LOCUS       NM_013356               2291 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 16 member 8 (SLC16A8),
            transcript variant 1, mRNA.
ACCESSION   NM_013356
VERSION     NM_013356.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2291)
  AUTHORS   Kopnick,A.L., Geistlinger,K. and Beitz,E.
  TITLE     Cysteine 159 delineates a hinge region of the alternating access
            monocarboxylate transporter 1 and is targeted by cysteine-modifying
            inhibitors
  JOURNAL   FEBS J 288 (20), 6052-6062 (2021)
   PUBMED   33999492
REFERENCE   2  (bases 1 to 2291)
  AUTHORS   Klipfel,L., Cordonnier,M., Thiebault,L., Clerin,E., Blond,F.,
            Millet-Puel,G., Mohand-Said,S., Goureau,O., Sahel,J.A.,
            Nandrot,E.F. and Leveillard,T.
  TITLE     A Splice Variant in SLC16A8 Gene Leads to Lactate Transport Deficit
            in Human iPS Cell-Derived Retinal Pigment Epithelial Cells
  JOURNAL   Cells 10 (1), 179 (2021)
   PUBMED   33477551
  REMARK    GeneRIF: A Splice Variant in SLC16A8 Gene Leads to Lactate
            Transport Deficit in Human iPS Cell-Derived Retinal Pigment
            Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2291)
  AUTHORS   Hellinen,L., Sato,K., Reinisalo,M., Kidron,H., Rilla,K.,
            Tachikawa,M., Uchida,Y., Terasaki,T. and Urtti,A.
  TITLE     Quantitative Protein Expression in the Human Retinal Pigment
            Epithelium: Comparison Between Apical and Basolateral Plasma
            Membranes With Emphasis on Transporters
  JOURNAL   Invest Ophthalmol Vis Sci 60 (15), 5022-5034 (2019)
   PUBMED   31791063
REFERENCE   4  (bases 1 to 2291)
  AUTHORS   Sharma,K., Tyagi,R., Singh,R., Sharma,S.K. and Anand,A.
  TITLE     Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD
            Cases
  JOURNAL   J Cell Biochem 118 (8), 2087-2095 (2017)
   PUBMED   27966779
  REMARK    GeneRIF: The expression level of LIPC, SLC16A8, and TIMP-3 was
            significantly associated with age-related macular degeneration
            pathology.
REFERENCE   5  (bases 1 to 2291)
  AUTHORS   Fritsche,L.G., Chen,W., Schu,M., Yaspan,B.L., Yu,Y.,
            Thorleifsson,G., Zack,D.J., Arakawa,S., Cipriani,V., Ripke,S.,
            Igo,R.P. Jr., Buitendijk,G.H., Sim,X., Weeks,D.E., Guymer,R.H.,
            Merriam,J.E., Francis,P.J., Hannum,G., Agarwal,A., Armbrecht,A.M.,
            Audo,I., Aung,T., Barile,G.R., Benchaboune,M., Bird,A.C.,
            Bishop,P.N., Branham,K.E., Brooks,M., Brucker,A.J., Cade,W.H.,
            Cain,M.S., Campochiaro,P.A., Chan,C.C., Cheng,C.Y., Chew,E.Y.,
            Chin,K.A., Chowers,I., Clayton,D.G., Cojocaru,R., Conley,Y.P.,
            Cornes,B.K., Daly,M.J., Dhillon,B., Edwards,A.O., Evangelou,E.,
            Fagerness,J., Ferreyra,H.A., Friedman,J.S., Geirsdottir,A.,
            George,R.J., Gieger,C., Gupta,N., Hagstrom,S.A., Harding,S.P.,
            Haritoglou,C., Heckenlively,J.R., Holz,F.G., Hughes,G.,
            Ioannidis,J.P., Ishibashi,T., Joseph,P., Jun,G., Kamatani,Y.,
            Katsanis,N., N Keilhauer,C., Khan,J.C., Kim,I.K., Kiyohara,Y.,
            Klein,B.E., Klein,R., Kovach,J.L., Kozak,I., Lee,C.J., Lee,K.E.,
            Lichtner,P., Lotery,A.J., Meitinger,T., Mitchell,P.,
            Mohand-Said,S., Moore,A.T., Morgan,D.J., Morrison,M.A., Myers,C.E.,
            Naj,A.C., Nakamura,Y., Okada,Y., Orlin,A., Ortube,M.C.,
            Othman,M.I., Pappas,C., Park,K.H., Pauer,G.J., Peachey,N.S.,
            Poch,O., Priya,R.R., Reynolds,R., Richardson,A.J., Ripp,R.,
            Rudolph,G., Ryu,E., Sahel,J.A., Schaumberg,D.A., Scholl,H.P.,
            Schwartz,S.G., Scott,W.K., Shahid,H., Sigurdsson,H., Silvestri,G.,
            Sivakumaran,T.A., Smith,R.T., Sobrin,L., Souied,E.H.,
            Stambolian,D.E., Stefansson,H., Sturgill-Short,G.M., Takahashi,A.,
            Tosakulwong,N., Truitt,B.J., Tsironi,E.E., Uitterlinden,A.G., van
            Duijn,C.M., Vijaya,L., Vingerling,J.R., Vithana,E.N., Webster,A.R.,
            Wichmann,H.E., Winkler,T.W., Wong,T.Y., Wright,A.F., Zelenika,D.,
            Zhang,M., Zhao,L., Zhang,K., Klein,M.L., Hageman,G.S.,
            Lathrop,G.M., Stefansson,K., Allikmets,R., Baird,P.N., Gorin,M.B.,
            Wang,J.J., Klaver,C.C., Seddon,J.M., Pericak-Vance,M.A.,
            Iyengar,S.K., Yates,J.R., Swaroop,A., Weber,B.H., Kubo,M.,
            Deangelis,M.M., Leveillard,T., Thorsteinsdottir,U., Haines,J.L.,
            Farrer,L.A., Heid,I.M. and Abecasis,G.R.
  CONSRTM   AMD Gene Consortium
  TITLE     Seven new loci associated with age-related macular degeneration
  JOURNAL   Nat Genet 45 (4), 433-439 (2013)
   PUBMED   23455636
REFERENCE   6  (bases 1 to 2291)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
REFERENCE   7  (bases 1 to 2291)
  AUTHORS   Philp,N.J., Wang,D., Yoon,H. and Hjelmeland,L.M.
  TITLE     Polarized expression of monocarboxylate transporters in human
            retinal pigment epithelium and ARPE-19 cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (4), 1716-1721 (2003)
   PUBMED   12657613
REFERENCE   8  (bases 1 to 2291)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 2291)
  AUTHORS   Yoon,H., Donoso,L.A. and Philp,N.J.
  TITLE     Cloning of the human monocarboxylate transporter MCT3 gene:
            localization to chromosome 22q12.3-q13.2
  JOURNAL   Genomics 60 (3), 366-370 (1999)
   PUBMED   10493836
REFERENCE   10 (bases 1 to 2291)
  AUTHORS   Cori,C.F.
  TITLE     The glucose-lactic acid cycle and gluconeogenesis
  JOURNAL   Curr Top Cell Regul 18, 377-387 (1981)
   PUBMED   7273846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031587.3.
            
            On Nov 21, 2019 this sequence version replaced NM_013356.2.
            
            Summary: SLC16A8 is a member of a family of proton-coupled
            monocarboxylate transporters that mediate lactate transport across
            cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by
            OMIM, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.3661327.1,
                                           SRR14372079.78112.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2144333,
                                           SAMEA2145245 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681075.2/ ENSP00000506669.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-197               AL031587.3         141266-141462       c
            198-517             AL031587.3         140320-140639       c
            518-739             AL031587.3         139938-140159       c
            740-883             AL031587.3         139167-139310       c
            884-1723            AL031587.3         138118-138957       c
            1724-2291           AL031587.3         135415-135982       c
FEATURES             Location/Qualifiers
     source          1..2291
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2291
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /note="solute carrier family 16 member 8"
                     /db_xref="GeneID:23539"
                     /db_xref="HGNC:HGNC:16270"
                     /db_xref="MIM:610409"
     exon            1..197
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /inference="alignment:Splign:2.1.0"
     exon            198..517
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /inference="alignment:Splign:2.1.0"
     exon            518..739
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..2040
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monocarboxylate transporter 3; solute carrier 16
                     (monocarboxylic acid transporters), member 8; MCT 3;
                     solute carrier family 16, member 8 (monocarboxylic acid
                     transporter 3); solute carrier family 16 (monocarboxylate
                     transporter), member 8"
                     /codon_start=1
                     /product="monocarboxylate transporter 3 isoform 1"
                     /protein_id="NP_037488.2"
                     /db_xref="CCDS:CCDS13966.1"
                     /db_xref="GeneID:23539"
                     /db_xref="HGNC:HGNC:16270"
                     /db_xref="MIM:610409"
                     /translation="MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFR
                     ALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILA
                     SFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSAL
                     SPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPG
                     EAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVN
                     YAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTD
                     LSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAV
                     LIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGG
                     ASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV"
     exon            740..883
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1723
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..2291
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /note="hexamer: GATAAA"
     polyA_site      2291
                     /gene="SLC16A8"
                     /gene_synonym="MCT3; REMP"
                     /note="major polyA site"
ORIGIN      
        1 acacactcta agctccaggc ctggggcagg gagcgtcagg cgggagtcgg ccagaggctc
       61 agcccaggct ggtgggaagc tggggtgtct ggcagccccc atccgggtaa gcttcaccgg
      121 gagctgcggc ggcggcccct ccctgcaggc ctcaggagat gtgaggctgg acccccaaac
      181 ccacgaggca ggctcagtca tttgtgatca ctgagaaaca ttaggaacat ggcggaaggc
      241 taaagaggaa aatcacgcac agcggccctt tgcagccggc atctgcccct ctgctgtttg
      301 ttctgttgtc ccgagaccct cacgcgtacg gggcgacttt ggtgctggac gcccacctcc
      361 aggcacatac ctgctccact tcccgacgcc ttccacctga ggccctgagg ggccagcagt
      421 tgtccttcag agggagcctg cagaggtgca gagtcaggtg ggacccgtcg tcctcccctc
      481 gtccttcagc gccctttgca ggagaaggag acttgggagg cagcgatggg cgctggcggc
      541 ccccggcggg gcgagggccc cccagacggc ggctggggct gggtggtgct gggcgcctgc
      601 tttgtggtca ccggcttcgc ctacggcttc cccaaagccg tgagcgtctt cttccgcgcg
      661 ctcatgcgcg acttcgacgc cggctacagc gacacggcct gggtgtcctc catcatgcta
      721 gccatgctct acggcacggg ccccgtgtcc agcatcctcg tgacccgctt tggctgtcgc
      781 ccggtgatgc tggcgggtgg gctgctggct tccgcgggca tgatcctagc ttcctttgcc
      841 acgcgcctcc tggagctcta cctgaccgct ggggtgctca caggcctggg cctggccctc
      901 aacttccagc cgtcgctcat catgctgggg ctgtacttcg agcggcggcg gcctctggcc
      961 aacgggctgg cggcggcggg cagccccgtg ttcctgtccg cgctgtcgcc gctcggccag
     1021 cagctgctgg agcgcttcgg ctggcgcggc ggcttcctgc tgctcggcgg gctcctgctg
     1081 cactgctgcg cctgcggggc tgtcatgagg ccgccgcccg ggccgggccc gcgaccgcgc
     1141 agggacagcg ccggcgaccg cgccggggac gctccgggcg aggcggaggc tgacggtgcg
     1201 gggctgcagc tgcgcgaggc atcccccagg gtccggcccc gccggcgcct gctggacttg
     1261 gcagtgtgca ccgaccgcgc cttcgccgtg tacgccgtca ccaagttcct gatggcgctc
     1321 gggctcttcg tccccgccat cctgctggtg aactacgcca aggacgcggg cgtgcccgac
     1381 accgacgccg ccttcctgct gtccatcgtg ggcttcgtgg acatcgtggc gcgcccggcg
     1441 tgcggcgccc tggcgggcct ggcgcgtctg cggccgcacg tcccgtatct gttcagcctg
     1501 gccctgctgg ccaatgggct cacagacctg agcagcgcac gcgcgcgctc ctacggcgcc
     1561 ctcgtcgcct tctgcgtcgc cttcggcctc tcctacggca tggtgggcgc gctgcagttc
     1621 gaggtgctca tggcggctgt gggcgcgccc cgcttcccca gtgcgctggg cctggtgttg
     1681 ctcgtggagg ccgcggctgt gctcatcgga ccgccctctg ccggccgcct ggtggatgtg
     1741 ttgaagaact atgagatcat cttctacctg gccggctctg aggtggccct ggctggggtc
     1801 ttcatggctg tcgccaccaa ctgctgcctg cgttgtgcta aagctgcccc gtcaggccca
     1861 ggcactgagg gcggagccag tgacactgag gacgctgagg ctgaagggga ctctgagccc
     1921 ctgcctgttg ttgcagagga acccggcaac ctggaggccc tggaggtgct cagcgcccgg
     1981 ggcgagccca cagaaccaga aatagaggcg aggccgaggc tggctgccga gtctgtataa
     2041 ctcagggtgc tctgggtggg gtggcccagt gacttgggaa cacagcttct tgtctcagag
     2101 agcctggtac gctgggaggc tggtctgggg tggtcactcc cggggtccac gtctgggctc
     2161 cagttgatcc cctgggtgtc tgggaactgc ctccctcatc tgtgccccaa gttccgccag
     2221 gccctgcccc atcgccagtg aagctgctat ggagcaacag gaaactggtg ataaagctca
     2281 gctgaacgac a
//
