LOCUS       NM_004695               1940 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 16 member 5 (SLC16A5),
            transcript variant 1, mRNA.
ACCESSION   NM_004695 XM_941071
VERSION     NM_004695.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Meng,X., Yuan,H., Li,W., Xiong,Z., Dong,W., Xiao,W. and Zhang,X.
  TITLE     Solute carrier family 16 member 5 downregulation and its
            methylation might serve as a prognostic indicator of prostate
            cancer
  JOURNAL   IUBMB Life 73 (11), 1363-1377 (2021)
   PUBMED   34549875
  REMARK    GeneRIF: Solute carrier family 16 member 5 downregulation and its
            methylation might serve as a prognostic indicator of prostate
            cancer.
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Drogemoller,B.I., Monzon,J.G., Bhavsar,A.P., Borrie,A.E.,
            Brooks,B., Wright,G.E.B., Liu,G., Renouf,D.J.,
            Kollmannsberger,C.K., Bedard,P.L., Aminkeng,F., Amstutz,U.,
            Hildebrand,C.A., Gunaretnam,E.P., Critchley,C., Chen,Z.,
            Brunham,L.R., Hayden,M.R., Ross,C.J.D., Gelmon,K.A. and
            Carleton,B.C.
  TITLE     Association Between SLC16A5 Genetic Variation and Cisplatin-Induced
            Ototoxic Effects in Adult Patients With Testicular Cancer
  JOURNAL   JAMA Oncol 3 (11), 1558-1562 (2017)
   PUBMED   28448657
  REMARK    GeneRIF: Identify a novel association between protein-coding
            variation in SLC16A5 and cisplatin-induced ototoxic effects in
            testicular cancer patients.
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Sugito,K., Kawashima,H., Uekusa,S., Yoshizawa,S., Hoshi,R.,
            Furuya,T., Kaneda,H., Hosoda,T., Masuko,T., Ohashi,K., Ikeda,T.,
            Koshinaga,T., Fujiwara,K., Igarashi,J., Ghosh,S., Held,W.A. and
            Nagase,H.
  TITLE     Identification of aberrant methylation regions in neuroblastoma by
            screening of tissue-specific differentially methylated regions
  JOURNAL   Pediatr Blood Cancer 60 (3), 383-389 (2013)
   PUBMED   22911660
  REMARK    GeneRIF: We demonstrated that SLC16A5 and ZNF206 displayed altered
            methylation patterns in the neuroblastoma genome
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Murakami,Y., Kohyama,N., Kobayashi,Y., Ohbayashi,M., Ohtani,H.,
            Sawada,Y. and Yamamoto,T.
  TITLE     Functional characterization of human monocarboxylate transporter 6
            (SLC16A5)
  JOURNAL   Drug Metab Dispos 33 (12), 1845-1851 (2005)
   PUBMED   16174808
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Halestrap,A.P. and Price,N.T.
  TITLE     The proton-linked monocarboxylate transporter (MCT) family:
            structure, function and regulation
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 281-299 (1999)
   PUBMED   10510291
  REMARK    Review article
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Price,N.T., Jackson,V.N. and Halestrap,A.P.
  TITLE     Cloning and sequencing of four new mammalian monocarboxylate
            transporter (MCT) homologues confirms the existence of a
            transporter family with an ancient past
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 321-328 (1998)
   PUBMED   9425115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI820515.1, BC009684.1,
            BC033611.1, AK000416.1 and AW452009.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004695.3.
            
            Summary: This gene encodes a member of the monocarboxylate
            transporter family and the major facilitator superfamily. The
            encoded protein is localized to the cell membrane and acts as a
            proton-linked transporter of bumetanide. Transport by the encoded
            protein is inhibited by four loop diuretics, nateglinide,
            thiazides, probenecid, and glibenclamide. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2012].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009684.1, SRR1163655.311910.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329783.9/ ENSP00000330141.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BI820515.1         14-19
            7-267               BC009684.1         1-261
            268-413             BC033611.1         171-316
            414-1935            AK000416.1         493-2014
            1936-1940           AW452009.1         14-18               c
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..1940
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /note="solute carrier family 16 member 5"
                     /db_xref="GeneID:9121"
                     /db_xref="HGNC:HGNC:10926"
                     /db_xref="MIM:603879"
     exon            1..91
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            92..245
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            246..492
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1811
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /note="monocarboxylate transporter 5; solute carrier
                     family 16 (monocarboxylic acid transporters), member 5;
                     solute carrier family 16, member 5 (monocarboxylic acid
                     transporter 6); solute carrier family 16 (monocarboxylate
                     transporter), member 5"
                     /codon_start=1
                     /product="monocarboxylate transporter 6"
                     /protein_id="NP_004686.1"
                     /db_xref="CCDS:CCDS11713.1"
                     /db_xref="GeneID:9121"
                     /db_xref="HGNC:HGNC:10926"
                     /db_xref="MIM:603879"
                     /translation="MPQALERADGSWAWVVLLATMVTQGLTLGFPTCIGIFFTELQWE
                     FQASNSETSWFPSILTAVLHMAGPLCSILVGRFGCRVTVMLGGVLASLGMVASSFSHN
                     LSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRRRVLANALASMGVSLGITLWPLLSR
                     YLLENLGWRGTFLVFGGIFLHCCICGAIIRPVATSVAPETKECPPPPPETPALGCLAA
                     CGRTIQRHLAFDILRHNTGYCVYILGVMWSVLGFPLPQVFLVPYAMWHSVDEQQAALL
                     ISIIGFSNIFLRPLAGLMAGRPAFASHRKYLFSLALLLNGLTNLVCAASGDFWVLVGY
                     CLAYSVSMSGIGALIFQVLMDIVPMDQFPRALGLFTVLDGLAFLISPPLAGLLLDATN
                     NFSYVFYMSSFFLISAALFMGGSFYALQKKEQGKQAVAADALERDLFLEAKDGPGKQR
                     SPEIMCQSSRQPRPAGVNKHLWGCPASSRTSHEWLLWPKAVLQAKQTALGWNSPT"
     exon            493..636
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            637..1446
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1657
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1940
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1914..1919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /note="hexamer: AATAAA"
     polyA_site      1940
                     /gene="SLC16A5"
                     /gene_synonym="MCT5; MCT6"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgcgg tcctcgtcgc gaccggcccg ggccgcagga cgccgcgctc gggggagctg
       61 agccacctct ccgccaggcc cgtgcgagcg gtacaaagaa aagagcactt ccctgctggg
      121 gcagaggcca agccagagcc ctggccccat cacctctctg ccctgcttga gtctggaatg
      181 gacctccctg cctggaagct gcattgccct tggtcctggg cctgcctgcc ccctggggaa
      241 cacaggcagc agccacattg gcagtgaggc cgtggcagcg tcggcagcag aggatgcccc
      301 aggccctgga gcgtgcagat ggcagctggg cctgggtggt gctgctggcc accatggtga
      361 cccagggcct caccctgggc ttccccacgt gtatcggcat cttcttcact gaattgcaat
      421 gggagttcca ggccagcaac agcgagacct cttggttccc ctccatcctc acggctgtgc
      481 tccacatggc agggcccctg tgcagcatcc tggtgggacg cttcggctgc cgagtgaccg
      541 tgatgctggg gggcgtgctg gccagcctgg gcatggtggc cagctccttc tctcacaacc
      601 tcagccagct ctacttcaca gcaggattca tcacaggcct gggcatgtgc ttcagcttcc
      661 agtcaagcat cacggtgctg ggcttctact ttgtccgccg gcgggtgctg gccaacgcgc
      721 tggcctcgat gggcgtctcc ctgggcatca ccctctggcc gctgctctcc cgctaccttc
      781 tggagaacct gggctggagg ggtaccttcc ttgtcttcgg cgggatcttt ctccactgct
      841 gcatctgcgg ggccatcata aggcctgtgg ccaccagtgt ggcccctgag accaaagaat
      901 gtcccccgcc acctcccgag acacctgcac ttggctgcct ggctgcatgc ggccggacca
      961 tccagcgcca cctggccttc gacatcctgc ggcacaacac aggctactgc gtgtacatac
     1021 tgggtgtgat gtggtccgtc ctgggcttcc cactgccaca agtcttcctg gtgccatatg
     1081 ccatgtggca cagcgtggac gagcagcagg cagccctcct catctccatc atcggcttca
     1141 gcaacatctt cctgaggccc ctagccgggc tgatggcagg acggccggcc tttgctagcc
     1201 accgcaagta cctgttcagc ctggcactcc tgctcaatgg gctcactaac ctggtgtgtg
     1261 cggcatcagg tgacttctgg gtgctcgtgg gctactgcct ggcgtacagc gtgtccatga
     1321 gtggcatcgg cgccctcatc ttccaggttc tcatggacat cgtccccatg gatcagttcc
     1381 ccagagccct gggactcttc actgtcctgg acggccttgc tttcctcatc tccccaccac
     1441 tggccgggtt gctcctggac gccaccaaca actttagcta tgttttctac atgtccagct
     1501 tcttcctcat ctcagctgcc ctcttcatgg gtggcagctt ctacgccctg cagaagaagg
     1561 agcaaggcaa gcaggctgtc gcggcggatg ccctggagcg ggatcttttc ttggaagcca
     1621 aagacggtcc tgggaagcaa cggtcccctg agatcatgtg ccagtcttcc cgccagccac
     1681 gtccagctgg cgtcaataag catctttggg gatgtcctgc ctcctccagg accagccatg
     1741 agtggctctt atggccaaag gcggtactgc aggccaagca aacggctctg ggctggaata
     1801 gccctacctg agtgccctgt ttgactccgc cactatctgc catgtgagtt gggcaaattg
     1861 ttgaccacct ctgagccttg aaaaagtagg aggttacttt gttagagcaa aataataaaa
     1921 tttaatttta aaaaagaaaa
//
