LOCUS       NM_005628               2882 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens solute carrier family 1 member 5 (SLC1A5), transcript
            variant 1, mRNA.
ACCESSION   NM_005628
VERSION     NM_005628.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Borowska,A.M., Chiariello,M.G., Garaeva,A.A., Rheinberger,J.,
            Marrink,S.J., Paulino,C. and Slotboom,D.J.
  TITLE     Structural basis of the obligatory exchange mode of human neutral
            amino acid transporter ASCT2
  JOURNAL   Nat Commun 15 (1), 6570 (2024)
   PUBMED   39095408
  REMARK    GeneRIF: Structural basis of the obligatory exchange mode of human
            neutral amino acid transporter ASCT2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2882)
  AUTHORS   Yang,R., Zhang,S., Wang,L., Chen,Y., Chen,X., Xia,J., Ren,X.,
            Cheng,B. and Chen,X.
  TITLE     Radiation-induced exosomes promote oral squamous cell carcinoma
            progression via enhancing SLC1A5-glutamine metabolism
  JOURNAL   J Oral Pathol Med 53 (7), 458-467 (2024)
   PUBMED   38802300
  REMARK    GeneRIF: Radiation-induced exosomes promote oral squamous cell
            carcinoma progression via enhancing SLC1A5-glutamine metabolism.
REFERENCE   3  (bases 1 to 2882)
  AUTHORS   Zhang,G., Yu,J. and Wan,Y.
  TITLE     USP48 deubiquitination stabilizes SLC1A5 to inhibit retinal pigment
            epithelium cell inflammation, oxidative stress and ferroptosis in
            the progression of diabetic retinopathy
  JOURNAL   J Bioenerg Biomembr 56 (3), 311-321 (2024)
   PUBMED   38427128
  REMARK    GeneRIF: USP48 deubiquitination stabilizes SLC1A5 to inhibit
            retinal pigment epithelium cell inflammation, oxidative stress and
            ferroptosis in the progression of diabetic retinopathy.
REFERENCE   4  (bases 1 to 2882)
  AUTHORS   Zhang,Z., Liu,W., Huang,T., Li,J., Hu,H., Xu,X. and Fan,Z.
  TITLE     CircCPA4 induces ASCT2 expression to promote tumor property of
            non-small cell lung cancer cells in a miR-145-5p-dependent manner
  JOURNAL   Thorac Cancer 15 (10), 764-777 (2024)
   PUBMED   38400818
  REMARK    GeneRIF: CircCPA4 induces ASCT2 expression to promote tumor
            property of non-small cell lung cancer cells in a
            miR-145-5p-dependent manner.
REFERENCE   5  (bases 1 to 2882)
  AUTHORS   Awad,S., Skipper,W., Vostrejs,W., Ozorowski,K., Min,K., Pfuhler,L.,
            Mehta,D. and Cooke,A.
  TITLE     The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5
            mRNA in proliferating and differentiating skeletal muscle cells
  JOURNAL   J Biol Chem 300 (2), 105602 (2024)
   PUBMED   38159852
  REMARK    GeneRIF: The YBX3 RNA-binding protein posttranscriptionally
            controls SLC1A5 mRNA in proliferating and differentiating skeletal
            muscle cells.
REFERENCE   6  (bases 1 to 2882)
  AUTHORS   Tailor,C.S., Marin,M., Nouri,A., Kavanaugh,M.P. and Kabat,D.
  TITLE     Truncated forms of the dual function human ASCT2 neutral amino acid
            transporter/retroviral receptor are translationally initiated at
            multiple alternative CUG and GUG codons
  JOURNAL   J Biol Chem 276 (29), 27221-27230 (2001)
   PUBMED   11350958
REFERENCE   7  (bases 1 to 2882)
  AUTHORS   Broer,A., Wagner,C., Lang,F. and Broer,S.
  TITLE     Neutral amino acid transporter ASCT2 displays substrate-induced Na+
            exchange and a substrate-gated anion conductance
  JOURNAL   Biochem J 346 Pt 3 (Pt 3), 705-710 (2000)
   PUBMED   10698697
REFERENCE   8  (bases 1 to 2882)
  AUTHORS   Tailor,C.S., Nouri,A., Zhao,Y., Takeuchi,Y. and Kabat,D.
  TITLE     A sodium-dependent neutral-amino-acid transporter mediates
            infections of feline and baboon endogenous retroviruses and simian
            type D retroviruses
  JOURNAL   J Virol 73 (5), 4470-4474 (1999)
   PUBMED   10196349
REFERENCE   9  (bases 1 to 2882)
  AUTHORS   Rasko,J.E., Battini,J.L., Gottschalk,R.J., Mazo,I. and Miller,A.D.
  TITLE     The RD114/simian type D retrovirus receptor is a neutral amino acid
            transporter
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2129-2134 (1999)
   PUBMED   10051606
REFERENCE   10 (bases 1 to 2882)
  AUTHORS   Kekuda,R., Prasad,P.D., Fei,Y.J., Torres-Zamorano,V., Sinha,S.,
            Yang-Feng,T.L., Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning of the sodium-dependent, broad-scope, neutral amino acid
            transporter Bo from a human placental choriocarcinoma cell line
  JOURNAL   J Biol Chem 271 (31), 18657-18661 (1996)
   PUBMED   8702519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008622.6, U53347.1, AB209738.1 and AK301661.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005628.2.
            
            Summary: The SLC1A5 gene encodes a sodium-dependent neutral amino
            acid transporter that can act as a receptor for RD114/type D
            retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by
            OMIM, Jan 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF105423.1, AK292690.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000542575.6/ ENSP00000444408.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC008622.6         73641-73649         c
            10-43               U53347.1           1-34
            44-1740             AB209738.1         1-1697
            1741-2563           AK301661.1         596-1418
            2564-2882           AC008622.6         59938-60256         c
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..2882
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /note="solute carrier family 1 member 5"
                     /db_xref="GeneID:6510"
                     /db_xref="HGNC:HGNC:10943"
                     /db_xref="MIM:109190"
     exon            1..1195
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..2255
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     baboon M7 virus receptor; RD114 virus receptor; neutral
                     amino acid transporter B; neutral amino acid transporter
                     B(0); ATB(0); RD114/simian type D retrovirus receptor;
                     sodium-dependent neutral amino acid transporter type 2;
                     solute carrier family 1 (neutral amino acid transporter),
                     member 5; Alanine/serine/cysteine transporter 2; ASC amino
                     acid transporter-2"
                     /codon_start=1
                     /product="neutral amino acid transporter B(0) isoform 1"
                     /protein_id="NP_005619.1"
                     /db_xref="CCDS:CCDS12692.1"
                     /db_xref="GeneID:6510"
                     /db_xref="HGNC:HGNC:10943"
                     /db_xref="MIM:109190"
                     /translation="MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQ
                     VRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRM
                     IILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASA
                     AINASVGAAGSAENAPSKEVLDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRV
                     KVPVGQEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWY
                     APVGIMFLVAGKIVEMEDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPY
                     RFLWGIVTPLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAAL
                     FQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVNLPV
                     DHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDRTESRSTEPELIQVKSELPLD
                     PLPVPTEEGNPLLKHYRGPAGDATVASEKESVM"
     exon            1196..1238
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1286
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1453
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1687
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1882
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2017
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2882
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /note="hexamer: AATAAA"
     polyA_site      2882
                     /gene="SLC1A5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC"
                     /note="major polyA site"
ORIGIN      
        1 agagccacgc ggcacgcccg ggaggctttc tctggctggt aaccgctact cccggacacc
       61 agaccaccgc cttccgtaca caggggcccg catcccaccc tcccggacct aagagcctgg
      121 gtcccctgtt tccggaggtc cgcttcccgg cccccagatt ctggcatccc agccctcagt
      181 gtccaagacc caggcagccc gggtccccgc ctcccggatc caggcgtccg ggatctgcgc
      241 caccagaacc tagcctcctg cagacctccg ccatctgggg gcactcaacc tcctggagcc
      301 aagggcccca cgtcccaccc agagaaactc tcgtattccc agctcctagg gccaaggaac
      361 ccgggcgctc cgaactccca gctttcggac atctggcaca cggggcagag cagagaagcc
      421 tcagcgccca gcctggggaa tttaaacact ccagcttcca agagccaagg aacttcagtg
      481 ctgtgaactc acaactctaa ggagccctcc aaagttccag tctccaggtg ctgttactca
      541 actcagtcct aggaacgtcg ggtcctggga aggagcccaa gcgctcccag ccagcttcca
      601 ggcgctaaga aaccccggtg cttcccatca tggtggccga tcctcctcga gactccaagg
      661 ggctcgcagc ggcggagccc accgccaacg ggggcctggc gctggcctcc atcgaggacc
      721 aaggcgcggc agcaggcggc tactgcggtt cccgggacca ggtgcgccgc tgccttcgag
      781 ccaacctgct tgtgctgctg acagtggtgg ccgtggtggc cggcgtggcg ctgggactgg
      841 gggtgtcggg ggccgggggt gcgctggcgt tgggcccgga gcgcttgagc gccttcgtct
      901 tcccgggcga gctgctgctg cgtctgctgc ggatgatcat cttgccgctg gtggtgtgca
      961 gcttgatcgg cggcgccgcc agcctggacc ccggcgcgct cggccgtctg ggcgcctggg
     1021 cgctgctctt tttcctggtc accacgctgc tggcgtcggc gctcggagtg ggcttggcgc
     1081 tggctctgca gccgggcgcc gcctccgccg ccatcaacgc ctccgtggga gccgcgggca
     1141 gtgccgaaaa tgcccccagc aaggaggtgc tcgattcgtt cctggatctt gcgagaaata
     1201 tcttcccttc caacctggtg tcagcagcct ttcgctcata ctctaccacc tatgaagaga
     1261 ggaatatcac cggaaccagg gtgaaggtgc ccgtggggca ggaggtggag gggatgaaca
     1321 tcctgggctt ggtagtgttt gccatcgtct ttggtgtggc gctgcggaag ctggggcctg
     1381 aaggggagct gcttatccgc ttcttcaact ccttcaatga ggccaccatg gttctggtct
     1441 cctggatcat gtggtacgcc cctgtgggca tcatgttcct ggtggctggc aagatcgtgg
     1501 agatggagga tgtgggttta ctctttgccc gccttggcaa gtacattctg tgctgcctgc
     1561 tgggtcacgc catccatggg ctcctggtac tgcccctcat ctacttcctc ttcacccgca
     1621 aaaaccccta ccgcttcctg tggggcatcg tgacgccgct ggccactgcc tttgggacct
     1681 cttccagttc cgccacgctg ccgctgatga tgaagtgcgt ggaggagaat aatggcgtgg
     1741 ccaagcacat cagccgtttc atcctgccca tcggcgccac cgtcaacatg gacggtgccg
     1801 cgctcttcca gtgcgtggcc gcagtgttca ttgcacagct cagccagcag tccttggact
     1861 tcgtaaagat catcaccatc ctggtcacgg ccacagcgtc cagcgtgggg gcagcgggca
     1921 tccctgctgg aggtgtcctc actctggcca tcatcctcga agcagtcaac ctcccggtcg
     1981 accatatctc cttgatcctg gctgtggact ggctagtcga ccggtcctgt accgtcctca
     2041 atgtagaagg tgacgctctg ggggcaggac tcctccaaaa ttacgtggac cgtacggagt
     2101 cgagaagcac agagcctgag ttgatacaag tgaagagtga gctgcccctg gatccgctgc
     2161 cagtccccac tgaggaagga aaccccctcc tcaaacacta tcgggggccc gcaggggatg
     2221 ccacggtcgc ctctgagaag gaatcagtca tgtaaacccc gggagggacc ttccctgccc
     2281 tgctgggggt gctctttgga cactggatta tgaggaatgg ataaatggat gagctagggc
     2341 tctgggggtc tgcctgcaca ctctggggag ccaggggccc cagcaccctc caggacagga
     2401 gatctgggat gcctggctgc tggagtacat gtgttcacaa gggttactcc tcaaaacccc
     2461 cagttctcac tcatgtcccc aactcaaggc tagaaaacag caagatggag aaataatgtt
     2521 ctgctgcgtc cccaccgtga cctgcctggc ctcccctgtc tcagggagca ggtcacaggt
     2581 caccatgggg aattctagcc cccactgggg ggatgttaca acaccatgct ggttattttg
     2641 gcggctgtag ttgtgggggg atgtgtgtgt gcacgtgtgt gtgtgtgtgt gtgtgtgtgt
     2701 gtgtgtgtgt gttctgtgac ctcctgtccc catggtacgt cccaccctgt ccccagatcc
     2761 cctattccct ccacaataac agaaacactc ccagggactc tggggagagg ctgaggacaa
     2821 atacctgctg tcactccaga ggacattttt tttagcaata aaattgagtg tcaactattt
     2881 aa
//
