LOCUS       NM_001302643            3580 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens solute carrier family 17 member 9 (SLC17A9),
            transcript variant 2, mRNA.
ACCESSION   NM_001302643 XM_005260228
VERSION     NM_001302643.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3580)
  AUTHORS   Li,H., Liu,J., Lai,J., Su,X., Wang,X., Cao,J., Mao,S., Zhang,T. and
            Gu,Q.
  TITLE     The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties
            and tumorigenesis in HCC
  JOURNAL   J Transl Med 22 (1), 537 (2024)
   PUBMED   38844969
  REMARK    GeneRIF: The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like
            properties and tumorigenesis in HCC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3580)
  AUTHORS   Xu,Z., Yu,Y., Ni,H., Sun,W. and Kuang,Y.
  TITLE     LINC01836 Promotes Colorectal Cancer Progression and Functions as
            ceRNA to Target SLC17A9 by Sponging miR-1226-3p
  JOURNAL   Protein Pept Lett 31 (1), 43-60 (2024)
   PUBMED   38058092
  REMARK    GeneRIF: LINC01836 Promotes Colorectal Cancer Progression and
            Functions as ceRNA to Target SLC17A9 by Sponging miR-1226-3p.
REFERENCE   3  (bases 1 to 3580)
  AUTHORS   Soeda,M., Ohka,S., Nishizawa,D., Hasegawa,J., Nakayama,K.,
            Ebata,Y., Fukuda,K.I. and Ikeda,K.
  TITLE     Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are
            significantly associated with phantom tooth pain
  JOURNAL   Mol Pain 18, 17448069221089592 (2022)
   PUBMED   35266813
  REMARK    GeneRIF: Single-nucleotide polymorphisms of the SLC17A9 and P2RY12
            genes are significantly associated with phantom tooth pain.
REFERENCE   4  (bases 1 to 3580)
  AUTHORS   Hasuzawa,N., Tatsushima,K., Tokubuchi,R., Kabashima,M. and
            Nomura,M.
  TITLE     [VNUT Is a Therapeutic Target for Type 2 Diabetes and NASH]
  JOURNAL   Yakugaku Zasshi 141 (4), 517-526 (2021)
   PUBMED   33790119
  REMARK    GeneRIF: [VNUT Is a Therapeutic Target for Type 2 Diabetes and
            NASH].
            Review article
REFERENCE   5  (bases 1 to 3580)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3580)
  AUTHORS   Inoue,K., Komatsu,R., Imura,Y., Fujishita,K., Shibata,K.,
            Moriyama,Y. and Koizumi,S.
  TITLE     Mechanism underlying ATP release in human epidermal keratinocytes
  JOURNAL   J Invest Dermatol 134 (5), 1465-1468 (2014)
   PUBMED   24292772
  REMARK    GeneRIF: It is suggested that the functions of VNUT, in addition to
            P2 receptors may be a target for anti-inflammatory response in
            skin.
REFERENCE   7  (bases 1 to 3580)
  AUTHORS   Sesma,J.I., Kreda,S.M., Okada,S.F., van Heusden,C., Moussa,L.,
            Jones,L.C., O'Neal,W.K., Togawa,N., Hiasa,M., Moriyama,Y. and
            Lazarowski,E.R.
  TITLE     Vesicular nucleotide transporter regulates the nucleotide content
            in airway epithelial mucin granules
  JOURNAL   Am J Physiol Cell Physiol 304 (10), C976-C984 (2013)
   PUBMED   23467297
  REMARK    GeneRIF: These results suggest that SLC17A9 is the relevant
            nucleotide transporter responsible for the uptake of cytosolic
            nucleotides into mucin granules.
            Erratum:[Am J Physiol Cell Physiol. 2014 Feb 15;306(4):C415]
REFERENCE   8  (bases 1 to 3580)
  AUTHORS   Sathe,M.N., Woo,K., Kresge,C., Bugde,A., Luby-Phelps,K., Lewis,M.A.
            and Feranchak,A.P.
  TITLE     Regulation of purinergic signaling in biliary epithelial cells by
            exocytosis of SLC17A9-dependent ATP-enriched vesicles
  JOURNAL   J Biol Chem 286 (28), 25363-25376 (2011)
   PUBMED   21613220
  REMARK    GeneRIF: the existence of an SLC17A9-dependent ATP-enriched
            vesicular pool in biliary epithelium that undergoes regulated
            exocytosis to initiate purinergic signaling.
REFERENCE   9  (bases 1 to 3580)
  AUTHORS   Tokunaga,A., Tsukimoto,M., Harada,H., Moriyama,Y. and Kojima,S.
  TITLE     Involvement of SLC17A9-dependent vesicular exocytosis in the
            mechanism of ATP release during T cell activation
  JOURNAL   J Biol Chem 285 (23), 17406-17416 (2010)
   PUBMED   20382737
  REMARK    GeneRIF: analysis of involvement of SLC17A9-dependent vesicular
            exocytosis in the mechanism of ATP release during T cell activation
REFERENCE   10 (bases 1 to 3580)
  AUTHORS   Sawada,K., Echigo,N., Juge,N., Miyaji,T., Otsuka,M., Omote,H.,
            Yamamoto,A. and Moriyama,Y.
  TITLE     Identification of a vesicular nucleotide transporter
  JOURNAL   Proc Natl Acad Sci U S A 105 (15), 5683-5686 (2008)
   PUBMED   18375752
  REMARK    GeneRIF: SLC17A9 protein acts as a vesicular nucleotide transporter
            (VNUT) and plays an essential role in vesicular storage of ATP in
            the ATP-secreting cells [SLC17A9]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121673.41.
            
            On Jun 1, 2019 this sequence version replaced NM_001302643.1.
            
            Summary: This gene encodes a member of a family of transmembrane
            proteins that are involved in the transport of small molecules. The
            encoded protein participates in the vesicular uptake, storage, and
            secretion of adenoside triphosphate (ATP) and other nucleotides. A
            mutation in this gene was found in individuals with autosomal
            dominant disseminated superficial actinic porokeratosis-8.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (2) contains an alternate exon in
            the 5' UTR and 5' coding region and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (2) has a distinct, shorter N-terminus than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025312.1, SRR14038193.1189322.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AL121673.41        13326-13506
            182-243             AL121673.41        13828-13889
            244-441             AL121673.41        17382-17579
            442-581             AL121673.41        18058-18197
            582-681             AL121673.41        21121-21220
            682-812             AL121673.41        23241-23371
            813-909             AL121673.41        23890-23986
            910-1006            AL121673.41        24201-24297
            1007-1094           AL121673.41        24845-24932
            1095-1129           AL121673.41        25749-25783
            1130-1245           AL121673.41        26227-26342
            1246-1301           AL121673.41        27142-27197
            1302-1331           AL121673.41        27320-27349
            1332-3580           AL121673.41        27954-30202
FEATURES             Location/Qualifiers
     source          1..3580
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..3580
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="solute carrier family 17 member 9"
                     /db_xref="GeneID:63910"
                     /db_xref="HGNC:HGNC:16192"
                     /db_xref="MIM:612107"
     exon            1..181
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            182..243
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1495
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="isoform 2 is encoded by transcript variant 2;
                     vesicular nucleotide transporter SLC17A9; solute carrier
                     family 17 (vesicular nucleotide transporter), member 9;
                     voltage-gated purine nucleotide uniporter SLC17A9"
                     /codon_start=1
                     /product="voltage-gated purine nucleotide uniporter
                     SLC17A9 isoform 2"
                     /protein_id="NP_001289572.2"
                     /db_xref="CCDS:CCDS77600.1"
                     /db_xref="GeneID:63910"
                     /db_xref="HGNC:HGNC:16192"
                     /db_xref="MIM:612107"
                     /translation="MTLTSRRQDSQEARPECQAWTGTLLLGTCLLYCARSSMPICTVS
                     MSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGSITAVTP
                     LLAHLSSAHLAFMTFSRILMGLLQGVYFPALTSLLSQKVRESERAFTYSIVGAGSQFG
                     TLLTGAVGSLLLEWYGWQSIFYFSGGLTLLWVWYVYRYLLSEKDLILALGVLAQSRPV
                     SRHNRVPWRRLFRKPAVWAAVVSQLSAACSFFILLSWLPTFFEETFPDAKGWIFNVVP
                     WLVAIPASLFSGFLSDHLINQGYRAITVRKLMQGMGLGLSSVFALCLGHTSSFCESVV
                     FASASIGLQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLGGYLMETTG
                     SWTCLFNLVAIISNLGLCTFLVFGQAQRVDLSSTHEDL"
     exon            244..441
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            442..581
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            582..681
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            682..812
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            813..909
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1006
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1094
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1129
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1245
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1301
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1331
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..3580
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="hexamer: ATTAAA"
     polyA_site      2592
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="major polyA site"
     regulatory      3560..3565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
                     /note="hexamer: AATAAA"
     polyA_site      3580
                     /gene="SLC17A9"
                     /gene_synonym="C20orf59; POROK8; VNUT"
ORIGIN      
        1 agacggaagc gcgctgggac tgacacgtgg acttgggcgg tgctgcccgg gtgggtcagc
       61 ctgggctggg aggcagcccc gggacacagc tgtgcccacg ccgtctgagc accccaagcc
      121 cgatgcagcc acccccagac gaggcccgca gggacatggc cggggacacc cagtggtcca
      181 ggtggaacca ccctgtgtat gcatgaccct gacaagcagg cgccaggaca gtcaggaggc
      241 caggcccgag tgccaggcat ggacggggac gctgctgctg ggcacatgcc ttctgtactg
      301 cgcccgctcc agcatgccca tctgcaccgt ctccatgagc caggacttcg gctggaacaa
      361 gaaggaggcc ggcatcgtgc tcagcagctt cttctggggc tactgcctga cacaggttgt
      421 gggcggccac ctcggggatc ggattggggg tgagaaggtc atcctgctgt cagcctctgc
      481 ctggggctcc atcacggccg tcaccccact gctcgcccac ctgagcagtg cccacctggc
      541 cttcatgacc ttctcacgca tcctcatggg cttgctccaa ggggtttact tccctgccct
      601 gaccagcctg ctgtcgcaga aggtgcggga gagtgagcga gccttcacct acagcatcgt
      661 gggcgccggc tcccagtttg ggacgctgct gaccggggcg gtgggctccc tgctcctgga
      721 atggtacggc tggcagagca tcttctattt ctccggcggc ctcaccttgc tttgggtgtg
      781 gtacgtgtac aggtacctgc tgagtgaaaa agatctcatc ctggccttgg gtgtcctggc
      841 ccaaagccgg ccggtgtcca ggcacaacag agtcccctgg agacggctct tccggaagcc
      901 tgctgtctgg gcagccgtcg tctcccagct ctctgcagcc tgctccttct tcatcctcct
      961 ctcctggctg cccaccttct tcgaggagac cttccccgac gccaagggct ggatcttcaa
     1021 cgtggttcct tggttggtgg cgattccggc cagtctattc agcgggtttc tctctgatca
     1081 tctcatcaat cagggttaca gagccatcac ggtgcggaag ctcatgcagg gcatgggcct
     1141 tggcctctcc agcgtctttg ctctgtgcct gggccacacc tccagcttct gtgagtctgt
     1201 ggtctttgca tcagcctcca tcggcctcca gaccttcaac cacagtggca tttctgttaa
     1261 catccaggac ttggccccgt cctgcgccgg ctttctgttt ggtgtggcca acacagccgg
     1321 ggccttggca ggtgtcgtgg gtgtgtgtct aggcggctac ttgatggaga ccacgggctc
     1381 ctggacttgc ctgttcaacc ttgtggccat catcagcaac ctggggctgt gcaccttcct
     1441 ggtgtttgga caggctcaga gggtggacct gagctctacc catgaggacc tctagctccc
     1501 aaccccacag cctctccaag gacccaggcg ccagcagccc caggacacag gggactcagt
     1561 gtgtgggact tggtcactcc atgtcagaca cacgagcaga gaggaacaca aaccactgtg
     1621 gagcctgaag ctccttaaga agagtccaca acagctggtg ggagggtggg gtgggcctgg
     1681 gtccagacca ggctcgctgc tctctgggcc tcagtttccc cacctgccag cgggctcggc
     1741 cctgtcctcc tcacaggctg gtgtggccgt cagggtgggt ggggttattg ttagtaggcg
     1801 cagcctcatt cccaccacga tctgttccgc gtggttcccg ccaaacctcc ctcggtcgcc
     1861 gtgttctccg caagcctcct gcagcgcccg cctgccaatg tgaggctggc accaggctgc
     1921 agcctcccca atcccagccc actttgctgt gtctctggcg ggctgtcctc cttggtggga
     1981 gctgtcctgc acactgtagg atgcttaaag gtatccctgg cctccaccca cccctagcca
     2041 gcagctccca gtcagacaac agccagaaat gtctccagac tctgcccagc ctccccaggt
     2101 agccaccctc gagacacgac ctcagagtct ctgtgtctcc tagaagcctg acagagaccc
     2161 ccagggcagt gggtgggtgg cgggctagag acccttgcct gtgtccggga ccctggcgcc
     2221 gctctcccct cctgtggatc cctccgcact aacagtgttc tcagtgggca gacgcctggg
     2281 caccccttgg gccctgccca gcatggccat ggcgcaggct ctcgaacccg catggctttc
     2341 ccaggcctgg tgattctgct ctccagggac ggttggcacc ttcctcgggg gcgggcccca
     2401 cgcaccccag aacacacaga cccacctttc tggcgttctt tctacctccc ttttcgttgc
     2461 ctgaggagct ggtggtttca tgagttaatg atacatcttg caaggtgtac acatagagaa
     2521 aaaaacctaa aaatgtggaa aagcacgcca aagccttatt taaataataa ctattaaact
     2581 attcaaaaag aagactgtta ttttatttaa cacctttgtt ttttaagaat gaacacgtgt
     2641 taaagacttt ctgtaactaa tttcatgagg aaacgagtga cacgttggaa tcaggtcaaa
     2701 ggagaatccc aggaacggac tcctaggccg ggagtgttga aatgagcatg ccagcagagc
     2761 caggctgggt ttcggggttc ctttgccgcc aggggtcctg cgtgtccaca gatgacagcg
     2821 atgtaccctg ctatcagctg tccacccagc tttcccaaga tgtggggccc ccatggagtc
     2881 agacagccca gctgtgctgt ggaaagacaa agtggagttt tgcacttgag cacaaatgtt
     2941 cccctacaat ctctccagtt tcggtcagcc caaccctgtg gcaccatggg tacagcctag
     3001 agcatcaccc ccacagaggc ttcgggacgg tcctgctgga ctgctggacg ctgctgtggg
     3061 gtcttggggc aggaggggct tccagaagcc tggcagttgc tgtctggagg ccaggaagcc
     3121 aagcccagga agcccacctg cggctgagtt cagaggtggg gcctgtgcgt tgtgaatgaa
     3181 ttgctgtctc tctcctcctc atcttgcact aaatctacat aacttaaaat ttaccatttt
     3241 agccattttt aagtgcacgg ttctgtggca ttaggtacat tcgcattgtg cagccaccgc
     3301 caccctccgc cttcagaact ttctcatctt cccaaaccga agctctgtgc tcattaaagg
     3361 ctagctcccc gttgctctcc cccagccccg gcaaccccat tccactttgt gtctcgaccg
     3421 taagtgtggc tgctctggga ccagtgccag tgggcgcacg ctgggtttgc ctacgtctgg
     3481 cttacttcac tcagcagagt gtccttcggt tttatcagtt ttgtcacaag tgtcagcatt
     3541 tttctcattt ttaaggctga ataaaatatt gtgtggataa
//
