LOCUS       NM_001270623           11936 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 16 member 7 (SLC16A7),
            transcript variant 1, mRNA.
ACCESSION   NM_001270623
VERSION     NM_001270623.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11936)
  AUTHORS   Sheng,G., Gao,Y., Wu,H., Liu,Y. and Yang,Y.
  TITLE     Functional heterogeneity of MCT1 and MCT4 in metabolic
            reprogramming affects osteosarcoma growth and metastasis
  JOURNAL   J Orthop Surg Res 18 (1), 131 (2023)
   PUBMED   36814318
  REMARK    GeneRIF: Functional heterogeneity of MCT1 and MCT4 in metabolic
            reprogramming affects osteosarcoma growth and metastasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11936)
  AUTHORS   Medel,V., Crossley,N., Gajardo,I., Muller,E., Barros,L.F.,
            Shine,J.M. and Sierralta,J.
  TITLE     Whole-brain neuronal MCT2 lactate transporter expression links
            metabolism to human brain structure and function
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2204619119 (2022)
   PUBMED   35939682
  REMARK    GeneRIF: Whole-brain neuronal MCT2 lactate transporter expression
            links metabolism to human brain structure and function.
REFERENCE   3  (bases 1 to 11936)
  AUTHORS   Kopnick,A.L., Geistlinger,K. and Beitz,E.
  TITLE     Cysteine 159 delineates a hinge region of the alternating access
            monocarboxylate transporter 1 and is targeted by cysteine-modifying
            inhibitors
  JOURNAL   FEBS J 288 (20), 6052-6062 (2021)
   PUBMED   33999492
REFERENCE   4  (bases 1 to 11936)
  AUTHORS   Yamaguchi,A., Narumi,K., Furugen,A., Iseki,K. and Kobayashi,M.
  TITLE     Identification of the essential extracellular aspartic acids
            conserved in human monocarboxylate transporters 1, 2, and 4
  JOURNAL   Biochem Biophys Res Commun 529 (4), 1061-1065 (2020)
   PUBMED   32819565
  REMARK    GeneRIF: Identification of the essential extracellular aspartic
            acids conserved in human monocarboxylate transporters 1, 2, and 4.
REFERENCE   5  (bases 1 to 11936)
  AUTHORS   Zhang,B., Jin,Q., Xu,L., Li,N., Meng,Y., Chang,S., Zheng,X.,
            Wang,J., Chen,Y., Neculai,D., Gao,N., Zhang,X., Yang,F., Guo,J. and
            Ye,S.
  TITLE     Cooperative transport mechanism of human monocarboxylate
            transporter 2
  JOURNAL   Nat Commun 11 (1), 2429 (2020)
   PUBMED   32415067
  REMARK    GeneRIF: Cooperative transport mechanism of human monocarboxylate
            transporter 2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11936)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
REFERENCE   7  (bases 1 to 11936)
  AUTHORS   Fayol,L., Baud,O., Monier,A., Pellerin,L., Magistretti,P.,
            Evrard,P. and Verney,C.
  TITLE     Immunocytochemical expression of monocarboxylate transporters in
            the human visual cortex at midgestation
  JOURNAL   Brain Res Dev Brain Res 148 (1), 69-76 (2004)
   PUBMED   14757520
  REMARK    GeneRIF: MCT2 immunoreactivity was noted in astrocytic cell bodies
            from week 19 and spread subsequently to the astrocyte end-feet in
            contact with blood vessels of visual cortex.
REFERENCE   8  (bases 1 to 11936)
  AUTHORS   Fishbein,W.N., Merezhinskaya,N. and Foellmer,J.W.
  TITLE     Relative distribution of three major lactate transporters in frozen
            human tissues and their localization in unfixed skeletal muscle
  JOURNAL   Muscle Nerve 26 (1), 101-112 (2002)
   PUBMED   12115955
REFERENCE   9  (bases 1 to 11936)
  AUTHORS   Lin,R.Y., Vera,J.C., Chaganti,R.S. and Golde,D.W.
  TITLE     Human monocarboxylate transporter 2 (MCT2) is a high affinity
            pyruvate transporter
  JOURNAL   J Biol Chem 273 (44), 28959-28965 (1998)
   PUBMED   9786900
REFERENCE   10 (bases 1 to 11936)
  AUTHORS   Cori,C.F.
  TITLE     The glucose-lactic acid cycle and gluconeogenesis
  JOURNAL   Curr Top Cell Regul 18, 377-387 (1981)
   PUBMED   7273846
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC119793.3, DR000391.1,
            BC007463.1, AF049608.1, BC030693.2, AF058056.1 and AC079905.28.
            
            On Nov 23, 2018 this sequence version replaced NM_001270623.1.
            
            Summary: This gene is a member of the monocarboxylate transporter
            family. Members in this family transport metabolites, such as
            lactate, pyruvate, and ketone bodies. The protein encoded by this
            gene catalyzes the proton-linked transport of monocarboxylates and
            has the highest affinity for pyruvate. This protein has been
            reported to be more highly expressed in prostate and colorectal
            cancer specimens when compared to control specimens. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.32399.1,
                                           SRR1660803.55459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547379.6/ ENSP00000448071.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC119793.3         24793-24803
            12-38               DR000391.1         9-35
            39-178              BC007463.1         1-140
            179-210             AF049608.1         4-35
            211-211             BC007463.1         173-173
            212-412             AF049608.1         36-236
            413-2138            BC030693.2         232-1957
            2139-2139           AF058056.1         1930-1930
            2140-3722           BC030693.2         1959-3541
            3723-11936          AC079905.28        42473-50686         c
FEATURES             Location/Qualifiers
     source          1..11936
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..11936
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="solute carrier family 16 member 7"
                     /db_xref="GeneID:9194"
                     /db_xref="HGNC:HGNC:10928"
                     /db_xref="MIM:603654"
     exon            1..208
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..307
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            308..554
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             338..1774
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="solute carrier family 16 (monocarboxylate
                     transporter), member 7; solute carrier family 16, member 7
                     (monocarboxylic acid transporter 2)"
                     /codon_start=1
                     /product="monocarboxylate transporter 2"
                     /protein_id="NP_001257552.1"
                     /db_xref="CCDS:CCDS8961.1"
                     /db_xref="GeneID:9194"
                     /db_xref="HGNC:HGNC:10928"
                     /db_xref="MIM:603654"
                     /translation="MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFF
                     KEIQQIFHTTYSEIAWISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVL
                     ASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSS
                     LAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDS
                     SPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQG
                     IDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLA
                     QDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPL
                     AGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYRLLAKERKEENARQKTRESEP
                     LSKSKHSEDVNVKVSNAQSVTSERETNI"
     exon            555..698
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1517
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..11936
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10911..10916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="hexamer: AATAAA"
     polyA_site      10943
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="major polyA site"
     regulatory      11905..11910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="hexamer: ATTAAA"
     regulatory      11916..11921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="hexamer: AATAAA"
     polyA_site      11925
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="major polyA site"
     polyA_site      11936
                     /gene="SLC16A7"
                     /gene_synonym="MCT2"
                     /note="major polyA site"
ORIGIN      
        1 gctcctccgc acccacaagg gcgttcagca gccgcgcctc cccttcccgc caccgcctcc
       61 ttctccgctg gctgtggcgg gcgaggacac gtcaggggcc ataaataaat aaataattcc
      121 attcacccgt tgacagcgag gcgaatcggc tgcggtttgc tgggaacgga gggctgcagc
      181 gcccaccctg cgccagagac cagataaaga gtcaatctta agatgtgata ctttcctgtg
      241 aaacctgaaa caaggtgatc tggggaacca aagactctgg gactcttggt gccaacagag
      301 ttactctgtt acttgaattt ccactagagg agcagaaatg ccaccaatgc caagtgcccc
      361 acctgtgcat ccacctccag atggaggatg gggttggatt gtggttggag cagcttttat
      421 ctccattgga ttttcctatg cattccccaa agctgtcacc gtattcttca aagaaattca
      481 gcaaatattc cacactacct acagtgaaat agcatggatt tcatccatta tgctggctgt
      541 tatgtacgca ggaggtcctg taagtagtgt tttggtgaat aaatacggca gccggccggt
      601 ggtgatagca ggaggcttat tatgctgtct tggaatggtg ttggcctcct ttagtagcag
      661 cgtggtacag ctgtacctca ctatgggatt cattacaggt ttaggtttag ccttcaacct
      721 gcaacccgcc ttaaccataa ttggcaaata cttctatagg aagcgaccca tggcaaatgg
      781 attggccatg gcaggaagtc ctgttttctt aagttcattg gctcctttca atcagtacct
      841 ttttaatact tttggctgga aaggaagctt cctgattttg ggaagtctac ttttgaatgc
      901 ctgtgtggct ggttccctca tgagacccct tggacccaat caaaccactt ctaagtctaa
      961 aaataagact ggcaaaacag aagatgattc aagcccaaag aaaatcaaaa cgaagaaatc
     1021 aacttgggaa aaagttaata agtatttaga tttctccctt tttaagcata gaggatttct
     1081 gatatatctg tctggaaatg tcattatgtt cctaggtttt tttgccccca ttatattctt
     1141 ggctccatat gctaaagacc aaggaattga tgagtactcg gcagcttttc tgctatctgt
     1201 tatggctttc gttgatatgt ttgctaggcc ttctgtagga ttaattgcaa actccaaata
     1261 tattcgacct cgaattcagt acttcttcag ttttgcaatc atgttcaatg gagtgtgtca
     1321 cctcttgtgc ccactggcac aggactacac aagcctggta ttatatgctg tattttttgg
     1381 ccttggattt gggagtgtta gcagtgttct ctttgaaact ctcatggacc tcgtgggtgc
     1441 accaagattt tccagtgccg tcggacttgt cacaattgtg gagtgtggcc cagttcttct
     1501 tggccctcct cttgcaggta aattggtgga tttaactgga gaatataaat acatgtacat
     1561 gtcctgtggg gctattgtgg tagcagcaag cgtgtggctg ctcattggca atgctatcaa
     1621 ctatagattg cttgcaaagg aaaggaagga ggaaaatgca aggcagaaga ccagagaatc
     1681 tgaacccttg agcaaatcta aacattcgga agatgttaac gtcaaagttt caaatgcaca
     1741 gagtgtaacc tcagaaagag aaactaacat ttaacaagaa tcacatctct gatttcagtg
     1801 tttatgactt tatctaggag tttgtttttc attttgtttt tttaaagtat tagaaaaggt
     1861 tttagctgaa atgaggagtc acaattaagg atggaggtga tattttcctc aatggcaaat
     1921 tttaaattag tttttaaaaa cttacttatt tgggtagtta aattttgaga ttatgcatag
     1981 aaagaatcca tgctataggt ttatttccat acctgactct gggtgtggtg gttaaaatac
     2041 taattttaaa gtcttccagt gactttcggt cttggttata tggagaattc tgaatcccaa
     2101 acccctggtt taagtaggta gaaggaggat gcctaatcct acaaagtgac cctttataca
     2161 tttcattttt tatttgatat taaagtatga gatagagttg agagacaatt aattatcccc
     2221 tcttacacac aaacacacat actcccacat acttacccac atgtacacag agtatctgga
     2281 gaataaaacc caaattcaaa aaaaaaaatg ataatttatt tttaaggtaa aaataatcca
     2341 tgaagataaa agaaacatat gtctgcgtgc tactttacaa tgttggtttt aaagataagc
     2401 acatgggtaa aaatgagggt gatccttatt caaaaataac atctgactac tataaaaata
     2461 tttgcatata taagtttgac aaagaaaaga aaatcaatgt taaaccatta aatctgagca
     2521 ctgttagact tgattaatcc atgcacatga ttttttttga gtagggagca ttagtacctg
     2581 gtgctagaga atagaaccct caaataattt ttagaattct tacctaatat gtaaaagtct
     2641 gcatgactct taacaatgag tcacatccat tgattttaca gggattttag ttcgtaatcc
     2701 agaaagtaat aatcagggat tttattttaa tcaggcatca atccagattc actgttatac
     2761 tgaaatatca aagtaaaatc ctagttggca ggattgtaag tagaccgaat tctaattttt
     2821 cccaacacat agtggtaatt ggaggttact gttatgaata ctccatctga ctacgactaa
     2881 gagagtgagg ggtggtttta atgaaccctc taagctctct cagttccttc ccttccacaa
     2941 aatgcaagag caaaagcaaa ctacaaacag gccttgtgct caaccactgg aaatgcctcc
     3001 tgggataaga atggcagcac ttgaaaattc tgccctctac tgatgagact tcctgctgcc
     3061 tttggacata actaagccag gaaactttaa aagccttcta gaaatagagg cactgtatga
     3121 cttgcaatcg taggtatagt ttataacctg atagcaaaaa acttgaaata ttgcagccca
     3181 gtttaattca gcactttccc attttcataa ctatgtgaaa acatctggga atttgaatca
     3241 ctcctgaata cagaggcata ttctttttaa actataaata ccattttgag tgagaaagta
     3301 cttttaaaca agaaagaaat tgtacattat gactaaagtt ataaatacaa tatttatatc
     3361 tataaatctg aagtttaaca tgattaattt aaaaagtatt tagtgcttga caaagtagtg
     3421 tcactcttaa gatgtcaaag ggaattagcc atttttttta ttgtaataaa ggcaggtgct
     3481 atttttttct ggtgagattg cacctggata ccaggctttt gtaatagtta acattaaaca
     3541 tttgattcat aaagttaatt cactgcttaa gcatgtggct catatttagg aagctatata
     3601 aaattcagtt tttcatttaa catttgctct tttgcatatg aagagatatt tgtatttttc
     3661 aaatgttaag taaaacaaga tgtgccaata tcataggtaa ataaattagg gaaaatgtgg
     3721 gactttatgg ctgtttttaa tttagtttca cccgatcttg attcttgaat tagctatgtt
     3781 tatattttta gttctttttt attcaactca gatttgtcaa gaaatgtaac ctctaaattg
     3841 tgtagtacct ctccaatcat aaattttcaa aaaaaaattc tactttccaa aaagtgtctt
     3901 gaattctctg aaaaggcaca ttaaactaat atgaacatca gataccaggg ggaaataaat
     3961 ggcaaagtaa taatcatgag gttttaggtc aaagactaca ttatatatat tttttattac
     4021 cttctagtag agacatcctc ctgggtgcat ttcagtggcc ttctccaggg aggaggttta
     4081 tttacttact gatgagtttc tcgtcacgtc aaaaccagtt cacatttgtc tggctgctct
     4141 ttggttgtct tcattcgtta tttatttcta acactgtatt aaattgttag aaaagaaagt
     4201 aaaacttgca cattcaaagc acatgatttg tacagtcaca cctggcagta gcactgcaca
     4261 gttacaaata tgcacacacg ttaactgcta tgcataaata ttgacagtta aaccagaaca
     4321 caattgaaac agtgacataa atacctacag gattcagaat tgttccaggg taatataaat
     4381 tattctactt gttcactctc cccaccctct tgaacttgtt agaagatttg ctgctttagc
     4441 agaatctttc caagattgag aaaagtgtat caacctagga ttttcattac tatatagtca
     4501 cataaatgga ggaggagata tatttggctt ctgcctctgc aacaattagt atgaacatat
     4561 ttctttctct agggaataat aggttttaaa catttgagat atcatgaagc aaagtcaggg
     4621 tataccacta caatccccac taatctctat tcccacatta tgaaattgta cagaagaaag
     4681 ggtgtcatta aatcaaggta tccagataat tcatggctac tttaactatt ttttcattcg
     4741 tgttaactga gccccccata ttttttacta cttaacctta aatatgccat cactaattta
     4801 tgaatagaac attgtgtttg cacttttcct gacctatcct cacccccttt cctgatcctt
     4861 tttgcattca cctagcacac cttaagagac aaaaaatcag gttttagtgt atttcacatt
     4921 ggaagacatg atgttttctc agtataaatc tacaggactc ataaacaatc acttttttgg
     4981 tgccaagttt caacccttta gctcatggac tcattggcct cagcctaata ctaagaaaca
     5041 agtaaaataa ttagattttc tatgtttgaa tgtgcacttt aaaaaatcta gataatttat
     5101 actcattctt ttctggctgt acaacatgac aatcaagaat atagaaaaga agactaaaag
     5161 atatatgata taaatgtaag tttttatgta gatgacataa atatgaagag atattcttgg
     5221 tcagttggtt gaaacatttt ttatctaaaa cacctttaaa aaatcccttt catatgtaga
     5281 atgtggaagg cttttaataa aacaaaaatt attattttta ggcttaattt aatagggaga
     5341 ttggatgcat agtggaaagg gaactaatat ttatatgtta tgcattttgc ttatgtaatg
     5401 cctttcaata tgaaaaccaa aaccatggca gaattattac tagcttgata tgacagatga
     5461 gtgaaaacaa aaaacaagct cagcagacta cccaaagtta aaaggtagta tgaaccaaaa
     5521 ttaaaactca ggtttacgta accagaaaga tccccgaggt gttcactacc gtgctgcctc
     5581 ccaatagagg ccagagaagc aaaggaagat aaaatatagg tacaaaaaag atacatccta
     5641 tatagtaaaa caattaggtt taactgtaac ttgtattatg atttatttag tgtttattag
     5701 agaactgcat ttgctagaac ctgaatatgt aatttctttc tttctttctt tttttttttt
     5761 tttgagactg agtctcgttc ttgtcgccca ggctggcgtg cagtggcaca atctcggctt
     5821 actacaacct ctgcctccca ggttcaagca attctcctgc ctcagcctcc cgagtaactg
     5881 gaattacagg catgtgccac catgcccggc taattttgtg gctttttttg ttttgttttg
     5941 ttttgttttg ttttagtaga gatggggttt ctccttgttg gtcaggctgg tcttgaactc
     6001 tgacctcagg tgattcactc gcctctgcct cccaaagtgc tgggattaca ggcgtgagcc
     6061 actgcgccca gccttgaata tgtaatttct gattgcctgc ttttctcccc aatgcaaatt
     6121 atctcaaata atgataatta ttacatatag acataattac ttcaatatga ctctttttct
     6181 cataaaaata atgacatatt tgagtcaggc ataatacatt ttttctgagg ttggagttag
     6241 caggaaaatg ttatctttta tgaataaata attcccagat tggttgctac atatcatgat
     6301 tcaaaaagta aaataattac ctggatgtgg tgatgtgcac ctgtagtccc agctactcgg
     6361 gaggctgaga cgagagggtc atttgagccc aggaagttga ggcttcagtg agctataatg
     6421 gccccacttg cagtccagcc taggcaatag agtgagaatc tgtctctatt aaaaaaaaaa
     6481 taaaatgttc ttactagaaa acattatatt tagaatttta gtgattattc catttataat
     6541 attatccgta gctaccaaaa aaaagattat aagatacaaa tgatttggtt tacccataca
     6601 gttacatatt aattttcatc atttaataca acttacccta caccgtagct tatttttcaa
     6661 gtttctctga acatctttgt tgtcattcac ctctttgtct atttgttctg tagagaaaac
     6721 aagtgtcatt gcttttgtct tctccatcta gacttttgca gtccttagac tatagttctc
     6781 cttagctcta ttcaaatagt gcacttgcaa ggcgctgcat tcttctcaaa gtcagccatg
     6841 atgcacatat ttataattac atacacatat aattgaatat gattttagag tcttgaaaaa
     6901 ctgatcttct ttggcactat cctgaatgtt tctgattttc ttaaagtgcc tgacaatatt
     6961 gagtaacaaa gcttaccatc accacattgc accattatgt attattctgt ctccatcaat
     7021 gcagtgacat cactgataca tcataccaac aagatttcta accacaacca ttcagagcac
     7081 taattagcat ctatattgag aatataagat taatattaca aacttgactt tactcatctc
     7141 tctttaagat tttgatttct gcacaaccat atgcagaact catgtttgag aaggcactta
     7201 aaagctgaaa ggcccaatta tcagtaatta taatgcttgc atgatcaaaa ttacaaatta
     7261 tctttgttga tacaattaaa aatgagtaat tttctgagct tatgtcactt ttttatagtt
     7321 ctgattttct cttctttcct atcagttgtt tgtacactgg agattttagc tctttacagg
     7381 gtgctacaat ctggtttatt ttagtcttct ctcctctact gctttttctt cactttaatt
     7441 catttatgtg caaatcaggg aagaattgct gtagtattga gaatggtcat tttaaaagtc
     7501 tctaccttaa gagcaaaatt aatattgcaa aatgaatttt tgattttaca gaagcatatg
     7561 ggaatttaga tcaaattaca tctcccatcc caatctcctg cttcttcatc atctcctaaa
     7621 tgttttcctt tctatgtttt tataatatct aggtaaaact tgtttagcat tttttattta
     7681 attatggaca tatttagtat ggacttttgt ttctttggta tagttagtta cacttgtttg
     7741 catgatctac atgtttttca gtctccatat atacttgtta ataaggtgag caatattcag
     7801 gaatatttca gtaggcaatt aatgatcata aatttattca catttcagta aatatttttc
     7861 acatgatcaa acaggatttt ttgtttcttt ttaatttaaa tatggcaaaa taagctagag
     7921 aatctcagtg tgaaaacact gatactgaac attctattaa aatagaataa gttcgtgtag
     7981 ggacatggat gaaattagaa atcatcattc tcagtaaact atcgcaagaa caaaaaacca
     8041 aacaccgcat attctcactc ataggtggga actgaacaat gagaacacat ggacacagga
     8101 aggggaacat cacactctgg ggactgtggt ggggtcgggg gaggggggag ggatagcatt
     8161 gggagatata cctaatgcta ggtgacgagt tagtgggtgc agcgcaccag catggcacat
     8221 gtatacatat gtaactaacc tgcacattgt gcacatgtac cctaaaactt aaagtataat
     8281 aataataaat aaaataaaat aaaataataa aaataaaaat aaaatagaat aagttgataa
     8341 aagctcctct gttcagaaaa acaaaagaat ggcattttat ctcacataaa tttaggatga
     8401 aattttaaaa cattcttttg actaagactt taattcttat atgcatctaa aataaatgtt
     8461 ttgagttaga ctcagtttat atagcttcct cgttagagta cacatttttt ttctcatcct
     8521 ccgaatctca agagtacata tttctgacaa gcttttcaat ggtacgatgg attttatttt
     8581 tctatcatca actttctata tttaactaaa gcattagtat ttctagattt agtgaaatag
     8641 caaatatgaa ttaaaatatt tatttctaaa cattagatct aattgtattt tgatttgttt
     8701 tgatatattt atgtctcaga agatatgttt aatgaattca tttcatcctc tcaaccctca
     8761 gttttgatag gtatccacat ttttaccata taaaactaga ctggattaag gattttgcct
     8821 aaacctatac caatactctg aataaatgca gggttggaga tagaattcag gtcttttaac
     8881 ttctaacaca cttttttctc cattgcacta cagaagccgt aaggtcataa tgatgatctt
     8941 tgtagagtaa ataaaatatt ttcctagaaa tatatataac aaccctactt gatagtttat
     9001 agcccaaatg aatatatttt tccaatcatg gtttgcaaaa tcatgtttgc aaacttactt
     9061 tgaagactat ttcctgattg ccacggcaga taattcgtgg caaatcagaa ataatattta
     9121 gtgagattaa ttattttgca caatatatgt tgttatagca atatcaaaat catttaaaac
     9181 atcaatattg tattaataga aaacatgtca atatctcatt aattcctttt ttattttatg
     9241 ttccttttta ttttagaagc agtgttcatt tttttctgaa gtagaacgcc agagcacaga
     9301 acacacagtt caagtttaaa ttattaaatt gtatgcaaga aattattgcc atagcatagt
     9361 cttgaggaga acacctctac agtatttctt gatctaagaa cctgaacata tgttaatgaa
     9421 attattagag taagttctat ctcaaaaatt tcttatttta tgaatgtttt cttcacctaa
     9481 taaacaatac taaaatccat aacagctgtc tggcaacagt gtaattagag cttcttttat
     9541 gttagagatt ccatctacct ctgcatctta tctagctaga tacagtcttt ctaaactttc
     9601 tcctttattc ccatgtagag aacaaacaaa aatcacacct aaattaaaga tctgtggtga
     9661 aggggaagag gggttgctat taggagtttt cccggtaaaa ctgtaaaaac agtaatctgc
     9721 attcagtatt tgtttgccta gttcatcaag atatttaccc taaaaacaca ttttaataaa
     9781 aatttgggta aactcatgta tcgcagtaaa atcttttatg aattgggtgg gccctaaaaa
     9841 catctgtagt acgtgatgtg tttggttaga ttcagccaaa ccgacacccg tatgctaaga
     9901 ctgcattgtc attctgacag gaggcaggcc tcagtagttg cagtgagtgc atttactaat
     9961 ataaggatcc ttctttgtag tgacaacaaa aatgagattg taacttaatc aaatatgagt
    10021 cagatatagt aattcctgat attgcagatg aaagagcagg gtcttttcaa gtgcttgcta
    10081 caactgacta aatttgaagc tttttatgta aaagttcttc tcccagatat tttaaaccag
    10141 tatgttaatt atttcctaga atgaataatt ctcctttttt gatagatttt tgaaattgtt
    10201 ttacttacta cttacatact ttgaacaaat atgtttttct aatcccagca ttaaattgaa
    10261 acaaatattt aaaataagat tgttggaata aaagttatag atagtcactt gttgctaata
    10321 aaagacattc cttggcaaca gccacatcca gctaactttt gcaagaattt tttaagggat
    10381 tagatttagg ggttaatgtt tagaattatt tttaaaatat aaattatatt ttaggctgta
    10441 tttttgtgat ttttaagtga aaaaaataaa atgtagttgt cttgtttatt ctatagatat
    10501 cttaatgacc actgaacaaa tgatcatatt gccacatggt ctatcaacta tggttactat
    10561 gatagtgaaa taaagaggat agttttgctt gacacctaaa tgatccaaac agttgttttt
    10621 acatgactta aatcatggct gtattatttc atttttaaag aaaataaagt ataaaataat
    10681 acatttaaaa tacctgtcaa agttttaaaa tataagatag aaccttcttt ttttgccttc
    10741 ttacacatga atgtacttaa agtattgtta tgtgatcttg ggatacttat ttatttttga
    10801 aatttttgta tatatagcat ttctgaactt agcaaataat atgtgtaaag gaattaacca
    10861 aaaatgaaag aactggcatt ttcatatgga tacatatttt gcttaaacta aataaaataa
    10921 cttagattta tttaaatcag gaatatttta cgttgttgat catttttaaa gtatattttg
    10981 ttcaaatatt cctaatttgt ttttcagcac acttgtttaa gttcttgcct ttcaggtata
    11041 ctacagcgtt atatgaacat aatgttttaa aaaaatcttg gttgtagttt ctaattttca
    11101 ctgcataaca aatttgaaac caaatgttga atttctctgt gagggtactt attttgccta
    11161 cagtttcaaa tatattttca aattcatctc tttcttacta gactgtgagc tccttgtgga
    11221 caaggatgtt attttagtta taatgacaac tttaatatct agcaaagtgc caggcataga
    11281 gtattccttt attgaaatga attgatagat attgattatt aaaatgctac tacagtattc
    11341 tacgatgcag gctgaatgta tattacagta attctctggc taattttaaa agtaagacat
    11401 agaaaacaaa acacctgtag cattttcttt atttaaaatt gaaactctgt tttgaatcct
    11461 ttttattttg tcaaacattc tatgcaaata ttgaaatatg caacagctaa actttatggt
    11521 acatattaat tagttttatt ttcttttcaa aatcagaaat gctgtattta agcttcctgg
    11581 aaatgtcgac aatcatttta atgaccaaag gtgctactta tttttcaaca ttgaccttga
    11641 tcataagtgc ttctatctgc tgagctttat ttattgtttt tggacagaaa gtttggtggg
    11701 aaggttgcaa taaaatcaga atctctcttg tctgaattat gcagtttaac cctgtccatg
    11761 ttcctctgta ctctattctt actgtatttt agttattgtt tcttacttat cactaatttt
    11821 tactgcaggt ctgtgctgtt tcttagaaag tacatgcata tatatttcta taatatgtaa
    11881 gaaaaaacct gtattgctta ttaaattaaa attaaaataa aaaaattcat gttaaa
//
