LOCUS       NM_152527               4315 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 16 member 14 (SLC16A14), mRNA.
ACCESSION   NM_152527
VERSION     NM_152527.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4315)
  AUTHORS   Roshanbin,S., Lindberg,F.A., Lekholm,E., Eriksson,M.M., Perland,E.,
            Ahlund,J., Raine,A. and Fredriksson,R.
  TITLE     Histological characterization of orphan transporter MCT14
            (SLC16A14) shows abundant expression in mouse CNS and kidney
  JOURNAL   BMC Neurosci 17 (1), 43 (2016)
   PUBMED   27364523
  REMARK    GeneRIF: Study presented a phylogenetic analysis revealing that
            Slc16a14 is closely related to Slc16a2, Slc16a9 and Slc16a10;
            provided a detailed expression analysis of Slc16a14 expression,
            finding widespread expression in the mouse brain and establishing
            its expression in neurons and epithelial cells. QRT-PCR on a panel
            of mouse tissues revealed high Slc16a14 expression in the kidney
            and moderate levels in the CNS.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4315)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA044472.1, BC065524.1 and AL833470.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152527.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.9485.1,
                                           SRR1660807.22601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267770 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295190.9/ ENSP00000295190.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               DA044472.1         76-580
            506-2365            BC065524.1         485-2344
            2366-3658           AL833470.1         940-2232
            3659-4315           BC065524.1         3638-4294
FEATURES             Location/Qualifiers
     source          1..4315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q36.3"
     gene            1..4315
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /note="solute carrier family 16 member 14"
                     /db_xref="GeneID:151473"
                     /db_xref="HGNC:HGNC:26417"
     exon            1..370
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /inference="alignment:Splign:2.1.0"
     exon            371..643
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1917
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 14; MCT 14; monocarboxylic acid
                     transporter 14"
                     /codon_start=1
                     /product="monocarboxylate transporter 14"
                     /protein_id="NP_689740.2"
                     /db_xref="CCDS:CCDS2473.1"
                     /db_xref="GeneID:151473"
                     /db_xref="HGNC:HGNC:26417"
                     /translation="MYTSHEDIGYDFEDGPKDKKTLKPHPNIDGGWAWMMVLSSFFVH
                     ILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQT
                     AIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALA
                     QGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSPGKNP
                     NDPGEKDVRGLPAHSTESVKSTGQQGRTEEKDGGLGNEETLCDLQAQECPDQAGHRKN
                     MCALRILKTVSWLTMRVRKGFEDWYSGYFGTASLFTNRMFVAFIFWALFAYSSFVIPF
                     IHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCISVWNVFLLANFTL
                     VLSIFILPLMHTYAGLAVICALIGFSSGYFSLMPVVTEDLVGIEHLANAYGIIICANG
                     ISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQPCIRIIEQSRRKYMDGA
                     HV"
     exon            644..787
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1765
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..4315
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4294..4299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /note="hexamer: AATAAA"
     polyA_site      4315
                     /gene="SLC16A14"
                     /gene_synonym="MCT14"
                     /note="major polyA site"
ORIGIN      
        1 agaattagcc ggtataggaa tgaacgagca tgaagatttg aaattgctcc gattggaagg
       61 aagcccaggt taggtttggg cacctccaaa cgcacccgtt ttaaagccac ctggactgag
      121 gcgtcgagct ttcagctcca ccaaacgctc acctggcctg gcagcgagcg gcggaagagc
      181 ccgggagccc ctcacagagc gcaccgagcc gggcggagag ctgagccgca ggcacccgcg
      241 tctccaggat gataggcgac attgcaacaa atctctacac ccagcagctc agggggctcc
      301 aagcagagca gcaagttcga ggatccgggc gtggagccga gtgaggccgc agcccagcgg
      361 gcctcgggcg aaaaatcttg gaaaatgtat accagtcatg aagatattgg gtatgatttt
      421 gaagatggcc ccaaagacaa aaagacactg aagccccacc caaacattga tggcggatgg
      481 gcttggatga tggtgctctc ctctttcttt gtgcacatcc tcatcatggg ctcccagatg
      541 gccctgggtg tcctcaacgt ggaatggctg gaagaattcc accagagccg cggcctgacc
      601 gcctgggtca gctccctcag catgggcatc accttgatag tgggcccttt catcggcttg
      661 ttcattaaca cctgtgggtg ccgccagact gcgatcattg gagggctcgt caactccctg
      721 ggctgggtgt tgagtgccta tgctgcaaac gtgcattatc tcttcattac ttttggagtc
      781 gcagctggcc tgggcagcgg gatggcctac ctgccagcgg tggtcatggt gggcaggtat
      841 ttccagaaga gacgcgccct cgcccagggc ctcagcacca cggggaccgg attcggtacg
      901 ttcctaatga ctgtgctgct gaagtacctg tgcgcagagt acggctggag gaatgccatg
      961 ttgatccaag gtgccgtttc cctaaacctg tgtgtttgtg gggcgctcat gaggcccctc
     1021 tctcctggta aaaacccaaa cgacccagga gagaaagatg tgcgtggcct gccagcgcac
     1081 tccacagaat ctgtgaagtc aactggacag cagggaagaa cagaagagaa ggatggtggg
     1141 ctcgggaacg aggagaccct ctgcgacctg caagcccagg agtgccccga tcaggccggg
     1201 cacaggaaga acatgtgtgc cctccggatt ctgaagactg tcagctggct caccatgaga
     1261 gtcaggaagg gcttcgagga ctggtattcg ggctactttg ggacagcctc tctatttaca
     1321 aatcgaatgt ttgtagcctt tattttctgg gctttgtttg catacagcag ctttgtcatc
     1381 cccttcattc acctcccaga aatcgtcaat ttgtataact tatcggagca aaacgacgtt
     1441 ttccctctga cgtcaattat agcaatagtt cacatctttg gaaaagtgat cctgggcgtc
     1501 atagccgact tgccttgcat tagtgtttgg aatgtcttcc tgttggccaa cttcaccctt
     1561 gtcctcagta tttttattct gccgttgatg cacacgtacg ctggcctggc ggtcatctgt
     1621 gcgctgatag ggttttccag tggttatttc tccctaatgc ccgtagtgac tgaagacttg
     1681 gttggcattg aacacctggc caatgcctac ggcatcatca tctgtgctaa tggcatctct
     1741 gcattgctgg gaccaccttt tgcagggtgg atctatgaca tcacgcaaaa atatgatttt
     1801 tccttctaca tatgtggttt gctttacatg ataggaatac tctttttact tattcagccg
     1861 tgcattcgaa ttatagaaca atccagaaga aaatacatgg atggtgcaca tgtttagtat
     1921 catgtaatgt tccgtgtagg tttcattgta atactcatgc ctacctcgca tggttgctgt
     1981 gaggcaccta tgacaggacg tgggaaagca ttttgtacgg taactggcac tgtcatttgt
     2041 aaatgccatt gtcacagcct catttgtaag cagcactgcc tctctgtttg gggagatgta
     2101 atgctggaag atcttaagga ctacatacat tctagagatg acagtgttgt tcaaagacag
     2161 cctagtaagt aattggtaga aatgccctta taaaaaccat tctcttgtca tctactggga
     2221 ctagggtttt aaatacagct tttaaaaaca aaaacaggga ataaaagctt ttcaactcaa
     2281 ccacttcttt gtaagacaaa actgaagtat ctgtgtgctt ccagaaagct tacagataaa
     2341 tgggtttcaa gcacaagaat atgactagat ttcagaaatt aattattaca gggagctatt
     2401 gatctactag catcaaacaa aggcaagctc taattccaca ggtaatacaa tttagtgcaa
     2461 ttaaagaaac acggcttgta tttttatgag ggaattctgc agctagggat tgtgactcct
     2521 aaatcctcct ctaaaagaag gcacttgcca ttaatcctaa ttcagtgcta tccagttata
     2581 aatggaatct tgagacaaaa ccttaacaaa gaaataacag taatgatttc cttagcagaa
     2641 gccgtatttg tacgcacaac attaaatcaa gggctacaat tcaagcactt ttattcgtat
     2701 cattggcctc ttagatgata taagcatgag gtggggcctg taatattttt ttctgagttt
     2761 cttctgccca aaaatataat atagaactaa ttgctaactg acaaataaag ttaatagtta
     2821 aatcatctcc aaggaatgtt gctaatccaa agtataacac tatcaatttg tgaggataat
     2881 aaatggaatg ccattagtgt agatgtctgt gccacatctg acactggagt agtgataaca
     2941 aatagcccat ctctagactc tcgtgttgtt atatagacca ttcatttgcc tgagcgtggc
     3001 acagttttaa aaatagttct cttgattgat ttcatacaga agatgactgt gatccatgac
     3061 atctaataat gccctttctt tatctgagat gtctattttt ctaagccaaa cgtttttcag
     3121 actgcagaat gttcttccca gatcatttga aatttctggc tgccttactt gtttacagat
     3181 agtttaagac tatttaaatt tctactcaca atttgatcat cacacacaca caaatccttg
     3241 aatatcattg ccagtgtctt aggtcaaatt tacctaaagt gaatacagcc cattctcaat
     3301 tatccttcac aattagacgc aggaatgcta ctaggaattg gaatcaaaca atgccacccc
     3361 aagcgtaatt ttagccagca gtttcagtta tactcaacca tgcccttctg agctgttaac
     3421 aagtgattca atggacaagt tctctttttg ttccatctcc attatttcct gctctaatgt
     3481 atagtgggag tggttgtgta atgaaaggac caccaaaata ataaaaggca gctaatggaa
     3541 aggagagaca aaagcatggt taatatatat acttaatatt acctccaatg actcgggaat
     3601 tgcctgtaaa ttattataga caatagattg catgtcatac tccatttggt tcaacacaac
     3661 aacctatgtg ttatcattac agctttggct gctgttaaag aatccagctc tctattttga
     3721 taaagataat cttaaagctg aggcaatgct ccctcctcta tctctctctg tgtaatttac
     3781 catagaatta ggatgattag attgaaacac atgttgtatg ttttaaaaac tacattgctt
     3841 cattactttc attttccgac aacatcaaac taacaagagg cagtgttaaa tattttaaat
     3901 ggtgctatag ccaatgtatt tgaatgcttg cactgctggt tgtgtatcat caatatgaac
     3961 tttttatcca atgactcaac tctaattaca tctaagttag acttgctcac gttcagtttg
     4021 tacagttgtg tgttgactta ctatgttttg aaagtggtga cttctaccga atgagtggaa
     4081 gttcccattg tcaaaaaaaa taaagacctg cttgcagtat tcatgttgac aacagagtaa
     4141 aagagaatac tgtaaagaat tactgcaaat atttcctgtt tatgttattt gccgttgttt
     4201 gaagatatta taaagggtta attgtatatt tatatcatgt gctttatcgt tttcccctca
     4261 tgtatccaag taatttttat ttacatacaa ctaaataaat gttgtcctct ttgaa
//
