LOCUS       NM_005495               3581 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 17 member 4 (SLC17A4),
            transcript variant 1, mRNA.
ACCESSION   NM_005495
VERSION     NM_005495.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3581)
  AUTHORS   Li,H., Gu,J., Tian,Y., Li,S., Zhang,H., Dai,Z., Wang,Z., Zhang,N.
            and Peng,R.
  TITLE     A prognostic signature consisting of metabolism-related genes and
            SLC17A4 serves as a potential biomarker of immunotherapeutic
            prediction in prostate cancer
  JOURNAL   Front Immunol 13, 982628 (2022)
   PUBMED   36325340
  REMARK    GeneRIF: A prognostic signature consisting of metabolism-related
            genes and SLC17A4 serves as a potential biomarker of
            immunotherapeutic prediction in prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3581)
  AUTHORS   Groeneweg,S., van Geest,F.S., Chen,Z., Farina,S., van
            Heerebeek,R.E.A., Meima,M.E., Peeters,R.P., Heuer,H., Medici,M. and
            Visser,W.E.
  TITLE     Functional Characterization of the Novel and Specific Thyroid
            Hormone Transporter SLC17A4
  JOURNAL   Thyroid 32 (3), 326-335 (2022)
   PUBMED   34937426
  REMARK    GeneRIF: Functional Characterization of the Novel and Specific
            Thyroid Hormone Transporter SLC17A4.
REFERENCE   3  (bases 1 to 3581)
  AUTHORS   Teumer,A., Chaker,L., Groeneweg,S., Li,Y., Di Munno,C.,
            Barbieri,C., Schultheiss,U.T., Traglia,M., Ahluwalia,T.S.,
            Akiyama,M., Appel,E.V.R., Arking,D.E., Arnold,A., Astrup,A.,
            Beekman,M., Beilby,J.P., Bekaert,S., Boerwinkle,E., Brown,S.J., De
            Buyzere,M., Campbell,P.J., Ceresini,G., Cerqueira,C., Cucca,F.,
            Deary,I.J., Deelen,J., Eckardt,K.U., Ekici,A.B., Eriksson,J.G.,
            Ferrrucci,L., Fiers,T., Fiorillo,E., Ford,I., Fox,C.S.,
            Fuchsberger,C., Galesloot,T.E., Gieger,C., Gogele,M., De Grandi,A.,
            Grarup,N., Greiser,K.H., Haljas,K., Hansen,T., Harris,S.E., van
            Heemst,D., den Heijer,M., Hicks,A.A., den Hollander,W., Homuth,G.,
            Hui,J., Ikram,M.A., Ittermann,T., Jensen,R.A., Jing,J.,
            Jukema,J.W., Kajantie,E., Kamatani,Y., Kasbohm,E., Kaufman,J.M.,
            Kiemeney,L.A., Kloppenburg,M., Kronenberg,F., Kubo,M., Lahti,J.,
            Lapauw,B., Li,S., Liewald,D.C.M., Lim,E.M., Linneberg,A.,
            Marina,M., Mascalzoni,D., Matsuda,K., Medenwald,D., Meisinger,C.,
            Meulenbelt,I., De Meyer,T., Meyer Zu Schwabedissen,H.E.,
            Mikolajczyk,R., Moed,M., Netea-Maier,R.T., Nolte,I.M., Okada,Y.,
            Pala,M., Pattaro,C., Pedersen,O., Petersmann,A., Porcu,E.,
            Postmus,I., Pramstaller,P.P., Psaty,B.M., Ramos,Y.F.M., Rawal,R.,
            Redmond,P., Richards,J.B., Rietzschel,E.R., Rivadeneira,F.,
            Roef,G., Rotter,J.I., Sala,C.F., Schlessinger,D., Selvin,E.,
            Slagboom,P.E., Soranzo,N., Sorensen,T.I.A., Spector,T.D.,
            Starr,J.M., Stott,D.J., Taes,Y., Taliun,D., Tanaka,T., Thuesen,B.,
            Tiller,D., Toniolo,D., Uitterlinden,A.G., Visser,W.E., Walsh,J.P.,
            Wilson,S.G., Wolffenbuttel,B.H.R., Yang,Q., Zheng,H.F., Cappola,A.,
            Peeters,R.P., Naitza,S., Volzke,H., Sanna,S., Kottgen,A.,
            Visser,T.J. and Medici,M.
  CONSRTM   Lifelines Cohort Study
  TITLE     Genome-wide analyses identify a role for SLC17A4 and AADAT in
            thyroid hormone regulation
  JOURNAL   Nat Commun 9 (1), 4455 (2018)
   PUBMED   30367059
  REMARK    GeneRIF: Thyroid hormone transporter (SLC17A4) single nucleotide
            polymorphism is associated with replicated free thyroxine (FT4)
            susceptibility loci in genome wide association study. Genetic
            variant SLC17A4-rs9356988 is associated with the
            3,3',5-triiodothyronine (T3)/T4 ratio.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3581)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 3581)
  AUTHORS   Togawa,N., Miyaji,T., Izawa,S., Omote,H. and Moriyama,Y.
  TITLE     A Na+-phosphate cotransporter homologue (SLC17A4 protein) is an
            intestinal organic anion exporter
  JOURNAL   Am J Physiol Cell Physiol 302 (11), C1652-C1660 (2012)
   PUBMED   22460716
  REMARK    GeneRIF: SLC17A4 is an intestinal organic anion exporter that acts
            in delta-psi and Chloride dependent manners
REFERENCE   6  (bases 1 to 3581)
  AUTHORS   Middelberg,R.P., Ferreira,M.A., Henders,A.K., Heath,A.C.,
            Madden,P.A., Montgomery,G.W., Martin,N.G. and Whitfield,J.B.
  TITLE     Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are
            associated with multiple cardiovascular-related traits
  JOURNAL   BMC Med Genet 12, 123 (2011)
   PUBMED   21943158
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3581)
  AUTHORS   Elmariah,S. and Gunn,R.B.
  TITLE     Kinetic evidence that the Na-PO4 cotransporter is the molecular
            mechanism for Na/Li exchange in human red blood cells
  JOURNAL   Am J Physiol Cell Physiol 285 (2), C446-C456 (2003)
   PUBMED   12672655
REFERENCE   8  (bases 1 to 3581)
  AUTHORS   Shibui,A., Tsunoda,T., Seki,N., Suzuki,Y., Sugane,K. and Sugano,S.
  TITLE     Isolation and chromosomal mapping of a novel human gene showing
            homology to Na+/PO4 cotransporter
  JOURNAL   J Hum Genet 44 (3), 190-192 (1999)
   PUBMED   10319585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB020527.1 and AL391194.13.
            
            On May 17, 2019 this sequence version replaced NM_005495.2.
            
            Summary: Phosphate homeostasis is maintained by regulating intake,
            intestinal absorption, bone deposition and resorption, and renal
            excretion of phosphate. The central molecule in the control of
            phosphate excretion from the kidney is the sodium/phosphate
            cotransporter NPT1 (SLC17A1; MIM 182308), which is located in the
            renal proximal tubule. NPT1 uses the transmembrane electrochemical
            potential gradient of sodium to transport phosphate across the cell
            membrane. SLC17A4 is a similar sodium/phosphate cotransporter in
            the intestinal mucosa that plays an important role in the
            absorption of phosphate from the intestine (summary by Shibui et
            al., 1999 [PubMed 10319585]).[supplied by OMIM, Feb 2011].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024903.1, AB020527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377905.9/ ENSP00000367137.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AB020527.1         33-290
            259-304             AL391194.13        26363-26408
            305-1545            AB020527.1         337-1577
            1546-3557           AL391194.13        36451-38462
            3558-3581           AL391194.13        38463-38486
FEATURES             Location/Qualifiers
     source          1..3581
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..3581
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /note="solute carrier family 17 member 4"
                     /db_xref="GeneID:10050"
                     /db_xref="HGNC:HGNC:10932"
                     /db_xref="MIM:604216"
     exon            1..40
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            41..167
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1570
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /note="isoform a is encoded by transcript variant 1;
                     Na/PO4 cotransporter; solute carrier family 17 (sodium
                     phosphate), member 4; probable small intestine urate
                     exporter; putative small intestine sodium-dependent
                     phosphate transport protein"
                     /codon_start=1
                     /product="probable small intestine urate exporter isoform
                     a"
                     /protein_id="NP_005486.1"
                     /db_xref="CCDS:CCDS4564.1"
                     /db_xref="GeneID:10050"
                     /db_xref="HGNC:HGNC:10932"
                     /db_xref="MIM:604216"
                     /translation="MSTGPDVKATVGDISSDGNLNVAQEECSRKGFCSVRHGLALILQ
                     LCNFSIYTQQMNLSIAIPAMVNNTAPPSQPNASTERPSTDSQGYWNETLKEFKAMAPA
                     YDWSPEIQGIILSSLNYGSFLAPIPSGYVAGIFGAKYVVGAGLFISSFLTLFIPLAAN
                     AGVALLIVLRIVQGIAQVMVLTGQYSIWVKWAPPLERSQLTTIAGSGSMLGSFIVLLA
                     GGLLCQTIGWPYVFYIFGGIGCACCPLWFPLIYDDPVNHPFISAGEKRYIVCSLAQQD
                     CSPGWSLPIRAMIKSLPLWAILVSYFCEYWLFYTIMAYTPTYISSVLQANLRDSGILS
                     ALPFVVGCICIILGGLLADFLLSRKILRLITIRKLFTAIGVLFPSVILVSLPWVRSSH
                     SMTMTFLVLSSAISSFCESGALVNFLDIAPRYTGFLKGLLQVFAHIAGAISPTAAGFF
                     ISQDSEFGWRNVFLLSAAVNISGLVFYLIFGRADVQDWAKEQTFTHL"
     exon            168..373
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            374..607
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            608..695
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            696..782
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            783..901
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1063
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1196
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1344
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1435
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..3581
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /note="hexamer: AATGAA"
     polyA_site      2599
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /note="major polyA site"
     regulatory      3560..3565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /note="hexamer: AAGAAA"
     polyA_site      3577
                     /gene="SLC17A4"
                     /gene_synonym="KAIA2138"
                     /note="major polyA site"
ORIGIN      
        1 atttgaaagg aatgaggatc ctgcactctt cctccctcag taagtaaatg ccagtcccta
       61 ggaagagaga accaaaatgt ctaccggacc agatgtcaag gctacagtgg gggacatttc
      121 cagtgatggc aatttaaacg tggctcaaga ggaatgctcc aggaaaggtt tttgttcagt
      181 ccgacatggg ctggccctca tcttgcagct ctgtaatttt tcaatttaca cccaacaaat
      241 gaacttgagc attgccatcc cagctatggt gaacaacaca gccccaccta gccagcccaa
      301 tgcttccaca gaacggccct ccactgactc ccagggctac tggaatgaaa ctctaaaaga
      361 atttaaagca atggcccctg catatgactg gagtcctgaa atccagggaa tcatcctcag
      421 ctccctcaac tatggctcat tcttggctcc aatccccagt ggctatgtgg ctggaatatt
      481 tggagccaag tatgtggttg gtgctggctt gtttatttcc tcattcctga ccctcttcat
      541 tccactggca gctaatgcgg gagtggcctt gctcattgtc ctccggattg tacaaggcat
      601 agcccaggtt atggtattaa ctggtcagta ttcaatttgg gtcaaatggg ctcccccact
      661 ggaaaggagt caactcacca ccattgctgg atcagggtca atgctggggt ccttcattgt
      721 tctacttgct ggtggtctcc tctgccagac cataggatgg ccttacgtct tctatatctt
      781 tggaggaatt ggctgtgctt gttgtcctct ctggtttcct ctcatttatg atgatcctgt
      841 gaatcatccc tttatcagtg ctggtgagaa gagatacatt gtgtgttcat tggctcagca
      901 ggactgttca ccaggctggt ctcttcccat tagggctatg atcaaatcct taccactctg
      961 ggccatttta gtctcttatt tctgtgaata ctggcttttt tataccatta tggcgtacac
     1021 accaacgtac atcagctcgg tacttcaagc caacctcaga gatagtggga tcctgtctgc
     1081 cttgccgttt gttgttggat gtatctgcat tatccttgga ggtctactgg cagactttct
     1141 tctctccaga aaaatcctca gactcatcac catcaggaaa ctcttcactg ccattggggt
     1201 tctcttccca tccgtgatcc tcgtgtccct gccctgggtc agatccagcc acagcatgac
     1261 catgaccttc ttggtgctgt cttctgccat cagcagcttc tgtgaatcag gagcccttgt
     1321 taacttcttg gatattgctc ctcggtacac tggctttctc aaaggactat tgcaagtctt
     1381 tgcacacata gctggagcca tctctcctac tgctgctgga tttttcatca gtcaggattc
     1441 agagtttggt tggagaaatg tcttcttgct ttcagctgct gttaacatat cgggcctggt
     1501 tttctacctc atctttggcc gagcagatgt gcaggactgg gctaaagagc agacattcac
     1561 ccacctctga gcaaaccgag agatgtgcta gatcctggtg cttagttcat cattgttttc
     1621 cctcacagac atttctcttt catgcctgct tgactgataa gccattagct agaccctgac
     1681 tatgtaacgc taaagatttt accatgcctg gaaattttac aggggaagaa aacacgctag
     1741 ttatttaact gcaagctact aaaagcatag gtgtgttgag atttctgtgt tctccactct
     1801 tccactgtta tcctagtaaa agcatcaggg gctggggaca atttctttcc aaagcaaaag
     1861 aggaagccag accttgggac cgagaactga gaatcacaag ggagttgcgc ccaacatgca
     1921 gaacatgaat cctctgagct gtcctcaaaa gaaagcccca aacaacagaa agcatagtgt
     1981 tttccattgt tggtgaaaaa tgtcaaggag gaaagaacaa taatgattcc atcatgataa
     2041 gaggaatgaa cgtgtctgca actaatggga gcaagatagt acactttaac tctttcagac
     2101 aacttgcatt ctgtggatgc cagctttgga atcagagccg cctctggaat acctgtgctt
     2161 ccagagttag cttttggaca gttaccttct ttctggccat cttgacttct gccccacatc
     2221 tgctttttgg ctttgtgcag atctttaaca tgttagtgaa cagacattgc ccagtgtctc
     2281 ttctagcccc tccaacagtt cttcatgtag cactgctttt ggacagtgac ccatgatatc
     2341 tgccttcgtt tgcccctctg actgttggaa tcccacgcac cattcagtag gattcaattc
     2401 aatgtggaac cattcaacat tcacctcatt aacctaaaat gtctcccaaa gatgtatgta
     2461 agacacacac tgccctaacc tcactccaaa tgtctggaga aatgtgtgta gtgcttttgt
     2521 taaagcccct atatgggcag catggaggat cataagatag caaaaccatt tcaacactaa
     2581 atgaatatta atgtacacac accttgtgtg gatggcagaa atcaaatcat acacagtatt
     2641 aaggagttca gtgtctcggg agggcagata actttaatca aagtatcaca caagtgaata
     2701 tgtaataaca actgtagaaa taatgagtgg ttacatgggt tatgagagtg gatgataagt
     2761 gcactaatct gagtgtaagg aagggccacc cctgcaaagt ttcagctgag ctgggatctg
     2821 aaggataata gttaactgtt gtgggagact gagaggagaa tattttagga agaaagaaca
     2881 gcataagcaa aagtttcatg gcaggaggga gaaattagct atggccagag tatagagaat
     2941 aagggaagta tgatttgtga ggagactgta gaagaattaa ggtcaggagc acacaggatg
     3001 atgtaggccc agtgaagtgc gttggtcttt attttgaaat cagtaggaag tgtcctggtt
     3061 ttcaaaggca ctctgcatga gagattaggt tggagtagga gcttacagtg tagtccagga
     3121 gagaacaatg gcccctggca tgaggcaata gacatggtga gaggtgaatg gattatttga
     3181 tttaggtgga ttatttgatt tagggaataa acctgacggg tcctattact aagtgagaga
     3241 gtgaaagatg tccagagtaa ctcctgagtt ttggtttgct attatattaa tggggatgcc
     3301 tctaacacag acagcaacac agatagcaat tatatccaag tgtagacaac aagaaggaaa
     3361 atggacacat gactctggat ttctcttgtg agacctgggc tccatttaca aacgtataaa
     3421 tcatcttgat ataggtagtg attacaattt ttgcatggat gagtcatcca tgggtgaaag
     3481 tggcataaga aaaggaagct tgggaataag ccttaaagaa ttccagtatt taatggtcag
     3541 ctggaggatg attagcagaa agaaagaaag aaagaaagaa a
//
