LOCUS       NM_052831               2452 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 18 member B1 (SLC18B1), mRNA.
ACCESSION   NM_052831
VERSION     NM_052831.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Hiasa,M., Miyaji,T., Haruna,Y., Takeuchi,T., Harada,Y.,
            Moriyama,S., Yamamoto,A., Omote,H. and Moriyama,Y.
  TITLE     Identification of a mammalian vesicular polyamine transporter
  JOURNAL   Sci Rep 4, 6836 (2014)
   PUBMED   25355561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Jacobsson,J.A., Stephansson,O. and Fredriksson,R.
  TITLE     C6ORF192 forms a unique evolutionary branch among solute carriers
            (SLC16, SLC17, and SLC18) and is abundantly expressed in several
            brain regions
  JOURNAL   J Mol Neurosci 41 (2), 230-242 (2010)
   PUBMED   19697161
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137783.12, CD635228.1, BC069570.1, AK124442.1 and CB218467.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052831.2.
            
            Summary: This gene encodes a protein, which has high sequence
            similarity to rat, xenopus and zebrafish proteins. The protein
            function is unknown. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124442.1, AK289918.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275227.9/ ENSP00000275227.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL137783.12        384-412             c
            30-333              CD635228.1         1-304
            334-510             BC069570.1         225-401
            511-2444            AK124442.1         361-2294
            2445-2452           CB218467.1         236-243
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..2452
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /note="solute carrier family 18 member B1"
                     /db_xref="GeneID:116843"
                     /db_xref="HGNC:HGNC:21573"
                     /db_xref="MIM:613361"
     exon            1..224
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1552
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /note="MFS-type transporter C6orf192; solute carrier
                     family 18, subfamily B, member 1; vesicular polyamine
                     transporter"
                     /codon_start=1
                     /product="MFS-type transporter SLC18B1"
                     /protein_id="NP_439896.1"
                     /db_xref="CCDS:CCDS5163.1"
                     /db_xref="GeneID:116843"
                     /db_xref="HGNC:HGNC:21573"
                     /db_xref="MIM:613361"
                     /translation="MEALGDLEGPRAPGGDDPAGSAGETPGWLSREQVFVLISAASVN
                     LGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFM
                     FVAGMFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFP
                     NNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPN
                     YESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLV
                     FLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWL
                     LVLILVVSGLSAGMSIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGP
                     TLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTT
                     LLPNET"
     exon            225..364
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            365..460
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            461..534
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            535..682
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            683..839
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            840..976
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1078
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1170
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1266
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1341
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1435
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1485
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..2452
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2427..2432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /note="hexamer: AATAAA"
     polyA_site      2452
                     /gene="SLC18B1"
                     /gene_synonym="C6orf192; dJ55C23.6; VPAT"
                     /note="major polyA site"
ORIGIN      
        1 agagtcctgg aaggctttgg ggagctccgg gccgggcgga tcgctgcctg cagggagtcg
       61 gggatgccag gttccagctg agcagcggcc gcccgccaga gtgccagtgg ctccttggag
      121 gtcgagtcca aggacgtggc ttgaagccgg gagctggggc gccggagtcc acgcaccggg
      181 gatggaggcg ctgggtgacc tggagggacc acgcgcacca ggaggtgatg atcctgcagg
      241 aagtgcagga gagacccccg ggtggctttc gagagaacag gtttttgtac tgatatcggc
      301 agcttcggtg aacttaggtt ccatgatgtg ctattctata cttggaccgt ttttccccaa
      361 agaggctgaa aagaagggag ccagcaatac aattatcggt atgatctttg gatgttttgc
      421 tttgttcgag ttgctggcat ccttggtatt tggaaactat cttgtacata ttggagcaaa
      481 atttatgttt gtagcaggaa tgtttgtctc aggaggagtt acaattctct ttggtgtatt
      541 ggaccgagtt ccagatgggc cagtatttat tgctatgtgt tttctagtga gagtaatgga
      601 tgcagttagc tttgctgcag caatgactgc atcttcttct atcctggcaa aggcttttcc
      661 aaataacgtg gctacggtat tgggaagtct tgagactttt tctggactgg ggctaatact
      721 aggtcctcct gtaggtggct ttttgtatca atcctttggc tatgaagtgc cttttattgt
      781 tctgggatgc gtcgttttgc tgatggtacc actcaatatg tatattttac ccaattacga
      841 gtctgatcca ggtgaacact cattctggaa actgatcgct ttacccaaag ttggccttat
      901 agccttcgtc atcaactcac tcagctcgtg ttttggcttc ctcgatccta ctctgtctct
      961 ctttgttttg gagaagttca atttaccagc tggatatgtg ggactagtat tcctgggtat
     1021 ggcactgtcc tatgccatct cttcaccact atttggtctc ctaagtgata aaaggccacc
     1081 tctaaggaaa tggcttctgg tgtttggcaa cttaatcaca gccgggtgct acatgctctt
     1141 agggcctgtc ccaatcttgc atattaaaag tcagctctgg ctgctggtgc tgatattagt
     1201 tgtaagtggc ctctctgctg gaatgagtat aattccaact ttcccggaaa ttctcagttg
     1261 tgcacatgaa aatgggtttg aagagggatt aagtacattg ggacttgtat caggtctttt
     1321 tagtgcaatg tggtcaattg gtgcttttat gggaccaacg ctgggtggat ttctgtatga
     1381 gaaaattggt tttgaatggg cagcagctat acaaggtcta tgggctctga taagtggatt
     1441 agccatgggc ttgttttatc tactggagta ttcaaggaga aaaaggtcta aatctcaaaa
     1501 catcctcagc acagaggagg aacgaactac tctcttgcct aatgaaacct agtccgatgg
     1561 atcctggatt gatacaaggt tgagaaatga atgctcctgg ccttaaacat caccgtagga
     1621 agggttttta aaattttacg cgcaaaactc cgtggacccc gtgccagtgt cttggaagtg
     1681 tcaacgtgtt tttggatgat cctgtattgg gctgtactta ctgtgatact gaaaagctgt
     1741 cctgctgaag cagctatatt tgaaatatta agtatgaaag gagtaattaa aaacaagcaa
     1801 aacaaaacaa gacttagttt ttaaatgacc aaacttgtcc ttaaagatgt tgttattaac
     1861 tcgagttagt tcttatttcc tctgtttatt ttttattcta agtacactga ttctgtgaat
     1921 gtaccttttt tattaacagg gaaagaaatg aattaatttg atatgctcta aatacataaa
     1981 ggtgcttcaa aatatgtaga aacattacta tgaaatcagt ttttaaaaga tatactttct
     2041 ctttgtcctg aggtttttcg gtcttgttca aaaggaagaa ttcttgcctg ccatacagaa
     2101 actctctagc actccctgac cttaagcttt tctaaaaatt ctgtttgtgt gaaaagtaca
     2161 agaataacaa tacttacaac ttccattttt gtaacctacg ttcacttatg atctggattt
     2221 ataaacatta cttggtataa cgtttttcat ttcctttaat gtctctgttt tttggctcta
     2281 ccatctgttt tgtttttgtt tttatctata tcttggtaga tgtatttcat ccctagagca
     2341 ggtcagcctc cttcccctaa tgcgaatgct tgttttgtta gggaagggct tcctccaact
     2401 tcgtgtgaaa ttgtgatgtt gaagtgaata aatgtctatt gtgtaactct ca
//
