatagctt gaaagaagac catgaagaaa caaagttgtc
     1321 tgttggtgat attgaaaaca agcatcctgt ttctgaggta gggcctgcca ctgtgcccct
     1381 ccaggctgtg gtggaggaga gaacagtctc attcaaactt ggagatttgg aggaagctcc
     1441 agagagagag aggcttccca gcgtggactt gaaagaggaa accagcatag atagcaccgt
     1501 gaatggtgca gtgcagttgc ctaatgggaa ccttgtccag ttcagtcaag ccgtcagcaa
     1561 ccaaataaac tccagtggcc actaccagta tcacaccgtg cataaggatt ccggcctgta
     1621 caaagagcta ctccataaat tacatcttgc caaggtggga gattgcatgg gagactccgg
     1681 tgacaaaccc ttaaggcgca ataatagcta tacttcctat accatggcaa tatgtggcat
     1741 gcctctggat tcattccgtg ccaaagaagg tgaacagaag ggcgaagaaa tggagaagct
     1801 gacatggcct aatgcagact ccaagaagcg aattcgaatg gacagttaca ccagttactg
     1861 caatgctgtg tctgaccttc actcagcatc tgagatagac atgagtgtca aggcagagat
     1921 gggtctaggt gacagaaaag gaagtaatgg ctctctagaa gaatggtatg accaggataa
     1981 gcctgaagtc tctctcctct tccagttcct gcagatcctt acagcctgct ttgggtcatt
     2041 cgcccatggt ggcaatgacg taagcaatgc cattgggcct ctggttgctt tatatttggt
     2101 ttatgacaca ggagatgttt cttcaaaagt ggcaacacca atatggcttc tactctatgg
     2161 tggtgttggt atctgtgttg gtctgtgggt ttggggaaga agagttatcc agaccatggg
     2221 gaaggatctg acaccgatca caccctctag tggcttcagt attgaactgg catctgccct
     2281 cactgtggtg attgcatcaa atattggcct tcccatcagt acaacacatt gtaaagtggg
     2341 ctctgttgtg tctgttggct ggctccggtc caagaaggct gttgactggc gtctctttcg
     2401 taacattttt atggcctggt ttgtcacagt ccccatttct ggagttatca gtgctgccat
     2461 catggcaatc ttcagatatg tcatcctcag aatgtgaagc tgtttgagat taaaatttgt
     2521 gtcaatgttt gggaccatct taggtattcc tgctcccctg aagaatgatt acagtgttaa
     2581 cagaagactg acaagagtct ttttatttgg gagccagagg agggaagtgt tacttgtgct
     2641 ataactgctt ttgtgctaaa tatgaattgt ctcaaaatta gctgtgtaaa atagcccggg
     2701 ttccactggc tcctgctgag gtcccctttc cttctgggct gtgaattcct gtacatattt
     2761 ctctactttt tgtatcaggc ttcaattcca ttatgtttta atgttgtctc tgaagatgac
     2821 ttgtgatttt tttttctttt ttttaaacca tgaagagccg tttgacagag catgctctgc
     2881 gttgttggtt tcaccagctt ctgccctcac atgcacaggg atttaacaac aaaaatataa
     2941 ctacaacttc ccttgtagtc tcttatataa gtagagtcct tggtactctg ccctcctgtc
     3001 agtagtggca ggatctattg gcatattcgg gagcttctta gagggatgag gttctttgaa
     3061 cacagtgaaa atttaaatta gtaacttttt tgcaagcagt ttattgactg ttattgctaa
     3121 gaagaagtaa gaaagaaaaa gcctgttggc aatcttggtt atttctttaa gatttctggc
     3181 agtgtgggat ggatgaatga agtggaatgt gaactttggg caagttaagt gggacagcct
     3241 tccatgttca tttgtctacc tcttaactga ataaaaaagc ctacagtttt tagaaaa
//
