LOCUS       NM_022082               3518 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens solute carrier family 17 member 9 (SLC17A9),
            transcript variant 1, mRNA.
ACCESSION   NM_022082
VERSION     NM_022082.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Li,H., Liu,J., Lai,J., Su,X., Wang,X., Cao,J., Mao,S., Zhang,T. and
            Gu,Q.
  TITLE     The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties
            and tumorigenesis in HCC
  JOURNAL   J Transl Med 22 (1), 537 (2024)
   PUBMED   38844969
  REMARK    GeneRIF: The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like
            properties and tumorigenesis in HCC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Xu,Z., Yu,Y., Ni,H., Sun,W. and Kuang,Y.
  TITLE     LINC01836 Promotes Colorectal Cancer Progression and Functions as
            ceRNA to Target SLC17A9 by Sponging miR-1226-3p
  JOURNAL   Protein Pept Lett 31 (1), 43-60 (2024)
   PUBMED   38058092
  REMARK    GeneRIF: LINC01836 Promotes Colorectal Cancer Progression and
            Functions as ceRNA to Target SLC17A9 by Sponging miR-1226-3p.
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Soeda,M., Ohka,S., Nishizawa,D., Hasegawa,J., Nakayama,K.,
            Ebata,Y., Fukuda,K.I. and Ikeda,K.
  TITLE     Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are
            significantly associated with phantom tooth pain
  JOURNAL   Mol Pain 18, 17448069221089592 (2022)
   PUBMED   35266813
  REMARK    GeneRIF: Single-nucleotide polymorphisms of the SLC17A9 and P2RY12
            genes are significantly associated with phantom tooth pain.
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Hasuzawa,N., Tatsushima,K., Tokubuchi,R., Kabashima,M. and
            Nomura,M.
  TITLE     [VNUT Is a Therapeutic Target for Type 2 Diabetes and NASH]
  JOURNAL   Yakugaku Zasshi 141 (4), 517-526 (2021)
   PUBMED   33790119
  REMARK    GeneRIF: [VNUT Is a Therapeutic Target for Type 2 Diabetes and
            NASH].
            Review article
REFERENCE   5  (bases 1 to 3518)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3518)
  AUTHORS   Inoue,K., Komatsu,R., Imura,Y., Fujishita,K., Shibata,K.,
            Moriyama,Y. and Koizumi,S.
  TITLE     Mechanism underlying ATP release in human epidermal keratinocytes
  JOURNAL   J Invest Dermatol 134 (5), 1465-1468 (2014)
   PUBMED   24292772
  REMARK    GeneRIF: It is suggested that the functions of VNUT, in addition to
            P2 receptors may be a target for anti-inflammatory response in
            skin.
REFERENCE   7  (bases 1 to 3518)
  AUTHORS   Sesma,J.I., Kreda,S.M., Okada,S.F., van Heusden,C., Moussa,L.,
            Jones,L.C., O'Neal,W.K., Togawa,N., Hiasa,M., Moriyama,Y. and
            Lazarowski,E.R.
  TITLE     Vesicular nucleotide transporter regulates the nucleotide content
            in airway epithelial mucin granules
  JOURNAL   Am J Physiol Cell Physiol 304 (10), C976-C984 (2013)
   PUBMED   23467297
  REMARK    GeneRIF: These results suggest that SLC17A9 is the relevant
            nucleotide transporter responsible for the uptake of cytosolic
            nucleotides into mucin granules.
            Erratum:[Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C415]
REFERENCE   8  (bases 1 to 3518)
  AUTHORS   Sathe,M.N., Woo,K., Kresge,C., Bugde,A., Luby-Phelps,K., Lewis,M.A.
            and Feranchak,A.P.
  TITLE     Regulation of purinergic signaling in biliary epithelial cells by
            exocytosis of SLC17A9-dependent ATP-enriched vesicles
  JOURNAL   J Biol Chem 286 (28), 25363-25376 (2011)
   PUBMED   21613220
  REMARK    GeneRIF: the existence of an SLC17A9-dependent ATP-enriched
            vesicular pool in biliary epithelium that undergoes regulated
            exocytosis to initiate purinergic signaling.
REFERENCE   9  (bases 1 to 3518)
  AUTHORS   Tokunaga,A., Tsukimoto,M., Harada,H., Moriyama,Y. and Kojima,S.
  TITLE     Involvement of SLC17A9-dependent vesicular exocytosis in the
            mechanism of ATP release during T cell activation
  JOURNAL   J Biol Chem 285 (23), 17406-17416 (2010)
   PUBMED   20382737
  REMARK    GeneRIF: analysis of involvement of SLC17A9-dependent vesicular
            exocytosis in the mechanism of ATP release during T cell activation
REFERENCE   10 (bases 1 to 3518)
  AUTHORS   Sawada,K., Echigo,N., Juge,N., Miyaji,T., Otsuka,M., Omote,H.,
            Yamamoto,A. and Moriyama,Y.
  TITLE     Identification of a vesicular nucleotide transporter
  JOURNAL   Proc Natl Acad Sci U S A 105 (15), 5683-5686 (2008)
   PUBMED   18375752
  REMARK    GeneRIF: SLC17A9 protein acts as a vesicular nucleotide transporter
            (VNUT) and plays an essential role in vesicular storage of ATP in
            the ATP-secreting cells [SLC17A9]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121673.41.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_022082.3.
            
            Summary: This gene encodes a member of a family of transmembrane
            proteins that are involved in the transport of small molecules. The
            encoded protein participates in the vesicular uptake, storage, and
            secretion of adenoside triphosphate (ATP) and other nucleotides. A
            mutation in this gene was found in individuals with autosomal
            dominant disseminated superficial actinic porokeratosis-8.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095473.1, BC038593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370351.9/ ENSP00000359376.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AL121673.41        13326-13506
            182-379             AL121673.41        17382-17579
            380-519             AL121673.41        18058-18197
            520-619             AL121673.41        21121-21220
            620-750             AL121673.41        23241-23371
            751-847             AL121673.41        23890-23986
            848-944             AL121673.41        24201-24297
            945-1032            AL121673.41        24845-24932
            1033-1067           AL121673.41        25749-25783
            1068-1183           AL121673.41        26227-26342
            1184-1239           AL121673.41        27142-27197
            1240-1269           AL121673.41        27320-27349
            1270-3518           AL121673.41        27954-30202
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3518
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="solute carrier family 17 member 9"
                     /db_xref="GeneID:63910"
                     /db_xref="HGNC:HGNC:16192"
                     /db_xref="MIM:612107"
     exon            1..181
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1433
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vesicular nucleotide transporter SLC17A9; solute carrier
                     family 17 (vesicular nucleotide transporter), member 9;
                     voltage-gated purine nucleotide uniporter SLC17A9"
                     /codon_start=1
                     /product="voltage-gated purine nucleotide uniporter
                     SLC17A9 isoform 1"
                     /protein_id="NP_071365.4"
                     /db_xref="CCDS:CCDS42901.1"
                     /db_xref="GeneID:63910"
                     /db_xref="HGNC:HGNC:16192"
                     /db_xref="MIM:612107"
                     /translation="MQPPPDEARRDMAGDTQWSRPECQAWTGTLLLGTCLLYCARSSM
                     PICTVSMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGS
                     ITAVTPLLAHLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVG
                     AGSQFGTLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEKDLILALGVL
                     AQSRPVSRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGW
                     IFNVVPWLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSS
                     FCESVVFASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGY
                     LMETTGSWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHEDL"
     exon            182..379
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            380..519
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            520..619
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            620..750
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            751..847
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            848..944
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1032
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1067
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1183
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1239
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1269
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..3518
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="hexamer: ATTAAA"
     polyA_site      2530
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="major polyA site"
     regulatory      3498..3503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
ORIGIN      
        1 agacggaagc gcgctgggac tgacacgtgg acttgggcgg tgctgcccgg gtgggtcagc
       61 ctgggctggg aggcagcccc gggacacagc tgtgcccacg ccgtctgagc accccaagcc
      121 cgatgcagcc acccccagac gaggcccgca gggacatggc cggggacacc cagtggtcca
      181 ggcccgagtg ccaggcatgg acggggacgc tgctgctggg cacatgcctt ctgtactgcg
      241 cccgctccag catgcccatc tgcaccgtct ccatgagcca ggacttcggc tggaacaaga
      301 aggaggccgg catcgtgctc agcagcttct tctggggcta ctgcctgaca caggttgtgg
      361 gcggccacct cggggatcgg attgggggtg agaaggtcat cctgctgtca gcctctgcct
      421 ggggctccat cacggccgtc accccactgc tcgcccacct gagcagtgcc cacctggcct
      481 tcatgacctt ctcacgcatc ctcatgggct tgctccaagg ggtttacttc cctgccctga
      541 ccagcctgct gtcgcagaag gtgcgggaga gtgagcgagc cttcacctac agcatcgtgg
      601 gcgccggctc ccagtttggg acgctgctga ccggggcggt gggctccctg ctcctggaat
      661 ggtacggctg gcagagcatc ttctatttct ccggcggcct caccttgctt tgggtgtggt
      721 acgtgtacag gtacctgctg agtgaaaaag atctcatcct ggccttgggt gtcctggccc
      781 aaagccggcc ggtgtccagg cacaacagag tcccctggag acggctcttc cggaagcctg
      841 ctgtctgggc agccgtcgtc tcccagctct ctgcagcctg ctccttcttc atcctcctct
      901 cctggctgcc caccttcttc gaggagacct tccccgacgc caagggctgg atcttcaacg
      961 tggttccttg gttggtggcg attccggcca gtctattcag cgggtttctc tctgatcatc
     1021 tcatcaatca gggttacaga gccatcacgg tgcggaagct catgcagggc atgggccttg
     1081 gcctctccag cgtctttgct ctgtgcctgg gccacacctc cagcttctgt gagtctgtgg
     1141 tctttgcatc agcctccatc ggcctccaga ccttcaacca cagtggcatt tctgttaaca
     1201 tccaggactt ggccccgtcc tgcgccggct ttctgtttgg tgtggccaac acagccgggg
     1261 ccttggcagg tgtcgtgggt gtgtgtctag gcggctactt gatggagacc acgggctcct
     1321 ggacttgcct gttcaacctt gtggccatca tcagcaacct ggggctgtgc accttcctgg
     1381 tgtttggaca ggctcagagg gtggacctga gctctaccca tgaggacctc tagctcccaa
     1441 ccccacagcc tctccaagga cccaggcgcc agcagcccca ggacacaggg gactcagtgt
     1501 gtgggacttg gtcactccat gtcagacaca cgagcagaga ggaacacaaa ccactgtgga
     1561 gcctgaagct ccttaagaag agtccacaac agctggtggg agggtggggt gggcctgggt
     1621 ccagaccagg ctcgctgctc tctgggcctc agtttcccca cctgccagcg ggctcggccc
     1681 tgtcctcctc acaggctggt gtggccgtca gggtgggtgg ggttattgtt agtaggcgca
     1741 gcctcattcc caccacgatc tgttccgcgt ggttcccgcc aaacctccct cggtcgccgt
     1801 gttctccgca agcctcctgc agcgcccgcc tgccaatgtg aggctggcac caggctgcag
     1861 cctccccaat cccagcccac tttgctgtgt ctctggcggg ctgtcctcct tggtgggagc
     1921 tgtcctgcac actgtaggat gcttaaaggt atccctggcc tccacccacc cctagccagc
     1981 agctcccagt cagacaacag ccagaaatgt ctccagactc tgcccagcct ccccaggtag
     2041 ccaccctcga gacacgacct cagagtctct gtgtctccta gaagcctgac agagaccccc
     2101 agggcagtgg gtgggtggcg ggctagagac ccttgcctgt gtccgggacc ctggcgccgc
     2161 tctcccctcc tgtggatccc tccgcactaa cagtgttctc agtgggcaga cgcctgggca
     2221 ccccttgggc cctgcccagc atggccatgg cgcaggctct cgaacccgca tggctttccc
     2281 aggcctggtg attctgctct ccagggacgg ttggcacctt cctcgggggc gggccccacg
     2341 caccccagaa cacacagacc cacctttctg gcgttctttc tacctccctt ttcgttgcct
     2401 gaggagctgg tggtttcatg agttaatgat acatcttgca aggtgtacac atagagaaaa
     2461 aaacctaaaa atgtggaaaa gcacgccaaa gccttattta aataataact attaaactat
     2521 tcaaaaagaa gactgttatt ttatttaaca cctttgtttt ttaagaatga acacgtgtta
     2581 aagactttct gtaactaatt tcatgaggaa acgagtgaca cgttggaatc aggtcaaagg
     2641 agaatcccag gaacggactc ctaggccggg agtgttgaaa tgagcatgcc agcagagcca
     2701 ggctgggttt cggggttcct ttgccgccag gggtcctgcg tgtccacaga tgacagcgat
     2761 gtaccctgct atcagctgtc cacccagctt tcccaagatg tggggccccc atggagtcag
     2821 acagcccagc tgtgctgtgg aaagacaaag tggagttttg cacttgagca caaatgttcc
     2881 cctacaatct ctccagtttc ggtcagccca accctgtggc accatgggta cagcctagag
     2941 catcaccccc acagaggctt cgggacggtc ctgctggact gctggacgct gctgtggggt
     3001 cttggggcag gaggggcttc cagaagcctg gcagttgctg tctggaggcc aggaagccaa
     3061 gcccaggaag cccacctgcg gctgagttca gaggtggggc ctgtgcgttg tgaatgaatt
     3121 gctgtctctc tcctcctcat cttgcactaa atctacataa cttaaaattt accattttag
     3181 ccatttttaa gtgcacggtt ctgtggcatt aggtacattc gcattgtgca gccaccgcca
     3241 ccctccgcct tcagaacttt ctcatcttcc caaaccgaag ctctgtgctc attaaaggct
     3301 agctccccgt tgctctcccc cagccccggc aaccccattc cactttgtgt ctcgaccgta
     3361 agtgtggctg ctctgggacc agtgccagtg ggcgcacgct gggtttgcct acgtctggct
     3421 tacttcactc agcagagtgt ccttcggttt tatcagtttt gtcacaagtg tcagcatttt
     3481 tctcattttt aaggctgaat aaaatattgt gtggataa
//
