LOCUS       NM_001370549            1726 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens solute carrier family 16 member 11 (SLC16A11),
            transcript variant 1, mRNA.
ACCESSION   NM_001370549 XM_005256488
VERSION     NM_001370549.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1726)
  AUTHORS   Williams,R.C., Hanson,R.L., Peters,B., Kearns,K., Knowler,W.C.,
            Bogardus,C. and Baier,L.J.
  TITLE     Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces
            Odds for Type 2 Diabetes in Southwest American Indians
  JOURNAL   Diabetes 73 (6), 1002-1011 (2024)
   PUBMED   38530923
  REMARK    GeneRIF: Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T
            Reduces Odds for Type 2 Diabetes in Southwest American Indians.
REFERENCE   2  (bases 1 to 1726)
  AUTHORS   Sevilla-Domingo,M., Olivo-Ramirez,C.G., Huerta-Padilla,V.M.,
            Gomez-Diaz,R.A., Gonzalez-Carranza,E., Acevedo-Rodriguez,G.E.,
            Hernandez-Zuniga,V.E., Gonzalez,A.L.V., Mateos-Sanchez,L.,
            Mondragon-Gonzalez,R., Garrido-Magana,E.P., Ramirez-Garcia,L.A.,
            Wacher,N.H. and Vargas,M.S.
  TITLE     Downregulation of SLC16A11 is Present in Offspring of Mothers with
            Gestational Diabetes
  JOURNAL   Arch Med Res 53 (5), 516-523 (2022)
   PUBMED   35831226
  REMARK    GeneRIF: Downregulation of SLC16A11 is Present in Offspring of
            Mothers with Gestational Diabetes.
REFERENCE   3  (bases 1 to 1726)
  AUTHORS   Mardones,L., Petermann-Rocha,F., Martinez-Sanguinetti,M.A.,
            Leiva,A.M., Troncoso-Pantoja,C., Martorell,M., Lasserre,N.,
            Ulloa,N., Perez-Bravo,F., Celis-Morales,C. and Villagran,M.
  CONSRTM   ELHOC group (Epidemiology of Lifestyle and Health Outcomes in
            Chile)
  TITLE     Genetic variants in the SLC16A11 gene are associated with increased
            BMI and insulin levels in nondiabetic Chilean population
  JOURNAL   Arch Endocrinol Metab 65 (3), 305-314 (2021)
   PUBMED   33909378
  REMARK    GeneRIF: Genetic variants in the SLC16A11 gene are associated with
            increased BMI and insulin levels in nondiabetic Chilean population.
REFERENCE   4  (bases 1 to 1726)
  AUTHORS   Kimura,Y., Higuchi,I., Kobayashi,M., Furugen,A., Narumi,K.,
            Suzuki,Y., Miyoshi,H., Nakamura,A., Atsumi,T. and Iseki,K.
  TITLE     The association between SLC16A11 haplotype and lipid metabolism in
            Japanese patients with type 2 diabetes
  JOURNAL   Drug Metab Pharmacokinet 37, 100376 (2021)
   PUBMED   33561739
  REMARK    GeneRIF: The association between SLC16A11 haplotype and lipid
            metabolism in Japanese patients with type 2 diabetes.
REFERENCE   5  (bases 1 to 1726)
  AUTHORS   Hidalgo,B.A., Sofer,T., Qi,Q., Schneiderman,N., Chen,Y.I.,
            Kaplan,R.C., Aviles-Santa,M.L., North,K.E., Arnett,D.K., Szpiro,A.,
            Cai,J., Yu,B., Boerwinkle,E., Papanicolaou,G., Laurie,C.C.,
            Rotter,J.I. and Stilp,A.M.
  TITLE     Associations between SLC16A11 variants and diabetes in the Hispanic
            Community Health Study/Study of Latinos (HCHS/SOL)
  JOURNAL   Sci Rep 9 (1), 843 (2019)
   PUBMED   30696834
  REMARK    GeneRIF: The previously reported effects of SLC16A11 variants shown
            to be associated with diabetes in Mexicans was replicated in a
            large Mexican-American sample, but these effects were not
            significant in five non-Mexican Hispanic/Latino groups sampled from
            U.S. populations.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1726)
  AUTHORS   Miranda-Lora,A.L., Cruz,M., Molina-Diaz,M., Gutierrez,J.,
            Flores-Huerta,S. and Klunder-Klunder,M.
  TITLE     Associations of common variants in the SLC16A11, TCF7L2, and ABCA1
            genes with pediatric-onset type 2 diabetes and related glycemic
            traits in families: A case-control and case-parent trio study
  JOURNAL   Pediatr Diabetes 18 (8), 824-831 (2017)
   PUBMED   28101933
  REMARK    GeneRIF: rs13342232 might be involved in the risk of
            pediatric-onset type 2 diabetes in Mexican families
REFERENCE   7  (bases 1 to 1726)
  AUTHORS   Traurig,M., Hanson,R.L., Marinelarena,A., Kobes,S., Piaggi,P.,
            Cole,S., Curran,J.E., Blangero,J., Goring,H., Kumar,S.,
            Nelson,R.G., Howard,B.V., Knowler,W.C., Baier,L.J. and Bogardus,C.
  TITLE     Analysis of SLC16A11 Variants in 12,811 American Indians:
            Genotype-Obesity Interaction for Type 2 Diabetes and an Association
            With RNASEK Expression
  JOURNAL   Diabetes 65 (2), 510-519 (2016)
   PUBMED   26487785
  REMARK    GeneRIF: Our study identified an association between the SLC16A11
            variant rs75493593 and type 2 diabetes in American Indians, where
            the effect on diabetes was much more pronounced in nonobese
            individuals. rs75493593 was also associated with RNASEK gene
            expression.
REFERENCE   8  (bases 1 to 1726)
  AUTHORS   Lara-Riegos,J.C., Ortiz-Lopez,M.G., Pena-Espinoza,B.I.,
            Montufar-Robles,I., Pena-Rico,M.A., Sanchez-Pozos,K.,
            Granados-Silvestre,M.A. and Menjivar,M.
  TITLE     Diabetes susceptibility in Mayas: Evidence for the involvement of
            polymorphisms in HHEX, HNF4alpha, KCNJ11, PPARgamma, CDKN2A/2B,
            SLC30A8, CDC123/CAMK1D, TCF7L2, ABCA1 and SLC16A11 genes
  JOURNAL   Gene 565 (1), 68-75 (2015)
   PUBMED   25839936
  REMARK    GeneRIF: Genetic association studies show that common variants in
            ABCA1 and SLC16A11 are involved in type 2 diabetes (T2D)
            susceptibility. Particularly, the variants rs10811661 (CDKN2A/2B)
            and rs9282541 (ABCA1) are associated with T2D in adult Maya
            population.
REFERENCE   9  (bases 1 to 1726)
  AUTHORS   Williams,A.L., Jacobs,S.B., Moreno-Macias,H., Huerta-Chagoya,A.,
            Churchhouse,C., Marquez-Luna,C., Garcia-Ortiz,H.,
            Gomez-Vazquez,M.J., Burtt,N.P., Aguilar-Salinas,C.A.,
            Gonzalez-Villalpando,C., Florez,J.C., Orozco,L., Haiman,C.A.,
            Tusie-Luna,T. and Altshuler,D.
  CONSRTM   SIGMA Type 2 Diabetes Consortium
  TITLE     Sequence variants in SLC16A11 are a common risk factor for type 2
            diabetes in Mexico
  JOURNAL   Nature 506 (7486), 97-101 (2014)
   PUBMED   24390345
  REMARK    GeneRIF: Despite type 2 diabetes having been well studied by GWAS
            in other populations, analysis in Mexican and Latin American
            individuals identified SLC16A11 as a novel candidate gene for type
            2 diabetes with a possible role in triacylglycerol metabolism.
REFERENCE   10 (bases 1 to 1726)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC040977.10.
            
            On May 10, 2019 this sequence version replaced XM_005256488.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.300489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574600.3/ ENSP00000460927.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC040977.10        168619-168936       c
            319-526             AC040977.10        168156-168363       c
            527-670             AC040977.10        167774-167917       c
            671-1438            AC040977.10        166840-167607       c
            1439-1726           AC040977.10        166465-166752       c
FEATURES             Location/Qualifiers
     source          1..1726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1726
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /note="solute carrier family 16 member 11"
                     /db_xref="GeneID:162515"
                     /db_xref="HGNC:HGNC:23093"
                     /db_xref="MIM:615765"
     exon            1..318
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /inference="alignment:Splign:2.1.0"
     exon            319..526
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1668
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 16 (monocarboxylic acid
                     transporters), member 11; monocarboxylate transporter 11;
                     monocarboxylic acid transporter 11"
                     /codon_start=1
                     /product="monocarboxylate transporter 11 isoform 1"
                     /protein_id="NP_001357478.1"
                     /db_xref="CCDS:CCDS11086.2"
                     /db_xref="GeneID:162515"
                     /db_xref="HGNC:HGNC:23093"
                     /db_xref="MIM:615765"
                     /translation="MTPQPAGPPDGGWGWVVAAAAFAINGLSYGLLRSLGLAFPDLAE
                     HFDRSAQDTAWISALALAVQQAASPVGSALSTRWGARPVVMVGGVLASLGFVFSAFAS
                     DLLHLYLGLGLLAGFGWALVFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPAL
                     QLLLDTFGWRGALLLLGAITLHLTPCGALLLPLVLPGDPPAPPRSPLAALGLSLFTRR
                     AFSIFALGTALVGGGYFVPYVHLAPHALDRGLGGYGAALVVAVAAMGDAGARLVCGWL
                     ADQGWVPLPRLLAVFGALTGLGLWVVGLVPVVGGEESWGGPLLAAAVAYGLSAGSYAP
                     LVFGVLPGLVGVGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLLSGSLI
                     LSGSFIYIGLPRALPSCGPASPPATPPPETGELLPAPQAVLLSPGGPGSTLDTTC"
     exon            527..670
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /inference="alignment:Splign:2.1.0"
     exon            671..1438
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1726
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1696..1701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /note="hexamer: AATAAA"
     polyA_site      1726
                     /gene="SLC16A11"
                     /gene_synonym="MCT 11; MCT11"
                     /note="major polyA site"
ORIGIN      
        1 catttctcgc cgctcccccc tcccccgggc ctgggggttg tgtgtgtaca taattcaatc
       61 cccgtgggac tggcgtctgg cctcacgcgc ggcttgccgg attggctgtt tcagctcgcc
      121 cccgccctcc gtacaccccg cgtcccaggt ggctcaggcc cctgtggtga tctctgttta
      181 ccgagagagc ccgtccaagt tgggctccat cgctgccctc gctccccttc ggggcccccg
      241 cccgcctggg aagcagagag aaagccgggc ccagcccttc ctcacccttc ccctccccgc
      301 accgcccgga gaggtcggac ggcgatgacc ccccagcccg ccggaccccc ggatgggggc
      361 tggggctggg tggtggcggc cgcagccttc gcgataaacg ggctgtccta cgggctgctg
      421 cgctcgctgg gccttgcctt ccctgacctt gccgagcact ttgaccgaag cgcccaggac
      481 actgcgtgga tcagcgccct ggccctggcc gtgcagcagg cagccagccc cgtgggcagc
      541 gccctgagca cgcgctgggg ggcccgcccc gtggtgatgg ttgggggcgt cctcgcctcg
      601 ctgggcttcg tcttctcggc tttcgccagc gatctgctgc atctctacct cggcctgggc
      661 ctcctcgctg gctttggttg ggccctggtg ttcgcccccg ccctaggcac cctctcgcgt
      721 tacttctccc gccgtcgagt cttggcggtg gggctggcgc tcaccggcaa cggggcctcc
      781 tcgctgctcc tggcgcccgc cttgcagctt cttctcgata ctttcggctg gcggggcgct
      841 ctgctcctcc tcggcgcgat caccctccac ctcaccccct gtggcgccct gctgctaccc
      901 ctggtccttc ctggagaccc cccagcccca ccgcgtagtc ccctagctgc cctcggcctg
      961 agtctgttca cacgccgggc cttctcaatc tttgctctag gcacagccct ggttgggggc
     1021 gggtacttcg ttccttacgt gcacttggct ccccacgctt tagaccgggg cctgggggga
     1081 tacggagcag cgctggtggt ggccgtggct gcgatggggg atgcgggcgc ccggctggtc
     1141 tgcgggtggc tggcagacca aggctgggtg cccctcccgc ggctgctggc cgtattcggg
     1201 gctctgactg ggctggggct gtgggtggtg gggctggtgc ccgtggtggg cggcgaagag
     1261 agctgggggg gtcccctgct ggccgcggct gtggcctatg ggctgagcgc ggggagttac
     1321 gccccgctgg ttttcggtgt actccccggg ctggtgggcg tcggaggtgt ggtgcaggcc
     1381 acagggctgg tgatgatgct gatgagcctc ggggggctcc tgggccctcc cctgtcaggc
     1441 ttcctaaggg atgagacagg agacttcacc gcctctttcc tcctgtctgg ttctttgatc
     1501 ctctccggca gcttcatcta catagggttg cccagggcgc tgccctcctg tggtccagcc
     1561 tcccctccag ccacgcctcc cccagagacg ggggagctgc ttcccgctcc ccaggcagtc
     1621 ttgctgtccc caggaggccc tggctccact ctggacacca cttgttgatt attttcttgt
     1681 ttgagcccct cccccaataa agaattttta tcgggttttc ctgaaa
//
