LOCUS       NM_005074               1819 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 17 member 1 (SLC17A1), mRNA.
ACCESSION   NM_005074
VERSION     NM_005074.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1819)
  AUTHORS   Vavra,J., Pavelcova,K., Masinova,J., Hasikova,L., Bubenikova,E.,
            Urbanova,A., Mancikova,A. and Stiburkova,B.
  TITLE     Examining the Association of Rare Allelic Variants in Urate
            Transporters SLC22A11, SLC22A13, and SLC17A1 with Hyperuricemia and
            Gout
  JOURNAL   Dis Markers 2024, 5930566 (2024)
   PUBMED   38222853
  REMARK    GeneRIF: Examining the Association of Rare Allelic Variants in
            Urate Transporters SLC22A11, SLC22A13, and SLC17A1 with
            Hyperuricemia and Gout.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1819)
  AUTHORS   Nakayama,A., Nakaoka,H., Yamamoto,K., Sakiyama,M., Shaukat,A.,
            Toyoda,Y., Okada,Y., Kamatani,Y., Nakamura,T., Takada,T., Inoue,K.,
            Yasujima,T., Yuasa,H., Shirahama,Y., Nakashima,H., Shimizu,S.,
            Higashino,T., Kawamura,Y., Ogata,H., Kawaguchi,M., Ohkawa,Y.,
            Danjoh,I., Tokumasu,A., Ooyama,K., Ito,T., Kondo,T., Wakai,K.,
            Stiburkova,B., Pavelka,K., Stamp,L.K., Dalbeth,N., Sakurai,Y.,
            Suzuki,H., Hosoyamada,M., Fujimori,S., Yokoo,T., Hosoya,T.,
            Inoue,I., Takahashi,A., Kubo,M., Ooyama,H., Shimizu,T., Ichida,K.,
            Shinomiya,N., Merriman,T.R. and Matsuo,H.
  CONSRTM   Eurogout Consortium; Eurogout Consortium
  TITLE     GWAS of clinically defined gout and subtypes identifies multiple
            susceptibility loci that include urate transporter genes
  JOURNAL   Ann Rheum Dis 76 (5), 869-877 (2017)
   PUBMED   27899376
  REMARK    GeneRIF: A meta-analysis of all gout with Japanese, Caucasian and
            NZ Polynesian populations revealed that rs2285340 of SLC22A12 and
            rs1165196 of SLC17A1 showed a significant association but did not
            reach a genome-wide significance level.
REFERENCE   3  (bases 1 to 1819)
  AUTHORS   Sakiyama,M., Matsuo,H., Nagamori,S., Ling,W., Kawamura,Y.,
            Nakayama,A., Higashino,T., Chiba,T., Ichida,K., Kanai,Y. and
            Shinomiya,N.
  TITLE     Expression of a human NPT1/SLC17A1 missense variant which increases
            urate export
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 35 (10-12), 536-542 (2016)
   PUBMED   27906618
  REMARK    GeneRIF: I269T, a common missense variant of NPT1, might have
            faster conformation changes than NPT1 wild type in terms of the
            alternating-access model of transporters, and increases renal urate
            export in humans.
REFERENCE   4  (bases 1 to 1819)
  AUTHORS   Wang,T., Su,Y., Wang,Z., Ma,Q. and Yao,H.
  TITLE     [Polymorphisms of SLC17A1 gene and their interaction with alcohol
            drinking among Uygur patients with hyperuricemia]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 32 (6), 881-885 (2015)
   PUBMED   26663070
  REMARK    GeneRIF: Data suggest that single nucleotide polymorphisms (SNPs)
            rs9467596 and rs2096386 of the solute carrier family 17 (sodium
            phosphate), member 1 protein (SLC17A1) gene may have a correlation
            between hyperuricemia and alcohol drinking among Uygur patients.
REFERENCE   5  (bases 1 to 1819)
  AUTHORS   Koyama,T., Matsui,D., Kuriyama,N., Ozaki,E., Tanaka,K., Oze,I.,
            Hamajima,N., Wakai,K., Okada,R., Arisawa,K., Mikami,H.,
            Shimatani,K., Hirata,A., Takashima,N., Suzuki,S., Nagata,C.,
            Kubo,M. and Tanaka,H.
  TITLE     Genetic variants of SLC17A1 are associated with cholesterol
            homeostasis and hyperhomocysteinaemia in Japanese men
  JOURNAL   Sci Rep 5, 15888 (2015)
   PUBMED   26524967
  REMARK    GeneRIF: Data suggest that single nucleotide polymorphisms (SNPs)
            of solute carrier family 17 member 1 (SLC17A1) are potential
            biomarkers for altered cholesterol homeostasis and
            hyperhomocysteinaemia in Japanese men.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1819)
  AUTHORS   Taketani,Y., Miyamoto,K., Chikamori,M., Tanaka,K., Yamamoto,H.,
            Tatsumi,S., Morita,K. and Takeda,E.
  TITLE     Characterization of the 5' flanking region of the human NPT-1
            Na+/phosphate cotransporter gene
  JOURNAL   Biochim Biophys Acta 1396 (3), 267-272 (1998)
   PUBMED   9545579
REFERENCE   7  (bases 1 to 1819)
  AUTHORS   Totaro,A., Roetto,A., Rommens,J.M., Grifa,A., Carella,M.,
            d'Agruma,L., Valentino,M.A., D'Ambrosio,L., Cicilano,M.,
            Camaschella,C., Franco,B. and Gasparini,P.
  TITLE     Generation of a transcription map of a 1 Mbase region containing
            the HFE gene (6p22)
  JOURNAL   Eur J Hum Genet 6 (2), 105-113 (1998)
   PUBMED   9781053
REFERENCE   8  (bases 1 to 1819)
  AUTHORS   Miyamoto,K., Tatsumi,S., Sonoda,T., Yamamoto,H., Minami,H.,
            Taketani,Y. and Takeda,E.
  TITLE     Cloning and functional expression of a Na(+)-dependent phosphate
            co-transporter from human kidney: cDNA cloning and functional
            expression
  JOURNAL   Biochem J 305 (Pt 1) (Pt 1), 81-85 (1995)
   PUBMED   7826357
REFERENCE   9  (bases 1 to 1819)
  AUTHORS   Li,H. and Xie,Z.
  TITLE     Molecular cloning of two rat Na+/Pi cotransporters: evidence for
            differential tissue expression of transcripts
  JOURNAL   Cell Mol Biol Res 41 (5), 451-460 (1995)
   PUBMED   8867793
REFERENCE   10 (bases 1 to 1819)
  AUTHORS   Chong,S.S., Kristjansson,K., Zoghbi,H.Y. and Hughes,M.R.
  TITLE     Molecular cloning of the cDNA encoding a human renal sodium
            phosphate transport protein and its assignment to chromosome
            6p21.3-p23
  JOURNAL   Genomics 18 (2), 355-359 (1993)
   PUBMED   8288239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC362172.1, BC101745.1, BG054690.1 and D28532.1.
            
            On Aug 31, 2019 this sequence version replaced NM_005074.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3225573.1,
                                           SRR14243140.696672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244527.10/ ENSP00000244527.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               DC362172.1         8-132
            126-1608            BC101745.1         70-1552
            1609-1818           BG054690.1         1-210               c
            1819-1819           D28532.1           1705-1705
FEATURES             Location/Qualifiers
     source          1..1819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..1819
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /note="solute carrier family 17 member 1"
                     /db_xref="GeneID:6568"
                     /db_xref="HGNC:HGNC:10929"
                     /db_xref="MIM:182308"
     exon            1..59
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            60..143
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1513
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /note="solute carrier family 17 (vesicular glutamate
                     transporter), member 1; sodium/phosphate type I
                     cotransporter; sodium phosphate transporter; na/Pi-4;
                     sodium/phosphate cotransporter 1; solute carrier family 17
                     (organic anion transporter), member 1; solute carrier
                     family 17 (sodium phosphate), member 1; renal
                     sodium-phosphate transport protein 1; renal
                     Na(+)-dependent phosphate cotransporter 1; renal
                     sodium-dependent phosphate transport protein 1; Na(+)/PI
                     cotransporter 1"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 1"
                     /protein_id="NP_005065.2"
                     /db_xref="CCDS:CCDS4565.1"
                     /db_xref="GeneID:6568"
                     /db_xref="HGNC:HGNC:10929"
                     /db_xref="MIM:182308"
                     /translation="MQMDNRLPPKKVPGFCSFRYGLSFLVHCCNVIITAQRACLNLTM
                     VVMVNSTDPHGLPNTSTKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFS
                     GIYSTKKMIGFALCLSSVLSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVK
                     WAPPLERGRLTSMSTSGFLLGPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFV
                     LFYDDPKDHPCISISEKEYITSSLVQQVSSSRQSLPIKAILKSLPVWAISTGSFTFFW
                     SHNIMTLYTPMFINSMLHVNIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVI
                     AVRKLFTAAGFLLPAIFGVCLPYLSSTFYSIVIFLILAGATGSFCLGGVFINGLDIAP
                     RYFGFIKACSTLTGMIGGLIASTLTGLILKQDPESAWFKTFILMAAINVTGLIFYLIV
                     ATAEIQDWAKEKQHTRL"
     exon            144..316
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..550
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..638
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            639..725
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            726..844
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1006
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1139
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1287
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1378
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1515
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1819
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /note="hexamer: AATACA"
     polyA_site      1819
                     /gene="SLC17A1"
                     /gene_synonym="NAPI-1; NPT-1; NPT1"
                     /note="major polyA site"
ORIGIN      
        1 aaagttgaga gaaaagtctt cacagcggaa gaagaaatca cttttttgtc ccgaatcagt
       61 gggtggaggc aaaacccttc agcaagaaga gaagcaactt cagccgtgta tgcaaatgga
      121 taaccggttg cctcccaaaa aagttccagg tttctgttcc tttcgctatg gattgtcttt
      181 ccttgtgcac tgttgtaatg ttataataac agcacagcgt gcgtgcctga acctcacaat
      241 ggtagtcatg gtgaatagca cagatccaca tggtttgccc aacacctcca caaagaagct
      301 cctggataat ataaagaacc ctatgtataa ttggagccca gatatccagg gaatcatctt
      361 gagttccacc tcctatggtg tcatcatcat ccaagttcct gttggatact tctctggaat
      421 atattctaca aagaaaatga ttggctttgc attatgcctc agctctgtgt taagcctgct
      481 catcccacca gcagctggaa ttggagtagc ttgggtcgtt gtatgtcgag cagttcaggg
      541 agcagcccag gggatagttg caacagccca gtttgaaata tatgtcaaat gggctcctcc
      601 cctggaacga ggccgactta cttctatgag tacatcaggg tttttgctgg gaccctttat
      661 tgtcctactt gtgactggag ttatctgtga atctctgggc tggcccatgg tcttctatat
      721 ttttggtgct tgtggctgtg ccgtatgtct tctctggttc gttctgtttt atgatgaccc
      781 caaagaccac ccatgtataa gcatcagtga aaaggaatac atcacatcct ccctggtcca
      841 gcaggtcagt tcaagtagac aatctctgcc tatcaaggct atacttaagt cgcttccagt
      901 ctgggctatt tccactggta gttttacgtt tttctggtca cataacatca tgacactata
      961 cactccaatg tttatcaact ccatgcttca tgttaatata aaagagaatg ggttcttgtc
     1021 ttcccttccc tatttgtttg cctggatctg tggtaaccta gcaggtcagt tatcagactt
     1081 cttcctgacc aggaatattc tcagcgtaat tgctgtccgg aaactcttca cagcagcagg
     1141 atttctcctt cctgcaatct ttggtgtctg cctgccttac ctgagttcca ccttctacag
     1201 cattgtcatt ttcctaatac ttgctggtgc aacaggcagc ttttgcttgg gtggagtgtt
     1261 tataaatggc ttggatattg ctcccagata ttttggattt attaaagcat gttcaacttt
     1321 aactggaatg ataggaggac taattgcttc cactttgact ggattgatcc ttaagcagga
     1381 tccggaatcc gcctggttta aaaccttcat cctgatggca gccattaatg tgactggcct
     1441 aattttctac cttatagttg ctacagcaga aattcaggac tgggctaaag aaaaacaaca
     1501 cacacgtctc tgaagtgtga aacagagcac ttgcagagcc tgggacaacc tccttattga
     1561 agggaagagg gaccagcaca tgaggctgag gctgaggggc agtcaccagc accaggaaga
     1621 aggtggtagg aggagtccta ggggccagtt ttaccctccc acatatcctg tgtgcatcgt
     1681 tttttaacat gtgttgtttg taacatgtaa tatatctgaa ttttaaatgg gggtggtgat
     1741 ttatctcagt cttcctctct gcatcagttg ctttataaat gattgtcaaa ccaataaata
     1801 cacacaagat aaaatttta
//
