LOCUS       NM_213606               4655 bp    mRNA    linear   PRI 15-JAN-2025
DEFINITION  Homo sapiens solute carrier family 16 member 12 (SLC16A12), mRNA.
ACCESSION   NM_213606
VERSION     NM_213606.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4655)
  AUTHORS   Flogel,S., Strater,M., Fischer,D. and Grundemann,D.
  TITLE     A creatine efflux transporter in oligodendrocytes
  JOURNAL   FEBS J (2025) In press
   PUBMED   39792585
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4655)
  AUTHORS   Jomura,R., Tanno,Y., Akanuma,S.I., Kubo,Y., Tachikawa,M. and
            Hosoya,K.I.
  TITLE     Monocarboxylate transporter 12 as a guanidinoacetate efflux
            transporter in renal proximal tubular epithelial cells
  JOURNAL   Biochim Biophys Acta Biomembr 1862 (11), 183434 (2020)
   PUBMED   32781157
  REMARK    GeneRIF: Monocarboxylate transporter 12 as a guanidinoacetate
            efflux transporter in renal proximal tubular epithelial cells.
REFERENCE   3  (bases 1 to 4655)
  AUTHORS   Takahashi,M., Kishimoto,H., Shirasaka,Y. and Inoue,K.
  TITLE     Functional characterization of monocarboxylate transporter 12
            (SLC16A12/MCT12) as a facilitative creatine transporter
  JOURNAL   Drug Metab Pharmacokinet 35 (3), 281-287 (2020)
   PUBMED   32249133
  REMARK    GeneRIF: Functional characterization of monocarboxylate transporter
            12 (SLC16A12/MCT12) as a facilitative creatine transporter.
REFERENCE   4  (bases 1 to 4655)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4655)
  AUTHORS   Futagi,Y., Narumi,K., Furugen,A., Kobayashi,M. and Iseki,K.
  TITLE     Molecular characterization of the orphan transporter SLC16A9, an
            extracellular pH- and Na+-sensitive creatine transporter
  JOURNAL   Biochem Biophys Res Commun 522 (2), 539-544 (2020)
   PUBMED   31784090
REFERENCE   6  (bases 1 to 4655)
  AUTHORS   Abplanalp,J., Laczko,E., Philp,N.J., Neidhardt,J., Zuercher,J.,
            Braun,P., Schorderet,D.F., Munier,F.L., Verrey,F., Berger,W.,
            Camargo,S.M. and Kloeckener-Gruissem,B.
  TITLE     The cataract and glucosuria associated monocarboxylate transporter
            MCT12 is a new creatine transporter
  JOURNAL   Hum Mol Genet 22 (16), 3218-3226 (2013)
   PUBMED   23578822
  REMARK    GeneRIF: study identified a second creatine transporter
            monocarboxylate transporter 12 (MCT12), encoded by the cataract and
            glucosuria associated gene SLC16A12; Rssults show SLC6A8 was
            predominantly found in brain, heart and muscle, while SLC16A12 was
            more abundant in kidney and retina. In the lens, the two
            transcripts were found at comparable levels.
REFERENCE   7  (bases 1 to 4655)
  AUTHORS   Castorino,J.J., Gallagher-Colombo,S.M., Levin,A.V.,
            Fitzgerald,P.G., Polishook,J., Kloeckener-Gruissem,B., Ostertag,E.
            and Philp,N.J.
  TITLE     Juvenile cataract-associated mutation of solute carrier SLC16A12
            impairs trafficking of the protein to the plasma membrane
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6774-6784 (2011)
   PUBMED   21778275
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4655)
  AUTHORS   Zuercher,J., Neidhardt,J., Magyar,I., Labs,S., Moore,A.T.,
            Tanner,F.C., Waseem,N., Schorderet,D.F., Munier,F.L.,
            Bhattacharya,S., Berger,W. and Kloeckener-Gruissem,B.
  TITLE     Alterations of the 5'untranslated region of SLC16A12 lead to
            age-related cataract
  JOURNAL   Invest Ophthalmol Vis Sci 51 (7), 3354-3361 (2010)
   PUBMED   20181839
  REMARK    GeneRIF: The monocarboxylate transporter SLC16A12 may contribute to
            age-related cataract. Sequences within the 5'UTR modulate
            translational efficiency with pathogenic consequences.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4655)
  AUTHORS   Kloeckener-Gruissem,B., Vandekerckhove,K., Nurnberg,G.,
            Neidhardt,J., Zeitz,C., Nurnberg,P., Schipper,I. and Berger,W.
  TITLE     Mutation of solute carrier SLC16A12 associates with a syndrome
            combining juvenile cataract with microcornea and renal glucosuria
  JOURNAL   Am J Hum Genet 82 (3), 772-779 (2008)
   PUBMED   18304496
  REMARK    GeneRIF: SLC16A12 is important for lens and kidney homeostasis; its
            potential role in age-related cataract is discussed.
REFERENCE   10 (bases 1 to 4655)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355342.12, AK127303.1, AL353146.9 and BC086873.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_213606.3.
            
            Summary: This gene encodes a transmembrane transporter that likely
            plays a role in monocarboxylic acid transport. A mutation in this
            gene has been associated with juvenile cataracts with microcornea
            and renal glucosuria. [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127303.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1970526
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371790.5/ ENSP00000360855.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL355342.12        21804-21841         c
            39-386              AK127303.1         1-348
            387-387             AL353146.9         73670-73670         c
            388-421             AK127303.1         350-383
            422-1339            AK127303.1         385-1302
            1340-3398           BC086873.1         255-2313
            3399-4655           BC086873.1         2315-3571
FEATURES             Location/Qualifiers
     source          1..4655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..4655
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /note="solute carrier family 16 member 12"
                     /db_xref="GeneID:387700"
                     /db_xref="HGNC:HGNC:23094"
                     /db_xref="MIM:611910"
     exon            1..153
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     exon            154..293
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     exon            294..539
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1890
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /note="monocarboxylic acid transporter 12; creatine
                     transporter 2"
                     /codon_start=1
                     /product="monocarboxylate transporter 12"
                     /protein_id="NP_998771.3"
                     /db_xref="CCDS:CCDS7404.2"
                     /db_xref="GeneID:387700"
                     /db_xref="HGNC:HGNC:23094"
                     /db_xref="MIM:611910"
                     /translation="MPSGSHWTANSSKIITWLLEQPGKEEKRKTMAKVNRARSTSPPD
                     GGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCA
                     PLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPA
                     IAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLC
                     VCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRVSPYSSLTKEWAQTCLCCCLQQEYS
                     FLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNI
                     TFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVT
                     LIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSM
                     IFSSVLLGFARLIKRMRKTQLQFIAKESDPKLQLWTNGSVAYSVARELDQKHGEPVAT
                     AVPGYSLT"
     exon            540..643
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     exon            644..787
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1367
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1627
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..4655
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4631..4636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /note="hexamer: AATAAA"
     polyA_site      4655
                     /gene="SLC16A12"
                     /gene_synonym="CJMG; CRT2; CTRCT47; MCT12"
                     /note="major polyA site"
ORIGIN      
        1 agagcgctgg agcgctggag ctctgggctg tcccgggctc agtctcgccg gcggcccccg
       61 ctcccggatc cccagcgccc tggccaagaa gcttcctcgg ctccccctct tccctctccc
      121 tgacacggtt gtgcagaggg cgcggtggct cagatacagg atttcgacat attggccggt
      181 ttgctctcga gctcctgggc tcaagcgatc tgcccgcttt agcctcccaa agtgatggga
      241 ttacaggcgt gagccaccgt gcctggccat aatttttaaa aatgtctagt cagatggcga
      301 gtaacccatg ggccaggtag cgttctatgc caaccttgaa tgccatcagg aagtcactgg
      361 acagcaaact cttccaagat cataacttgg ctgttggagc aacctggaaa agaagaaaaa
      421 agaaaaacca tggcaaaagt aaatagagct cggtctacct cccctccaga tggaggctgg
      481 ggctggatga ttgtggctgg ctgtttcctt gttaccatct gcacacgggc agtcacaaga
      541 tgtatctcaa ttttttttgt ggagttccag acatacttca ctcaggatta cgcacaaacg
      601 gcatggatcc attccattgt agattgtgtg accatgctct gtgctccact tgggagtgtt
      661 gtcagtaacc atttatcctg tcaagtggga atcatgctgg gtggcttgct tgcatctact
      721 ggactcatcc tgagctcatt tgccacgagt ctgaagcatc tctacctcac tctgggagtt
      781 cttacaggtc ttggatttgc actttgttac tctccagcta ttgccatggt tggcaagtac
      841 ttcagcagac ggaaagccct tgcttatggt atcgccatgt caggaagtgg cattggcacc
      901 ttcatcctgg ctcctgtggt tcagctcctt attgaacagt tttcctggcg gggagcctta
      961 ctcattcttg ggggctttgt cttgaatctc tgtgtatgtg gtgccttgat gaggccaatt
     1021 actcttaaag aggaccacac aactccagag cagaaccatg tgtgtagaac tcagaaagaa
     1081 gacattaagc gggtgtctcc ctattcatct ttgaccaaag aatgggcaca gacttgcctc
     1141 tgttgctgtt tgcagcaaga gtacagtttt ttactcatgt cagactttgt tgtgttagcc
     1201 gtctccgttc tgtttatggc ttatggctgc agccctctct ttgtgtactt ggtgccttat
     1261 gctttgagtg ttggagtgag tcatcagcaa gctgcttttc ttatgtccat acttggagtg
     1321 attgacatta ttggcaatat cacatttgga tggctgaccg acagaaggtg tctgaagaat
     1381 taccagtatg tttgctacct ctttgccgtg ggaatggatg ggctctgcta tctctgcctc
     1441 ccaatgcttc aaagtctccc tctgctcgtg cctttctctt gtacctttgg ctactttgat
     1501 ggtgcctatg tgactttgat cccagtagtg accacagaga tagtggggac cacctctttg
     1561 tcatcagcgc ttggtgtggt atacttcctt cacgcagtgc catacttggt gagcccaccc
     1621 atcgcaggac ggctggtaga taccaccggc agctacactg cagcattcct cctctgtgga
     1681 ttttcaatga tatttagttc tgtgttgctt ggctttgcta gacttataaa gagaatgaga
     1741 aaaacccagt tgcagttcat tgccaaagaa tctgatccta agctgcagct atggaccaat
     1801 ggatcagtgg cttattctgt ggcaagagaa ttagatcaga aacatgggga gcctgtggct
     1861 acagcagtgc ctggctacag cctcacatga ccaaaggcct tgagccccag aatcttcagg
     1921 tttgagagag gtggggccac cagattcttc atgtttctga aactttttat tttggcagaa
     1981 ggattgcctt ccaaggaaat tattattatt gttttgttaa catattaata tttataaggg
     2041 aaaacagcac ataataagga aagctggact agcccagagc cttctcattt gggatttgtg
     2101 ctcataactg aactcgtatc ttttggtcaa tgggcatagc tctgtaagaa atgtaaggac
     2161 acagctgata taattagctg taattaggga taatttcaaa gcataaccaa agcagatgac
     2221 actgggcagc agctttgttc cagtctcagg cccttcatgt tccctcctca gaaagaaaat
     2281 ggaaacatta acgtgtagct ttgcttacct tgttctggtt agagaaggga ggtcagcttg
     2341 ggtgtggtgg tgaagagtga agatgccata ctttttcatg gtggagtttc tcattagggt
     2401 tttacttggg attgttaaag aatacttgag attcttcaaa aagtggtgat taatatagaa
     2461 agaaactctt attttttttt tctcttagtc ttccagccag cccttgcctc tgcccaaggg
     2521 tagacaccac tatgagaatc caaataatca tggaatgcca tggttggaat agatcttaaa
     2581 gggcatctgg taagatccat ttgaaattgt ccactggaaa ccgaaagctc ttttcctaag
     2641 actgggttcc aggctctcac atttgttacc atcacatata atacttactc taaatttagc
     2701 agaacacact tagtcacaag gacaacctct caatcttacc tgaaatgtca acaacaccaa
     2761 aacttcccgt cttttacctt cagagaagaa gctcttactt agactgcaga cgcattcctg
     2821 ttaggttgga aaaatgttgg cagtattcca attgggcagg aactgaattc ttgaatcagc
     2881 aggtctctgg tgagagtttt ctttgcagat cagacattta gttttatcat tacccaaaag
     2941 aggattggag ggagtcagtt gtctgaaaaa tattatccta gagatattct aaaggtgaga
     3001 ttcctttctc cctgtgttaa ttcttgttcc actatccact gctcttcatc tctttataga
     3061 taataattag aaatctactc attggattat aagtttattc attctcaaat actccacttt
     3121 tctatggttt gggataattt ctgagtcttc agattgaaga gggaaggcat ggagggaaga
     3181 aaaagtccag atcccccagc ttgtttccaa ccattttaag tccaaagaat tataatcctg
     3241 aatctcacag tgtgtcacac ctgtaatagg agtaaattat gcaatcaatt ttaattacca
     3301 ggagtttaaa atccaaatgt caaggaactg ttttgaccct gaaggctatt taatccactg
     3361 tcccctacaa ggcctcacaa gtgctggggg aaaaaaaaca gcaatgagga tgatcctgag
     3421 ttaatgtgta tgctccgcaa gagagcttgc ctataccttg attatttcat aaaatcacat
     3481 gttaatacat tgctttcaga atgaaatact gacttgatct gataggagaa aatggtaata
     3541 tttcatagtt gttttccaaa gacaaattta aatgttgtct gttatctcct tacttagttt
     3601 aagaatttag ttttgaaccc cattgacttt gtcatttgca attttaaaaa tatttgggac
     3661 tgggcatggt cgctcacgcc tgtaatccca gcactttggg aggctgaggc gggtggatca
     3721 tgaggtcagg agatcaagac catcctggct aacatcgtga aactccgtct ctactaaaaa
     3781 tgcaaaaaat tagccaggcg tggtggcggg cgcctgtagt cccagctact catgaggctg
     3841 aggccggaca atcgcttgaa cccaggaggt ggaggttgca gtgagccaaa atcatgccac
     3901 tgcactccac cctgggcgac agagcaagac tccatctcaa aaaaaaaaaa ttggaaggta
     3961 tctgtaaaat gtcaaagtta agatgaagtt atatctgttt ggaatagcac tttgccctaa
     4021 atatcatttc ttgaattttc aagcctaaag atgtttaaaa atatgaatag ttacaaatat
     4081 tcttatacat attttttatc atgatcacaa caaaattttg tttatgtggt tctgcaatat
     4141 aatttctgtg aagtattaca agtatttatg aaaaataagc atagtgatca gaaattttaa
     4201 agattttgta taaaaacatt tgggagattt gactttatac atgcatagat ttgcatttta
     4261 ctttcccttt tgaggcagca tttttagaaa atcagtaaga aaaatgtaca tcttaaggtc
     4321 tactatttta catttctaca cagaatttta gtgttaatgt tccatgtgtc tatactgttt
     4381 atttcaaaac tgagaaattc atgggaatga tgtattttgt ggaatcaaga acaaaattat
     4441 agtgggataa ttttacatct taaatatttc tttctactac tgtaagctct actttggaat
     4501 tatctgagta gaaaatcaga agacattatc taactttgta gatacactgt atgattgggc
     4561 tttttgttca gattgtaatt tcattaatag atgaaatatt tatgctaata ttttcttatt
     4621 tcaaaagcaa aataaaatga atttattgtc ctgtg
//
