LOCUS       NM_004207               2599 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens solute carrier family 16 member 3 (SLC16A3),
            transcript variant 3, mRNA.
ACCESSION   NM_004207
VERSION     NM_004207.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Yu,T., Liu,Z., Tao,Q., Xu,X., Li,X., Li,Y., Chen,M., Liu,R.,
            Chen,D., Wu,M. and Yu,J.
  TITLE     Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via
            tumor immune microenvironment reprogramming
  JOURNAL   Cancer Lett 589, 216824 (2024)
   PUBMED   38522774
  REMARK    GeneRIF: Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1
            efficacy via tumor immune microenvironment reprogramming.
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Li,Q., Li,Z., Li,J., Qin,X., Wu,F. and Chen,C.
  TITLE     Bone Morphogenetic Protein-4 Promotes Phenotypic Modulation via
            SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells
  JOURNAL   J Vasc Res 61 (3), 99-108 (2024)
   PUBMED   38151007
  REMARK    GeneRIF: Bone Morphogenetic Protein-4 Promotes Phenotypic
            Modulation via SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells.
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   Fang,Y., Liu,W., Tang,Z., Ji,X., Zhou,Y., Song,S., Tian,M., Tao,C.,
            Huang,R., Zhu,G., Jiang,X., Gao,J., Qu,W., Wang,H., Zhou,P., Wu,X.,
            Jin,L., Sun,H., Ding,Z., Peng,Y., Zhao,S., Zhou,J., Fan,J., Xu,W.
            and Shi,Y.
  TITLE     Monocarboxylate transporter 4 inhibition potentiates hepatocellular
            carcinoma immunotherapy through enhancing T cell infiltration and
            immune attack
  JOURNAL   Hepatology 77 (1), 109-123 (2023)
   PUBMED   35043976
  REMARK    GeneRIF: Monocarboxylate transporter 4 inhibition potentiates
            hepatocellular carcinoma immunotherapy through enhancing T cell
            infiltration and immune attack.
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Mukai,Y., Yamaguchi,A., Sakuma,T., Nadai,T., Furugen,A., Narumi,K.
            and Kobayashi,M.
  TITLE     Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport
            in the hepatocellular carcinoma cell line
  JOURNAL   Biopharm Drug Dispos 43 (5), 183-191 (2022)
   PUBMED   36104287
  REMARK    GeneRIF: Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate
            transport in the hepatocellular carcinoma cell line.
REFERENCE   5  (bases 1 to 2599)
  AUTHORS   Tang,Y., Xu,L., Ren,Y., Li,Y., Yuan,F., Cao,M., Zhang,Y., Deng,M.
            and Yao,Z.
  TITLE     Identification and Validation of a Prognostic Model Based on Three
            MVI-Related Genes in Hepatocellular Carcinoma
  JOURNAL   Int J Biol Sci 18 (1), 261-275 (2022)
   PUBMED   34975331
  REMARK    GeneRIF: Identification and Validation of a Prognostic Model Based
            on Three MVI-Related Genes in Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2599)
  AUTHORS   Manning Fox,J.E., Meredith,D. and Halestrap,A.P.
  TITLE     Characterisation of human monocarboxylate transporter 4
            substantiates its role in lactic acid efflux from skeletal muscle
  JOURNAL   J Physiol 529 Pt 2 (Pt 2), 285-293 (2000)
   PUBMED   11101640
REFERENCE   7  (bases 1 to 2599)
  AUTHORS   Kirk,P., Wilson,M.C., Heddle,C., Brown,M.H., Barclay,A.N. and
            Halestrap,A.P.
  TITLE     CD147 is tightly associated with lactate transporters MCT1 and MCT4
            and facilitates their cell surface expression
  JOURNAL   EMBO J 19 (15), 3896-3904 (2000)
   PUBMED   10921872
REFERENCE   8  (bases 1 to 2599)
  AUTHORS   Halestrap,A.P. and Price,N.T.
  TITLE     The proton-linked monocarboxylate transporter (MCT) family:
            structure, function and regulation
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 281-299 (1999)
   PUBMED   10510291
  REMARK    Review article
REFERENCE   9  (bases 1 to 2599)
  AUTHORS   Price,N.T., Jackson,V.N. and Halestrap,A.P.
  TITLE     Cloning and sequencing of four new mammalian monocarboxylate
            transporter (MCT) homologues confirms the existence of a
            transporter family with an ancient past
  JOURNAL   Biochem J 329 (Pt 2) (Pt 2), 321-328 (1998)
   PUBMED   9425115
REFERENCE   10 (bases 1 to 2599)
  AUTHORS   Cori,C.F.
  TITLE     The glucose-lactic acid cycle and gluconeogenesis
  JOURNAL   Curr Top Cell Regul 18, 377-387 (1981)
   PUBMED   7273846
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132872.17.
            
            On Feb 27, 2020 this sequence version replaced NM_004207.3.
            
            Summary: Lactic acid and pyruvate transport across plasma membranes
            is catalyzed by members of the proton-linked monocarboxylate
            transporter (MCT) family, which has been designated solute carrier
            family-16. Each MCT appears to have slightly different substrate
            and inhibitor specificities and transport kinetics, which are
            related to the metabolic requirements of the tissues in which it is
            found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2
            (SLC16A7; MIM 603654), are characterized by 12 predicted
            transmembrane domains (Price et al., 1998 [PubMed
            9425115]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223040.1, SRR14038194.1872021.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000582743.6/ ENSP00000462405.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC132872.17        116971-117035       c
            66-314              AC132872.17        109846-110094       c
            315-458             AC132872.17        109205-109348       c
            459-1214            AC132872.17        108184-108939       c
            1215-2599           AC132872.17        105991-107375       c
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2599
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /note="solute carrier family 16 member 3"
                     /db_xref="GeneID:9123"
                     /db_xref="HGNC:HGNC:10924"
                     /db_xref="MIM:603877"
     exon            1..65
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     exon            66..314
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1489
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /note="monocarboxylate transporter 3; solute carrier
                     family 16 (monocarboxylic acid transporters), member 3;
                     solute carrier family 16, member 3 (monocarboxylic acid
                     transporter 4); solute carrier family 16 (monocarboxylate
                     transporter), member 3"
                     /codon_start=1
                     /product="monocarboxylate transporter 4"
                     /protein_id="NP_004198.1"
                     /db_xref="CCDS:CCDS11804.1"
                     /db_xref="GeneID:9123"
                     /db_xref="HGNC:HGNC:10924"
                     /db_xref="MIM:603877"
                     /translation="MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSV
                     FFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGM
                     VAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFL
                     CALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLL
                     DLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIF
                     ARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGM
                     VGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAG
                     AEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAE
                     PEKNGEVVHTPETSV"
     exon            315..458
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     exon            459..1214
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..2599
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /note="hexamer: AATAAA"
     polyA_site      1996
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /note="major polyA site"
     regulatory      2246..2251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
                     /note="hexamer: AACAAG"
     polyA_site      2280
                     /gene="SLC16A3"
                     /gene_synonym="MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4"
ORIGIN      
        1 ggcagaggcg ggcagaggcg gcgagaggcg gcgagaggcg ggctgaggcg gcccagcggc
       61 ggcaggtgag gcggaaccaa ccctcctggc catgggaggg gccgtggtgg acgagggccc
      121 cacaggcgtc aaggcccctg acggcggctg gggctgggcc gtgctcttcg gctgtttcgt
      181 catcactggc ttctcctacg ccttccccaa ggccgtcagt gtcttcttca aggagctcat
      241 acaggagttt gggatcggct acagcgacac agcctggatc tcctccatcc tgctggccat
      301 gctctacggg acaggtccgc tctgcagtgt gtgcgtgaac cgctttggct gccggcccgt
      361 catgcttgtg gggggtctct ttgcgtcgct gggcatggtg gctgcgtcct tttgccggag
      421 catcatccag gtctacctca ccactggggt catcacgggg ttgggtttgg cactcaactt
      481 ccagccctcg ctcatcatgc tgaaccgcta cttcagcaag cggcgcccca tggccaacgg
      541 gctggcggca gcaggtagcc ctgtcttcct gtgtgccctg agcccgctgg ggcagctgct
      601 gcaggaccgc tacggctggc ggggcggctt cctcatcctg ggcggcctgc tgctcaactg
      661 ctgcgtgtgt gccgcactca tgaggcccct ggtggtcacg gcccagccgg gctcggggcc
      721 gccgcgaccc tcccggcgcc tgctagacct gagcgtcttc cgggaccgcg gctttgtgct
      781 ttacgccgtg gccgcctcgg tcatggtgct ggggctcttc gtcccgcccg tgttcgtggt
      841 gagctacgcc aaggacctgg gcgtgcccga caccaaggcc gccttcctgc tcaccatcct
      901 gggcttcatt gacatcttcg cgcggccggc cgcgggcttc gtggcggggc ttgggaaggt
      961 gcggccctac tccgtctacc tcttcagctt ctccatgttc ttcaacggcc tcgcggacct
     1021 ggcgggttct acggcgggcg actacggcgg cctcgtggtc ttctgcatct tctttggcat
     1081 ctcctacggc atggtggggg ccctgcagtt cgaggtgctc atggccatcg tgggcaccca
     1141 caagttctcc agtgccattg gcctggtgct gctgatggag gcggtggccg tgctcgtcgg
     1201 gcccccttcg ggaggcaaac tcctggatgc gacccacgtc tacatgtacg tgttcatcct
     1261 ggcgggggcc gaggtgctca cctcctccct gattttgctg ctgggcaact tcttctgcat
     1321 taggaagaag cccaaagagc cacagcctga ggtggcggcc gcggaggagg agaagctcca
     1381 caagcctcct gcagactcgg gggtggactt gcgggaggtg gagcatttcc tgaaggctga
     1441 gcctgagaaa aacggggagg tggttcacac cccggaaaca agtgtctgag tggctgggcg
     1501 gggccggcag gcacagggag gaggtacaga agccggcaac gcttgctatt tattttacaa
     1561 actggactgg ctcaggcagg gccacggctg ggctccagct gccggcccag cggatcgtcg
     1621 cccgatcagt gttttgaggg ggaaggtggc ggggtgggaa ccgtgtcatt ccagagtgga
     1681 tctgcggtga agccaagccg caaggttaca aggcatcctc accaggggcc ccgcctgctg
     1741 ctcccaggtg gcctgcggcc actgctatgc tcaaggacct ggaaacccat gcttcgagac
     1801 aacgtgactt taatgggagg gtgggtgggc cgcagacagg ctggcagggc aggtgctgcg
     1861 tggggccctc tccagcccgt cctaccctgg gctcacatgg ggcctgtgcc cacccctctt
     1921 gagtgtcttg gggacagctc tttccacccc tggaagatgg aaataaacct gcgtgtgggt
     1981 ggagtgttag gaccaacggt ttcctaggag tatgtggttt tgctgtgtgg cctgtgtcct
     2041 gactcgcacg tctgctgatg gcctggctgt tcctaccgtg gctctgtcct cgccagcttt
     2101 ccctgcagcg gcatagcatt cgtagcaggg gcaggcgctg catggagggg gctgcggggc
     2161 aggtgcctgg aggccgctgt gccagggtgg cctctgaaat gtgccaggga gcccctacgt
     2221 ggtggttaga tgggagctga ggtggaacaa gccactttat tcactgctgt gtttaagaaa
     2281 caggaccctc ctgccttccc tttttcgccc ctctgcctgg ctggcagtgt gcgtggtgtg
     2341 gtcagtgccc agggctggtc tttgcaccct gtcctccatc cagcccggcc cagcgcttgg
     2401 gcttgtcctg gacacctaac acccacctgc cctcgtggcc agcagtggcc tgcgtggctg
     2461 ggagcccggt cagaggccgc cggggccctc agtaggtgcg tcgtgggcgc tggggacggc
     2521 agcgggtgcc ctggcgggcc gcgtgcagcc ggagagatgc catgtccctg ctcctctgca
     2581 atgaaaagca agcgaaaag
//
