LOCUS       NM_018593              10757 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 16 member 10 (SLC16A10), mRNA.
ACCESSION   NM_018593
VERSION     NM_018593.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10757)
  AUTHORS   Lu,L., Ning,Y., Gu,F., Lin,Z., Qin,Y., Feng,L., Tang,M. and Cao,Y.
  TITLE     The circular RNA circSLC16A10 alleviates diabetic retinopathy by
            improving mitochondrial function via the miR-761-5p/MFN2 axis
  JOURNAL   Cell Signal 121, 111283 (2024)
   PUBMED   38960059
  REMARK    GeneRIF: The circular RNA circSLC16A10 alleviates diabetic
            retinopathy by improving mitochondrial function via the
            miR-761-5p/MFN2 axis.
REFERENCE   2  (bases 1 to 10757)
  AUTHORS   Zeng,H., Zhou,Y., Liu,Z. and Liu,W.
  TITLE     MiR-21-5p modulates LPS-induced acute injury in alveolar epithelial
            cells by targeting SLC16A10
  JOURNAL   Sci Rep 14 (1), 11160 (2024)
   PUBMED   38750066
  REMARK    GeneRIF: MiR-21-5p modulates LPS-induced acute injury in alveolar
            epithelial cells by targeting SLC16A10.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10757)
  AUTHORS   Jensen,C.Z., Isaksen,J.L., Ahlberg,G., Olesen,M.S., Nygaard,B.,
            Ellervik,C. and Kanters,J.K.
  TITLE     Association of DIO2 and MCT10 Polymorphisms With Persistent
            Symptoms in LT4-Treated Patients in the UK Biobank
  JOURNAL   J Clin Endocrinol Metab 109 (2), e613-e622 (2024)
   PUBMED   37740545
  REMARK    GeneRIF: Association of DIO2 and MCT10 Polymorphisms With
            Persistent Symptoms in LT4-Treated Patients in the UK Biobank.
REFERENCE   4  (bases 1 to 10757)
  AUTHORS   Uter,J.C., Kramer,U.M., Schols,L., Rodriguez-Fornells,A., Gobel,A.,
            Heldmann,M., Lichtner,P., Brabant,G. and Munte,T.F.
  TITLE     Single Nucleotide Polymorphisms in Thyroid Hormone Transporter
            Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to
            Inter-Individual Variance of Executive Functions and Personality
            Traits
  JOURNAL   Exp Clin Endocrinol Diabetes 128 (9), 573-581 (2020)
   PUBMED   31820424
  REMARK    GeneRIF: Single Nucleotide Polymorphisms in Thyroid Hormone
            Transporter Genes MCT8, MCT10 and Deiodinase DIO2 Contribute to
            Inter-Individual Variance of Executive Functions and Personality
            Traits.
            Erratum:[Exp Clin Endocrinol Diabetes. 2020 Sep;128(9):e2. doi:
            10.1055/a-1102-8862.. PMID: 31978935]
REFERENCE   5  (bases 1 to 10757)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 10757)
  AUTHORS   Park,S.Y., Kim,J.K., Kim,I.J., Choi,B.K., Jung,K.Y., Lee,S.,
            Park,K.J., Chairoungdua,A., Kanai,Y., Endou,H. and Kim,D.K.
  TITLE     Reabsorption of neutral amino acids mediated by amino acid
            transporter LAT2 and TAT1 in the basolateral membrane of proximal
            tubule
  JOURNAL   Arch Pharm Res 28 (4), 421-432 (2005)
   PUBMED   15918515
REFERENCE   7  (bases 1 to 10757)
  AUTHORS   Halestrap,A.P. and Meredith,D.
  TITLE     The SLC16 gene family-from monocarboxylate transporters (MCTs) to
            aromatic amino acid transporters and beyond
  JOURNAL   Pflugers Arch 447 (5), 619-628 (2004)
   PUBMED   12739169
  REMARK    Review article
REFERENCE   8  (bases 1 to 10757)
  AUTHORS   Kim,D.K., Kanai,Y., Matsuo,H., Kim,J.Y., Chairoungdua,A.,
            Kobayashi,Y., Enomoto,A., Cha,S.H., Goya,T. and Endou,H.
  TITLE     The human T-type amino acid transporter-1: characterization, gene
            organization, and chromosomal location
  JOURNAL   Genomics 79 (1), 95-103 (2002)
   PUBMED   11827462
REFERENCE   9  (bases 1 to 10757)
  AUTHORS   Toure,A., Morin,L., Pineau,C., Becq,F., Dorseuil,O. and Gacon,G.
  TITLE     Tat1, a novel sulfate transporter specifically expressed in human
            male germ cells and potentially linked to rhogtpase signaling
  JOURNAL   J Biol Chem 276 (23), 20309-20315 (2001)
   PUBMED   11278976
REFERENCE   10 (bases 1 to 10757)
  AUTHORS   Kim,D.K., Kanai,Y., Chairoungdua,A., Matsuo,H., Cha,S.H. and
            Endou,H.
  TITLE     Expression cloning of a Na+-independent aromatic amino acid
            transporter with structural similarity to H+/monocarboxylate
            transporters
  JOURNAL   J Biol Chem 276 (20), 17221-17228 (2001)
   PUBMED   11278508
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360227.17, AB057445.1 and BC017968.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018593.4.
            
            Summary: SLC16A10 is a member of a family of plasma membrane amino
            acid transporters that mediate the Na(+)-independent transport of
            aromatic amino acids across the plasma membrane.[supplied by OMIM,
            Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126183.1, SRR1660805.257163.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368851.10/ ENSP00000357844.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AL360227.17        4328-4402
            76-2019             AB057445.1         1-1944
            2020-2968           BC017968.1         956-1904
            2969-10757          AL360227.17        140231-148019
FEATURES             Location/Qualifiers
     source          1..10757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..10757
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="solute carrier family 16 member 10"
                     /db_xref="GeneID:117247"
                     /db_xref="HGNC:HGNC:17027"
                     /db_xref="MIM:607550"
     exon            1..593
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1798
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="T-type amino acid transporter 1; solute carrier
                     family 16 (monocarboxylic acid transporters), member 10;
                     MCT 10; aromatic amino acid transporter 1; solute carrier
                     family 16, member 10 (aromatic amino acid transporter);
                     solute carrier family 16 (aromatic amino acid
                     transporter), member 10"
                     /codon_start=1
                     /product="monocarboxylate transporter 10"
                     /protein_id="NP_061063.2"
                     /db_xref="CCDS:CCDS5089.1"
                     /db_xref="GeneID:117247"
                     /db_xref="HGNC:HGNC:17027"
                     /db_xref="MIM:607550"
                     /translation="MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVE
                     KVEVELAGPATAEPHEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETF
                     GSKDDDKMVFKTAWVGSLSMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSS
                     FVSSIEPLYLTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLP
                     LLLRVLIDSVGLFYTLRVLCIFMFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKF
                     SPPKKIFNFAIFKVTAYAVWAVGIPLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMC
                     IGVTSGVGRLLFGRIADYVPGVKKVYLQVLSFFFIGLMSMMIPLCSIFGALIAVCLIM
                     GLFDGCFISIMAPIAFELVGAQDVSQAIGFLLGFMSIPMTVGPPIAGLLRDKLGSYDV
                     AFYLAGVPPLIGGAVLCFIPWIHSKKQREISKTTGKEKMEKMLENQNSLLSSSSGMFK
                     KESDSII"
     exon            594..738
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..1192
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1336
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1565
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..10757
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="hexamer: AATAAA"
     regulatory      2559..2564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="hexamer: AGTAAA"
     polyA_site      2574
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="major polyA site"
     polyA_site      2583
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="major polyA site"
     regulatory      4384..4389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="hexamer: AATAAA"
     polyA_site      4408
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
     regulatory      10734..10739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
                     /note="hexamer: AATAAA"
     polyA_site      10757
                     /gene="SLC16A10"
                     /gene_synonym="MCT10; PRO0813; TAT1"
ORIGIN      
        1 agtcgggggt gcggggctgt gacctagagg cttcagtgtc gatccccgag gtgttcgcgc
       61 gcgccagctg tcctcgcggc cgcctgcgcg ctggccgcct gcgcgctgcc agcccgcccg
      121 cccgccaggg gctccgccgc cctcgcctcg gcctcgttag cccgccagga gccccgcagc
      181 tcctccggga gcccgctggt aactcgcgtc cctcgcgctt ctccggcgcc tgaggggccc
      241 gcctcgggcc atggtgctct cccaggagga gccggactcc gcgcggggca cgagcgaggc
      301 gcagccgctc ggccccgcgc ccacgggggc cgctccgccg cccggcccgg gaccctcgga
      361 cagccccgag gcggctgtcg agaaggtgga ggtggagctg gcggggccgg cgaccgcgga
      421 gccccatgag ccccccgaac cccccgaggg cggctggggc tggctggtga tgctggcggc
      481 catgtggtgc aacgggtcgg tgttcggcat ccagaacgct tgcggggtgc tcttcgtgtc
      541 catgctggaa accttcggct ccaaagacga tgacaagatg gtctttaaga cagcatgggt
      601 aggttctctc tccatgggga tgattttctt ttgctgccca atagtcagcg tcttcacaga
      661 cctatttggt tgtcggaaaa cagctgtcgt gggtgctgct gttggatttg ttgggctcat
      721 gtccagttct tttgtaagtt ccatcgagcc tctgtacctt acctatggaa tcatatttgc
      781 ctgcggctgc tcctttgcat accagccttc attggtcatt ttgggacact atttcaagaa
      841 gcgccttgga ctggtgaatg gcattgtcac tgctggcagc agtgtcttca caatcctgct
      901 gcctttgctc ttaagggttc tgattgacag cgtgggcctc ttttacacat tgagggtgct
      961 ctgcatcttc atgtttgttc tctttctggc tggctttact taccgacctc ttgctaccag
     1021 taccaaagat aaagagagtg gaggtagcgg atcctccctc ttttccagga aaaagttcag
     1081 tcctccaaaa aaaattttca attttgccat cttcaaggtg acagcttatg cagtgtgggc
     1141 agttggaata ccacttgcac tttttggata ctttgtgcct tatgttcact tgatgaaaca
     1201 tgtaaatgaa agatttcaag atgaaaaaaa taaagaggtt gttctcatgt gcattggcgt
     1261 cacttcagga gttggacgac tgctctttgg ccggattgca gattatgtgc ctggtgtgaa
     1321 gaaggtttat ctacaggtac tctccttttt cttcattggt ctgatgtcca tgatgattcc
     1381 tctgtgtagc atctttgggg ccctcattgc tgtgtgcctc atcatgggtc tcttcgatgg
     1441 atgcttcatt tccattatgg ctcccatagc ctttgagtta gttggtgccc aggatgtctc
     1501 ccaagcaatt ggatttctgc tcggattcat gtctataccc atgactgttg gcccacccat
     1561 tgcagggtta cttcgtgaca aactgggctc ctatgatgtg gcattctacc tcgctggagt
     1621 ccctcccctt attggaggtg ctgtgctttg ttttatcccg tggatccata gtaagaagca
     1681 aagagagatc agtaaaacca ctggaaaaga aaagatggag aaaatgttgg aaaaccagaa
     1741 ctctctgctg tcaagttcat ctggaatgtt caagaaagaa tctgactcta ttatttaata
     1801 tcttacatac ctccaccaga ctggacttgc tttttgaatt ttaagcaagt ttcctttcct
     1861 tttatacaaa ttgcaaattt catatttttt taatcacatc ctaggaatag cacaataatt
     1921 gggaaataga acccttatca ctagaagaac cattttctgc cactaaatat ctctgatgtt
     1981 tccatgagtc tgagggcaga gactctggta tatgaaaacg tctgaaagtc acatattgtg
     2041 aaaatttgaa gctatctcag taaaaagcag ctttggaaac tgtgaatgat ctttagcttg
     2101 tacaaatgtt taaaaatacc tcaggctata ctgaaagggt tgcagtttgg ttaggagtgg
     2161 aaatattttg tttgttaatg atgtcttcag ttctggtacc tctgttttac tttcttatgc
     2221 tctttggaaa ctttttgcaa aatttaagcc tgggttctag ataataccag atctacctaa
     2281 acctcaagtc tatgttaaag ttgctttcct gctgttaaat aagctatgat attaagatat
     2341 tctgacttgc tccagtgtca agggaccttc tgggagcagg tgctaacata gtgttcagaa
     2401 tcaatatgtg agatgaaaag gatcccctcc aggaggatcc tgagctgttc agaaatcatt
     2461 taagtttaca gcgttgttcc ctttgcgttt gcagtgcgtt ttactcaagt agccagaaac
     2521 accccacgtt tctgaatttg tttaaactgt aacaataaag taaaatagaa tgcatgaaag
     2581 atattctggc gattgtaact tagaattttt ctgacttctg gatttgttgg cactagaacc
     2641 tgatatttaa agtcttactg agcagctatc aagtggcagt tacaggcaca aattggtgga
     2701 ggctggagga tggggagggg agcaaaaccc tttatatttg tgaagaaaat atctgtagct
     2761 gatagaaata attgcttaaa ttggtttatg aaattaatga gtctgaaaag gttaaaagca
     2821 cttataaaaa gaaccaagtc ctacatttcc agaactttct ggcaaaaatt tgcactcata
     2881 ttatttatcc tatgaacatt cccattgttt ttttttgcta tttatataca gattatcata
     2941 agaaagctct cagtttgagg acccaaaata aaaccaaagt catgccatga cccatactca
     3001 tttacaaaaa caagaacact ttcctctatc cctaaaatta tgctttagta cttgaggcct
     3061 ttaaaagtta gtgcttttga ttgtgaagac attcagcaac ttactttgtc atacatgcag
     3121 ttgcacctta ccacttctaa tagtgtcata tttcatattc aggggactta gataatttgc
     3181 ctgtggatgg ttcttttgca ggaaaaaaaa tctacatttt gaccatacta ccctttcatg
     3241 tccttattat aagcttttag aaaatgattt cattcagtca tgtccagtta tataaaacgt
     3301 tactttctca tttttgagaa gttcaacaaa acatactact aagaccaatc atcaaaccca
     3361 ctattataaa tgttaatttt ggctgggtaa ggtggcttgc gcctataatc ccagcacttt
     3421 gggaggctga ggagggaaga ttgcttgagc ccaggagttt gagaccagcc tgggcaacat
     3481 agcaagatcc tgtctctact aaaaataaaa aaaaaaatta ggccaagcat agtggctcat
     3541 gcctgtaatc ctagcacttt ggtagtccaa ggcaggggga tcacttgagc ccagaagttc
     3601 aagaccagct tgggtaacat aatgagaccc tgtgtctaca aaaaatttaa aaattagcca
     3661 ggcatgatgg tgcccacctg tagccccagc tactcagagg ctgaggtagt ggaaggattg
     3721 cttgagcctt gagatggagg ctgcagtgag ctatgccact gtactctagc ctgttcaact
     3781 gagcagaacc ctgtctgtaa aagaaaatca aaaacaaaaa ataaatgtta aattttgttt
     3841 taagttttag cacagactcc cctcaaaaca ccttctcccc aattttacag aaagtaattt
     3901 aaaaatgaaa actttactct gtaaagacct ctacagtgtt tttcttttca aaatttggct
     3961 gattttagga aaaaagtgat catctgaaac taaaagaaat tgcttggtta gtttccatat
     4021 taaaacagca gtgacaagta tatataactt agatctcagc atatgtgttt gtatattaaa
     4081 cttcacatat gtagttttca gtttaatgga atgaatcaaa ctggatctat aacactgaaa
     4141 aagttctatt gtaatagact catacggaga atactctgct ataataatat aaaattaaga
     4201 agaaaaagta taaacgtaag atgctaaatt ccataaatgc atatttagta ctatgttttt
     4261 tgtgggaaaa gttctaaaag tttaaaatgc acaaagaaaa tgaaaaatac taatataaaa
     4321 atttgtgctt taatctagtc aaactaaatc ctttctaatt tctgaatgaa gtgttactgc
     4381 tgcaataaag tgacctgata agcctaaatt ttttgtgttc aatccagaca cttttctgag
     4441 agtctgaaaa gaatacagag tcagaactct gtttttatct cctcatcctg tttttgataa
     4501 gactcagaaa attctcaaat tcgaaaggtt ctggcatttg aggccaaaaa aagcatgaaa
     4561 gggagtaaca ttccttttta tagatactct agattggata ctattgtaac agatggccaa
     4621 gaaacttcca gaaacatttt ggttaaattt tattgcaatg gatattgctg ggatccatcc
     4681 atttaagcag taatatacca cccagattat tgatacttta tgcaagatgt gttcatctct
     4741 ttgatcatat ttacaatgct tactccatag ccctgctaca agacttaaaa tttccactga
     4801 aaattgcata gttcttgtat taagattcaa attctggctg ggcgcagtgg ctcacgcttg
     4861 taatcccagc actttgggag gctgaggcag gcggattgcc tgagctcagg agttcgcaac
     4921 cagcctggga aacacggtga agctccatct ctactaaaat acaaaaaaat tagccaggcg
     4981 tgtcggcatg cacctgtagt cccagctact cgggaagctg aggcaggaga agaatccagg
     5041 aggcagaggt tgcagtgagg cgagattgcg ccactgcact ccagcctggg cgacagagcg
     5101 agactccatc tcaaaaaaaa aaaaaaaaag taaaagtaca cacagtttaa aagtaaacat
     5161 gtttacttcg gataattcta atccttttag ctgcatttaa gaatatttta atttatacga
     5221 atgttacttg aaattggcct atgtccagat gacttttgat gttaaatcaa tggaaaactg
     5281 aatagaaaat atgacacgag atcggggagg gggaaggcaa cctatagcat gggtggctct
     5341 gaggagttcc tgctggtgca ctttcatgcc ctttcttatg taccttttgt cttactcttc
     5401 ttacattatt cttatcctca tcattttttc atttcccttt acttcctcct atccttcaaa
     5461 aacctcctga agagtccatt aacatccatg cttagttcca ctggttgcat ggctgtattt
     5521 cctactgatc cctgtagttt cactgaatgg atccccaccc aatttcgtgt atcctggtga
     5581 atggctttct ctcagccttc gacttagttc taatgatcta cattgaattt aaattacatg
     5641 actgaaatat ttaagggaag aaataaattt catacaaatt agtatctttt atgctaacat
     5701 ttaaaactgt atttaaattt ttaaggtaaa tgctttgggg aaaaaaaaaa ccattgccaa
     5761 gtctttagca tattttcaga gagcgtaatt ttttactttg atttccagtt tcactaaggt
     5821 ttcattaaat cttagttccg agagcccagc atgaagggtg actgggaatg tagtgtgcct
     5881 ctctgatgca gttcctaatg attgttcttc agggaccttc cttaggttag gttacatttt
     5941 ctggtgaatg gtgttagagt aaattcccag agtttagaga tacaagtaga aatgcataag
     6001 ctaattagct ccaattttat aatatgtaaa caatttaaac aagtatttaa aactttttag
     6061 gaagtctcta acactgaaaa aaaggtcatt gttgctggta taaacattaa ggagcaactt
     6121 ttacattagg tcaaagattg ttgcttttcc agtgtgttgt cttaaaaata gaaggaaata
     6181 aaactattac cttcttttta catctatatg tttttataat ttgaaaggca agtagtatct
     6241 tggtgaataa gaaatgcatc atccataaca atttaattaa ctcttaaaaa gaccagcttt
     6301 ttgtcttgtt atgaaaacaa aacgcaattt gtcattcata atggtaatgt ggaataagaa
     6361 tacatcgtag aaggaagact tgctacttta ctgacttaat cattagttct aaggccatgt
     6421 gtggcggctc acgcctgtaa tcccagcact ttgggagtcc aaggcggtag gatcaccaga
     6481 gcccagggtt caagactcag cctgggcaac atagtgagat ttcgtctcta caaaaaaaat
     6541 ttagccagct tggtggcaca tgcctgtagt cccagctact caggaggctg aggcaagagg
     6601 attgcttgag catagcaggt caagtctgca gtgagctgtg gttgcaccac tgcactccag
     6661 cctgggtgac aaaatgagac cttgtctaca aaaaggaaaa aaaaatttgt tctgctctac
     6721 tatacatgct gacttttgtt gatagcttgg tctaaaaaga ctgtctagag ctgaatttaa
     6781 gaatggttct ggagcaaata ataacaaggt agacaagcag gccctgggct cactataatt
     6841 tcatagccac gacctgttta ttattagttg gcagagatta atgctttgtg ttataaatat
     6901 actatagaac aataggtcac gattctcaag aacaaagccg aatgctcgca gttaagtgtg
     6961 aagcttgcat aagtgtcgga accacaatta tggacccacc atcaatgtgc attttatcag
     7021 atgactcctc ctgagacagt aaagactcct ggaaaattca tgacatcttt gaatcactca
     7081 gaaaaatctt gaaactcagg acgtagttta cttagcttgc cttttttaaa attatcaaat
     7141 tttaaatcgt aaactttgtc ttcacttcca cacgttcaag gacacctctt ttaaagttca
     7201 gtgttccata ctaaaggggt gtaatcttgc tttctgggga aataaaattc cccatggtac
     7261 tatattcctg acagatataa aataacatga ggctacctca tttttgaaat agatttcaat
     7321 atttttatta gtaagttgga aagacagtag gaacaaaatg aaacctttct aagtacttga
     7381 tgacacccac ttgatcatga caattcatct acctccgctt tccgtgtcca gctgaaagcc
     7441 cagctgagtc aactcctgct tcatcagaag ggagctaatg gtgattctgg gattaaaaag
     7501 caaggggggt gcaaattgtt agtggggtca aaatatcagt aaaatttctt aagtgctttg
     7561 ttctgataaa cggatgtaaa agtaacaaaa aaggaataac aactaatatg gcctgtggat
     7621 ctgacaaaga aaaacctgaa gaaattcaga atctagatac acttagattc taaattagac
     7681 acactcagat tctaatgaac acttagaatg cttcgccagt ggcttttcaa gttacactgg
     7741 aagcttgatt atgaaaaagt tttgttttca ttggcaagag ggtagatgat cagtgatgac
     7801 agattgtaca gctgtgccca aacctgacaa cttacacatt aaactcctgt aagagacact
     7861 ccttcctagt agaacaagga ctgggacaat gaatttttga ctcactggag ttttttaaaa
     7921 tgctgttctt gagtgtggca atagtgtagg agttaaccca gtctacccaa agaagttgct
     7981 ttgcctttca atatgagtgc tataaaaaga gtattttgga gttcaatgtc cctaaacatg
     8041 tatgcgatag gaactaccaa tataaaataa cacttagaac tcaaattaga ttggtaatac
     8101 tattttggag cctgtgatgt atgactttta ttctttacta gatatttttc agtatccgtc
     8161 attagaagag tcagtttgtt aaatatttta aatgtgtaaa cacaaaacct ttctactgtg
     8221 atcttcccta atgagtcaaa gtatctttca taattcagtc tatattgaaa tgttatttca
     8281 ggaatggagg gtttgttatt aatagtgctg ggccgggcac ggtgactcat gcctgtaatc
     8341 ccagcacttt gggaggccga gacaggcgaa tcacctgagg tcagatgttg gagaccagcc
     8401 tgaccaacat ggagaaaccc catctctacc aaaaatacaa aattagccgg gcgtggtggc
     8461 tccatgctgt aatcccagct actcgggagg ctgaggcagg agaattgctt gaacccagga
     8521 ggtggaggtt gcagtgagcc aagattgcac catagcactc cagcctgggc aacaagagca
     8581 aaactctgtc tcaaaaaaaa aaaaaaaaaa aatagtgctg cattttgacc ctggactatg
     8641 aacagactgt atagttggtg cctctttttt ttctaccaaa gattattaga tcaagattgg
     8701 tgctatactt catgttcctt tcaaaattat ttttctttta aaaatattaa tatacaacac
     8761 aatagaaaat gtatacagcc agcaacgtta tgcatgttgc atgttatata catgactgag
     8821 gaaaaaagct cacctataca gtgattattg agttccagta tctagttaga ggtatgcaat
     8881 ttttgttaac atataagact ttaaattacg aaactcacaa gaaaatgatc accaaatgag
     8941 aatgttctaa tgaacacaac ctcccaaggt aataatttta aagaaaaagt cccttgtcaa
     9001 tgtttctagc acaaagtgag ggatttaaat atattctgta actttgaggc aatgtgaaaa
     9061 agttatatat aatagcttcc tattgagctg gcttatgtag acatttggac atttgaaact
     9121 atttcgcaac tttcaggcta aaatcagagt tttgagagtc atcaatctta aaacatggat
     9181 aatgagttat ttgcacagtt atatttttat aattatttga aatttatcac tgaaagtatc
     9241 attgtttgtc tttcagattt aacataaaca ataagtactg cggctgggtc actgtcagca
     9301 aatctcaggt ctatgattta tcaagggctc tcagcaccat cgttggtctg attgtgtaac
     9361 acctaagtaa aataacatat gggtctcctt ggccaggcgc cgtggctcac acctgtaatc
     9421 ccagcacttt gggaggccaa ggcaggcgga ttgcttgagg ccaggagttc gagacatacg
     9481 ggtctcttta atgttctgta ggtaggattc agatgaattg agaatgacag gtttcttttt
     9541 ctttctttgt ttcttttttt tttttttttt tgagatggag tcttgctcta ttgccaggct
     9601 ccatatagtg gcgcgatctc agctcactgc aacctccgcc tcccgggctc aagtgattct
     9661 cgtgcctcag tcttctgagt agctgggact acaggtgccc actaccacac cggctaattt
     9721 ttgtattttt ggtagagatg gagtttcacc atgttggcca gactggcctt aagtgatcca
     9781 cctgcctcag cctccccaag tgctggaatt acaggcatga gccaccatgc ccggctagag
     9841 aatgacaggt ttcagttgaa ttcttctctt ttaaaagacc ctgacttaac tgtattttat
     9901 gaggatttta taaatgtaaa ttaagaagac aatacacact ctcattttcc taattagaaa
     9961 gactatgcat tcacaatcca gtacactgga tttgctctgg taactaatga taacactttt
    10021 ctacgttaac atgagttata tttggcagag agaatggaag cttgctaatc agaagttaca
    10081 ttagggtgag attaaacatc actctaataa taacttctga tgtaacttaa tgtggtttga
    10141 gatgtgtaag attgtagagg cattgcacaa tgcttgataa aagttgcatt ttgcttttgt
    10201 tcttccacca gtttatttta gccttaaagt tatagctaca acaaattgaa ccctgtagtt
    10261 attactgaaa gagagtgtgg atattttaag tatctcctag tataatatga cattgttcat
    10321 gtggacttat tttaatgttt atttgaaaat taatttttta attattttgt atattttgag
    10381 ttagaaaaac acactttatc ttagacacca aagccaaatt attccaagtg tatgctatac
    10441 accgcagtgc agctctgctt ctctcccaac ctaccctggg gccatttttg gcacaatagt
    10501 tgttcaaatg tagatcacta tgctgaatgc tcatgctgga tttgaccagt atgcagtatt
    10561 ttagtacttt ttaaaaaatg tatgcttctt tttgaagact ataatttaca atttttttaa
    10621 taatgtgcaa tttaatatag ataaccaaaa tctttttaat gaaaagatct ttacaattgc
    10681 ttggaggata agattatttt actgtggaaa aatgtgatac tcttagtaaa tgcaataaaa
    10741 actttttagc aaattcc
//
