LOCUS       NM_004696               2567 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 16 member 4 (SLC16A4),
            transcript variant 1, mRNA.
ACCESSION   NM_004696
VERSION     NM_004696.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2567)
  AUTHORS   Zhang,Y., Jiang,H., Dong,M., Min,J., He,X., Tan,Y., Liu,F.,
            Chen,M., Chen,X., Yin,Q., Zheng,L., Shao,Y., Li,X. and Chen,H.
  TITLE     Macrophage MCT4 inhibition activates reparative genes and protects
            from atherosclerosis by histone H3 lysine 18 lactylation
  JOURNAL   Cell Rep 43 (5), 114180 (2024)
   PUBMED   38733581
  REMARK    GeneRIF: Macrophage MCT4 inhibition activates reparative genes and
            protects from atherosclerosis by histone H3 lysine 18 lactylation.
            Erratum:[Cell Rep. 2024 Oct 22;43(10):114884. doi:
            10.1016/j.celrep.2024.114884.. PMID: 39392757]
REFERENCE   2  (bases 1 to 2567)
  AUTHORS   Meng,S., Sorensen,E.E., Ponniah,M., Thorlacius-Ussing,J.,
            Crouigneau,R., Larsen,T., Borre,M.T., Willumsen,N., Flinck,M. and
            Pedersen,S.F.
  TITLE     MCT4 and CD147 colocalize with MMP14 in invadopodia and support
            matrix degradation and invasion by breast cancer cells
  JOURNAL   J Cell Sci 137 (8) (2024)
   PUBMED   38661040
  REMARK    GeneRIF: MCT4 and CD147 colocalize with MMP14 in invadopodia and
            support matrix degradation and invasion by breast cancer cells.
REFERENCE   3  (bases 1 to 2567)
  AUTHORS   Zhao,M., Huang,C., Yang,L., Pan,B., Yang,S., Chang,J., Jin,Y.,
            Zhao,G., Yue,D., Qie,S. and Ren,L.
  TITLE     SYVN1-mediated ubiquitylation directs localization of MCT4 in the
            plasma membrane to promote the progression of lung adenocarcinoma
  JOURNAL   Cell Death Dis 14 (10), 666 (2023)
   PUBMED   37816756
  REMARK    GeneRIF: SYVN1-mediated ubiquitylation directs localization of MCT4
            in the plasma membrane to promote the progression of lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2567)
  AUTHORS   Yao,R., Yang,P., Goetzinger,K.R., Atkins,K.L., Shen,W.B., Wang,B.
            and Yang,P.
  TITLE     Maternal obesity-associated disruption of polarized lactate
            transporter MCT4 expression in human placenta
  JOURNAL   Reprod Toxicol 112, 1-6 (2022)
   PUBMED   35750090
  REMARK    GeneRIF: Maternal obesity-associated disruption of polarized
            lactate transporter MCT4 expression in human placenta.
REFERENCE   5  (bases 1 to 2567)
  AUTHORS   Reyna-Hernandez,M.A., Alarcon-Romero,L.D.C., Ortiz-Ortiz,J.,
            Illades-Aguiar,B., Jimenez-Lopez,M.A., Ocampo-Barcenas,A.,
            Morrugares-Ixtepan,M.O. and Torres-Rojas,F.I.
  TITLE     GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer
            and Precursor Lesions
  JOURNAL   J Histochem Cytochem 70 (6), 437-446 (2022)
   PUBMED   35615882
  REMARK    GeneRIF: GLUT1, LDHA, and MCT4 Expression Is Deregulated in
            Cervical Cancer and Precursor Lesions.
REFERENCE   6  (bases 1 to 2567)
  AUTHORS   Philp,N.J., Wang,D., Yoon,H. and Hjelmeland,L.M.
  TITLE     Polarized expression of monocarboxylate transporters in human
            retinal pigment epithelium and ARPE-19 cells
  JOURNAL   Invest Ophthalmol Vis Sci 44 (4), 1716-1721 (2003)
   PUBMED   12657613
REFERENCE   7  (bases 1 to 2567)
  AUTHORS   Manning Fox,J.E., Meredith,D. and Halestrap,A.P.
  TITLE     Characterisation of human monocarboxylate transporter 4
            substantiates its role in lactic acid efflux from skeletal muscle
  JOURNAL   J Physiol 529 Pt 2 (Pt 2), 285-293 (2000)
   PUBMED   11101640
REFERENCE   8  (bases 1 to 2567)
  AUTHORS   Halestrap,A.P. and Price,N.T.
  TITLE     The proton-linked monocarboxylate transporter (MCT) family:
            structure, function and regulation
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 281-299 (1999)
   PUBMED   10510291
  REMARK    Review article
REFERENCE   9  (bases 1 to 2567)
  AUTHORS   Pilegaard,H., Terzis,G., Halestrap,A. and Juel,C.
  TITLE     Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4
            in human skeletal muscle
  JOURNAL   Am J Physiol 276 (5), E843-E848 (1999)
   PUBMED   10329977
REFERENCE   10 (bases 1 to 2567)
  AUTHORS   Price,N.T., Jackson,V.N. and Halestrap,A.P.
  TITLE     Cloning and sequencing of four new mammalian monocarboxylate
            transporter (MCT) homologues confirms the existence of a
            transporter family with an ancient past
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 321-328 (1998)
   PUBMED   9425115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313735.1, U59185.1 and AI245349.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004696.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129985.1, U59185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369779.9/ ENSP00000358794.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1658              AK313735.1         19-1676
            1659-2470           U59185.1           1647-2458
            2471-2567           AI245349.1         7-103               c
FEATURES             Location/Qualifiers
     source          1..2567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..2567
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /note="solute carrier family 16 member 4"
                     /db_xref="GeneID:9122"
                     /db_xref="HGNC:HGNC:10925"
                     /db_xref="MIM:603878"
     exon            1..162
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            163..281
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1658
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     monocarboxylate transporter 4; solute carrier family 16
                     (monocarboxylic acid transporters), member 4;
                     monocarboxylate transporter 5; MCT 4; MCT 5; solute
                     carrier family 16, member 4 (monocarboxylic acid
                     transporter 5)"
                     /codon_start=1
                     /product="monocarboxylate transporter 5 isoform 1"
                     /protein_id="NP_004687.1"
                     /db_xref="CCDS:CCDS823.1"
                     /db_xref="GeneID:9122"
                     /db_xref="HGNC:HGNC:10925"
                     /db_xref="MIM:603878"
                     /translation="MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIF
                     FVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYL
                     ISSWATSIPFLCVTMGLLPGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFL
                     LAPFTKFLIDLYDWTGALILFGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAH
                     GPEAHATETHCHETEESTIKDSTTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSD
                     EESDKVISWSCKQLFDISLFRNPFFYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIM
                     DASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITNLLAPLATTFPLL
                     MTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLASFFAGMAVLSGPPIAGWLYD
                     YTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSLT"
     exon            282..414
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            415..558
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            559..720
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            721..1224
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1436
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1530
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..2567
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2546..2551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /note="hexamer: AATAAA"
     polyA_site      2567
                     /gene="SLC16A4"
                     /gene_synonym="MCT4; MCT5"
                     /note="major polyA site"
ORIGIN      
        1 gtctgagccc tccttggctc ttacaatgct cacttgtttt cacaatgcag caaaatgaaa
       61 tgccttagaa aaagagtaac attccagaaa acggtgtaat ttatttttct tccttaattg
      121 ccccatctgt ggaggatttc tttgctgaac accacatcaa agggatcttc tgcatttaaa
      181 atagaagagg catcatgctg aagagggagg ggaaggtcca accttacact aaaaccctgg
      241 atggaggatg gggatggatg attgtgattc attttttcct ggtgaatgtg tttgtgatgg
      301 ggatgaccaa gacttttgca attttctttg tggtctttca agaagagttt gaaggcacct
      361 cagagcaaat tggttggatt ggatccatca tgtcatctct tcgtttttgt gcaggtcccc
      421 tggttgctat tatttgtgac atacttggag agaaaactac ctccattctt ggggctttcg
      481 ttgttactgg tggatatctg atcagcagct gggccacaag tattcctttt ctttgtgtga
      541 ctatgggact tctacccggt ttgggttctg ctttcttata ccaagtggct gctgtggtaa
      601 ctaccaaata cttcaaaaaa cgattggctc tttctacagc tattgcccgt tctgggatgg
      661 gactgacttt tcttttggca ccctttacaa aattcctgat agatctgtat gactggacag
      721 gagcccttat attatttgga gctatcgcat tgaatttggt gccttctagt atgctcttaa
      781 gacccatcca tatcaaaagt gagaacaatt ctggtattaa agataaaggc agcagtttgt
      841 ctgcacatgg tccagaggca catgcaacag aaacacactg ccatgagaca gaagagtcta
      901 ccatcaagga cagtactacg cagaaggctg gactacctag caaaaattta acagtctcac
      961 aaaatcaaag tgaagagttc tacaatgggc ctaacaggaa cagactgtta ttaaagagtg
     1021 atgaagaaag tgataaggtt atttcgtgga gctgcaaaca actgtttgac atttctctct
     1081 ttagaaatcc tttcttctac atatttactt ggtcttttct cctcagtcag ttagcatact
     1141 tcatccctac ctttcacctg gtagccagag ccaaaacact ggggattgac atcatggatg
     1201 cctcttacct tgtttctgta gcaggtatcc ttgagacggt cagtcagatt atttctggat
     1261 gggttgctga tcaaaactgg attaagaagt atcattacca caagtcttac ctcatcctct
     1321 gcggcatcac taacctgctt gctcctttag ccaccacatt tccactactt atgacctaca
     1381 ccatctgctt tgccatcttt gctggtggtt acctggcatt gatactgcct gtactggttg
     1441 atctgtgtag gaattctaca gtaaacaggt ttttgggact tgccagtttc tttgctggga
     1501 tggctgtcct ttctggacca cctatagcag gctggttata tgattatacc cagacataca
     1561 atggctcttt ctacttctct ggcatatgct atctcctctc ttcagtttcc tttttttttg
     1621 taccattggc cgaaagatgg aaaaacagtc tgacctgaaa gaaagaagac tgcaatcaag
     1681 tgagagctaa acaaaagaaa acctaaacta atgtcattgg aaacaaaagc ttgaaagaaa
     1741 cacatcgcat ctacatttgt aacatgagaa ggaaaacaat tttttttttt ttttttttga
     1801 gacggagtct cgctctttcg cccaggctgg agtgcagtgg cgcaatctcg gctcactgta
     1861 atctccgcct cctgggttca agggattctc ctgcctcagc ctcccaagta gctgggacta
     1921 caggcacacg ccaccacacc cagctaattt tttgtatttt tagtagaggc ggggtttcac
     1981 catgttagcc aggatggtct ccatctcctg acctcgtgat ccgcccgcct tgtcctccaa
     2041 agtgctggga ttacaggcat gagccactgg gcgcggccag ataagttttt aaggttcctt
     2101 cttgctttag cattctgaga aatgtctaat tggtagtaag acaagagtaa tagcaacctg
     2161 tattgttagt atttaaccaa ataggctaaa attttaatca ggtaccttat gtattaaata
     2221 gaaatcggaa tgtaccataa taaatccaaa ctctcaatta cgccatggta attcagtcac
     2281 taaaatatgt aaagatagaa aattttttaa tttaaagaag tgtgaaacat agccattgat
     2341 tgatcagaat tctggaatct gaatattaaa accttactta gtgactggaa tggtatatgc
     2401 tccctccaaa agtttatctt tgtttattga ttaaaggtaa tccttacttt ctttgtatta
     2461 cttaggttct taattaaagg taatccttac tttctttgta ttacttaggt tcttaaattt
     2521 ctatgataaa catgtattgc taaataataa aaagtatata aaaattg
//
