LOCUS       NM_194298               3946 bp    mRNA    linear   PRI 15-JAN-2025
DEFINITION  Homo sapiens solute carrier family 16 member 9 (SLC16A9),
            transcript variant 1, mRNA.
ACCESSION   NM_194298 XM_166145
VERSION     NM_194298.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3946)
  AUTHORS   Flogel,S., Strater,M., Fischer,D. and Grundemann,D.
  TITLE     A creatine efflux transporter in oligodendrocytes
  JOURNAL   FEBS J (2025) In press
   PUBMED   39792585
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3946)
  AUTHORS   Yamaguchi,A., Mukai,Y., Sakuma,T., Suganuma,Y., Furugen,A.,
            Narumi,K. and Kobayashi,M.
  TITLE     Molecular characteristic analysis of single-nucleotide
            polymorphisms in SLC16A9/hMCT9
  JOURNAL   Life Sci 334, 122205 (2023)
   PUBMED   37879602
  REMARK    GeneRIF: Molecular characteristic analysis of single-nucleotide
            polymorphisms in SLC16A9/hMCT9.
REFERENCE   3  (bases 1 to 3946)
  AUTHORS   Sohrabi,E., Moslemi,M., Rezaie,E., Nafissi,N., Khaledi,M.,
            Afkhami,H., Fathi,J. and Zekri,A.
  TITLE     The tissue expression of MCT3, MCT8, and MCT9 genes in women with
            breast cancer
  JOURNAL   Genes Genomics 43 (9), 1065-1077 (2021)
   PUBMED   34097251
  REMARK    GeneRIF: The tissue expression of MCT3, MCT8, and MCT9 genes in
            women with breast cancer.
REFERENCE   4  (bases 1 to 3946)
  AUTHORS   Yoo,A., Lee,H., Jung,J., Koh,S.S. and Lee,S.
  TITLE     Monocarboxylate transporter 9 (MCT9) is down-regulated in renal
            cell carcinoma
  JOURNAL   Genes Genomics 43 (4), 351-359 (2021)
   PUBMED   33555501
  REMARK    GeneRIF: Monocarboxylate transporter 9 (MCT9) is down-regulated in
            renal cell carcinoma.
REFERENCE   5  (bases 1 to 3946)
  AUTHORS   Zhou,J., Xie,Z., Cui,P., Su,Q., Zhang,Y., Luo,L., Li,Z., Ye,L.,
            Liang,H. and Huang,J.
  TITLE     SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for the
            Occurrence of Colorectal Cancer
  JOURNAL   Biomed Res Int 2020, 1204605 (2020)
   PUBMED   32566650
  REMARK    GeneRIF: SLC1A1, SLC16A9, and CNTN3 Are Potential Biomarkers for
            the Occurrence of Colorectal Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3946)
  AUTHORS   van der Harst,P., Bakker,S.J., de Boer,R.A., Wolffenbuttel,B.H.,
            Johnson,T., Caulfield,M.J. and Navis,G.
  TITLE     Replication of the five novel loci for uric acid concentrations and
            potential mediating mechanisms
  JOURNAL   Hum Mol Genet 19 (2), 387-395 (2010)
   PUBMED   19861489
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3946)
  AUTHORS   Stark,K., Reinhard,W., Grassl,M., Erdmann,J., Schunkert,H.,
            Illig,T. and Hengstenberg,C.
  TITLE     Common polymorphisms influencing serum uric acid levels contribute
            to susceptibility to gout, but not to coronary artery disease
  JOURNAL   PLoS One 4 (11), e7729 (2009)
   PUBMED   19890391
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3946)
  AUTHORS   Kolz,M., Johnson,T., Sanna,S., Teumer,A., Vitart,V., Perola,M.,
            Mangino,M., Albrecht,E., Wallace,C., Farrall,M., Johansson,A.,
            Nyholt,D.R., Aulchenko,Y., Beckmann,J.S., Bergmann,S., Bochud,M.,
            Brown,M., Campbell,H., Connell,J., Dominiczak,A., Homuth,G.,
            Lamina,C., McCarthy,M.I., Meitinger,T., Mooser,V., Munroe,P.,
            Nauck,M., Peden,J., Prokisch,H., Salo,P., Salomaa,V., Samani,N.J.,
            Schlessinger,D., Uda,M., Volker,U., Waeber,G., Waterworth,D.,
            Wang-Sattler,R., Wright,A.F., Adamski,J., Whitfield,J.B.,
            Gyllensten,U., Wilson,J.F., Rudan,I., Pramstaller,P., Watkins,H.,
            Doering,A., Wichmann,H.E., Spector,T.D., Peltonen,L., Volzke,H.,
            Nagaraja,R., Vollenweider,P., Caulfield,M., Illig,T. and Gieger,C.
  CONSRTM   EUROSPAN Consortium; ENGAGE Consortium; PROCARDIS Consortium; KORA
            Study; WTCCC
  TITLE     Meta-analysis of 28,141 individuals identifies common variants
            within five new loci that influence uric acid concentrations
  JOURNAL   PLoS Genet 5 (6), e1000504 (2009)
   PUBMED   19503597
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3946)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 3946)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA229807.1, BC126238.1, CX784319.1, AK125791.1 and BX092606.1.
            
            On Aug 11, 2020 this sequence version replaced NM_194298.2.
            
            Transcript Variant: This variant (1), as well as variant 2, encodes
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3390886.1,
                                           SRR14038193.2729370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395348.8/ ENSP00000378757.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               DA229807.1         42-441
            401-2165            BC126238.1         31-1795
            2166-2711           CX784319.1         90-635
            2712-3721           AK125791.1         2413-3422
            3722-3946           BX092606.1         450-674
FEATURES             Location/Qualifiers
     source          1..3946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..3946
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /note="solute carrier family 16 member 9"
                     /db_xref="GeneID:220963"
                     /db_xref="HGNC:HGNC:23520"
                     /db_xref="MIM:614242"
     exon            1..372
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /inference="alignment:Splign:2.1.0"
     exon            373..604
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..1938
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /note="isoform a is encoded by transcript variant 1;
                     solute carrier family 16 (monocarboxylic acid
                     transporters), member 9; monocarboxylate transporter 9;
                     MCT 9; monocarboxylic acid transporter 9"
                     /codon_start=1
                     /product="monocarboxylate transporter 9 isoform a"
                     /protein_id="NP_919274.1"
                     /db_xref="CCDS:CCDS7256.1"
                     /db_xref="GeneID:220963"
                     /db_xref="HGNC:HGNC:23520"
                     /db_xref="MIM:614242"
                     /translation="MELKKSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAF
                     GEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNI
                     YFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRM
                     LVEFYGLDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEDLPDKYSIYNEKG
                     KNLEENINILDKSYSSEEKCRITLANGDWKQDSLLHKNPTVTHTKEPETYKKKVAEQT
                     YFCKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSS
                     NVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFA
                     KSYVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIV
                     GWFYDWTQTYDIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFLYKVASN
                     V"
     exon            605..748
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /inference="alignment:Splign:2.1.0"
     exon            749..844
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1759
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..3946
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3921..3926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /note="hexamer: AATAAA"
     polyA_site      3946
                     /gene="SLC16A9"
                     /gene_synonym="C10orf36; MCT9"
                     /note="major polyA site"
ORIGIN      
        1 agactggccg gggtgccccg caaagagaga caagggagaa aaagacagca gggaaaaccc
       61 cggggaggag aaggcgaaag agaaggtgga gctcagagaa gggggccggc tccccagctc
      121 catgtggccg ccgccgctgc gggtctgtgg gggcagaggg cggcggctcc cggggcagcg
      181 cgtagcggga ccgattgcct aatactccgg caggggccgg ggccgcagct ggctcggata
      241 aatagccgcc cggctggccc ggagctgcag gggagagcgg cggccgcgat ccccaccaca
      301 ccaccagccc ggccgcacgg ggcactgagc cgggtgctga gcaccggagg ccccgccgag
      361 gccgggactc aggacctgca gagaaacgcc tcctgatttt gtcttacaat ggaacttaaa
      421 aagtcgcctg acggtggatg gggctgggtg attgtgtttg tctccttcct tactcagttt
      481 ttgtgttacg gatccccact agctgttgga gtcctgtaca tagaatggct ggatgccttt
      541 ggtgaaggaa aaggaaaaac agcctgggtt ggatccctgg caagtggagt tggcttgctt
      601 gcaagtcctg tctgcagtct ctgtgtctca tcttttggag caagacctgt cacaatcttc
      661 agtggcttca tggtggctgg aggcctgatg ttgagcagtt ttgctcccaa tatctacttt
      721 ctgttttttt cctatggcat tgttgtaggt cttggatgtg gtttattata cactgcaaca
      781 gtgaccatta cgtgccagta ttttgacgat cgccgaggcc tagcgcttgg cctgatttca
      841 acaggttcaa gcgttggcct tttcatatat gctgctctgc agaggatgct ggttgagttc
      901 tatggactgg atggatgctt gctgattgtg ggtgctttag ctttaaatat attagcctgt
      961 ggcagtctga tgagacccct ccaatcttct gattgtcctt tgcctaaaaa aatagctcca
     1021 gaagatctac cagataaata ctccatttac aatgaaaaag gaaagaatct ggaagaaaac
     1081 ataaacattc ttgacaagag ctacagtagt gaggaaaaat gcaggatcac gttagccaat
     1141 ggtgactgga aacaagacag cctacttcat aaaaacccca cagtgacaca cacaaaagag
     1201 cctgaaacgt acaaaaagaa agttgcagaa cagacatatt tttgcaaaca gcttgccaag
     1261 aggaagtggc agttatataa aaactactgt ggtgaaactg tggctctttt taaaaacaaa
     1321 gtattttcag cccttttcat tgctatctta ctctttgaca tcggagggtt tccaccttca
     1381 ttacttatgg aagatgtagc aagaagttca aacgtgaaag aagaagagtt tattatgcca
     1441 cttatttcca ttataggcat tatgacagca gttggtaaac tgcttttagg gatactggct
     1501 gacttcaagt ggattaatac cttgtatctt tatgttgcta ccttaatcat catgggccta
     1561 gccttgtgtg caattccatt tgccaaaagc tatgtcacat tggcgttgct ttctgggatc
     1621 ctagggtttc ttactggtaa ttggtccatc tttccatatg tgaccacgaa gactgtggga
     1681 attgaaaaat tagcccatgc ctatgggata ttaatgttct ttgctggact tggaaatagc
     1741 ctaggaccac ccatcgttgg ttggttttat gactggaccc agacctatga tattgcattt
     1801 tattttagtg gcttctgcgt cctgctggga ggttttattc tgctgctggc agccttgccc
     1861 tcttgggata catgcaacaa gcaactcccc aagccagctc caacaacttt cttgtacaaa
     1921 gttgcctcta atgtttagaa gaatattgga agacactatt tttgctattt tataccatat
     1981 agcaacgata ttttaacaga ttctcaagca aattttctag agtcaagact attttctcat
     2041 agcaaaattt cacaatgact gactctgaat gaattatttt tttttatata tcctattttt
     2101 tatgtagtgt atgcgtagcc tctatctcgt atttttttct atttctcctc cccacaccat
     2161 caatgggact attctgtttt gctgttattc actagttctt aacattgtaa aaagtttgac
     2221 cagcctcaga aggctttctc tgtgtaaaga agtataattt ctctgccgac tccatttaat
     2281 ccactgcaag gcacctagag agactgctcc tattttaaaa gtgatgcaag catcatgata
     2341 agatatgtgt gaagcccact aggaaataaa tcattctctt ctctatgttt gacttgctag
     2401 taaacagaag acttcaagcc agccaggaaa ttaaagtggc gactaaaaca gccttaagaa
     2461 ttgcagtgga gcaaattggt cattttttaa aaaaatatat tttaacctac agtcaccagt
     2521 tttcattatt ctatttacct cactgaagta ctcgcatgtt gtttggtacc cactgagcaa
     2581 ctgtttcagt tcctaaggta tttgctgaga tgtgggtgaa ctccaaatgg agaagtagtc
     2641 actgtagact ttcttcatgg ttgaccactc caaccttgct cacttttgct tcttggccat
     2701 ccactcagct gatgtttcct gggaagtgct aattttacct gtttccaaat tggaaacaca
     2761 tttctcaatc attccgttct ggcaaatggg aaacatccat ttgctttggg cacagtgggg
     2821 atgggctgca agttcttgca tatcctccca gtgaagcatt tatttgctac tatcagattt
     2881 taccactatc aaatataatt caagggcaga attaaacgtg agtgtgtgtg tgtgtgtgtg
     2941 tgtgtgctat gcatgctcta agtctgcatg ggatatggga atggaaaagg gcaataagaa
     3001 attaataccc ttatgcagtt gcatttaacc ttaagaaaaa tgtccttggg ataaactcca
     3061 atgtttaata cattgatttt ttttctaaag aaatgggttt taaactttgg tatgcatcag
     3121 aattccctat agatcttttt gaaaatatag gtacctgggt atcacacata gaacttttaa
     3181 ttctgctggt gtaggctgtt gcccaaacat ctataatttt actgagctct tcaagtgatt
     3241 ctgataacac agcctggatt gagaattttt ataagattgg caatggaaaa acatttattc
     3301 ttttaaataa taattttttt aaaacccaag aggtcagggg attttataaa ccaatagcca
     3361 agtgttcttt aaataggagg cacccttccc attgtgccaa aatcatcttt tcatttattt
     3421 tgaaatttgt atgattattt tatacttgta tgttgccttt cttcgaaggc gcctgaagca
     3481 ctttataaac acaaatcctc acaatacctc tgtgaggtag gtaaatagta cttttctatg
     3541 tagtaaacct ggaatatgga gaatttcata acagttcatt ctacttaata atgcaataat
     3601 ggagctccaa gttgtcttgg acttctacac cacactcaga cttctggaaa gttttctgta
     3661 cctcattctt tagtccctgt caaggttagt aaataaaata agtgacataa aaaaaaaaaa
     3721 aactaaacta cttgttgtgt tgaaagttcc tttttgccag ttatgttcag gaaacccaat
     3781 aacctgaaaa agtttgactt tgatgtgaca tcttcatatt catcaatgct gataattgtc
     3841 caaaggcatc ttcactatgt ctgctaaata acatccaatg tgggcgttat ctgttgtcta
     3901 ggggatgaat tttaagttac aataaaatat ttttctttgt tttgca
//
