LOCUS       NM_004694               3691 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens solute carrier family 16 member 6 (SLC16A6),
            transcript variant 2, mRNA.
ACCESSION   NM_004694
VERSION     NM_004694.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3691)
  AUTHORS   Higuchi,K., Sugiyama,K., Tomabechi,R., Kishimoto,H. and Inoue,K.
  TITLE     Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel
            facilitative taurine transporter
  JOURNAL   J Biol Chem 298 (4), 101800 (2022)
   PUBMED   35257743
  REMARK    GeneRIF: Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is
            a novel facilitative taurine transporter.
REFERENCE   2  (bases 1 to 3691)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3691)
  AUTHORS   Dai,W., Liu,H., Chen,K., Xu,X., Qian,D., Luo,S., Amos,C.I.,
            Lee,J.E., Li,X., Nan,H., Li,C. and Wei,Q.
  TITLE     Genetic variants in PDSS1 and SLC16A6 of the ketone body metabolic
            pathway predict cutaneous melanoma-specific survival
  JOURNAL   Mol Carcinog 59 (6), 640-650 (2020)
   PUBMED   32232919
  REMARK    GeneRIF: Genetic variants in PDSS1 and SLC16A6 of the ketone body
            metabolic pathway predict cutaneous melanoma-specific survival.
REFERENCE   4  (bases 1 to 3691)
  AUTHORS   Murakami,Y., Kohyama,N., Kobayashi,Y., Ohbayashi,M., Ohtani,H.,
            Sawada,Y. and Yamamoto,T.
  TITLE     Functional characterization of human monocarboxylate transporter 6
            (SLC16A5)
  JOURNAL   Drug Metab Dispos 33 (12), 1845-1851 (2005)
   PUBMED   16174808
  REMARK    GeneRIF: MCT6 is involved in the disposition of various drugs,
            including bumetanide.
REFERENCE   5  (bases 1 to 3691)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
REFERENCE   6  (bases 1 to 3691)
  AUTHORS   Halestrap,A.P. and Price,N.T.
  TITLE     The proton-linked monocarboxylate transporter (MCT) family:
            structure, function and regulation
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 281-299 (1999)
   PUBMED   10510291
  REMARK    Review article
REFERENCE   7  (bases 1 to 3691)
  AUTHORS   Price,N.T., Jackson,V.N. and Halestrap,A.P.
  TITLE     Cloning and sequencing of four new mammalian monocarboxylate
            transporter (MCT) homologues confirms the existence of a
            transporter family with an ancient past
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 321-328 (1998)
   PUBMED   9425115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064832.1 and AC005332.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004694.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064832.1, SRR14243140.652329.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000580666.6/ ENSP00000462985.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2520              BC064832.1         140-2659
            2521-3691           AC005332.1         60134-61304
FEATURES             Location/Qualifiers
     source          1..3691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..3691
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /note="solute carrier family 16 member 6"
                     /db_xref="GeneID:9120"
                     /db_xref="HGNC:HGNC:10927"
                     /db_xref="MIM:603880"
     exon            1..42
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /inference="alignment:Splign:2.1.0"
     exon            43..281
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1621
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /note="monocarboxylate transporter 6; breast cancer
                     protein BCY5; solute carrier family 16, member 6
                     (monocarboxylic acid transporter 7)"
                     /codon_start=1
                     /product="monocarboxylate transporter 7"
                     /protein_id="NP_004685.2"
                     /db_xref="CCDS:CCDS11675.1"
                     /db_xref="GeneID:9120"
                     /db_xref="HGNC:HGNC:10927"
                     /db_xref="MIM:603880"
                     /translation="MTQNKLKLCSKANVYTEVPDGGWGWAVAVSFFFVEVFTYGIIKT
                     FGVFFNDLMDSFNESNSRISWIISICVFVLTFSAPLATVLSNRFGHRLVVMLGGLLVS
                     TGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVTILSQYFGKRRSIVTAVASTGEC
                     FAVFAFAPAIMALKERIGWRYSLLFVGLLQLNIVIFGALLRPIFIRGPASPKIVIQEN
                     RKEAQYMLENEKTRTSIDSIDSGVELTTSPKNVPTHTNLELEPKADMQQVLVKTSPRP
                     SEKKAPLLDFSILKEKSFICYALFGLFATLGFFAPSLYIIPLGISLGIDQDRAAFLLS
                     TMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTVSLFAFTFATEFWGLMSCSIFF
                     GFMVGTIGGTHIPLLAEDDVVGIEKMSSAAGVYIFIQSIAGLAGPPLAGLLVDQSKIY
                     SRAFYSCAAGMALAAVCLALVRPCKMGLCQHHHSGETKVVSHRGKTLQDIPEDFLEMD
                     LAKNEHRVHVQMEPV"
     exon            282..425
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /inference="alignment:Splign:2.1.0"
     exon            426..554
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1370
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..3691
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3661..3666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /note="hexamer: AATAAA"
     polyA_site      3691
                     /gene="SLC16A6"
                     /gene_synonym="MCT6; MCT7"
                     /note="major polyA site"
ORIGIN      
        1 attgggagcc tttgggggtt tattctcttc ccttctaact tgattaagaa tgacccaaaa
       61 taaattaaag ctttgttcca aagccaatgt gtatactgaa gtgcctgatg gaggatgggg
      121 ctgggcggta gctgtttcat ttttcttcgt tgaagtcttc acctacggca tcatcaagac
      181 atttggtgtc ttctttaatg acttaatgga cagttttaat gaatccaata gcaggatctc
      241 atggataatc tcaatctgtg tgtttgtctt aacattttca gctcccctcg ccacagtcct
      301 gagcaatcgt ttcggacacc gtctggtagt gatgttgggg gggctacttg tcagcaccgg
      361 gatggtggcc gcctccttct cacaagaggt ttctcatatg tacgtcgcca tcggcatcat
      421 ctctggtctg ggatactgct ttagttttct cccaactgta accatcctat cacaatattt
      481 tggcaaaaga cgttccatag tcactgcagt tgcttccaca ggagaatgtt tcgctgtgtt
      541 tgctttcgca ccagcaatca tggctctgaa ggagcgcatt ggctggagat acagcctcct
      601 cttcgtgggc ctactacagt taaacattgt catcttcgga gcactgctca gacccatctt
      661 tatcagagga ccagcgtcac cgaaaatagt catccaggaa aatcggaaag aagcgcagta
      721 tatgcttgaa aatgagaaaa cacgaacctc aatagactcc attgactcag gagtagaact
      781 aactacctca cctaaaaatg tgcctactca cactaacctg gaactggagc cgaaggccga
      841 catgcagcag gtcctggtga agaccagccc caggccaagc gaaaagaaag ccccgctatt
      901 agacttctcc attttgaaag agaaaagttt tatttgttat gcattatttg gtctctttgc
      961 aacactggga ttctttgcac cttccttgta catcattcct ctgggcatta gtctgggcat
     1021 tgaccaggac cgcgctgctt ttttattatc tacgatggcc attgcagaag ttttcggaag
     1081 gatcggagct ggttttgtcc tcaacaggga gcccattcgt aagatttaca ttgagctcat
     1141 ctgcgtcatc ttattgactg tgtctctgtt tgcctttact tttgctactg aattctgggg
     1201 tctaatgtca tgcagcatat tttttgggtt tatggttgga acaataggag ggactcacat
     1261 tccactgctt gctgaggatg atgtcgtggg cattgagaag atgtcttctg cagctggggt
     1321 ctacatcttc attcagagca tagcaggact ggctggaccg ccccttgcag gtttgttggt
     1381 ggaccaaagt aagatctaca gcagggcctt ctactcctgc gcagctggca tggccctggc
     1441 tgctgtgtgc ctcgccctgg tgagaccgtg taagatggga ctgtgccagc atcatcactc
     1501 aggtgaaaca aaggtagtga gccatcgtgg gaagacttta caggacatac ctgaagactt
     1561 tctggaaatg gatcttgcaa aaaatgagca cagagttcac gtgcaaatgg agccggtatg
     1621 acacactttc ttacaacaac agccactgtg ttggctggag agggatgggg tgggcccaac
     1681 ggggacacaa ggaggcagag gagctaaccc ctctactcca ctttcaaaac tacattttaa
     1741 agggaatgtg tatgtgaaga gcactaccaa catcgctttt gttttgtttt gttttgtttt
     1801 aagctttttt tttttgcttg tttttaaagc caaaacaaaa aacaaccaag cactcttcca
     1861 tatataaatc tggctgtatt cagtagcaat acaagagata tgtagaaaga ctctttggtt
     1921 cacattccga tattaaaata gtgacatgaa ctggcaaagt ggttttaaaa gctttcacgt
     1981 gggataaatg attttctttt tttcttttct ttcttcctat ggtcttgtct gaataaacta
     2041 ctctcctgaa taaaacaaca tccaacccag gtcattgaaa tgaaattggc cagtcaaaaa
     2101 aaaaaagact tcaatcattt ttaaaattcc taattttcag aaatatgaat aaatagtttt
     2161 tgttaaaccc tttgtaaaat accaaggttc ccgttaacaa attacggcct ctgcttgctg
     2221 gaaatgaaat atagtttaag accaaacatt ttactaataa acaaatttta agtatatata
     2281 tatatatata acttgaactt cataaatgtg aagattacca cttcttttta tggccagtcc
     2341 ttatcagaag tgtttcagta cagaatatac aaaatggcat ttaaaaatgt gtttcctgtt
     2401 gcttttagtt atacagaaat atgtgactgt agtgtcttta atttaaaccg ctatttatta
     2461 ttaagttatt ctaggatgat taaagtaatc aaaagaaata aaatctgaga cataagcagc
     2521 atttttacct cctttctgca atcctttaaa tgcctcacag aatacgtctt atcttgtaaa
     2581 aatactttca taaaaggcca agttgtcatg attcttccat ttgattaggg gcaacgtgtg
     2641 ctattaaagg ggaaaaaata atggattgca aatcgcctta gctttcaaaa ctaatttgtt
     2701 ttatcattta agaatacttg aggaacttct ttgatcagaa ttatatttca gagaattgtt
     2761 aaagcatttc tgatttaaag aaaaaaccat ctaattattg aagcatttct gtatttcaca
     2821 tgggggtaac agagacaatt atgttatagc gagttacaag ttgcaattta catcttctat
     2881 aacacatgac ttgattggtc taagttgcca gaggtatcgg gtaactggtc attgttttgt
     2941 tttgtttgtt ttattcttcc tttttttttg gagtcacact acatgtatag tattgctcac
     3001 gttagcagtt ttctgtaagg agggcaagtg tcaggataat aggtggactt tttactcacc
     3061 tattttacca caatctcacc ctgcaggtga tggtcaatgc ttgctgctcc atctttattc
     3121 atcgttaatg ttaatttatg acaactcagg gggaaaaaca taacaagcct agtttggtta
     3181 caggtacaca caagcttgaa tatttctctg cactgaaatg aaagtggcat agttcatcac
     3241 cacctgctac attttgtaga gcatcttatc agccatagaa ataggacaat ctataaaact
     3301 ttggggaggg tgggggagga aatgacaaag tgtctgtcaa aaacaggcat aatctaaaac
     3361 aaggtggatg tagcaaatct ctgtcactgc ttgagaactt tgagcttgtg gcagttttgc
     3421 agacttacat gacttcagca ctttacgaca tattttttac tatgaatgtt caatacaatt
     3481 taatatttat aactgatttc tgagggatct gctccatgtc tattctgtta tctgcatgaa
     3541 aacaaaatgt atgccaattt cagtatgtca ataatcaagg ttttaaatgt ttggaagaaa
     3601 atacaaacaa gattgctgat ctgttctgta ttagtgacat tctggtactt ctagatttgc
     3661 aataaattta tggatttttt atttaaagag a
//
