LOCUS       NM_020346               3665 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens solute carrier family 17 member 6 (SLC17A6), mRNA.
ACCESSION   NM_020346
VERSION     NM_020346.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3665)
  AUTHORS   Buck,S.A., Erickson-Oberg,M.Q., Bhatte,S.H., McKellar,C.D.,
            Ramanathan,V.P., Rubin,S.A. and Freyberg,Z.
  TITLE     Roles of VGLUT2 and Dopamine/Glutamate Co-Transmission in Selective
            Vulnerability to Dopamine Neurodegeneration
  JOURNAL   ACS Chem Neurosci 13 (2), 187-193 (2022)
   PUBMED   34994539
  REMARK    GeneRIF: Roles of VGLUT2 and Dopamine/Glutamate Co-Transmission in
            Selective Vulnerability to Dopamine Neurodegeneration.
            Review article
REFERENCE   2  (bases 1 to 3665)
  AUTHORS   Cheret,C., Ganzella,M., Preobraschenski,J., Jahn,R. and
            Ahnert-Hilger,G.
  TITLE     Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic
            Phosphate Levels
  JOURNAL   Cell Rep 34 (2), 108623 (2021)
   PUBMED   33440152
REFERENCE   3  (bases 1 to 3665)
  AUTHORS   Wang,L., Chen,S.R., Ma,H., Chen,H., Hittelman,W.N. and Pan,H.L.
  TITLE     Regulating nociceptive transmission by VGluT2-expressing spinal
            dorsal horn neurons
  JOURNAL   J Neurochem 147 (4), 526-540 (2018)
   PUBMED   30203849
  REMARK    GeneRIF: These findings indicate that VGluT2-expressing excitatory
            neurons play a crucial role in mediating nociceptive transmission
            in the spinal dorsal horn
REFERENCE   4  (bases 1 to 3665)
  AUTHORS   McCollum,L.A. and Roberts,R.C.
  TITLE     Uncovering the role of the nucleus accumbens in schizophrenia: A
            postmortem analysis of tyrosine hydroxylase and vesicular glutamate
            transporters
  JOURNAL   Schizophr Res 169 (1-3), 369-373 (2015)
   PUBMED   26386900
  REMARK    GeneRIF: This study demonstrated that Protein levels of vGLUT2 were
            significantly increased in schizophrenia subjects compared to
            controls.
REFERENCE   5  (bases 1 to 3665)
  AUTHORS   Gautier,H.O., Evans,K.A., Volbracht,K., James,R., Sitnikov,S.,
            Lundgaard,I., James,F., Lao-Peregrin,C., Reynolds,R., Franklin,R.J.
            and Karadottir,R.T.
  TITLE     Neuronal activity regulates remyelination via glutamate signalling
            to oligodendrocyte progenitors
  JOURNAL   Nat Commun 6, 8518 (2015)
   PUBMED   26439639
  REMARK    GeneRIF: Vglut2 and oligodendrocyte progenitor cells co-localize in
            multiple sclerosis lesions, supporting evidence that neuronal
            activity and release of glutamate instruct OPCs to differentiate
            into new myelinating oligodendrocytes that recover lost function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3665)
  AUTHORS   Kashani,A., Lepicard,E., Poirel,O., Videau,C., David,J.P.,
            Fallet-Bianco,C., Simon,A., Delacourte,A., Giros,B., Epelbaum,J.,
            Betancur,C. and El Mestikawy,S.
  TITLE     Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated
            with cognitive decline in Alzheimer disease
  JOURNAL   Neurobiol Aging 29 (11), 1619-1630 (2008)
   PUBMED   17531353
  REMARK    GeneRIF: Our results suggest that VGLUT1 expression in the
            prefrontal cortex could be used as a valuable neurochemical marker
            of dementia in AD.
REFERENCE   7  (bases 1 to 3665)
  AUTHORS   Tsutsumi,S., Kamata,N., Vokes,T.J., Maruoka,Y., Nakakuki,K.,
            Enomoto,S., Omura,K., Amagasa,T., Nagayama,M., Saito-Ohara,F.,
            Inazawa,J., Moritani,M., Yamaoka,T., Inoue,H. and Itakura,M.
  TITLE     The novel gene encoding a putative transmembrane protein is mutated
            in gnathodiaphyseal dysplasia (GDD)
  JOURNAL   Am J Hum Genet 74 (6), 1255-1261 (2004)
   PUBMED   15124103
REFERENCE   8  (bases 1 to 3665)
  AUTHORS   Takamori,S., Rhee,J.S., Rosenmund,C. and Jahn,R.
  TITLE     Identification of differentiation-associated brain-specific
            phosphate transporter as a second vesicular glutamate transporter
            (VGLUT2)
  JOURNAL   J Neurosci 21 (22), RC182 (2001)
   PUBMED   11698620
REFERENCE   9  (bases 1 to 3665)
  AUTHORS   Aihara,Y., Onda,H., Teraoka,M., Yokoyama,Y., Seino,Y., Kasuya,H.,
            Hori,T., Tomura,H., Inoue,I., Kojima,I. and Takeda,J.
  TITLE     Assignment of SLC17A6 (alias DNPI), the gene encoding
            brain/pancreatic islet-type Na+-dependent inorganic phosphate
            cotransporter to human chromosome 11p14.3
  JOURNAL   Cytogenet Cell Genet 92 (1-2), 167-169 (2001)
   PUBMED   11306821
REFERENCE   10 (bases 1 to 3665)
  AUTHORS   Aihara,Y., Mashima,H., Onda,H., Hisano,S., Kasuya,H., Hori,T.,
            Yamada,S., Tomura,H., Yamada,Y., Inoue,I., Kojima,I. and Takeda,J.
  TITLE     Molecular cloning of a novel brain-type Na(+)-dependent inorganic
            phosphate cotransporter
  JOURNAL   J Neurochem 74 (6), 2622-2625 (2000)
   PUBMED   10820226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA392769.1, AB032435.1, CK823303.1, BQ188116.1 and BQ185289.1.
            
            On May 17, 2019 this sequence version replaced NM_020346.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.225536.1,
                                           SRR1660803.154912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263160.4/ ENSP00000263160.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               DA392769.1         285-587
            304-2729            AB032435.1         564-2989
            2730-2801           CK823303.1         517-588
            2802-3358           BQ188116.1         31-587
            3359-3665           BQ185289.1         14-320              c
FEATURES             Location/Qualifiers
     source          1..3665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.3"
     gene            1..3665
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /note="solute carrier family 17 member 6"
                     /db_xref="GeneID:57084"
                     /db_xref="HGNC:HGNC:16703"
                     /db_xref="MIM:607563"
     exon            1..239
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1902
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /note="differentiation-associated Na-dependent inorganic
                     phosphate cotransporter; differentiation-associated
                     Na(+)-dependent inorganic phosphate cotransporter;
                     differentiation-associated BNPI; solute carrier family 17
                     (vesicular glutamate transporter), member 6; solute
                     carrier family 17 (sodium-dependent inorganic phosphate
                     cotransporter), member 6"
                     /codon_start=1
                     /product="vesicular glutamate transporter 2"
                     /protein_id="NP_065079.1"
                     /db_xref="CCDS:CCDS7856.1"
                     /db_xref="GeneID:57084"
                     /db_xref="HGNC:HGNC:16703"
                     /db_xref="MIM:607563"
                     /translation="MESVKQRILAPGKEGLKNFAGKSLGQIYRVLEKKQDTGETIELT
                     EDGKPLEVPERKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNS
                     TIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAIL
                     LTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTS
                     FCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITD
                     EERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQP
                     AYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGG
                     FGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISN
                     GVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGEKQPWADP
                     EETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATTQANGGWPSGWEKKEEFVQ
                     GEVQDSHSYKDRVDYS"
     exon            240..492
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..611
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            612..726
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..814
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..901
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1044
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1194
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1327
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1438
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1566
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..3665
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3633..3638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /note="hexamer: AATAAA"
     polyA_site      3665
                     /gene="SLC17A6"
                     /gene_synonym="DNPI; VGLUT2"
                     /note="major polyA site"
ORIGIN      
        1 actctcactc ttgctggagg cgagccacta ccattctgct gagaaggaaa agcccgcaac
       61 tactttaaga gattaagaca atatgcgcaa tcctcgcctt tcctagcaat cactatttaa
      121 atctggcaag aactgacaac agtctttgca agaatggaat ccgtaaaaca aaggattttg
      181 gccccaggaa aagaggggct aaagaatttt gctggaaaat cactcggcca gatctacagg
      241 gtgctggaga agaagcaaga caccggggag acaatcgagc tgacggagga tgggaagccc
      301 ctagaggtgc ccgagaggaa ggcgccgctg tgcgactgca cgtgcttcgg cctgccccgc
      361 cgctacatta tcgccatcat gagcggcctg ggcttctgca tctccttcgg tatccgctgc
      421 aacctgggcg tggccattgt ggacatggtc aacaacagca ccatccaccg cgggggcaag
      481 gtcatcaagg agaaagccaa attcaactgg gacccggaaa ccgtggggat gatccacggt
      541 tccttctttt ggggctacat catcactcag attccgggag gctacatcgc gtctcggctg
      601 gcagccaaca gggttttcgg agctgccata cttcttacct ctaccctaaa tatgctaatt
      661 ccatcagcag ccagagtgca ttatggatgt gtcatctttg tcagaatact gcagggactt
      721 gttgagggtg tgacctaccc agcatgtcat gggatatgga gcaaatgggc cccacctcta
      781 gagaggagta gactggcaac cacctccttt tgtggttcct atgccggagc tgtgattgca
      841 atgcctttag ctggcattct tgtgcagtac actggctggt cttcagtgtt ttatgtctac
      901 ggaagctttg gaatggtctg gtacatgttt tggcttttgg tgtcttatga aagtcctgca
      961 aagcatccta ctattacaga tgaagaacgt aggtacatag aagaaagcat tggagagagt
     1021 gcaaatcttt taggtgcaat ggaaaaattc aagactccat ggaggaagtt ttttacatcc
     1081 atgccagtct atgcaataat tgttgcaaac ttctgcagaa gctggacttt ttatttattg
     1141 cttattagtc agccagcata ttttgaggaa gtctttggat ttgaaattag caaggttggt
     1201 atgctatctg ctgtgccaca cttagtaatg acaattattg tgcctattgg gggacaaatt
     1261 gcagattttc taagaagcaa gcagattctt tcaactacga cagtgagaaa gatcatgaat
     1321 tgtggtggtt ttggcatgga agccacactg ctcctggtcg ttggctattc tcatactaga
     1381 ggggtagcaa tctcattctt ggtacttgca gtgggattca gtggatttgc tatatctggt
     1441 ttcaatgtta accacttgga tatcgctcca agatatgcca gtatcttaat gggcatttcg
     1501 aatggtgttg gcacattgtc aggaatggtt tgtcctatca ttgttggtgc aatgacaaag
     1561 aataagtcac gtgaagagtg gcagtatgtc ttcctgatcg ctgccctagt ccactatggt
     1621 ggagttatat tttatgcaat atttgcctca ggagagaaac aaccctgggc agacccggag
     1681 gaaacaagtg aagaaaaatg tggatttatt catgaagatg aactcgatga agaaacaggg
     1741 gacattactc aaaattatat aaattatggt accaccaagt cttatggtgc cacaacacag
     1801 gccaatggag gttggcctag tggttgggaa aagaaagagg aatttgtaca aggagaagta
     1861 caagactcac atagctataa ggaccgagtt gattattcat aacaaaacta attactggat
     1921 ttatttttag tgtttgtgat taaattcatt gtgattgcac aaaaatttta aaaacacgtg
     1981 atgtaaactt gcaagcatat caaccaggca agtcttgctg taaaaatgaa aacaaaacaa
     2041 acccatgagg ttaccatcaa gtgcaatctg taaaattgtg aagttccatc atttccattc
     2101 aagtcatcca ttcttgcatt tgtgacttaa aggttgactg gtcaaaattg tagaaacaag
     2161 tagttaccca ttggattcat atgagctaaa actcatcact atttactaaa gcacaacatc
     2221 tcatcctaca aaagttaaga agccaaagct acttgatcat gcaaaatgca cttatatatt
     2281 tgttacactg tattgcaaga tagcacacag aagttggctg cgtcaagtag aggcgacatt
     2341 tattaagtga aaatcatgga gttgggatat ctctcaatta aagaaataca ttgtgaacta
     2401 tcagctacaa agttgtactg aataactatt agaattgcat aatgtgagat attttgttag
     2461 tcctcaaaag gaatatcttg cagtgttttc tatgaaatgc ttgggcacaa acacttattt
     2521 ctgtgaaaga gaacatgtaa gttgaggggt atgcttcatg ttcttccatc catttaccta
     2581 atagtatgaa acagttcaca tttcaataaa atcaaacttt tcatgtagcg tatcacataa
     2641 cttttttgca aaaaatataa aaagaaataa acttcaatgt attttttatt acaactttgt
     2701 actggttgta acttgcatta gaaaaaaaag agatatatac accacaaaga atctaataag
     2761 aaatttatta tggagatata gcccttaaaa tgcaatatta agaacaaaga aatagaaaat
     2821 ggtttagata tctttcttcc ttcataatta aatactatat gaaacttgtg ccacagagct
     2881 atatataata tgaaaagatt aacttcatag agatattgta agtaggtaat tttattattt
     2941 aaagtcctat taagaaatat ttgtcttaaa tatataggac aatacattat attaaaatgg
     3001 tctctctcta tatatatctg tatatcttat acatgtccat acacagaaac ataataaaca
     3061 atcttcacac gaaaccaaaa atagcataca cctaatgttg ggttagggaa ttgcaatttc
     3121 tactttcata gagtcataga attttaggtg gggaagaggc attttgcttg tcatttctta
     3181 atataactca acaagaattg caacatttgt gtaccaagca ataagtgcaa tgcataaaat
     3241 ttcctgtctg tatattacct tcattttgct tgtagtagct gtttgggtgg ttggaataat
     3301 tttatttttc ttttaaaaaa gctaacatca gaccccttta taatgtccta aaattatgat
     3361 aatacatttc ccaattcaac tcaaaatatt attggtgtat tttgtctatt ctggatattt
     3421 gatctgttca atgtactgtg ctagtgactg gaggccctgc tactgcaaat ataaaacata
     3481 aagtttgttt aaaaaaatgc aaatcattct ttaccttaag aaaaaaaaaa taccctttgc
     3541 tttgtgcctc aaagtgatgt aatgtgatca cagcttttgt tgtgttgaat gaaaatatgt
     3601 ggactgtcat tttgttgcag caaaaaagtg ttaataaaat gctctattta tccttttttt
     3661 aaaaa
//
